• Asian-Australasian Journal of Animal Sciences
• /
• 제20권10호
• /
• pp.1490-1495
• /
• 2007

Insulin-like growth factor binding protein-4 (IGFBP-4) is a member of the IGF super family, and regulates the action of IGFs. The polymorphism of porcine IGFBP-4 gene in 17 pig breeds (total n = 570) was detected by PCR-SSCP, and alleles A and B were detected. In these pig breeds, it was found that exotic pig breeds carried high frequencies of allele A, while Chinese native pig breeds carried high frequencies of allele B. The role of porcine IGFBP-4 was investigated in 172 F2 offspring of a $Lantang{\times}Lantang $ population. Forty eight growth traits were recorded for analyzing the association between IGFBP-4 gene polymorphism and quantitative performance traits. In this resource family, pigs with AA genotype had higher fore-body weight, bone weight of mid-body, bone weight of rear-body, fore-leg weight and rear-leg weight than those pigs with BB genotype (p<0.05); while pigs which carried BB genotype had higher back-fat thickness at C point and lard weight than those pigs with AA genotype (p<0.05); pigs with AA genotype had higher body weight than those with BB genotype; for meat quality traits, pigs with AA genotype had higher meat color than those of BB genotype (p<0.01), and pigs with BB genotype had higher marbling than those of AA and AB genotypes (p<0.01 and p<0.05, respectively).Based on these results, it is necessary to do more studies on IGFBP-4 before using the IGFBP-4 locus for the application of marker-assisted selection programs.

• Advances in concrete construction
• /
• 제9권4호
• /
• pp.413-421
• /
• 2020

For steel-concrete girders made composite using shear studs, initial damage on studs induced by weld defect, unexpected overloading, fatigue and others might degrade the service performance and even threaten the structural safety. This paper conducted a numerical study to investigate the static behavior of damaged stud shear connectors that were embedded in ultra high performance concrete (UHPC). Parameters included damage degree and damage location. The material nonlinear behavior was characterized by multi-linear stress-strain relationship and damage plasticity model. The results indicated that the shear strength was not sensitive to the damage degree when the damage occurred at 2/3d (d is the stud diameter) from the stud root. An increased stud area would be engaged in resisting shear force as the distance of damage location from stud root increased and the failure section becomes inclined, resulting in a less reduction in the shear strength and shear stiffness. The reduction factor was proposed to consider the degradation of the shear strength of the damaged stud. The reduction factor can be calculated using two approaches: a linear relationship and a square relationship with the damage degree corresponding to the shear strength dominated by the section area and the nominal diameter of the damaged stud. It was found that the proposed method is preferred to predict the shear strength of a stud with initial damage.

• Journal of Microbiology and Biotechnology
• /
• 제23권12호
• /
• pp.1737-1746
• /
• 2013

IbMYB1, a transcription factor (TF) for R2R3-type MYB TFs, is a key regulator of anthocyanin biosynthesis during storage of sweet potatoes. Anthocyanins provide important antioxidants of nutritional value to humans, and also protect plants from oxidative stress. This study aimed to increase transgenic potatoes' (Solanum tuberosum cv. LongShu No.3) tolerance to environmental stress and enhance their nutritional value. Transgenic potato plants expressing IbMYB1 genes under the control of an oxidative stress-inducible peroxidase (SWPA2) promoter (referred to as SM plants) were successfully generated through Agrobacterium-mediated transformation. Two representative transgenic SM5 and SM12 lines were evaluated for enhanced tolerance to salinity, UV-B rays, and drought conditions. Following treatment of 100 mM NaCl, seedlings of SM5 and SM12 lines showed less root damage and more shoot growth than control lines expressing only an empty vector. Transgenic potato plants in pots treated with 400 mM NaCl showed high amounts of secondary metabolites, including phenols, anthocyanins, and flavonoids, compared with control plants. After treatment of 400 mM NaCl, transgenic potato plants also showed high DDPH radical scavenging activity and high PS II photochemical efficiency compared with the control line. Furthermore, following treatment of NaCl, UV-B, and drought stress, the expression levels of IbMYB1 and several structural genes in the flavonoid biosynthesis such as CHS, DFR, and ANS in transgenic plants were found to be correlated with plant phenotype. The results suggest that enhanced IbMYB1 expression affects secondary metabolism, which leads to improved tolerance ability in transgenic potatoes.

• 한국환경생태학회지
• /
• 제24권1호
• /
• pp.78-86
• /
• 2010

국내 주요 도시에서 수행된 비오톱유형 분류는 생물서식처 관점보다는 토지이용 개념에 한정되어 분류되었고, 생태적 가치에 따라 상세하게 분류되지 못하였다. 비오톱유형은 지역적 특성을 고려하여 생물서식처 관점에 따라 분류되어야 한다. 본 논문은 비오톱유형 분류에 사용되는 분류위계, 분류항목, 분류요인, 분류지표, 분류기준, 분류key 등 분류인자의 개념적 틀을 명확하게 설정하고 사례도시의 비오톱유형 분류결과에 적용하여 문제점을 고찰하고 비오톱유형 분류체계 개선방향을 제안하였다. 비오톱유형 분류체계는 위계별로 분류의 기본 수준과 기준을 마련하여 일관된 분류 특성을 가져야 한다. 분류지표는 생물적 요인, 무생물적 요인, 인간행태적 요인을 고려하여 적용되어야 한다. 비오톱유형은 일반인들과 계획가들이 이해하기 쉽도록 분류지표와 분류key의 표준화와 더불어 지역 비오톱 특성을 반영할 수 있도록 분류key와 분류기준의 특성화를 반영하는 것이 필요하다.

• Journal of Power Electronics
• /
• 제17권3호
• /
• pp.766-776
• /
• 2017

In modern power systems, high penetration of distributed generators (DGs) results in high stress on system stability. Apart from the intermittent nature of DGs, most DGs do not contribute inertia or damping to systems. As a result, a new control method named virtual synchronous machine (VSM) was proposed, which brought new characteristics to inverters such as synchronous machines (SMs). In addition, different active power droop controls for VSMs are being proposed in literatures. However, they are quite different in terms of their dynamic characteristics despite of the similar control laws. In this paper, mathematical models of a VSM adopting different active power droop controls are built and analyzed. The dynamic performance of the VSM output active power and virtual rotor angular frequency are presented for different models. The influences of the damping factor and droop coefficient on the VSM dynamic behaviors are also investigated in detail. Finally, the theoretical analysis is verified by simulations and experimental results.

• Genomics & Informatics
• /
• 제20권3호
• /
• pp.26.1-26.19
• /
• 2022

Diabetes and its related complications are associated with long term damage and failure of various organ systems. The microvascular complications of diabetes considered in this study are diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy. The aim is to identify the weighted co-expressed and differentially expressed genes (DEGs), major pathways, and their miRNA, transcription factors (TFs) and drugs interacting in all the three conditions. The primary goal is to identify vital DEGs in all the three conditions. The overlapped five genes (AKT1, NFKB1, MAPK3, PDPK1, and TNF) from the DEGs and the co-expressed genes were defined as key genes, which differentially expressed in all the three cases. Then the protein-protein interaction network and gene set linkage analysis (GSLA) of key genes was performed. GSLA, gene ontology, and pathway enrichment analysis of the key genes elucidates nine major pathways in diabetes. Subsequently, we constructed the miRNA-gene and transcription factor-gene regulatory network of the five gene of interest in the nine major pathways were studied. hsa-mir-34a-5p, a major miRNA that interacted with all the five genes. RELA, FOXO3, PDX1, and SREBF1 were the TFs interacting with the major five gene of interest. Finally, drug-gene interaction network elucidates five potential drugs to treat the genes of interest. This research reveals biomarker genes, miRNA, TFs, and therapeutic drugs in the key signaling pathways, which may help us, understand the processes of all three secondary microvascular problems and aid in disease detection and management.

• 한국농공학회지
• /
• 제45권3호
• /
• pp.29-40
• /
• 2003

The objective of the paper is to compute the half-month rainfall-runoff erosivity factor for revised universal soil loss equation (RUSLE). RUSLE is being used to develop soil conservation programs and identify optimum management practices. Rainfall-runoff erosivity factor (R) is a key input parameter to RUSLE. Rainfall-runoff erosivity factor has been calculated for twenty six stations from the nationwide rainfall data from 1973 to 2002 in south Korea. The average annual Rainfall-runoff erosivity factor at the analyzed stations Is between 3,130 and 10,476 (MJ/ha)ㆍ(mm/h). According to the computation of the half-month Rainfall-runoff erosivity factor for locations, 66-85% of the average annual R value has occurred during the summer months, June-August. The half-month R values from this study can be used for RUSLE.

• Journal of Electrical Engineering and Technology
• /
• 제12권1호
• /
• pp.385-395
• /
• 2017

A new digitized decoupled dual-axis micro dynamically tuned gyroscope with three equilibrium rings (TMDTG) is proposed which can eliminate the constant torque disturbance (CTD) caused by the double rotation frequency of a driving shaft with a micro dynamically tuned gyroscope with one equilibrium ring (MDTG). A mechanical and kinematic model of the TMDTG is theoretically analyzed and the structure parameters are optimized in ANSYS to demonstrate reliability. By adjusting the thickness of each equilibrium ring, the CTD can be eliminated. The digitized model of the TMDTG system is then simulated and examined using MATLAB. Finally, a digitized prototype based on FPGA is created. The gyroscope can be dynamically tuned by adjusting feedback voltage. Experimental results show the TMDTG has good performance with a scale factor of $283LSB/^{\circ}/s$ in X-axis and $220LSB/^{\circ}/s$ in Y-axis, respectively. The scale factor non-linearity is 0.09% in X-axis and 0.13% in Y-axis. Results from analytical models, simulations, and experiments demonstrate the feasibility of the proposed TMDTG.

• BMB Reports
• /
• 제40권4호
• /
• pp.547-553
• /
• 2007

Many motifs along the 1.2 kb myostatin promoter (MSTNpro) in sheep have been found by the MatInspecter program in our recent study. To further verify the role of the motifs and better understand the transcriptional regulation mechanism of the myostatin gene in sheep, the reporter gene EGFP (enhanced green fluorescent protein) was selected and the wild-type (W) vector MSTNPro$^W$-EGFP or motif-mutational (M) vector MSTNPro$^M$-EGFP were constructed. The transcriptional regulation activities were analyzed by detecting the fluorescence strength of EGFP in C2C12 myoblasts transfected with the vectors. The results showed that E-box (E) 3, E4, E5 and E7, particularly E3, E5 and E7, had important effects on the activity of the 1.2 kb sheep myostatin promoter. In addition, we also detected several other important motifs such as MTBF (muscle-specific Mt binding factor), MEF2 (myocyte enhancer factor 2), GRE (glucocorticoid response elements) and PRE (progesterone response elements) along the sheep myostatin promoter by the mutational analysis.

• 시스템엔지니어링학술지
• /
• 제11권2호
• /
• pp.85-93
• /
• 2015

Warehouse Management System (WMS) is a key control for Material Handling System (MHS) and Inventory Control System (ICS). How to design and implement for WMS is crucial factor for achieving the key performance index for Manufacturing Industry. In particular, iron and steel making industry, where the volume and weight is large and hence FIFO (First Input First Out) is not working, how to design WMS is a key factor. In this paper, we systematically define the problem of WMS via developing StR (Stakeholders' Requirements) or ORD (Operational Requirement Documents), SyR (System Requirement), and SA (System Architecture) based on the emerging technologies. In particular, IoT (Internet of Things), CPS (Cyber Physical System) concepts and enabling technologies haves been incorporated in developing Smart WMS. The deliverables of the research can provide a conceptual framework for developing the next generation industrial WMS.