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http://dx.doi.org/10.5483/BMBRep.2013.46.6.208

Posttranscriptional deregulation of Src due to aberrant miR34a and miR203 contributes to gastric cancer development  

Hao, Qiang (The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, The Fourth Military Medical University)
Lu, Xiaozhao (Department of Nephrology, The 323 Hospital of PLA)
Liu, Nannan (The Preclinical Medical Teaching Experiment Center, School of Basic Medical Sciences, The Fourth Military Medical University)
Xue, Xiaochang (The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, The Fourth Military Medical University)
Li, Meng (The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, The Fourth Military Medical University)
Zhang, Cun (The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, The Fourth Military Medical University)
Qin, Xin (The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, The Fourth Military Medical University)
Li, Weina (The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, The Fourth Military Medical University)
Shu, Zhen (The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, The Fourth Military Medical University)
Song, Bin (Department of Urology, Tangdu Hospital, The Fourth Military Medical University)
Wang, Qing (Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University)
Song, Liqiang (Department of Respiratory Medicine, Xijing Hospital, The Fourth Military Medical University)
Zhang, Wei (The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, The Fourth Military Medical University)
Zhang, Yingqi (The State Key Laboratory of Cancer Biology, School of Pharmacy, Department of Biopharmaceutics, The Fourth Military Medical University)
Publication Information
BMB Reports / v.46, no.6, 2013 , pp. 316-321 More about this Journal
Abstract
Gastric cancer remains the main cause of cancer death all around the world, and upregulated activation of the nonreceptor tyrosine kinase c-SRC (SRC) is a key player in the development. In this study, we found that expression of Src is also increased in clinical gastric cancer samples, with the protein level increased more significantly than that at the RNA level. Further study revealed that miR34a and miR203, two tumor suppressive miRNAs, inversely correlate with the expression of Src. Restoration of miR34a and miR203 decreased Src expression in gastric cancer cell lines, which in turn inhibited cell growth and cell migration. In summary, our study here revealed that posttranscriptional regulation of Src contributes to the deregulated cell growth and metastasis in gastric cancer, and targeting Src by miR34a or miR203 mimics would be a promising strategy in therapy.
Keywords
Gastric cancer; miRNA; miR203; miR34a; Src;
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