• Molecules and Cells
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• 제44권8호
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• pp.613-622
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• 2021

In vertebrate eyes, the retinal pigment epithelium (RPE) provides structural and functional homeostasis to the retina. The RPE takes up retinol (ROL) to be dehydrogenated and isomerized to 11-cis-retinaldehyde (11-cis-RAL), which is a functional photopigment in mammalian photoreceptors. As excessive ROL is toxic, the RPE must also establish mechanisms to protect against ROL toxicity. Here, we found that the levels of retinol dehydrogenases (RDHs) are commonly decreased in phosphatase tensin homolog (Pten)-deficient mouse RPE, which degenerates due to elevated ROL and that can be rescued by feeding a ROL-free diet. We also identified that RDH gene expression is regulated by forkhead box O (FOXO) transcription factors, which are inactivated by hyperactive Akt in the Pten-deficient mouse RPE. Together, our findings suggest that a homeostatic pathway comprising PTEN, FOXO, and RDH can protect the RPE from ROL toxicity.

• 대한금속재료학회지
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• 제47권8호
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• pp.461-465
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• 2009

We study the diffusion of Ag based bimetallic nanoclusters supported on graphite. Using a molecular dynamics simulation, we reveal that the Ag clusters show rapid diffusion because of their hexagonal bottom layer. In order to decrease the rate of diffusion, we added Pt and Ni to distort the structure of the alloy cluster (i.e., the alloying method). We expected Pt to provide a stronger force on Ag atoms, and Ni to shorten the bond length and thereby change the structure of Ag cluster. However, the attempt was unsuccessful, because Pt and Ni atoms formed cores inside the Ag clusters. We therefore designed a collision system where large Ag clusters collide with small Pt or Ni clusters. Upon collision with Pt clusters, the diffusion showed little change, because Pt atoms are substituted at the Ag atomic site and form a perfectly ordered structure. The collision with Ni, however, deforms the bottom layer as well as the overall cluster structure and decreases diffusion. This outcome appoints toward the possibility of further application to the manufacture of durable nanocatalysts.

• 한국초전도ㆍ저온공학회논문지
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• 제8권2호
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• pp.11-16
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• 2006

Critical current densities were measured for a bicrystalline $(Sm_{0.8}Dy_{0.2})Ba_2Cu_3O_7$ film under various magnetic fields $({^{\rightarrow_{H}}}_a)$. The fields were varied from -0.7KOe to +0.7KOe for various orientations with respect to the film surface. The curves of the critical current densities $(J_{cb})\;vs\;{^{\rightarrow_{H}}}_a$ showed the well known butterfly-like hysteretic curves. Our data could be analyzed for the two components of field, which are normal and parallel to the film surface, respectively. We combined the effect of $H_\perp$ deduced from the data for the normal field $(\theta=90^{\circ})$ and the effect of $H_\parallel$ deduced from the data for the almost parallel field $(\theta=2^{\circ})$. Our analyses indicate that $(J_{cb})$ depends on the two components of flux density at the grain boundary. All the experimental data for various ${\theta}s$ fit well to this new formula which was obtained by multiplying the factors deduced from the field dependences of these two components.

• 한국정보과학회 언어공학연구회:학술대회논문집(한글 및 한국어 정보처리)
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• 한국정보과학회언어공학연구회 2021년도 제33회 한글 및 한국어 정보처리 학술대회
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• pp.16-21
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• 2021

소방 본부의 119 종합상황실에서는 24시간 국민의 안전을 위해 긴급 신고를 접수한다. 수보사 분들은 24시간 교대 근무를 하며 신고 전화에 접수 및 응대 뿐만 아니라 출동, 지휘, 관제 업무를 함께 수행한다. 이 논문에서는 이 같은 수보사의 업무 지원을 위해 우리가 구축한 음성 인식과 결합된 실시간 텍스트 분석 시스템에 대해서 소개하고, 출동 지령서 자동 작성을 위한 키워드 검출 및 대화 요약 및 개체명 인식에 기반한 대화 상태 추척 방법에 대해 설명하고자 한다. 대화 요약 기술은 음성 인식 결과를 실시간으로 분석하여 중요한 키워드의 검출 및 지령서 자동 작성을 위한 후처리를 수행하며, 문장 수준에서 개체명 인식 및 관계 분석을 통한 목적 대화의 대화 상태 추적을 수행한다. 이 같은 응용 시스템은 딥러닝 및 기계학습 기반의 자연어 처리 시스템이 실시간으로 텍스트 분석을 수행할 수 있는 기술 수준이 되었음을 보여주며, 긴급한 상황에서 많은 신고 전화를 접수하는 수보사의 업무 효율 증진 뿐만 아니라, 정확하고 신속한 위치 파악으로 신고자를 도와주어 국민안전 증진에 도움을 줄 수 있을 것으로 기대된다.

• 경영정보학연구
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• 제24권4호
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• pp.1-22
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• 2022

코로나19 이후 비대면 소비 사회로의 전환이 일어나며 생활밀착형 라스트마일 물류 서비스인 택배 기반의 세분화된 도시 물류의 중요성이 대두되고 있다. 본 연구는 소셜 네트워크 분석(SNA)을 활용하여 지역 및 상품 특성별로 수요의 관계성을 분석하고자 한다. 전자상거래에서 수요 파악에 활용되었던 장바구니 네트워크와 공동 구매 상품 네트워크를 확장한 분석 결과 택배 주문 건 수 데이터 속에서 상품 카테고리 패턴을 발견하고 지역별 차이를 확인하였다. 이를 바탕으로 본 연구에서 제시하는 SNA 기반 분석이 도시 물류의 재고 분산 배치나 상품(SKU) 선정 전략에 효과적으로 적용될 수 있음이 확인되었다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2009년도 제38회 동계학술대회 초록집
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• pp.121-121
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• 2010

ZnO is a promising material for the application of high efficiency light emitting diodes with short wavelength region for its large bandgap energy of 3.37 eV which is similar to GaN (3.39 eV) at room temperature. The large exciton binding energy of 60 meV in ZnO provide provides higher efficiency of emission for optoelectronic device applications. Several ZnO/ZnMgO multiple quantum well (MQW) structures have been grown on various substrates such as sapphire, GaN, Si, and so on. However, the achievement of high quality ZnO/ZnMgO MQW structures has been somehow limited by the use of lattice-mismatched substrates. Therefore, we propose the optical properties of ZnO/ZnMgO multiple quantum well (MQW) structures with different well widths grown on lattice-matched ZnO substrates by molecular beam epitaxy. Photoluminescence (PL) spectra show MQW emissions at 3.387 and 3.369 eV for the ZnO/ZnMgO MQW samples with well widths of 2 and 5 nm, respectively, due to the quantum confinement effect. Time-resolved PL results show an efficient photo-generated carrier transfer from the barrier to the MQWs, which leads to an increased intensity ratio of the well to barrier emissions for the ZnO/ZnMgO MQW sample with the wider width. From the power-dependent PL spectra, we observed no PL peak shift of MQW emission in both samples, indicating a negligible built-in electric field effect in the ZnO/$Zn_{0.9}Mg_{0.1}O$ MQWs grown on lattice-matched ZnO substrates.

• 방사선산업학회지
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• 제6권1호
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• pp.31-40
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• 2012

There are two methods to fabricate the readout electronic to a large-area CMOS image sensor (LACIS). One is to design and manufacture the sensor part and signal processing electronics in a single chip and the other is to integrate both parts with bump bonding or wire bonding after manufacturing both parts separately. The latter method has an advantage of the high yield because the optimized and specialized fabrication process can be chosen in designing and manufacturing each part. In this paper, LACIS chip, that is optimized design for the latter method of fabrication, is presented. The LACIS chip consists of a 3-TR pixel photodiode array, row driver (or called as a gate driver) circuit, and bonding pads to the external readout ICs. Among 4 types of the photodiode structure available in a standard CMOS process, $N_{photo}/P_{epi}$ type photodiode showed the highest quantum efficiency in the simulation study, though it requires one additional mask to control the doping concentration of $N_{photo}$ layer. The optimized channel widths and lengths of 3 pixel transistors are also determined by simulation. The select transistor is not significantly affected by channel length and width. But source follower transistor is strongly influenced by length and width. In row driver, to reduce signal time delay by high capacitance at output node, three stage inverter drivers are used. And channel width of the inverter driver increases gradually in each step. The sensor has very long metal wire that is about 170 mm. The repeater consisted of inverters is applied proper amount of pixel rows. It can help to reduce the long metal-line delay.

• Journal of Radiation Protection and Research
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• 제34권1호
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• pp.25-30
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• 2009

Micro-columnar CsI(Tl) is the most popular scintillator material which is used for many indirect digital X-ray imaging detectors. The light scattering at the surface of micro-columnar CsI(Tl) scintillator was studied to find the correlation between the surface roughness and the resultant image resolution of indirect X-ray imaging detectors. Using a commercially available optical simulation program, Light Tools, MTF (Modulation Transfer Function) curves of the CsI(Tl) film thermally evaporated on glass substrate with different thickness were calculated and compared with the experimental estimation of MTF values by the edge X-ray image method and CCD camera. It was found that the standard deviation value of Gaussian scattering model which is determined by the surface roughness of micro-columns could certainly change the MTF value of image sensors. This model and calculation methodology will be beneficial to estimate the overall performance of indirect X-ray imaging system with CsI(Tl) scintillator film for optimum design depending on its application.

• 정보보호학회논문지
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• 제23권2호
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• pp.181-192
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• 2013

기업 내의 문서 유출을 탐지 제어하기 위한 다양한 기술들이 연구되고 있다. 하지만 이러한 기술들은 대부분 외부에 의한 문서 유출을 대상으로 하고 있으며, 문서에 대한 정당한 권한을 가지고 있는 내부자에 의한 문서 유출을 탐지하고 제어하는 연구는 미비한 수준이다. 본 연구에서는 내부자에 의한 문서 유출을 탐지하고 제어하기 위하여 사용자의 문서 읽기 행위를 관찰한다. Microsoft Word 로거에서 추출할 수 있는 속성으로부터 각 사용자의 관찰된 문서 읽기 행위에 대한 패턴을 만들고 시스템에 적용함으로써 문서를 읽고 있는 사용자가 실제 사용자인지 여부를 판단한다. 이를 통하여 사용자가 문서를 읽는 행위를 바탕으로 효과적으로 문서 유출을 방지할 수 있을 것으로 기대한다.

• 한국가시화정보학회지
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• 제15권1호
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• pp.47-52
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• 2017

In droplet-based microfluidic systems, in-droplet preconcentration of a sample is one of the important prerequisites for biochemical or medical analysis. There have been a few studies on preconcentration in a moving droplet, but they are limited to practical applications since 1) their method are time-consuming or 2) they require specific properties such as electric and magnetic properties. In this study, we demonstrated the position control of polystyrene particles of 5 and $10{\mu}m$ in diameter inside a moving water-in-oil droplet using traveling surface acoustic waves. Since the frequencies for effective control of each diameter were found, microparticles with no labels could be utilized. In addition, the proposed method enabled on-demand preconcentration inside a polydimethylsiloxane microchannel. In-droplet preconcentration of microparticles was realized by splitting a mother droplet with manipulated particles at a downstream bifurcation zone. Given these advantages, the proposed system is a promising acoustofluidic lab-on-a-chip platform for preconcentration inside a droplet.