• BMB Reports
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• v.49 no.6
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• pp.325-330
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• 2016

T-complex protein 10A homolog 2 (TCP10L) was previously demonstrated to be a potential tumor suppressor in human hepatocellular carcinoma (HCC). However, little is known about the molecular mechanism. MAX dimerization protein 1 (MAD1) is a key transcription suppressor that is involved in regulating cell cycle progression and Myc-mediated cell transformation. In this study, we identified MAD1 as a novel TCP10L-interacting protein. The interaction depends on the leucine zipper domain of both TCP10L and MAD1. TCP10L, but not the interaction-deficient TCP10L mutant, synergizes with MAD1 in transcriptional repression, cell cycle G1 arrest and cell growth suppression. Mechanistic exploration further revealed that TCP10L is able to stabilize intracellular MAD1 protein level. Consistently, the MAD1-interaction-deficient TCP10L mutant exerts no effect on stabilizing the MAD1 protein. Taken together, our results strongly indicate that TCP10L stabilizes MAD1 protein level through direct interaction, and they cooperatively regulate cell cycle progression.

• Journal of the Korean Mathematical Society
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• v.54 no.3
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• pp.835-845
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• 2017

The $GCF_{\epsilon}$ expansion is a new class of continued fractions induced by the transformation $T_{\epsilon}:(0, 1]{\rightarrow}(0, 1]$: $T_{\epsilon}(x)={\frac{-1+(k+1)x}{1+k-k{\epsilon}x}}$ for $x{\in}(1/(k+1),1/k]$. Under the algorithm $T_{\epsilon}$, every $x{\in}(0,1]$ corresponds to an increasing digits sequences $\{k_n,n{\geq}1\}$. Their basic properties, including the ergodic properties, law of large number and central limit theorem have been discussed in [4], [5] and [7]. In this paper, we study the large deviation for the $GCF_{\epsilon}$ expansion and show that: $\{{\frac{1}{n}}{\log}k_n,n{\geq}1\}$ satisfies the different large deviation principles when the parameter ${\epsilon}$ changes in [-1, 1], which generalizes a result of L. J. Zhu [9] who considered a case when ${\epsilon}(k){\equiv}0$ (i.e., Engel series).

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2003.10a
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• pp.303-308
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• 2003

In this paper, wave numerical modeling was experimented for the analysis of impact factors for the wave transmission as the incident wave and topographic conditions in the narrow channel sea. Recently, Although the results of many researcher for the wave modelling, numerical equations have limited to simulation of wave transformation effects. Despite of thispresent problems, the models was used to design the coastal structures in barrow channel sites. Finally, this paper estimated the wave model(mild slope eq. model) as the analysis of the wave energy transmission according to changing of impact factors(width of channel, bottom slope in channel, incident wave angle, wave period). As the results of numerical experiment, the major impact factors which influence to wave energy transmission were the width of channel and incident wave direction. But in the case that the width of channel is larger than 3L(L=Length of wave), the reduction of wave energy was small.

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.865-866
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• 2005

• Proceedings of the KIPE Conference
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• 2002.07a
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• pp.763-768
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• 2002

In this paper digitally based excitation systems for the synchronous brushless generators are presented. System configuration, control functions with their structure functions are also shown. The control system has two feedback loops: main one based on a generator's voltage with digital controller and inner one based on excitation voltage of the exciter with analog controller. Usually the generator regulation of voltage Is made with transducers for the voltage measurement. This paper shows technique of measuring the voltage without harmonics affect, using Park's equation transformation.

• Journal of The Korean Society of Grassland and Forage Science
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• v.28 no.4
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• pp.273-280
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• 2008

In order to develop a simple and reproducible protocol for red top bentgrass (Agrostis alba L.), effect of different growth regulators was investigated for embrogenic calli induction and subsequent plant regeneration using mature seeds. MS medium containing 2 mg/L 2,4-D was optimal for embryogenic callus induction from mature seeds. The highest plant regeneration frequency (64.4%) was showed when the embryogenic callus tissues were cultured on N6 medium supplemented with 0.5 mg/L 2,4-D and 2 mg/L BA. Regenerated plantlets were grown normally when shoots transplanted to the soil. A high-frequency and efficient regeneration system from mature seeds would be helpful for molecular breeding of new variety of red top bentgrass through Agrobacterium-mediated genetic transformation.

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2005.11a
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• pp.292-292
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• 2005

• Korean Journal of Plant Resources
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• v.26 no.4
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• pp.511-515
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• 2013

Hypocotyls explants of melon seedling were cultured on Murashige and Skoog's (MS) medium supplemented with 1 mg/L 2,4-dichlorophenoxy acetic acid (2,4-D) and 0.5 mg/L benzyl aminopurine (BA) for 6 weeks to produce somatic embryos. In somatic embryos produced through intervening bright yellow friable (BYF) from the explants, somatic embryos with two-cotyledon (26%) and horn-type cotyledon (74%) were observed. The procambial strand of cotyledons was originated from circular procambial tissues of lower hypocotyls. The circular procambial independently divided into two procambial strand at the edge of cotyledonary-node, and then connected to each cotyledon to form somatic embryos with two-cotyledon. When cotyledon was horn-type, the circular procambial strand in lower hypocotyls would continuously remain connected to the cotyledon. However, somatic embryos with two or horn type cotyledon formed an abnormal shoot apex without the tunica-corpus structure or dome shape in the inter-cotyledonary area. These results demonstrated that the variation of cotyledon in somatic embryos was closely related to procambial tissue differentiation and shoot apical formation.

• Korean Journal of Medicinal Crop Science
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• v.13 no.3
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• pp.105-108
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• 2005

Culture conditions for plant regeneration of Camellia japonica were achieved by organogenesis in explants of cotyledon. Seed cotyledons were cultured on MS medium containing various auxin, 2,4-D or NAA and cytokinins BA. The adventitious shoot buds were efficiently formed without embryogenesis on the basal region of cotyledon cultured on MS medium supplemented with $0.1\;{\mu}g/m{\ell}$ 2.4-D and $1\;{\mu}g/m{\ell}$ BA. Seed cotyledons could be used as a source of explants in experiments of genetic transformation of the genotypes evaluated for improving the efficiency of production of transgenic Camellia plants.

• Journal of the Korean Institute of Gas
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• v.24 no.5
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• pp.39-46
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• 2020

This paper is considered about centerline segregation of API 5L steel used in pipeline. Mn/S, Nb and C were known as segregated elements in the centerline of pipe thickness. The Mn usually was accompanied by S consisting of long viscous shape. Microstructure of the centerline was composed of MnS and Nb/Ti indusions including oxide. The segregation effect in centerline region was analyzed by OM, SEM/EDS and micro Vickers hardness. The Mn, Nb and C are retarded elements in transformation from austenite to ferrite or martensite. These elements could derive a bainitic microstructure as a kind of martensite, which is different from difference and element segregation between in matrix and centerline derived from steel melting and heat treatment.