• Molecules and Cells
• /
• v.44 no.8
• /
• pp.613-622
• /
• 2021

In vertebrate eyes, the retinal pigment epithelium (RPE) provides structural and functional homeostasis to the retina. The RPE takes up retinol (ROL) to be dehydrogenated and isomerized to 11-cis-retinaldehyde (11-cis-RAL), which is a functional photopigment in mammalian photoreceptors. As excessive ROL is toxic, the RPE must also establish mechanisms to protect against ROL toxicity. Here, we found that the levels of retinol dehydrogenases (RDHs) are commonly decreased in phosphatase tensin homolog (Pten)-deficient mouse RPE, which degenerates due to elevated ROL and that can be rescued by feeding a ROL-free diet. We also identified that RDH gene expression is regulated by forkhead box O (FOXO) transcription factors, which are inactivated by hyperactive Akt in the Pten-deficient mouse RPE. Together, our findings suggest that a homeostatic pathway comprising PTEN, FOXO, and RDH can protect the RPE from ROL toxicity.

• Korean Journal of Metals and Materials
• /
• v.47 no.8
• /
• pp.461-465
• /
• 2009

We study the diffusion of Ag based bimetallic nanoclusters supported on graphite. Using a molecular dynamics simulation, we reveal that the Ag clusters show rapid diffusion because of their hexagonal bottom layer. In order to decrease the rate of diffusion, we added Pt and Ni to distort the structure of the alloy cluster (i.e., the alloying method). We expected Pt to provide a stronger force on Ag atoms, and Ni to shorten the bond length and thereby change the structure of Ag cluster. However, the attempt was unsuccessful, because Pt and Ni atoms formed cores inside the Ag clusters. We therefore designed a collision system where large Ag clusters collide with small Pt or Ni clusters. Upon collision with Pt clusters, the diffusion showed little change, because Pt atoms are substituted at the Ag atomic site and form a perfectly ordered structure. The collision with Ni, however, deforms the bottom layer as well as the overall cluster structure and decreases diffusion. This outcome appoints toward the possibility of further application to the manufacture of durable nanocatalysts.

• Progress in Superconductivity and Cryogenics
• /
• v.8 no.2
• /
• pp.11-16
• /
• 2006

Critical current densities were measured for a bicrystalline $(Sm_{0.8}Dy_{0.2})Ba_2Cu_3O_7$ film under various magnetic fields $({^{\rightarrow_{H}}}_a)$. The fields were varied from -0.7KOe to +0.7KOe for various orientations with respect to the film surface. The curves of the critical current densities $(J_{cb})\;vs\;{^{\rightarrow_{H}}}_a$ showed the well known butterfly-like hysteretic curves. Our data could be analyzed for the two components of field, which are normal and parallel to the film surface, respectively. We combined the effect of $H_\perp$ deduced from the data for the normal field $(\theta=90^{\circ})$ and the effect of $H_\parallel$ deduced from the data for the almost parallel field $(\theta=2^{\circ})$. Our analyses indicate that $(J_{cb})$ depends on the two components of flux density at the grain boundary. All the experimental data for various ${\theta}s$ fit well to this new formula which was obtained by multiplying the factors deduced from the field dependences of these two components.

• Annual Conference on Human and Language Technology
• /
• 2021.10a
• /
• pp.16-21
• /
• 2021

소방 본부의 119 종합상황실에서는 24시간 국민의 안전을 위해 긴급 신고를 접수한다. 수보사 분들은 24시간 교대 근무를 하며 신고 전화에 접수 및 응대 뿐만 아니라 출동, 지휘, 관제 업무를 함께 수행한다. 이 논문에서는 이 같은 수보사의 업무 지원을 위해 우리가 구축한 음성 인식과 결합된 실시간 텍스트 분석 시스템에 대해서 소개하고, 출동 지령서 자동 작성을 위한 키워드 검출 및 대화 요약 및 개체명 인식에 기반한 대화 상태 추척 방법에 대해 설명하고자 한다. 대화 요약 기술은 음성 인식 결과를 실시간으로 분석하여 중요한 키워드의 검출 및 지령서 자동 작성을 위한 후처리를 수행하며, 문장 수준에서 개체명 인식 및 관계 분석을 통한 목적 대화의 대화 상태 추적을 수행한다. 이 같은 응용 시스템은 딥러닝 및 기계학습 기반의 자연어 처리 시스템이 실시간으로 텍스트 분석을 수행할 수 있는 기술 수준이 되었음을 보여주며, 긴급한 상황에서 많은 신고 전화를 접수하는 수보사의 업무 효율 증진 뿐만 아니라, 정확하고 신속한 위치 파악으로 신고자를 도와주어 국민안전 증진에 도움을 줄 수 있을 것으로 기대된다.

• Information Systems Review
• /
• v.24 no.4
• /
• pp.1-22
• /
• 2022

The transition to a non-face-to-face consumer society has rapidly occurred since Covid-19. The need for a subdivided urban logistics policy centered on courier delivery, a life-friendly last-mile logistics service, has been raised. This study proposes a SNS-based method that can analyze the demand relationship by region and product, respectively. We extend the market basket network (MBN) and co-purchased product network (CPN), find product category patterns, and confirm regional differences by using delivery order data. Our results imply that SNA analysis can be effectively applied to inventory distribution or product (SKU) selection strategies in urban logistics.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2010.02a
• /
• pp.121-121
• /
• 2010

ZnO is a promising material for the application of high efficiency light emitting diodes with short wavelength region for its large bandgap energy of 3.37 eV which is similar to GaN (3.39 eV) at room temperature. The large exciton binding energy of 60 meV in ZnO provide provides higher efficiency of emission for optoelectronic device applications. Several ZnO/ZnMgO multiple quantum well (MQW) structures have been grown on various substrates such as sapphire, GaN, Si, and so on. However, the achievement of high quality ZnO/ZnMgO MQW structures has been somehow limited by the use of lattice-mismatched substrates. Therefore, we propose the optical properties of ZnO/ZnMgO multiple quantum well (MQW) structures with different well widths grown on lattice-matched ZnO substrates by molecular beam epitaxy. Photoluminescence (PL) spectra show MQW emissions at 3.387 and 3.369 eV for the ZnO/ZnMgO MQW samples with well widths of 2 and 5 nm, respectively, due to the quantum confinement effect. Time-resolved PL results show an efficient photo-generated carrier transfer from the barrier to the MQWs, which leads to an increased intensity ratio of the well to barrier emissions for the ZnO/ZnMgO MQW sample with the wider width. From the power-dependent PL spectra, we observed no PL peak shift of MQW emission in both samples, indicating a negligible built-in electric field effect in the ZnO/$Zn_{0.9}Mg_{0.1}O$ MQWs grown on lattice-matched ZnO substrates.

• Journal of Radiation Industry
• /
• v.6 no.1
• /
• pp.31-40
• /
• 2012

There are two methods to fabricate the readout electronic to a large-area CMOS image sensor (LACIS). One is to design and manufacture the sensor part and signal processing electronics in a single chip and the other is to integrate both parts with bump bonding or wire bonding after manufacturing both parts separately. The latter method has an advantage of the high yield because the optimized and specialized fabrication process can be chosen in designing and manufacturing each part. In this paper, LACIS chip, that is optimized design for the latter method of fabrication, is presented. The LACIS chip consists of a 3-TR pixel photodiode array, row driver (or called as a gate driver) circuit, and bonding pads to the external readout ICs. Among 4 types of the photodiode structure available in a standard CMOS process, $N_{photo}/P_{epi}$ type photodiode showed the highest quantum efficiency in the simulation study, though it requires one additional mask to control the doping concentration of $N_{photo}$ layer. The optimized channel widths and lengths of 3 pixel transistors are also determined by simulation. The select transistor is not significantly affected by channel length and width. But source follower transistor is strongly influenced by length and width. In row driver, to reduce signal time delay by high capacitance at output node, three stage inverter drivers are used. And channel width of the inverter driver increases gradually in each step. The sensor has very long metal wire that is about 170 mm. The repeater consisted of inverters is applied proper amount of pixel rows. It can help to reduce the long metal-line delay.

• Journal of Radiation Protection and Research
• /
• v.34 no.1
• /
• pp.25-30
• /
• 2009

Micro-columnar CsI(Tl) is the most popular scintillator material which is used for many indirect digital X-ray imaging detectors. The light scattering at the surface of micro-columnar CsI(Tl) scintillator was studied to find the correlation between the surface roughness and the resultant image resolution of indirect X-ray imaging detectors. Using a commercially available optical simulation program, Light Tools, MTF (Modulation Transfer Function) curves of the CsI(Tl) film thermally evaporated on glass substrate with different thickness were calculated and compared with the experimental estimation of MTF values by the edge X-ray image method and CCD camera. It was found that the standard deviation value of Gaussian scattering model which is determined by the surface roughness of micro-columns could certainly change the MTF value of image sensors. This model and calculation methodology will be beneficial to estimate the overall performance of indirect X-ray imaging system with CsI(Tl) scintillator film for optimum design depending on its application.

• Journal of the Korea Institute of Information Security & Cryptology
• /
• v.23 no.2
• /
• pp.181-192
• /
• 2013

There have been various techniques to detect and control document leakage; however, most techniques concentrate on document leakage by outsiders. There are rare techniques to detect and monitor document leakage by insiders. In this study, we observe user's document reading behavior to detect and control document leakage by insiders. We make each user's document reading patterns from attributes gathered by a logger program running on Microsoft Word, and then we apply the proposed system to help determine whether a current user who is reading a document matches the true user. We expect that our system based on document reading behavior can effectively prevent document leakage.

• Journal of the Korean Society of Visualization
• /
• v.15 no.1
• /
• pp.47-52
• /
• 2017

In droplet-based microfluidic systems, in-droplet preconcentration of a sample is one of the important prerequisites for biochemical or medical analysis. There have been a few studies on preconcentration in a moving droplet, but they are limited to practical applications since 1) their method are time-consuming or 2) they require specific properties such as electric and magnetic properties. In this study, we demonstrated the position control of polystyrene particles of 5 and $10{\mu}m$ in diameter inside a moving water-in-oil droplet using traveling surface acoustic waves. Since the frequencies for effective control of each diameter were found, microparticles with no labels could be utilized. In addition, the proposed method enabled on-demand preconcentration inside a polydimethylsiloxane microchannel. In-droplet preconcentration of microparticles was realized by splitting a mother droplet with manipulated particles at a downstream bifurcation zone. Given these advantages, the proposed system is a promising acoustofluidic lab-on-a-chip platform for preconcentration inside a droplet.