• Proceedings of the KSR Conference
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• 2005.11a
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• pp.799-804
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• 2005

In this work, the characteristics of train performance of Korean rubber-tired AGT system(K-AGT) are evaluated by using TPS(Train Performance Simulation) and these results are compared to those of other LRT(Light Rail Transit) systems. The performance characteristics of K-AGT was analyzed by comparing the scheduled speed and the energy consumption in case of station interval change and rail track condition change in, the scheduled construction line. In the scheduled construction line, scheduled speed of K-AGT was no difference with other systems and energy consumption was less than other LRT's. In case station intervals are increased, scheduled speed of K-AGT shows similar increasing rate and in curved and graded track conditions K-AGT has no difference in scheduled speed with other systems. As a simulation result by track condition change, when the track which is smaller than curved line of 250m dominates more than $50\%$ in whole track, K-AGT is similar to other systems to the point of scheduled speed and there is advantage in energy consumption.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.1644-1647
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• 2005

This study was aimed at evaluating the structural safety for rubber tired AGT system. Based on these, AGT system which was developed for first time in domestic is need to verify structural safety. So we measured the characteristics of guide-rail, switch rail, side wall in the constructed test track for rubber tired AGT system. Finally, all results of test showed that structural safety of the rubber tired AGT system.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.1341-1344
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• 2005

This study was aimed to verify the acceptable contact force between power collector and 3rd rail type conductor rail for the Korean standardized rubber-tired AGT light rail vehicle. The power collector was designed and manufactured to satisfy the Korean standardized Specifications of the rubber-tired AGT light rail vehicle. Based on the dynamic behavior, contact force variation and interruption in the worst installation tolerance of the conductor rail, its initial contact force was set up. At the test track for the Korean standardized rubber-tired AGT light rail vehicle, interruptions, stresses, vibrations, and contact force variations were measured. As the results, initial contact force was verified to ensure power collection stability.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.860-863
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• 2005

Dynamic model of the Korea standardized rubber-tired AGT light rail vehicle, and boundary conditions between vehicle and infrastructures (running track, guidance rail) were defined to analyze vehicular vibration behaviors occurred at the worst condition. Using the commercialized software RecurDyn, vibration accelerations of car body and bogies were analyzed. Based on the Korea performance test criteria for urban transit, vertical and lateral vibration of car body were calculated and evaluated. As the results, the Korea standardized rubber-tired AGT light rail vehicle satisfied the performance criteria and design requirement.

• Journal of the Korea Safety Management & Science
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• v.8 no.2
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• pp.91-102
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• 2006

Korea Railroad Research Institute developed the driverless rubber-tired Korean-AGT system from 1999 to 2005 and has done its performance and reliability tests on the test line at Gyeongsan-city. We made the reliability management program to control required the RAMS(reliability, availability, maintainability & safety) of the K-AGT system. Therefore, we demonstrated the development and application of Reliability DB program. The main functions of K-AGT Reliability DB program manages failures and maintenance data systematically from the test line through test period and provides various analysis results based on the inputted data.

• Proceedings of the KSR Conference
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• 2006.11b
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• pp.288-293
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• 2006

In this work, the characteristics and the improving method of train performance of Korean rubber-tired AGT system(K-AGT) and Urban MAGLEV system are evaluated by using Train Performance Simulation(TPS). The train performance characteristics of K-AGT were analysed according to the change of maximum running speed and those of Urban MAGLEV were evaluated according to a vehicle weight variation. In the result of simulation in virtual line, the scheduled speed and the running time of K-AGT system have no difference with Urban MAGLEV system if the maximum running speed is equal. But the energy consumption of Urban MAGLEV system is more than that of K-AGT system. The analyses showed that in case of a 20 percent vehicle weight reduction of Urban MAGLEV system, the energy consumption per person is similar with the K-AGT system. The Urban MAGLEV system is more efficient in long travel distance condition than in short running distance condition in the aspect of train performance.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.10a
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• pp.39-42
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• 2005

Dynamic model of the Korea standardized rubber-tired AGT light rail vehicle, and boundary conditions between vehicle and infrastructures (running track, guidance rail) were defined to analyze vehicular vibration behaviors occurred at the worst condition. Using the commercialized software RecurDyn, vibration accelerations of car body and bogies were analyzed. and, based on the ISO standard 2631-1, the vibration characteristic test is performed in the test track. As the results, the Korea standardized rubber-tired AGT light rail vehicle satisfied the ISO standard criteria and design requirement.

• Molecules and Cells
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• v.37 no.6
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• pp.487-496
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• 2014

Angiotensinogen (AGT), the precursor of angiotensin I, is known to be involved in tumor angiogenesis and associated with the pathogenesis of coronary atherosclerosis. This study was undertaken to determine the role played by AGT in endothelial progenitor cells (EPCs) in tumor progression and metastasis. It was found that the number of EPC colonies formed by AGT heterozygous knockout ($AGT^{+/-}$) cells was less than that formed by wild-type (WT) cells, and that the migration and tube formation abilities of $AGT^{+/-}$ EPCs were significantly lower than those of WT EPCs. In addition, the gene expressions of vascular endothelial growth factor (VEGF), Flk1, angiopoietin (Ang)-1, Ang-2, Tie-2, stromal derived factor (SDF)-1, C-X-C chemokine receptor type 4 (CXCR4), and of endothelial nitric oxide synthase (eNOS) were suppressed in $AGT^{+/-}$ EPCs. Furthermore, the expressions of hypoxia-inducible factor (HIF)-$1{\alpha}$and $-2{\alpha}$ were downregulated in $AGT^{+/-}$ early EPCs under hypoxic conditions, suggesting a blunting of response to hypoxia. Moreover, the activation of Akt/eNOS signaling pathways induced by VEGF, epithelial growth factor (EGF), or SDF-$1{\alpha}$ were suppressed in $AGT^{+/-}$ EPCs. In $AGT^{+/-}$ mice, the incorporation of EPCs into the tumor vasculature was significantly reduced, and lung tumor growth and melanoma metastasis were attenuated. In conclusion, AGT is required for hypoxia-induced vasculogenesis.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2006.05a
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• pp.413-414
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• 2006

This study was aimed to verify the stable interruption characteristics between power collector and 3rd rail type conductor rail for the Korean-standardized rubber-tired AGT light rail vehicle. At the test track for the Korean-standardized rubber-tired AGT light rail vehicle, interruption ratios, stresses, vibrations, and contact force variations were measured by test conditions, having various train speed. As the results, it was verified that developed 3rd rail type conductor maintains interruption characteristics, which can supply stable electric power.

• Proceedings of the KIEE Conference
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• 2005.07b
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• pp.1653-1656
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• 2005

Korea Railroad Research Institute(KRRI) has developed the rubber-tired AGT system from 1999 to 2005. The rubber-tired AGT system is now on test for its performance and function at the test line in Gyeong-San. This paper is concerned with the recent development of the AGT system and its reliability evaluation technology which are now being applied in test line. Also, we made the reliable program to assure required the RAMS((reliability, availability, maintainability & safety) of the AGT system.