• 천문학회지
• /
• 제43권5호
• /
• pp.169-181
• /
• 2010

We develop a proto-model of an off-axis reflective telescope for infrared wide-field observations based on the design of Schwarzschild-Chang type telescope. With only two mirrors, this design achieves an entrance pupil diameter of 50 mm and an effective focal length of 100 mm. We can apply this design to a mid-infrared telescope with a field of view of $8^{\circ}{\times}8^{\circ}$. In spite of the substantial advantages of off-axis telescopes in the infrared compared to refractive or on-axis reflective telescopes, it is known to be difficult to align the mirrors in off-axis systems because of their asymmetric structures. Off-axis mirrors of our telescope are manufactured at the Korea Basic Science Institute (KBSI). We analyze the fabricated mirror surfaces by fitting polynomial functions to the measured data. We accomplish alignment of this two-mirror off-axis system using a ray tracing method. A simple imaging test is performed to compare a pinhole image with a simulated prediction.

• 한국응용약물학회:학술대회논문집
• /
• 한국응용약물학회 2007년도 Proceedings of The Convention of The Korean Society of Applied Pharmacology
• /
• pp.25-44
• /
• 2007

The glucocorticoid receptor (GR) is an intracellular protein that is widely distributed throughout hippocampal and neocortical brain tissue. Mifepristone (RU486) is a potent GR antagonist that has also been shown to exhibit partial agonist-like effects. The precise location of the GR domain involved in the agonist-like activity of RU486 is unknown. Here, we examine this aspect of GR signaling by comparing human GR (hGR) construct with a Guyanese squirrel monkey GR (gsmGR) construct in which nuclear translocation and transactivation are known to be impaired. Using an objective translocation scoring method, we found that both hGR and gsmGR are translocated by RU486, and that nuclear translocation of hGR is significantly increased compared to gsmGR at 10 nM, 100 nM and 1000 nM RU486 in transiently transfected COS1 cells. While addition of RU486 to the cells transfected with hGR results in a 16-fold dose-dependent increase in transactivation compared to non-treated cells, no significant change in transactivation is observed with gsmGR at doses up to 100 nM RU486. Further experiments using six GR chimeras indicate that replacement of the hGR carboxyl-terminus of tau-1 transactivation domain (C-AF1, amino acids 132-428) with that from gsmGR diminishes hGR transactivation by RU486. These results demonstrate that RU486-induced transactivation of GR is determined in part by amino acids in the C-AF1 domain.

• 한국해양바이오학회지
• /
• 제6권1호
• /
• pp.17-25
• /
• 2014

Periodically, harmful algal blooms (HABs) have occurred, with impacts on various areas including public health, tourism, and aquatic ecosystems, especially aquacultured and caged fisheries. To prevent or manage invasions of HABs into fish farms on an emergency basis, many methods have been proposed. Frequently over the past 30 years in coastal countries, treatments of clay and clay mixed with polyaluminum chloride (PAC) and chitosan have been tested for HAB-removal effectiveness in both the laboratory and the field. In Korea, yellow loess clay (hwangto) has been dispersed using electrolytic clay dispensers, both to decrease the amount of yellow loess clay's usage in containers and enhance HAB-removal efficiency. However, this emergency method has limitations, among which is the requirement for more effective controlling agents for field applications. Thus, in this paper, we review technologies for clay-based red tides prevention and control and their limitations, and, further, introduce next-generation algicidal technologies for the emergency protection of fish farms.

• ETRI Journal
• /
• 제36권6호
• /
• pp.1051-1061
• /
• 2014

Technological advances made with the development of digital technology and the Internet have led to the emergence and evolution of digital convergence - the integration of media and communications. This, in turn, has led to the creation of the representative broadcast and communication convergence business model (IPTV service). This study examines the consumption patterns and behaviors of IPTV service customers and explores the process of their continuous use of the IPTV service, thereby endeavoring to contribute to the diffusion of digital convergence services. To survey customers' continuous use of the IPTV service, this study first designs a research framework based on an examination of the existing literature on satisfaction, loyalty, and so on. In addition, research is conducted on the switching barrier of the method of consolidating customers' adherence to a given IPTV service by increasing the burden on them, thereby developing a final research model with which to attempt yet another heterogeneous approach. This enables not only an analysis of the causal relationship with antecedent variables but also a measurement of the explanatory contribution of the antecedent variables' sub-variables.

• Bulletin of the Korean Chemical Society
• /
• 제34권3호
• /
• pp.815-819
• /
• 2013

Micropatterns of streptavidin and human epidermal carcinoma A431 cells were successfully imaged, as received and without any labeling, using cluster $Au_3{^+}$ ion beam-based time-of-flight secondary ion mass spectrometry (TOF-SIMS) together with a principal component analysis (PCA). Three different analysis ion beams ($Ga^+$, $Au^+$ and $Au_3{^+}$) were compared to obtain label-free TOF-SIMS chemical images of micropatterns of streptavidin, which were subsequently used for generating cell patterns. The image of the total positive ions obtained by the $Au_3{^+}$ primary ion beam corresponded to the actual image of micropatterns of streptavidin, whereas the total positive-ion images by $Ga^+$ or $Au^+$ primary ion beams did not. A PCA of the TOF-SIMS spectra was initially performed to identify characteristic secondary ions of streptavidin. Chemical images of each characteristic ion were reconstructed from the raw data and used in the second PCA run, which resulted in a contrasted - and corrected - image of the micropatterns of streptavidin by the $Ga^+$ and $Au^+$ ion beams. The findings herein suggest that using cluster-ion analysis beams and multivariate data analysis for TOF-SIMS chemical imaging would be an effectual method for producing label-free chemical images of micropatterns of biomolecules, including proteins and cells.

• 암석학회지
• /
• 제10권3호
• /
• pp.172-178
• /
• 2001

1997읜 이후 한국기초과학지원연구원에 K-Ar 연대 측정 시스템이 도입되어 현재 이용중이다. 이 시스템은 흑연전기로, 가스 전처리 장치, 질량분석기와 자료획득장치로 구성되어 있으며 K-Ar연대 측정은 $^{38}$ Ar을 스파이크로 이용하는 동위원소 희석법에 의한 정밀한 Ar 농도 측정과 원자흡광분석을 통한 K 정량분석에의해 이루어진다. 연대가 잘 알려진 K-Ar 연대측정용 표준물질을 이용하여 시스템의 정밀성과 정확성을 확인하였다. 백만년 이하의 연대를 갖는 시료의 경우 질량분석기의 감도와 질량차별지수의 미약한 변화에도 큰영향을 받기 때문에 정확한 연대 측정이 곤란하나 중생대 및 제 3기의 K-Ar 연대를 갖는 표준시료의 연대를 측정했을 때, 믿을 만한 결과를 내고 있다. $92.6\pm$0.6 Ma의 연대가 알려진 SORI93혹운모의 경우 92.1$\pm$1.1 Ma의 연대를 얻을 수 있었고, $18.5\pm$0.6 Ma의 Bern4M 백운모는 권고치와 유사한 $17.8\pm$0.2 Ma의 연대를 얻을 수 있었다. .

• 천문학회보
• /
• 제39권1호
• /
• pp.50.1-50.1
• /
• 2014

The Multi-purpose InfraRed Imaging System (MIRIS) is the main payload of Science and Technology Satellite 3 (STSAT-3), which was launched onboard Dnepr rocket from Russian Yasny Launch Base in November 2013. The MIRIS is an infrared (IR) camera, and the telescope has to be cooled down to below 200K in order to reduce thermal background noise. For the effective cooling and low-power consumption, we applied passive cooling method to the thermal design of the MIRIS. We also conducted thermal analysis and tested for the passive cooling before the launch of STSAT-3. After the launch, we have received State-of-Health (SOH) data from the satellite on orbit, including temperature monitoring results. It is important that the temperature of the telescope was shown to be cooled down to below 200K. In this paper, we present both the temperature data of the MIRIS on orbit and the thermal analysis results in the laboratory. We also compare these results and discuss the verification of the passive cooling.

• 생체재료학회지
• /
• 제22권4호
• /
• pp.352-359
• /
• 2018

Background: Black phosphorus (BP) has emerged as a novel class of nanomaterials owing to its unique optical and electronic properties. BP, a two-dimensional (2D) nanomaterial, is a structure where phosphorenes are stacked together in layers by van der Waals interactions. However, although BP nanodots have many advantages, their biosafety and biological effect have not yet been elucidated as compared to the other nanomaterials. Therefore, it is particularly important to assess the cytotoxicity of BP nanodots for exploring their potentials as novel biomaterials. Methods: BP nanodots were prepared by exfoliation with a modified ultrasonication-assisted solution method. The physicochemical properties of BP nanodots were characterized by transmission electron microscopy, dynamic light scattering, Raman spectroscopy, and X-ray diffractometry. In addition, the cytotoxicity of BP nanodots against C2C12 myoblasts was evaluated. Moreover, their cell imaging potential was investigated. Results: Herein, we concentrated on evaluating the cytotoxicity of BP nanodots and investigating their cell imaging potential. It was revealed that the BP nanodots were cytocompatible at a low concentration, although the cell viability was decreased with increasing BP nanodot concentration. Furthermore, our results demonstrated that the cells took up the BP nanodots, and the BP nanodots exhibited green fluorescence. Conclusions: In conclusion, our findings suggest that the BP nanodots have suitable biocompatibility, and are promising candidates as fluorescence probes for biomedical imaging applications.

• 한국콘텐츠학회:학술대회논문집
• /
• 한국콘텐츠학회 2007년도 추계 종합학술대회 논문집
• /
• pp.560-564
• /
• 2007

한국기초과학지원연구원(KBSI, Korea Basic Science Institute)에서는 국내 유일의 초고전압투과전자현미경(HVEM, High Voltage Electron Microscopy)을 비롯하여 3 대의 일반 전자현미경을 보유하고 있다. 전자현미경을 통하여 관찰된 이미지는 각 단계별로 tilting 되어 저장된 이미지로서 관찰자에게 보다 나은 관찰 환경의 구성을 위해 3D로의 reconstruction은 필수 과정이라고 할 수 있겠다. 이 과정 중 카메라 중심에서 벋어난 부분의 왜곡을 warping 기법을 통하여 최대한 감소시킨다. 이런 이미지 전처리 과정과 이를 바탕으로 3D로의 reconstruction과정은 고성능 컴퓨터의 수반을 기본으로 하는데 이 과정을 다수의 grid node PC들이 빠른 시간에 분담하여 처리하게 된다. Grid node PC들의 역할은 소유자가 서로 다른 다양한 컴퓨팅 자원의 효과적인 공유를 목적으로 하며, 시스템의 구축에 필요한 역할 스케줄링, 자원 관리, 보안, 성능 측정 및 상태 모니터링 등의 문제를 해결하기 위한 사용되고 있다. 일반 개인이 사용하기 힘들었던 고성능 PC의 역할을 Grid node PC들이 수행하고 이 기반위에 워핑 기법을 통한 이미지 전처리는 보다 실제 관찰 대상에 가까운 형태로의 재구성이 가능할 수 있는 바탕이 된다. 워핑 전처리를 통한 Grid node PC기반의 전자현미경 볼륨 랜더링 시스템의 구축은 관찰자에게 보다 편리하며 빠른 실험 환경을 제공하여 줄 수 있고, 이해하기 쉽고 실제 모습에 가까운 형태의 실험 결과물을 접할 수 있게 된다.

• 경영과정보연구
• /
• 제39권1호
• /
• pp.35-57
• /
• 2020

정부는 연구시설장비가 과학기술의 발전을 견인하는 매우 중요한 도구이자, 수단으로 여겨지면서 국가적으로 R&D와 연구시설장비에 대한 예산 투자를 지속적으로 확대하였다. 또한, 기 구축된 국가연구시설장비의 효율적 운영 및 체계적 관리의 필요성이 점차 대두되면서 2010년 12월, 국가연구시설장비 표준분류체계를 개발하였다. 그러나 연구현장에서는 국가연구시설장비의 NTIS(National Science and Technology Service) 정보수집 초기단계로 누적정보 부족에 따른 표준분류체계의 과학적 검증절차 부재와 동일계층 간 분류기준의 비일관성 문제가 여전히 한계로 제기되고 있다. 따라서 본 연구는 지난 2010년, 2015년 각 제/개정된 국가연구시설장비 표준분류체계(대분류 8개, 중분류 25개, 소분류 410개)의 분류 정확도를 측정하고자 선형판별분석(LDA)과 분산분석(ANOVA) 기법을 적용하여 2단계로 분석하였다. 또한, 본 연구 분석을 위해 지난 10년 동안 NTIS에 누적 등록된 정보데이터(Big-Data) 50,271건을 수집하여 이를 활용하였다. 이는 단순히 국내외 유사 분류체계와 전문가 의견을 토대로 만들어진 현(現) 국가연구시설 표준분류체계를 과학적으로 실증 검증한 첫 연구 사례에 해당된다. 본 연구 결과, 대분류 이하 중분류와 소분류로 분류된 개체 수의 집단별 판별정확도는 92.2% 로 매우 높은 수준이었고, 분산분석을 통한 사후검증에서는 대분류 8개 중 2개 집단의 변별력이 다소 낮게 나타나, 현(現) 표준분류체계 중 일부 개선이 필요한 것으로 조사되었다. 본 연구를 통해 현(現) 국가연구시설장비 표준분류체계가 향후 지속적으로 개선되길 바란다.