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Effect of Red ginseng extract on immune function of Israeli carp, Cyprinus carpio.  

Choi, Min-Soon (Department of Aqualife Medicine, Kunsan National University)
Park, Sung-Woo (Department of Aqualife Medicine, Kunsan National University)
Park, Kwan-Ha (Department of Aqualife Medicine, Kunsan National University)
Publication Information
Journal of fish pathology / v.18, no.3, 2005 , pp. 277-285 More about this Journal
Abstract
Israeli carps were intraperitoneally injected with an aqueous extract of red ginseng (RG) at five different concentrations (0, 1, 10, 25 and 50 mg/kg of body weight). The fish were sacrificed after 3 days and measured the neutrophil activity and plasma components. The activity of lysozyme, Ht, TIC and NBT reduction were significantly enhanced in the concentrations of more than 10 mg/kg. Further attempts were made to measure the effects of RG on leucocyte function at five different concentrations (1-100 ${\mu}g/m{\ell}$), in vitro. The proliferation of lymphocytes co-incubated with phytohaemagglutin (PHA) and concanavalin A (Con A) was significantly increased at 10 ${\mu}g/m{\ell}$ concentration, but suppressed at the highest concentration (100 ${\mu}g/m{\ell}$). RG alone or with lipopolysaccharide (LPS) had no effect on proliferation at any concentrations tested. Migration and reactive oxygen intermediates (ROI) production of leucocytes were enhanced in all concentration higher than 10 ${\mu}g/m{\ell}$. These results suggest that the RG activates the leucocyte function and may be able to be used as a stimulant of fish innate defences.
Keywords
Red ginseng; Lymphocyte proliferation; Leucocyte function;
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