• Journal of fish pathology
• /
• v.18 no.3
• /
• pp.277-285
• /
• 2005

Israeli carps were intraperitoneally injected with an aqueous extract of red ginseng (RG) at five different concentrations (0, 1, 10, 25 and 50 mg/kg of body weight). The fish were sacrificed after 3 days and measured the neutrophil activity and plasma components. The activity of lysozyme, Ht, TIC and NBT reduction were significantly enhanced in the concentrations of more than 10 mg/kg. Further attempts were made to measure the effects of RG on leucocyte function at five different concentrations (1-100 ${\mu}g/m{\ell}$), in vitro. The proliferation of lymphocytes co-incubated with phytohaemagglutin (PHA) and concanavalin A (Con A) was significantly increased at 10 ${\mu}g/m{\ell}$ concentration, but suppressed at the highest concentration (100 ${\mu}g/m{\ell}$). RG alone or with lipopolysaccharide (LPS) had no effect on proliferation at any concentrations tested. Migration and reactive oxygen intermediates (ROI) production of leucocytes were enhanced in all concentration higher than 10 ${\mu}g/m{\ell}$. These results suggest that the RG activates the leucocyte function and may be able to be used as a stimulant of fish innate defences.

• Research in Plant Disease
• /
• v.23 no.2
• /
• pp.114-149
• /
• 2017

World-wide crop loss caused by insect pest and nematode reaches critical level. In Korea, similar crop loss has been gradually augmented in the field and greenhouse due to continuous crop rotation. The current methods on controlling herbivorous insects and plant parasitic nematodes are mostly depended on agro-chemicals that have resulted additional side-effect including occurrence of resistant insects and nematodes, environmental contamination, and accumulation in human body. To overcome the pitfalls, microbe-based control method have been introduced and applied for several decades. Here, we revised biological control using by the bacteria, fungi, and virus in order to kill insect and nematode and to attenuate its virulence mechanism. The introduced microbes mainly secreted out the hydrolysing enzymes and toxic compounds to target host membrane or cell wall directly. Indirectly, the microbe-triggered plant innate immunity against insects and nematodes was also reported. In conclusion, we provide a new frontier of microbe-based environmentally friendly procedure and effective methods to manage insects and nematodes.

• Korean Journal of Veterinary Research
• /
• v.36 no.1
• /
• pp.39-49
• /
• 1996

The present study was performed to investigate the distribution of neuropeptide Y immunoreactivities in the corpus striatum of the Korean squirrels. The animals were perfused with 4%-paraformaldehyde and the brain was cut serially into $40{\mu}m$ thick coronal sections. Sections either were stained with cresyl violet or were stained immunohistochemically. The corpus striatum was divided into the caudate nucleus, putamen and globus pallidus. Anterior part. however, of the striatum was observed as the combined caudate-putamen. NPY immunoreactive (NPY-IR) neurons were medium-sized. The corpus striatum contained a low level of NPY-IR fibers, whose distribution appeared to be related to the immunoreactive perikarya. Large numbers of NPY-IR neurons in the caudate-putamen and caudate nucleus were expressed in medial and ventral parts. In the anterior part of the putamen NPY-IR neurons were scattered throughout the nucleus; in posterior part were found generally in the lateral and ventral parts. The density of NPY-IR fibers of the putamen were low, whose distribution appeared to be related to the perikarya. The globus pallidus contained NPY-IR fibers only in the lowest density. In brief, NPY-immunoreactivities in the corpus striatum are heterogenous in distribution. These findings may reflect innate characteristics of the specific neural circuit in the corpus striatum itself.

• Korean Journal of Food Science and Technology
• /
• v.41 no.2
• /
• pp.220-224
• /
• 2009

Toll-like receptors(TLRs) are pattern recognition receptors(PRRs) that recognize pathogen-associated molecular patterns(PAMPs) and regulate the activation of innate immunity. All TLR signaling pathways culminate in the activation of NF-${\kappa}$B, leading to the induction of inflammatory gene products such as COX-2. Licorice (Glycyrrhiza uralensis) has been used for centuries as an herbal medicine. Isoliquiritigenin(ILG), a simple chalcone-type flavonoid, is an active component present in licorice and has been used to treat many chronic diseases. However, the mechanism as to how ILG mediates health effects is still largely unknown. In the present report, we present biochemical evidence that ILG inhibits the NF-${\kappa}$B activation induced by TLR agonists and the overexpression of downstream signaling components of TLRs, MyD88, IKK${\beta}$, and p65. ILG also inhibits TLR agonists-induced COX-2 expression. These results suggest that anti-inflammatory effects of ILG are caused by modulation of the immune responses regulated by TLR signaling pathways.

• Korean Journal of Head & Neck Oncology
• /
• v.30 no.2
• /
• pp.53-61
• /
• 2014

Background and Objectives : Anaplastic thyroid carcinoma(ATC) is a rare but highly aggressive thyroid malignancy that is associated with an extremely poor survival despite the best multidisciplinary care. BRAF(V600E) mutation is detected in about a quarter of ATC, but unlike its high treatment response to selective BRAF inhibitor (PLX4032) in metastatic melanoma, the treatment response of ATC is reported to be low. The purpose of this study is to investigate the innate resistance mechanism responsible for this low treatment response to BRAF inhibitor and its effect on epithelial-mesenchymal transition(EMT). Materials and Methods : Two ATP cell lines, 8505C and FRO were selected and treated with PLX4032 and its drug sensitivity and effects on cell migration and EMT were examined and compared. Further investigation on the changes in signals responsible for the different treatment response to PLX4032 was carried out and the same experiment was performed on both orthotopic and ectopic xenograft mouse models. Results : FRO cell line was more sensitive to PLX4032 treatment compared to 8505C cell line. The resistance to BRAF inhibition in 8505C was due to increased expression of EGFR. Effective inhibition of both EGFR and p-AKT was achieved after dual treatment with BRAF inhibitor(PLX4032) and EGFR inhibitor(Erlotinib). Similar results were confirmed on in vivo study. Conclusion : EGFR-mediated reactivation of the PI3K/AKT pathway and MAPK pathway contributes to the relative insensitivity of BRAF(V600E) mutant ATC cells to PLX4032. Dual inhibition of BRAF and EGFR leads to sustained treatment response including cell invasiveness.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.11 no.5
• /
• pp.1863-1872
• /
• 2010

Researches recently made in advanced countries into entrepreneurship found that various resources and information are mainly provided to ventures through social capital, which is a resource capital based on a network, and through corporate entrepreneurship. This research is an exploratory study on the effects of social capital and corporate entrepreneurship of new ventures upon their corporate performance, conducted from the standpoint of dynamic capability. For that purpose, a questionnaire investigation was made of 171 venture entrepreneurs in Korea, and the following are the results of an empirical analysis of responses to the questionnaire. First, it was found that social capital, which is a resource capital based on a network, had a significant effect on corporate entrepreneurship. Second, social capital also had a significant effect on ventures corporate performance. Third, corporate entrepreneurship had a significant effect on corporate performance. These results imply that social capital and corporate entrepreneurship have a significant effect on the corporate performance of ventures, which have innate disadvantages concerning the supply of resources. On the other hand, ventures, which encounter relatively more intense demands for change and renovation, can be managed in a sustainable manner just when they adequately accumulate their social capital and utilize their external resources and appropriately conduct their corporate entrepreneurship activities.

• The Journal of the Korea Contents Association
• /
• v.17 no.1
• /
• pp.465-474
• /
• 2017

This study aimed to identify the trends of related research as a basic study for the development of creative convergent formative education program of natural structure concept. This study sought to identify research trends present in previous studies. The nature structure of the preliminary research was limited to the three concepts: (i) fractal ; (ii) kinetic and (iii) biomimicry. In this study, the trends of domestic research in the last 10 years related to the concept of natural structure were analyzed using academic research information service. It was found that, to date, little research has been conducted on the three concepts across education fields. In relation to the fractal concept, previous research has focused on mathematics. This preliminary study sought to review the abovementioned three concepts or the development of a modeling education program. It should be significant, if an education program adopted unlimited modeling principles to understand the innate features of the nature structure. However, very few education programs have adopted the three concepts of the nature structure. Future studies would seek to review international research trends based on the three concepts of the nature structure and combine the results on international research trends with the results on domestic research trends found in this study.

• Korean Journal of Food Science and Technology
• /
• v.47 no.4
• /
• pp.511-516
• /
• 2015

In the present study, we investigated changes in the nutritional components of pre- and post-germinated barley seeds and also investigated their immune-enhancing effects such as production of nitric oxide (NO), interleukin (IL)-6, and tumor necrosis factor (TNF)-${\alpha}$ on the RAW 264.7 macrophage cell line. Protein and total sugar contents increased slightly with increase in germination time. The major neutral sugars of germinated balrey seeds were arabinose, glucose, and xylose. Glucose content decreased during germination, whereas arabinose and xylose contents increased during germination. Amino acid contents of barley germinated for 24 and 48 hours increased 1.03-fold and 1.24-fold, respectively, compared to that of pre-germinated barley. Moreover, RAW 264.7 macrophages stimulated with barley germinated for 24 and 48 hours showed higher production of NO, IL-6, and TNF-${\alpha}$ compared to that observed in pre-germinated barley. The results of the present study indicate that germinated barley may have immune-enhancing effects derived from its ability to activate RAW 264.7 macrophages, which play a major role in innate immunity.

• Korean Journal of Social Welfare
• /
• v.66 no.1
• /
• pp.139-162
• /
• 2014

This paper critically examines the existing discourses about 'relationship', a key element of social work practice and questingly examines Lao-tzu's work of Tao Te Ching, the book of way and virtue, as an alternative theoretical framework for social work relationship. Compared to current discourses of relationship beleaguered by either modernism or postmodernism, both of which are in the deadlock of binary perspective, the insights and vision in Tao Te Ching are successfully able to overcome the limits of them and provide new and profound way of thinking about human, society and their relationship. Especially core cannons crystallized by natural humanistic concepts for cosmos coupled with innate critical power against artificial manipulations of world can extend the horizon of understanding concerning the relationship between client and social workers and therefore provide a new and attractive roles in professional relationship. Moreover, opposed to usual images of Lao-tzu's ideas such as nihilism and passivity, alternative relationship of social work can play an important role of caring the disordered reality where Dao disappered and criticise the selfish desires of individuals and comport the broken-hearted minds in modern society. In addition, results of this paper implies that more extended study articulating ideas of Tao Te Ching with the social work practice would have lots of potentials to promote later researches in quest of 'Korean' social work practice.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.21 no.6
• /
• pp.62-69
• /
• 2020

This study examined Internet discourse on inter-regional co-prosperity. In particular, the study is interested in the co-prosperity between the Daegu-Gyeongbuk regions. The Internet discourse was searched through a set of four keywords: co-prosperity, economy, business attraction, and cultural tourism. The study also conducted sentiment analysis of YouTube comments to determine how the Internet responds to co-prosperity topics. The findings of the analysis are as follows. First, Internet discourse related to co-prosperity has evolved from abstract concepts to concrete cooperative measures and policy contents. Second, the discussion of co-prosperity has moved from outside help or support to self-sustaining innate motivation. Finally, YouTube sentiment analysis showed that if co-prosperity efforts between regions are promoted through concrete policy contents, it becomes easier to gain positive responses from citizens and lead a positive policy drive. In this regard, a study on Internet discourse is a useful means to detect citizens' response to inter-regional co-prosperity.