• Molecules and Cells
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• v.42 no.9
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• pp.672-685
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• 2019

Currently, liver transplantation is the only available remedy for patients with end-stage liver disease. Conservation of transplanted liver graft is the most important issue as it directly related to patient survival. Carbonyl reductase 1 (CBR1) protects cells against oxidative stress and cell death by inactivating cellular membrane-derived lipid aldehydes. Ischemia-reperfusion (I/R) injury during living-donor liver transplantation is known to form reactive oxygen species. Thus, the objective of this study was to investigate whether CBR1 transcription might be increased during liver I/R injury and whether such increase might protect liver against I/R injury. Our results revealed that transcription factor Nrf2 could induce CBR1 transcription in liver of mice during I/R. Pre-treatment with sulforaphane, an activator of Nrf2, increased CBR1 expression, decreased liver enzymes such as aspartate aminotransferase and alanine transaminase, and reduced I/R-related pathological changes. Using oxygen-glucose deprivation and recovery model of human normal liver cell line, it was found that oxidative stress markers and lipid peroxidation products were significantly lowered in cells overexpressing CBR1. Conversely, CBR1 knockdown cells expressed elevated levels of oxidative stress proteins compared to the parental cell line. We also observed that Nrf2 and CBR1 were overexpressed during liver transplantation in clinical samples. These results suggest that CBR1 expression during liver I/R injury is regulated by transcription factor Nrf2. In addition, CBR1 can reduce free radicals and prevent lipid peroxidation. Taken together, CBR1 induction might be a therapeutic strategy for relieving liver I/R injury during liver transplantation.

• Journal of Science Education
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• v.43 no.2
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• pp.239-257
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• 2019

This study attempts to understand the context of shared learning in the trading zone formed by teachers from different backgrounds and the process in which this shared learning varies in the educational context, focusing on the case of 'Woodwork Science Education Study Group.' To do this, data was collected through in-depth interviews with eight teachers who participated in the 'Woodworking Science Education Research Group' and analyzed their responses based on grounded theory. As a result, the causal conditions of the teachers' research group were 'various contexts of entering the trading zone' and the central phenomenon was 'encounter with learning in the trading zone.' Contextual conditions affecting this phenomenon were 'woodwork as a boundary object and individual transfiguration experience,' and action/interaction strategy was 'various efforts and influences in the field.' The intervention condition was 'practical effort and experience in educational field.' Final result in this model is 'the new practice of learning shared in the trading zone.' In selective coating, it was found that the practice of the teacher's research group appears as four types of' 'Extracurricular creative experience type,' 'career education type,' 'curricula education type,' and 'school management type.' The results of this study suggest that the shared learning and antonymous practice among teachers in the teachers' research group as trading zone do not only meet their learning needs but also lead to various teaching practices in the individual teachers' context of education and improve the diversity and quality of education.

• Convergence Security Journal
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• v.18 no.2
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• pp.167-177
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• 2018

Major countries, such as the U.S., UK and Germany have reformed their national intelligence systems in the face of transnational, asymmetric and comprehensive threats since September 11, 2001 and have strengthened the intelligence capacity involved in countering terrorism and WMD proliferation, right/left extremism threats. The Korean Moon Jae-in government is preparing a reform plan to eliminate illegal political intervention and abuse of power by the National Intelligence Service(NIS) and to rebuild it as an efficient national intelligence agency for national security. In discussing the reform direction of the NIS, it is necessary to discuss in detail whether adopting a separate model of intelligence agencies to restrict domestic intelligence activities of the NIS and concentrate on foreign intelligence activities or establish new domestic intelligence agencies. Second, as for the issue of transferring anti-Communism investigation authority of the NIS to the police, it needs to be carefully considered in terms of balancing the efficiency and professionalism of intelligence agency activity in the context of North Korea's continuous military provocation, covert operations and cyber threats. Third, it should strive to strengthen the control and supervision functions of the administration and the National Assembly to ensure the political neutrality of the NIS in accordance with the democratization era, to guarantee citizens' basic rights and to improve the transparency of budget execution.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.6
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• pp.38-47
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• 2019

The purpose of this study was to identify latent classes in executive function difficulty of first graders depends on evaluations from their mother and teacher and to investigate how its related with their school adaption and academic performance in second grade. Based on the model of the latent profile analysis, the 8th and 9th wave data from Korean Children and Youth Panel Survey were analyzed. The results of this study were as following. First, results showed that there were three types of latent classes in the executive function difficulty depend on evaluations from their mother and teacher: 'low executive function,' 'students who were highly evaluated by mother,' and 'students who were highly evaluated by teacher.' Second, students' executive function difficulty had a direct effect on the students' school adaption and academic performance in their second year of school. Especially students who were evaluated as having the lowest executive function difficulty showed significant higher means than students who were evaluated higher by mother and teacher. This study emphasized the importance of multiple evaluation in students' executive function difficulty to provide an educational intervention.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.7
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• pp.393-405
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• 2019

This study is descriptive survey research to find out factors which violence experience, violence coping and social support affect. This study aims at reducing burnout of psychiatry nurses and founding problem-oriented violence handling standardized intervention. The subjects were 204 nurses who have worked for more than a year in a hospital. The data collection period was conducted with structured survey from July 1, 2018 to August 31, 2018. Collected data was analysed with average, standard deviation, t-test, ANOVA, Pearson's Correlation confident, Multiple Regression and this data will go to by SPSS. The results of the study were as follows. 92.2% of psychiatry nurses are experiencing verbal violence, 92.2% are experiencing physical threat and 75.5% are experiencing physical violence. Relations between violence experience and violence coping(r=0.15. p<.027), violence experience and burnout(r=0.16, p<.017) were positive correlation. Relation between violence coping and social support(r=0.30, p<.001) was positive correlation, and social support and burnout(r=-0.28, p<.001) was negative correlated. Also we found out that nursing job satisfaction, social support and physical violence experience affect burnout. Which shows model's explanatory power was 33.3%. Therefore preventive discipline which can reduce violence experience of psychiatry nurses, founding systems to reinforce social support and creating circumstance where nursing job satisfaction can increase will help reduce burnout and serve better nursing.

• Journal of the Korea Convergence Society
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• v.10 no.5
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• pp.385-395
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• 2019

This was a descriptive study to investigate the effect of social support and resilience on sick role behaviors of hemodialysis patients, and aims to provide base data on nursing intervention programs for improving the sick role behaviors of hemodialysis patients. The study subjects was patients with chronic kidney disease undergoing hemodialysis treatment at a general hospital in D city. The final analysis has been made on 131 questionnaires. The average of social support score was $3.93{\pm}0.84$, and resilience score was $2.67{\pm}0.80$. At last sick role behavior score was $3.99{\pm}0.80$. According to the analysis on the correlations among the study subjects' social support, resilience and sick-role behaviors, the social support had statistically and significantly positive correlation. In regression analysis, frequency of dialysis, social support and resilience have appeared to be the variables influencing sick role behavior, and the explanatory power of this model is 44.0%.

• The Journal of the Korea Contents Association
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• v.21 no.4
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• pp.278-291
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• 2021

This study performed a longitudinal research on the causal relationship between multidimensionality of problem drinking and poverty, and multidimensional deprivation meaning the inequality, focusing on gender difference. For this, this study examined the latent group of problem drinking change trajectory through the latent class growth analysis targeting total 3,770 men and 5,632 women by using the 6th-year Korea Welfare Panel Study data from 2013 to 2018, and then conducted the multinominal logistic regression analysis to verify the influence of multidimensional deprivation factors on this latent group. The main results of this study are as follows. First, the latent group of problem drinking change trajectory according to gender was classified into three latent groups in both men and women while the development aspect was different from each other. The male latent group with 'moderate level' or higher showed higher level of problem drinking than women. However, in case of 'drinking group with high level' according to gender, as time passed, the men tended to maintain it while the women tended to increase it. Second, in the results of examining the effects of multidimensional deprivation on the latent group of problem drinking change trajectory, the men with more experiences of social deprivation and the women with more experiences of social security deprivation showed the higher possibility to belong to the 'drinking group with high level' compared to the 'drinking group with low level'. Based on such results above, this study discussed the preventive/intervention measures for problem drinking according to gender.

• Journal of Digital Convergence
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• v.17 no.11
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• pp.269-278
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• 2019

This study ascertained convergent influence on self-leadership and its association with self-competence, self-efficacy and locus of control among female freshmen in health majors studying TOEIC. Data collection was carried out using a self-administered questionnaire from April 29, 2019 to May 10, 2019 and the target was randomly selected 201 female freshmen in health majors in TOEIC class from college located in J city. Self-leadership was positively correlated with self-competence, self-efficacy and locus of control. The covariance structure analysis showed that the higher self-competence, the higher self-efficacy and the lower locus of control tend to increase self-leadership. The results of the study indicate that the efforts, to increase self-competence and self-efficacy, to decrease locus of control, are required to improve self-leadership of female freshmen in health majors studying TOEIC. These results are expected to be used for educational counseling and intervention efforts to enhance self-leadership among female freshmen in health majors studying TOEIC. In future studies, further research on additional factors affecting self-leadership is needed.

• Journal of Digital Convergence
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• v.19 no.1
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• pp.443-451
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• 2021

The purpose of this study is to investigate the mediating effects of depression, academic helplessness, and smartphone addiction tendency in the relationship between self-esteem and grit of adolescents. Data from the 2018 (first-year) Korean Children and Youth Panel Survey were used in this study. The subjects of this study were 1,375 male and 1,166 female students in seventh grade school. The multiple mediation model analysis was conducted using the SPSS and PROCESS macro program. The results of this study are as follows. First, there was a positive correlation between self-esteem and grit, while self-esteem and grit had negative correlations with depression, academic helplessness, smartphone addiction. Second, it was found that the relationship between self-esteem and grit was mediated by depression, academic helplessness, and smartphone addiction tendency, respectively, and furthermore, it was found that all pathways mediated sequentially were also significant. These results suggest that education and intervention considering self-esteem, depression, academic helplessness, and smartphone addiction to be useful as a way to help adolescents develop interest in specific goals and continue their efforts in these days when smartphone use is common.

• The Journal of Society for e-Business Studies
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• v.26 no.1
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• pp.93-106
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• 2021

Many recent studies on deep learning-based road crack detection have shown significantly more improved performances than previous works using algorithm-based conventional approaches. However, many deep learning-based studies are still focused on classifying the types of cracks. The classification of crack types is highly anticipated in that it can improve the crack detection process, which is currently relying on manual intervention. However, it is essential to calculate the severity of the cracks as well as identifying the type of cracks in actual pavement maintenance planning, but studies related to road crack detection have not progressed enough to automated calculation of the severity of cracks. In order to calculate the severity of the crack, the type of crack and the area of the crack in the image must be identified together. This study deals with a method of using Mobilenet-SSD that is deep learning-based object detection techniques to effectively automate the simultaneous detection of crack types and crack areas. To improve the accuracy of object-detection for road cracks, several experiments were conducted to combine the U-Net for automatic segmentation of input image and object-detection model, and the results were summarized. As a result, image masking with U-Net is able to maximize object-detection performance with 0.9315 mAP value. While referring the results of this study, it is expected that the automation of the crack detection functionality on pave management system can be further enhanced.