• 디지털융복합연구
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• 제3권1호
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• pp.9-25
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• 2005

The purpose of this study is to explore conquest plans of the barrier and resistance in innovation management. In addition, this study is to describe the model of innovation resistance that reflects adoption process stages and identify the factors that drive the resistance of consumers and the barriers. Whenever organizations try to plan and implement some kind of innovation in organizations, they confront the resistance and barriers in many ways. By understanding innovation resistance and barrier, organizations can not only design better innovations but can develop strategies to reduce resistance and conquer the barriers. Thus they accelerate innovation. Also, these results indicate that people resist innovation strongly when it betrays their value, needs and beliefs or when they felt the pressure on self-conviction and mental risk, loss, and lack of knowledge. Understanding the factors that drive the innovation resistance and barrier has important implications for both theoretical development and managerial action.

• 디지털산업정보학회논문지
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• 제9권2호
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• pp.151-163
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• 2013

It goes without saying that the technology innovation plays an important role in the sustainable growth of the firm in the global economy. It, however, is not easy to fulfill this simple and obvious fact. Because there are a lot of barriers hindering innovation activities of firms and innovations are interrupted or don't even attempts by this barriers. So in this paper, I study barriers of firms that try to innovation and how much negative impact exist on firm's innovation performance by that. And also I try to find influence on firm's performance because of declined innovation activities. To prove this, KIS(Korean Innovation Survey) 2008, which was surveyed by STEPI(Science and Technology Policy Institute), is used to find relationships among variables; innovation barriers, innovation activities and firm's performance. In the result, I find that financial barrier influence negatively to the process innovation with small business, capable barrier influence negatively to the process innovation with large business and organizational barrier influence negatively to the process innovation with both small and large business. And, it also appear that organizational barrier has not moderating effect but process efficiency has moderating effect significantly with small business that have more positive effect.

• Korea Journal of Cosmetic Science
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• 제1권1호
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• pp.19-29
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• 2019

In this work, we fabricated liquid crystal (LC) emulsions with fatty alcohol in order to stabilize high content ceramide in cosmetic formulation. We investigated the role of fatty alcohol and surfactant in the formation of higher order structure. As a result, we found that they play a crucial role to form higher order structure. SAXS study shows that ceramide can be incorporated up to 3% in cosmetic formulation with higher order structure and its stability was maintained up to 12 weeks at room temperature. According to WAXS study, the higher order structure can suppress the re-crystallization of ceramide in cosmetic formulation. Finally, we performed in vivo skin barrier recovery test for the damaged skin. LC emulsions with ceramide and O/W emulsions show significant effect in skin barrier recovery at D 1, D 2 and D 6 compared to the untreated condition. While only LC emulsions show significant skin recovery effect at D 14. We expect that LC emulsions are the promising skin carrier to stabilize ceramide and LC emulsions with ceramide can improve the skin barrier function.

• 한국디지털정책학회:학술대회논문집
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• 한국디지털정책학회 2005년도 춘계학술대회
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• pp.13-28
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• 2005

The purpose of this study is to explore conquest plans of the barrier and resistance in innovation management. This paper focuses to understand the model of innovation that reflects adoption process stages and identify the factors that drive the resistance of consumers. Whenever organizations try to plan and implement some kind of innovation in organizations, they confront resistance in many ways. By understanding innovation resistance, organizations can not only design better innovations but can develop strategies to reduce resistance. Thus they accelerate innovation. Understanding the factors that drive the innovation resistance has important implications for both theoretical development and managerial action. These results indicate that people resist innovation strongly when it betrays their value, needs and beliefs or when they felt the pressure on self-conviction and mental risk, loss, and lack of knowledge.

• 한국비블리아학회지
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• 제31권1호
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• pp.5-20
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• 2020

본 연구는 건강관리에 대한 인식이 높아지면서 많은 양의 건강 앱이 생산되고 있지만 이에 대한 이용 수준이 낮은 원인을 파악하고자 하였다. 즉, 이용자가 지닌 혁신저항(사용 장벽 정도, 가치 장벽 정도, 위험 장벽 정도, 전통 장벽 정도, 이미지 장벽 정도)이 건강 앱 이용의도에 미치는 영향을 살펴보았다. 본 연구를 위해 대학생들을 대상으로 설문을 진행하여 378개의 유효한 응답을 얻었다. 연구 결과, 이용자의 이미지장벽 정도가 높을수록 건강 앱에 대한 혁신저항 정도가 높아지며, 혁신저항 정도가 높을수록 지속적 이용의도 정도와 추천의지 정도가 낮게 나타났다. 또한, 사용장벽 정도, 가치장벽 정도 그리고 전통장벽 정도는 혁신저항 정도에 유의한 영향을 미치지 않는 것으로 나타났다. 본 연구는 건강 앱의 이용행태를 혁신저항이론으로 설명함으로써 신기술의 수용 및 지속적 사용에 대한 학문적 논의를 심화시켰다. 연구 결과는 건강 앱의 수용 및 지속적 이용을 위해서는 사용장벽, 가치장벽 그리고 전통장벽보다는 이미지장벽을 낮추는 것이 효과적일 것이라는 실질적 함의를 제공한다.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2008년도 International Meeting on Information Display
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• pp.617-619
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• 2008

Inorganic-organic hybrid multilayers were formed on the plastic substrate to enhance the barrier properties of substrate to water vapor and oxygen transport. Plasma pretreatment of substrate with $Ar/O_2$ lead to adhesion improvement and the densification of inorganic layer on the substrates. Combination of $SiO_xN_y$ layer and silanenanoclay composite layer offered quite good barrier properties (WVTR and OTR) to PES substrate.

• Animal Bioscience
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• 제35권8호
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• pp.1235-1249
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• 2022

Objective: The purpose of this study was to evaluate the protection of glutamate (GLU) against the impairment in intestinal barrier function induced by lipopolysaccharide (LPS) stress in weaned pigs. Methods: Twenty-four weaned pigs were divided into four treatments containing: i) non-challenged control, ii) LPS-challenged control, iii) LPS+1.0% GLU, and iv) LPS+2.0% GLU. On day 28, pigs were treated with LPS or saline. Blood samples were collected at 0, 2, and 4 h post-injection. After blood samples collection at 4 h, all pigs were slaughtered, and spleen, mesenteric lymph nodes, liver and intestinal samples were obtained. Results: Dietary GLU supplementation inhibited the LPS-induced oxidative stress in pigs, as demonstrated by reduced malondialdehyde level and increased glutathione level in jejunum. Diets supplemented with GLU enhanced villus height, villus height/crypt depth and claudin-1 expression, attenuated intestinal histology and ultrastructure impairment induced by LPS. Moreover, GLU supplementation reversed intestinal intraepithelial lymphocyte number decrease and mast cell number increase induced by LPS stress. GLU reduced serum cortisol concentration at 4 h after LPS stress and downregulated the mRNA expression of intestinal corticotropin-releasing factor signal (corticotrophin-releasing factor [CRF], CRF receptor 1 [CRFR1], glucocorticoid receptor, tryptase, nerve growth factor, tyrosine kinase receptor A), and prevented mast cell activation. GLU upregulated the mRNA expression of intestinal transforming growth factor β. Conclusion: These findings indicate that GLU attenuates LPS-induced intestinal mucosal barrier injury, which is associated with modulating CRF signaling pathway.

• 대한화장품학회지
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• 제46권1호
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• pp.73-80
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• 2020

심리적 스트레스는 피부의 생리적 상태에 영향을 미치고 다양한 피부 질환을 일으킬 수 있다. 스트레스 호르몬인 코티솔은 섬유질, 케라틴세포, 멜라노사이트와 같은 다양한 피부세포에 의해 분비된다. 밀착연접(tight junction, TJ) 은 포유류 피부의 과립증에서 장벽을 형성하는 세포 접합부위이다. TJ은 다른 피부 장벽기능에도 영향을 미칠 수 있으며 화학, 미생물 또는 면역학적 피부장벽에게 영향을 받는다. 스트레스로 인한 피부 장벽 손상에 관한 보고는 있지만 사람피부에서 코티솔이 TJ을 조절한다는 보고는 없다. 스트레스 호르몬 코티솔이 TJ을 조절하는 기능을 확인하기 위해 각질형성세포에 코티솔을 처리하였다. 코티솔은 TJ 구성 성분의 유전자 발현과 구조를 조절하여 피부 장벽 기능을 손상시켰다. 또한 코티솔은 인공피부 모델에서 과립층 형성을 억제하였다. 이러한 실험결과를 통해 스트레스 호르몬 코티솔이 TJ를 조절함으로써 피부 장벽 기능에 손상을 일으키는 것을 확인할 수 있었다.

• 대한약리학회:학술대회논문집
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• 대한약리학회 2006년도 The 6th Congress of the Federation of Asian and Oceanian Physiological Societies
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• pp.126.2-126.2
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• 2006

• Asian-Australasian Journal of Animal Sciences
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• 제30권2호
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• pp.236-245
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• 2017

Objective: The study was to investigate the effects of alanyl-glutamine (Ala-Gln) and glutamine (Gln) supplementation on the intestinal mucosa barrier in piglets. Methods: A total of 180 barrows with initial weight $10.01{\pm}0.03kg$ were randomly allocated to three treatments, and each treatment consisted of three pens and twenty pigs per pen. The piglets of three groups were fed with control diet [0.62% alanine (Ala)], Ala-Gln diet (0.5% Ala-Gln), Gln diet (0.34% Gln and 0.21% Ala), respectively. Results: The results showed that in comparison with control diet, dietary Ala-Gln supplementation increased the height of villi in duodenum and jejunum (p<0.05), Gln supplementation increased the villi height of jejunum (p<0.05), Ala-Gln supplementation up-regulated the mRNA expressions of epidermal growth factor receptor and insulin-like growth factor 1 receptor in jejunal mucosa (p<0.05), raised the mRNA expressions of Claudin-1, Occludin, zonula occludens protein-1 (ZO-1) and the protein levels of Occludin, ZO-1 in jejunal mucosa (p<0.05), Ala-Gln supplementation enlarged the number of goblet cells in duodenal and ileal epithelium (p<0.05), Gln increased the number of goblet cells in duodenal epithelium (p<0.05) and Ala-Gln supplementation improved the concentrations of secretory immunoglobulin A and immunoglobulin G in the jejunal mucosa (p<0.05). Conclusion: These results demonstrated that dietary Ala-Gln supplementation could maintain the integrity of small intestine and promote the functions of intestinal mucosa barriers in piglets.