• 한국어병학회지
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• 제18권3호
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• pp.227-237
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• 2005

본 연구에서는 주요 어류 병원성 그람음성세균인 E. tarda 및 V. anguillarum에 대하여 14 종의 생약 추출물의 항균활성을 검색하였다. 그 결과, 감초, 지유 및 칠피 추출물이 항균활성을 나타냄을 밝혔다. 그 중, 가장 우수한 항균활성을 나타낸 칠피 추출물에 대하여 활성지향적인 분리기법을 적용하여 활성분획물인 EtOAc분획물로부터 항균활성물질 1종을 분리하고 페놀성 화합물인 methyl gallate로 동정하였다. methyl gallate는 실험에 사용된 E. tarda 및 V. anguillarum의 균주들의 증식을 효과적으로 저해하였으며 이에 대한 MIC는 모두 1 mg/ml로 측정되었다.

• Radiation Oncology Journal
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• 제17권3호
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• pp.195-202
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• 1999

목적 : 국소 진행된 비소세포성 폐암의 치료에 있어서 예후 인자를 분석하고, 유도 화학요법이 생존율 및 치료 실패양상에 미치는 영향을 알아 보고자 본 연구를 시행하였다. 대상 및 방법 : 1986년 1월부터 1996년 10월까지 국소 진행된 비소세포성 폐암으로 진단받고 근치적 목적으로 방사선치료 혹은 병합요법(유도 화학요법 및 방사선치료)을 받은 130명의 환자를 대상으로 후향적 분석을 시행하였다. 방사선치료 단독군이 85명, 병합요법군이 45명이었다. 연령, 성별, 전신 수행능력, 병리조직학적 유형, 그리고 병기 등은 양군에서 고르게 분포하였다. 방사선치료는 6 MV 혹은 10 MV 선형가속기를 사용하였고, 일일 선량 $1.8\~2.0$ Gy를 주 5회 조사하였다. 총 방사선량은 129명에서 59.6 Gy 이상($56\~66$ Gy, 중앙값 60 Gy) 조사되었다. 유도 화학요법은 $2\~5$회(중앙값 2회) 시행하였다. 사용된 약제는 CAP (Cyclophosphamide, Adriamycin, Cisplatin)가 6명, MVP (Mitomycin, Vinblastine, Cisplatin)가 9명, MIC (Mitomycin, ifosfamide Cisplatin)이 13례, 그리고 EP (Etoposide, Cisplatin)가 17명에서 시행되었으며, 모든 요법이 Cis-platinum을 포함하였다. 결과 : 전체 환자의 생존율은 1, 2, 3 년 전체 생존율이 각각 41.5, 13.7, $7\%$였고, 중앙 생존기간은 11개월이었다. 치료 방법별 1, 2, 3 년 전체 생존율, 그리고 중앙 생존기간은, 방사선치료 단독군의 경우 각각 32.9, 10.5, $6\%$, 9개월이었으며, 병합요법군의 경우는 각각 57.8, 20, $7.6\%$, 14 개월이었다(p=0.0005). 최종 치료반응을 관찰할 수 있었던 126명 중 38명($30.2\%$)에서 완전관해를 보였고, 치료 방법별로 나누어 분석하였을 경우, 방사선치료 단독군에서 완전관해가 $25\%$ (21/84), 병합요법군의 경우는 $40.5\%$, (17/42)에서 완전관해를 보였다(p=0.09). 생존율에 영향을 미치는 예후인자는 혈색소치(p=0.04), NSE (neuron-specific enolase)치(p=0.004), 그리고 최종 치료반응(p=0.004)등이었다. 치료 방법별로 나누어서 분석한 결과, 방사선치료 단독군의 경우는 WSE치(p=0.006)와 최종 치료반응(p=0.003), 병합요법군의 경우는 최종 치료반응(p=0.007)이 예후인자였다. 치료 실패양상은 추적 관찰이 가능했고 치료에 대한 반응을 알 수 있었던 120명을 대상으로 분석한 결과, 양 군간에 특이한 차이를 보이지 않았다. 그러나, 치료에 완전관해를 보인 환자들을 대상으로 살펴보면 병합요법 군에서 원격전이가 감소하는 경향을 보였는데, 방사선치료 단독군은 19명중 11명에서, 병합요법군은 13명중 3명에서 원격전이가 발견되었다(p=0.07). 국소 실패는 완전관해를 보인 환자에서도 양 군에서 차이가 없었다(10/19 vs 6/13). 결론 : 국소 진행된 비소세포성 폐암의 경우 유도 화학요법을 시행함으로써, 방사선치료 단독보다 2년 생존율이 향상 되었고, 적어도 완전관해를 보인 경우는 원격전이가 감소하는 경향을 보였다. 그러나, 국소 실패양상 및 장기생존율에는 유도 화학요법이 도움이 되지 않았다. 따라서, 국소 제어율을 높이기 위한 다각적인 노력이 요구된다.

• 한국학교보건학회지
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• 제22권2호
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• pp.113-124
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• 2009

Purpose : This study was to examine the emotional behavioral problem of children in low-income family who were participating in local children care center. Method : From June 2 to September 9, 2008, 322 elementary school children were surveyed using structured questionnaire. Emotional behavioral problem were measured using K-YSR. Result : In the distribution of three groups by emotional behavioral problems scores of subjects, normal group was 83.23%, borderline group was 9.32%, clinical group was 7.45% among 322 children. The emotional behavioral problem score of subjects showed attention problem .62(5.61), aggressive behavior .52(9.87), anxiety and depression .50(7.89), withdrawn .49(3.46), social problem .43(3.50), somatic complaints .35(3.17), thought problem .32(2.27), delinquent behavior .31(3.11) and total behavioral problem scores were .44(44.55). Also, total behavioral problem scores was not significantly difference by sex and grade, but the scores of girls students was higher compared with boys. Conclusion : This finding will be significant in that it can provide basic data for school mental health services, which can provide early intervention program for the students who belong to borderline and clinical groups.

• 대한간호학회지
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• 제39권5호
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• pp.700-708
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• 2009

Purpose: This study was done to test the validity and reliability of the Adolescent Mental Problem Questionnaire (AMPQ) for Korean high school students. Methods: The AMPQ was designed to assess adolescents', mental health status and problem behavior (Ahn, 2006). A methodological study design was used with exploratory factor analysis, Pearson's correlation coefficients, and a fitness of the modified model for validity. Also, Cronbach's alpha coefficients and alternative-form method for reliability were used. AMPQ was tested with a sample of 36,313 high school students. The participants consisted of 18,701 males and 17,612 females. Results: Seven factors were extracted through factor analysis: 'Psychiatric problems', 'Delinquency', 'Academic troubles', 'Family problems', 'Hazardous behavior', 'Harmful circumstance', 'Eating problems'. These factors explained 51.1% of the total variance. The fitness of the modified model was good ($X^2$=38,413.76, Goodness of Fit Index [GFI]=.94, Adjusted Goodness of Fit Index [AGFI]=.93, Comparative Fit Index [CFI]=.95, Root Mean Square Error of Approximation [RMSEA]=.05), and concurrent validity with Korea-Youth Self-Report [K-YSR] was .63. Cronbach's alpha coefficient of the 31 items was .85. Conclusion: The results of present study suggest that the modified AMPQ instrument may be useful for efficiently assessing mental health status and problem behavior in late adolescent, high school students.

• Child Health Nursing Research
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• 제11권1호
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• pp.132-141
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• 2005

Purpose: This study was conducted to describe mother's child-rearing attitudes and problem conduct of children as perceived by children and to examine correlation between maternal nurturing attitudes and child problem behavior. Method: The participants were 338 fifth and sixth graders who attended two randomly selected elementary schools in the city of G, Gangwon province. Child-rearing attitudes of the mother were rated on a 5-pointed scale that developed by Schaefer and added by Oh & Lee(1982). Problem conduct of children were rated on a 3-pointed scale of the K-YSR by Oh Kyung-Ja et al.(1997). The data were gathered from October 2 to October 28, 2004, and the collected data were analyzed with SPSS 10.0 program. Results: For the children's perception of mother's child-rearing attitude, student had a relatively high mean scores of 3.70±0.44. Correlations between the mother's child-rearing attitude and general characteristics of the children showed statistically significantly different according to grade, father-mother relations, type of residence and extent to which father shared household chores. The mean score for problem conducts of children was 0.47±0.25. The average for their internal behavior problems was 0.52±0.33, and for external behavior problems was 0.44±0.24. There were statistically significantly differences in the behavior problem scores of the children according to the general characteristics of grade, education, occupation, mother-father relations, extent to which father shared in household chores and religion. As to correlation between mother's child-rearing attitude and their problem conduct, every type of attitude had a significantly moderate reverse correlation to every type of behavior problem of the children(r=-.431, p=.000). Conclusion: Mother's child-rearing attitudes might affect the problem conduct of children, and mother should try to treat their children with affection and respect, to maintain good relations with father, and to bring their children up coherently in an autonomous, permissive, positive and democratic manner.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제21권2호
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• pp.95-102
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• 2010

Objectives : This study investigated the differences between the psychiatric characteristics of minor juvenile offenders and normal adolescents as well as differences in psychiatric symptoms after a six month protective disposition. Further, the current study aimed at determining psychiatric screening methods for evaluating delinquent adolescents. Methods : The Latent Delinquency Questionnaire (LDQ), the Revised Children's Manifest Anxiety Scale (RCMAS), the Children’s Depression Inventory (CDI), the Reynolds Suicidal Ideation Questionnaire (SIQ), the Piers-Harris Children's Self Concept Inventory (SCI), and the Korean Youth Self Report (K-YSR) were administered to 134 normal adolescents (114 males) and 109 minor offenders (97 males) aged 12 to 16 years. After six months, 46 offenders (all males) completed the RCMAS, CDI, SIQ, and SCI again. Results : Adolescents with minor offenses had more delinquent, aggressive behavior and externalizing behavior problems, but were significantly less depressive, anxious, or suicidal than normal controls. Further, recidivists had more anxiety, depression, and delinquent behavior than non-recidivists. Minor offenders reported that their anxiety and depressive mood decreased after six months of protective disposition. Conclusion : Adolescents with minor offenses had more delinquent, aggressive behavior and externalizing behavior problems suggesting that psychiatric screening tools for minor offenders should measure disruptive behavior disorder.

• 동의신경정신과학회지
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• 제28권2호
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• pp.61-72
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• 2017

Objectives: The Yin-Yang temperament and the Sasang Personality Questionnaire (SPQ) were reported to have relations with psychopathological problems in adolescents. The purpose of this study was to examine how domains of Yin-Yang temperament influence on problem behaviors in Korean middle school students. Methods: Subjects of 681 Korean middle school students completed the SPQ for measuring Yin-Yang temperament and the Youth Self-Report (YSR) for measuring problem behaviors. The differences of problem behaviors between Yin and Yang temperament groups were tested with T-test and profile analysis. The associations of the SPQ subscales on problem behaviors was also examined with Pearson's correlation and regression analysis. Results: Yang temperament was related to the externalizing problem while Yin temperament to the internalizing problem. The Emotionality and Behavior dimension of Yin-Yang temperament were found to be a factor of susceptibility and resilience for problem behaviors, respectively. Three dimensions of Yin-Yang temperament have different influences on externalizing and internalizing problems depending on the sex and Yin-Yang temperament groups of subjects. Conclusions: The Yin-Yang temperament would be useful for predicting and preventing the problem behaviors of middle school students. This study would be useful for screening the psychopathological problems and helping Korean adolescents to develop healthy character.

• Journal of Gastric Cancer
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• 제1권1호
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• pp.17-23
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• 2001

Purpose: The purpose of this study is to analyze the clinicopathologic characteristics of gastric cancer patients and to evaluate the survival and prognostic factors and effect of immunochemosurgery for gastric cancer patients. Materials and Methods: The clinicopathologic characteristics were analyzed for 12,277 consecutive patients who underwent operation for gastric cancer from 1970 to 1999. We also evaluated the survival and prognostic factors for 9,262 consecutive patients from 1981 to 1996. The prognostic significance of treatment modality [surgery alone, surgery+chemotherapy, surgery+immunotherapy+chemotherapy (immunochemosurgery)] were evaluated in stage III gastric cancer. Results: The 5-year survival rate (5-YSR) of overall patients was $55.8\%$, and that of patients who received curative resection was $64.8\%$. The 5-YSRs according to TNM stage were $92.9\%$ for Ia, $84.2\%$ for Ib, $69.3\%$ for II, $45.8\%$ for IIIa, $29.6\%$ for IIIb and $9.2\%$ for IV. Regarding adjuvant treatment modality, significant survival difference was observed in stage III patients. The 5-year survival rates were $44.8\%$ for immunochemosurgery group, $36.8\%$ for surgery+chemotherapy group and $27.2\%$ for surgery alone group. Curative resection, depth of invasion and lymph node metastasis were the most significant prognostic factors in gastric cancer. Conclusion: Consequently, early detection and curative resection with radical lymph node dissection, followed by immunochemotherapy especially in patients with stage III gastric cancer should be recommended as a standard treatment principle for patients with gastric cancer.

• 지역사회간호학회지
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• 제13권4호
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• pp.786-794
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• 2002

Purpose: The aim of the study was to investigate how adolescents' behavior is correlated with child abuse they experience, and how childrearing attitude of mothers perceived by the adolescents is correlated with child abuse experience by the adolescents. Method: A convenient sampling strategy was used. A total of 160 adolescents participated in this study. Of the 160 responses, 116 were used for final analysis. The data were analyzed using K-YSR program and SPSSWIN. Result: The results were as follows. Mild child abuse experiences reported by the subjects were Throwing the object at me (12.9%, N = 15), Clutching and pushing (12.9%, N = 15), and Slapping on the cheek (14.7%, N = 17)'. Severe child abuse experiences reported by the subjects were Kicking, pounding and biting (10.3%, N = 10), Rod, stick, belt, broom beating using various objects (41.4%, N = 38), and Beating all over the body (6.7%, N = 8). Very severe child abuse experiences reported by the subjects were Burning with cigarette (0.4%, N = 1), Threatening me with objects such as a knife, a hammer, an axe, or a gimlet (0.8%, N = 2). Injuring me with the objects (0.4%, N = 1), and Hospitalized by belting (0.4%, N = 1). In terms of correlations among the main study variables, physical child abuse had significant positive correlations with externalizing problem (r=.271, p=.001) and total behavioral problem (r=.288, p=.002). Physical child abuse also had a significant positive correlation with authoritarian childrearing attitude of mother (r=.363, p=.000). Physical child abuse had significant negative correlations with mothers affectionate childrearing attitude (r=-.191, p=.050) and active participative childrearing attitude (r=-.101, p=.035). Conclusion: Mothers childrearing attitude is a salient factor for preventing child abuse. In addition, child abuse is an important factor for preventing adolescent's behavioral problem.

• Radiation Oncology Journal
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• 제11권2호
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• pp.337-346
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• 1993

This is a retrospective cohort analysis of 58 patients who treated with postoperative radiation therapy following radical hysterectomy and bilateral pelvic adenectomy for early stage carcinoma of uterine cervix between January 1988 and December 1990 at department of radiation oncology, Keimyoung University Hospital. Sixteen percent of patients (9/58) had chemotherapy. Most patients were FIGO I b (47 patients), and FIGO I a and II a were one and ten patients, respectively. The median follow-up periods were 48.5 months. The indications for radiation therapy included pelvic lymph node metastasis, large tumor size, deep stromal invasion, lymphovascular invasion, positive surgical margin, endometrial invasion and parametrial invasion. Eighty five percent of the patients had more than one risk factor. The actuarial overall five year survival rate (5 YSR) and five year disease free survival rate (5 YDFSR) were $89.5\%,\;and\;87.8\%,$ respectively. Their overall recurrence rate was $12.1\%,$(758). Distant metastasis was the most common cause of treatment failure $(71.4\%:5/7).$ The univariate analysis of prognostic factors affecting to five year survival rate disclosed pelvic lymph node status (negative: $95.5\%,\;positive:69.2\%,$ p=0.006) and hemoglobin level $(\le11 :75\%,>11g/dl:93.3\%,p=0.05)$ as significant factor. The age status was marginally significant $(\le40:96.0\%,\;>\;40:84.3\%p=0.15).$ Multivariate analysis clarified three independent prognostic factors: pelvic lymph node metastasis (p=p.006), hemoglobin level (p=0.015) and age (p=0.035). Multivariate analysis of prognostic factor affecting to five year disease free survival rate disclosed pelvic lymph node status (p=0.0078) and status of surgical margin (p=0.008). Complications relating to radiotherapy were $10.3\%,(6/58).$ There were no severe major complication requiring surgical intervention or a long hospital stay. It is our opinion that the benefit of postoperative pelvic radiotherapy may be gained in such a high risk patient population with acceptible morbidity.