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The Study on Pharmacokinetics According to the Administration Route (흡수경로에 따른 약물동태학적 고찰)

  • Park, Min-Cheol;Kim, Hwan-Yeong;Jo, Eun-Hee
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.22 no.3
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    • pp.95-107
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    • 2009
  • Objective : The purpose of this study is to search for more effective administraion route of herbal medicine. Methods : Pharmacokinetic issues with the methods in experimental papers, which deal with finding the effectiveness of two or more administration routes of herbal medicine, searched from KERIS, KSI, KISTI and KTKP, have been analyzed by, first, categorizing the papers and comparing the validity of administration routes. Results and Conclusions : 1. Upon comparing in total of 24 papers on the basis of each administration route, per oral(PO)-herbal acupuncture(HA) was most superior in terms of number in that there were 13 cases and PO-per rectal(PR) was next superior in that there were 5 cases. PO-per dermal(PD)-inhalation therapy(IT), PO-IT and PO-PR-HA had 3, 2 and 1 cases respectively. 2. Out of the total 24 papers which compares different administration routes, 16 of them were pharmacokinetically appropriate, whereas, the remaining 8 were pharmacokinetically inappropriate. 3. Comparisons were made between PO-HA, PO-PR, PO-IT, PO-PD-IT and PO-PR-HA routes. However, none of them was not particularly effective regardless of the administered medicine or target organ. 4. No route was particularly effective against a particular drug target as a result of comparing damaged liver, asthma, endometriosis and anti-inflammation. 5. In the case of Injinhotang in medicine comparison, HA tended to be more associated with hepatotoxicity over PO. However, Cordyceps Militaris Mycelia, Gagamsohaphyangwon and Hongdeungtang showed no prominent effective administration route.

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Effect of Exercise Programs for Chronic Low Back Pain Patients : A Systematic Review (만성 허리통증환자의 운동프로그램에 대한 효과)

  • Kang, Kwon-Young;Kim, Eun-Kyung;Hong, Gi-Hoon
    • Journal of Korean Physical Therapy Science
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    • v.18 no.2
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    • pp.1-8
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    • 2011
  • Background: The purpose of this study was to systematic review the effect of exercise programs for chronic low back pain patients. We needs systematic development of low back pain exercise program to reduce economic cost further doing great service to public health promotion. Methods: We searched to the effects of exercise programs for chronic low back pain patients by Dankook University electronic library databases of DBPIA, KSI KISS, CINAHL, MEDLINE and PEDro combined with a hand search of papers published in relevant journals. Any type of study relevant to the topic published during time period from 1970 to 2007 was included. Results: The literature search identified 30 studies. 1.Performing the flexion exercise increased abdominal muscle activity but acute herniated intervertebral disc should be avoided. 2.The general lumbar extension exercise used lumbar extension machine and the muscle power increases, significant probability the change. 3.The spinal segments exercise for the patients offered significant efficacy and appeared to be a reasonable therapeutic option. 4.Spinal stabilization exercises appear to improve trunk endurance and balance to patients with chronic low back pain. This exercise programs had effective decrease pain and disability. Conclusion: The review suggests that although the exercise programs for chronic low back pain patients, and we expected the efficacy of the exercise programs for chronic low back pain patients used in this study should be further investigated in a long period study and objective outcomes.

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Trends in Treatment with and Mechanism of Moxibustion in Cancer Patients: A Review (암 환자에 대한 구법의 치료와 메커니즘에 대한 최신 국내외 연구 현황)

  • Yoon, Hae-chang;Kang, Ji-young;Kim, Jun-young;Joung, Jin-yong;Son, Chang-gue;Lee, Nam-heon;Cho, Jung-hyo
    • The Journal of Internal Korean Medicine
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    • v.36 no.3
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    • pp.361-379
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    • 2015
  • Objectives This study aims to review and summarize existing evidence on moxibustion treatment for cancer patients. Methods Literature published until May 2015 in international journals were searched on PubMed, CAJ (CNKI-Medicine), NDSL (National discovery for science leaders), Sage Journal, ScienceDirect, Taylor&Francis Online (HSS), and Wiley Interscience (including Blackwell); and articles in Korean journals were searched on Korean Studies Information Service System (KISS), DBPIA, E-Article, KSI e-book, New article, Korea Institute of Science and Technology Information (KISTI), and Kyobo scholar. Results We analyzed 65 relevant studies. The number of studies conducted annually has increased and most are conducted in Korea and China. Moxibustion decreases the side effects of palliative treatment, thereby synergizing with anticancer treatment; it also improves the immune system, reduces tumor factors, and relieves symptoms. The mechanism of moxibustion is multi-fold: thermo, chemo, aero and kinetic. Only the kinetic effect is not significant. It also needs a complement to moxibustion because of harmful smoke. Conclusions Thus, the effect and mechanism of moxibustion in cancer patients was reviewed. There is an unmet need to develop a model of moxibustion and test it based on Korean medicine.

Research Trends on Development of Basic Patterns of Clothing -Focus on Research Reported in Korean Journals- (의복원형설계 관련 연구의 동향 -국내 학술지에 게재된 원형설계 논문을 중심으로-)

  • Oh, Song-Yun;Choi, Hei-Sun;Kim, Eun-Kyong
    • Journal of the Korean Society of Clothing and Textiles
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    • v.34 no.10
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    • pp.1596-1610
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    • 2010
  • This study investigates the studies of development of apparel basic pattern published in domestic journals and the trends in related studies. It also provides basic information on directions for future studies. The data was collected from the theses of domestic journals of the Korean Studies Information (KSI) which were published until December 31, 2009 and retrieved by a keyword related to the design of basic apparel patterns. The data was classified by the journals, the year of publication, research themes, research subjects, and research methods. They were analyzed to find out the overall distribution status and characteristics by time. The number of theses for the analysis was 73 published in 11 Journals total. Reviewing the theses by dividing the times into 7 Chronicles of 5 years in each term since the first thesis was published in 1968, it was found that more active research had been done as time went by. The theme of the theses in most cases was the composition of western apparel. As for items, most cases were on the study of bodice torso basic patterns. Since the period of 5-6 Chronicles, studies in the pattern of underwear, jacket, shirts blouse have gradually increased and the development of patterns using elastic materials are increasing as well. Women were dominant in the studies as subjects and so were young people of both sexes. Unlike the studies in earlier times that focused on the average figure, studies on developing patterns for various figure types have been made since the 5-6 Chronicles. However, there were limited studies on the figures of infants, male youth, seniors, and obese males. As for the research methods, there were common processes for validity testing of patterns through the measurement of the human figure, survey of customers and companies, designing pilot patterns, and wearing trials. The studies showed characteristic the differences in research methods according to the period.

Distribution of Functional Feeding and Habitat Trait Groups of Benthic Macroinvertebrates and Biological Evaluation of Water Quality in Gayasan National Park (가야산의 저서성 대형무척추동물 섭식기능군 및 서식습성군 분포와 생물학적 수질평가)

  • Moon, Tae Young;An, Mi Soon;Kim, Hyoung Gon;Yoon, Chun Sik;Cheong, Seon Woo
    • Journal of Environmental Science International
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    • v.27 no.6
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    • pp.383-399
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    • 2018
  • In the present study, the community distribution, functional feeding groups, and habitat groups of the benthic macroinvertebrates from Gayasan National Park were investigated at eight different sites from 2015 to 2016. The correlation between habitat altitude and each group type was analyzed statistically. Biodiversity indices, including dominance, diversity, richness, and evenness indices, were calculated. The results showed a total of 4,216 individual benthic macroinvertebrates were collected, including 4 phyla, 6 classes, 16 orders, 40 families, and 100 species. Gammarus sobaegensis was dominant with 0.141% dominance, and the subdominant species was Epeorus nipponicus with 0.088% dominance. The EPT group(Ephemeroptera, Plecoptera and Tricoptera) accounted for 71.00% of the total species and 67.69% of the total individuals. The number of scraper species was highest, and the number of gathering collector individuals was highest among functional feeding groups. The individual number of scrapers(r=-0.358, p < 0.05) and gathering collectors(r=-0.343, p < 0.05) decreased with increasing altitude. The numbers of species and individuals of clingers and sprawlers were highest among the habitat groups. The individual number of clingers(r=-0.547, p < 0.01) and burrowers(r=-0.331, p < 0.05) significantly decreased with increasing altitude. The diversity and richness indices were higher in St. 3 than in the other sites. The dominance index was highest in St. 2, and the evenness index was highest in St. 7. We evaluated the biological water quality with several known methods, and concluded that ESB(Ecological score of benthic macrovertebrates community) and GPI(Group polution index) were more suitable than KSI(Korean saprobic index) and BMI (Benthic macrovertebrate index) to assess the biological water quality of Gayasan mountain stream water.

Effects of Habitat Changes Caused by Localized Heavy Rain on the Distribution of Benthic Macroinvertebrates (집중호우에 의한 서식지변동이 저서성 대형무척추동물의 분포에 미치는 영향)

  • Kim, Hyoung-Gon;Yoon, Chun-Sik;Cheong, Seon-Woo
    • Journal of Environmental Science International
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    • v.27 no.8
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    • pp.689-699
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    • 2018
  • The changes on community structures of benthic macroinvertebrates, relevance to the environment and interrelationship between benthos were studied over two years in stream with large environmental disturbance, which caused by localized heavy rain during Typhoon Chaba in October 2016. As a result, the number of species and individuals were increased after localized heavy rain, especially numbers of individuals of Ephemeroptera and Plecoptera were greatly increased. On the contrary, those of Semisulcospira libertina and Semisulcospira forticosta of Mesogastropoda were greatly decreased. Dominant species was Baetis fuscatus of Ephemeroptera, numbers of species and individuals of Ephemeroptera, Plecoptera and Trichoptera(EPT group) were dramatically increased from 26 species, 110 individuals to 32 species, 365 individuals respectively. This suggests that the change of river bed and flow velocity due to heavy rain provided a suitable environment for the EPT group that preferred the rift of a stream. In the functional feeding group, only gathering collectors and filtering collectors were identified in autumn of 2017 because some functional groups preferentially adapted to the changed environment. The interspecific competition and environmental condition were the worst in autumn after heavy rain due to the increase individuals of some species. The ecological score of benthic macroinvertebrate community(ESB) was higher after the heavy rain than before. Results of the Group Pollution Index(GPI), Korean Saprobic Index(KSI) and Benthic Macroinvertebrate Index(BMI) were similar to those before and after heavy rainfall. Therefore, ESB was the most discriminating method for estimating the biological water quality in this study. Some species that are sensitive to water quality changes still appear or increase individuals in the area under investigation after the heavy rain. On the other hand, the individuals of some pollutant species decreased. This is thought to be because the habitat fluctuation caused by heavy rainfall has improved the water environment.

Analysis of Research Trends on Domestic Stage Costumes (무대의상 연구의 동향 분석)

  • Choi, Hyunok;Yi, Kyonghwa
    • Journal of Fashion Business
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    • v.18 no.2
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    • pp.1-13
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    • 2014
  • This study examines research trends in the dissertations and journal articles on stage costume so as to provide basic information on directions for future studies. The data was collected from the theses of domestic journals of the Korean Studies Information (KSI) which were published until December, 2012 and retrieved by a keyword related to the "design of stage costume", "costume for performing art", and etc. Theses and articles for the analyses were a total of 200 published. Reviewing the theses by dividing the times into 8 Chronicles of 5 years in each term. The findings of the study are as follows: According to the chronological analysis, there has been a steady increase in the rates of the musical, ballet, dance, and circus costume and cutting edged technology such as LED has been utilized in the performing art, currently. The real production and making up of the costumes have been increasing as well by replacing of illustration and rendering of the costumes. In the recent costume of the performing arts show the tends of the visual effects and up-sizing, comprehensiveness and fusion. From the analysis of the background of the work, those were confirmed that the most common historical period was modern period, and places were France, England, and Egypt. In regard to research themes and methods, many of research papers utilized content analysis method, character analysis method as research methods. The most popular presentation of the costume designs was "rendering", "costumes schedule" and "illustration". However, development and explanation of the patterns was insufficient and constructions methods and real works(costumes) were usually omitted in the articles.

The Effect of Mn on the Elevated Temperature Sliding Wear Behavior of Fe-20Cr-1C-1Si Hardfacing Alloy (Fe-20Cr-1C-1Si 경면처리 합금의 고온 Sliding 마모거동에 미치는 Mn의 영향)

  • Kim, Geun-Mo;Kim, Jun-Gi;Yang, Yeong-Seok;Gang, Seong-Gun;Kim, Seon-Jin
    • Korean Journal of Materials Research
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    • v.9 no.9
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    • pp.937-942
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    • 1999
  • Fe계 합금의 적층결함에너지를 감소시키는 것으로 알려진 Mn이 Fe-20Cr-1C-Si 경면처리 합금의 변형유기 상변태거동과 상온 및 고온 마모저항성에 미치는 영향에 대하여 조사하였다. 15ksi의 접촉응력에 대하여 0~25wt.% Mn을 첨가한 시편은 모두 상온에서 마모손실량이 적은 우수한 마모저항성을 보였는데 Mn 첨가량이 5wt.% 이하인 시편의 경우 마모표면에서 ${\gamma}$$\longrightarrow$$\alpha$\`변형유기 상변태가 발생한 반면 15wt.% 이상 Mn을 첨가한 시편에서는 ${\gamma}$$\longrightarrow$$\varepsilon$변형유기 상변태가 발생하는 것으로 나타났다. 25$0^{\circ}C$까지 고온 마모시험결과 ${\gamma}$$\longrightarrow$$\alpha$\`변형유기 상변태가 발생한 5wt.% 이하 Mn 첨가시편은 Mn 첨가량이 증가할수록 마모손실량이 증가하는 것으로 보아 Mn 첨가는 ${\gamma}$$\longrightarrow$$\alpha$\`변형유기 상변태에 있어서 고온 마모저항성을 저하시키는 것으로 생각되며 이는 Mn이 ${\gamma}$$\longrightarrow$$\alpha$\`변형유기 상변태의 M(sub)d 온도를 감소시키기 때문으로 생각된다. 반면에 ${\gamma}$$\longrightarrow$$\varepsilon$변형유기 상변태가 일어난 15wt.% 이상 Mn 첨가 시편의 경우 Mn 첨가량 증가에 따른 고온 마모손실량의 차이가 없는 것으로 보아 ${\gamma}$$\longrightarrow$$\varepsilon$변형유기 상변태는 ${\gamma}$$\longrightarrow$$\alpha$\`변형유기 상변태에 비해 온도의 존성이 적은 것으로 생각된다.

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Review of Red Ginseng in terms of Mechanisms for Pharmacodynamics and Toxicity (홍삼의 약리와 독성 기전에 대한 고찰)

  • Park, Yeong-Chul;Lim, Jung-Dae;Kim, Jong-Bong;Lee, Sundong
    • The Journal of Korean Medicine
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    • v.33 no.3
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    • pp.200-230
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    • 2012
  • Objectives: Ginseng, Panax ginseng C. A., white ginseng, has been used for thousands of years in Traditional Korean Medicine. Red ginseng can be made by a steaming process of white ginseng changing a variety of ginsenosides and ingredients such as dencichine. This article reviews red ginseng for mechanisms for pharmacodynamics and toxicity based on the content of ginseng's active ingredients, ginsenoside changed by steaming. Methods: The following electronic databases were searched: PubMed, Science Direct and Chinese Scientific Journals full text database (CQVIP), and KSI (Korean Studies Information) from their respective inceptions to June 2012. Results: Compared with unsteamed ginseng, the content of ginsenosides Rg2, Rg3, Rg5, Rh1, Rh2 and Rk1 called red ginseng-specific ginsenosides increased after the steaming process. Different ginsenosides have shown a wide variety of effects such as lowering or raising blood sugar and blood pressure or stimulating or sedating the nervous system. Especially, the levels of Rg2, Rg3, Rg5, Rh1, Rh2 and Rk1 were increased by the steaming process, showing a variety of pharmacodynamics in biological systems. Also, various processing methods such as puffing and fermentation have been developed in processing crude ginseng or red ginseng, affecting the content of ginseng's ingredients. The safety issue could be the most critical, specifically, on changed ginseng's ingredients such as dencichine. The level of dencichine was significantly reduced in red ginseng by the steaming process. In addition, the possible toxicity for red ginseng was affected by cytochrome P450, a herbal-drug interaction. Conclusions: The variety of pharmacological and toxicological properties should be changed by steaming process of Panax ginseng C. A., white ginseng. Even if it is not sure whether the steaming process of white ginseng would be better pharmacologically, it is sure that steaming reduces the level of dencichine causing a lower toxicity to the nervous system.

A Literature Review on the Clinical Application of Microcurrent Electrical Neuromuscular Stimulation(MENS) : articles published for recent 10 years (미세전류치료의 최근 임상연구논문 고찰)

  • Ryu, Ji-Mi;Kim, Sung-Soo;Kim, Kyoung-Seok;Chung, Seok-Hee
    • Journal of Korean Medicine Rehabilitation
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    • v.18 no.4
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    • pp.121-133
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    • 2008
  • Objectives : MENS was used for wound healing and pain relief using bioelectric property. There are many articles on in vivo and clinical research. This article reviews articles on MENS published for recent 10 years to consider effectiveness of MENS and other fields to applicate MENS. Articles were collected from MAR, 2008 to JUN, 2008. Methods : We searched Pubmed, KSI, KERIS, KMBASE, and National assembly library using "Microcurrent Electrical Neuromuscular Stimulation" and classified the articles into subsets of foreign, Korean and wound healing, pain, relief, and increasing the range of movement(ROM). Also we evaluated their values according to the Jadad scale. Results : A total of 18 articles (Foreign-9, Korean-9) reconfirmed that MENS reduces pain, increases wound healing, ROM, and strength of muscle. In addition, MENS has effect on stress-hormone and various pain like low back pain, acute lateral epicondylitis, and plantar fascitis. And there are various styles developed. However, there is no standard protocol so the user is usually in trouble at clinic. Conclusions : MENS may be have application to various pain diseases, and further studies analysing its effectiveness are needed.