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NF-${\kappa}$ B Activation and Cyclooxygenase-2 Expression Induced by Toll-Like Receptor Agonists can be Suppressed by Isoliquiritigenin  

Park, Se-Jeong (Department of Medical Science, College of Medical Sciences, Soonchunhyang University)
Yang, Seung-Ju (Department of Biomedical Laboratory Science, Konyang University)
Youn, Hyung-Sun (Department of Medical Science, College of Medical Sciences, Soonchunhyang University)
Publication Information
Korean Journal of Food Science and Technology / v.41, no.2, 2009 , pp. 220-224 More about this Journal
Abstract
Toll-like receptors(TLRs) are pattern recognition receptors(PRRs) that recognize pathogen-associated molecular patterns(PAMPs) and regulate the activation of innate immunity. All TLR signaling pathways culminate in the activation of NF-${\kappa}$B, leading to the induction of inflammatory gene products such as COX-2. Licorice (Glycyrrhiza uralensis) has been used for centuries as an herbal medicine. Isoliquiritigenin(ILG), a simple chalcone-type flavonoid, is an active component present in licorice and has been used to treat many chronic diseases. However, the mechanism as to how ILG mediates health effects is still largely unknown. In the present report, we present biochemical evidence that ILG inhibits the NF-${\kappa}$B activation induced by TLR agonists and the overexpression of downstream signaling components of TLRs, MyD88, IKK${\beta}$, and p65. ILG also inhibits TLR agonists-induced COX-2 expression. These results suggest that anti-inflammatory effects of ILG are caused by modulation of the immune responses regulated by TLR signaling pathways.
Keywords
toll-like receptors; isoliquiritigenin; NF-${\kappa}$B; COX-2; LPS;
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