• 한국보육지원학회지
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• 제19권3호
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• pp.1-17
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• 2023

Objective: This study aims to provide empirical data on epidemic management measures and childcare teacher education in centers. It examines the relationship between infectious disease knowledge, health control knowledge, and self-efficacy in relation to the practice of preventive behaviors among infant and toddler teachers during the COVID-19 pandemic. Methods: The study involved 300 teachers from Seoul and Gyeonggi Province. Data were collected through questionnaires and analyzed using SPSS 23.0. Results: The study found that there is a positive relationship between childcare teachers' knowledge of infectious diseases and their engagement in preventive behavior. Additionally, internal control among the health care factors of childcare teachers also showed a positive relationship. Furthermore, the study revealed that the self-efficacy of childcare teachers is positively associated with their practice of preventive behavior. Overall, infectious disease knowledge, internal control measures, and self-efficacy were all found to have positive relationships with preventive behavior. Conclusion/Implications: This study proposes a new direction for future teacher education by highlighting the effectiveness of psychological factors, specifically health control materials and self-efficacy, in addition to focusing on improving infectious disease knowledge.

• The Korean Journal of Medicine
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• 제91권1호
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• pp.88-91
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• 2016

혈구포식 림프조직구증식증(HLH)은 대식세포와 림프구의 증식과 활성화가 조절되지 않아 발생하게 되는 드문 과염증 증후군으로, 치명적인 예후를 초래하는 경우가 많다. 저자들은 기저 질환이 없는 환자에서 B형 인플루엔자 감염과 연관되어 발생한 혈구포식 림프조직구증식증으로 인하여 사망한 증례를 경험하여 이를 보고하는 바이다.

• 한국지리정보학회지
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• 제25권2호
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• pp.18-29
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• 2022

본 연구의 목적은 2020년 1월부터 8월까지 발생한 COVID-19 감염증 발생의 공간적 확산의 패턴을 파악하고 영향요인을 추정하고자 하는 것이다. 우리나라 시·군·구별 COVID-19 확진자를 대상으로 탐색적 공간자료분석과 공간회귀모형을 활용하여 분석하였다. 분석의 결과 COVID-19는 기존에 논의되던 감염병 출현의 요인이었던 숙주와 환경요인이 큰 영향을 미치는 것으로 나타나지 않았으며 공간적으로 인접한 지역과의 관계가 높게 나타났다. 특히 신종 감염병인 4군 감염병의 발생 패턴과 밀접한 관련이 있는 것으로 나타났다. 이 연구의 결과는 COVID-19가 새로운 감염병임에도 불구하고 기존에 발생하였던 신종 감염병의 발생과 전혀 다른 패턴이 아니라는 점을 보여준다. 이는 신종 감염병을 효과적으로 통제하기 위해서 과거 새로운 감염병이 출현하였던 공간의 특성을 지속적으로 관리해야 함을 의미한다.

• Infection and chemotherapy
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• 제50권4호
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• pp.346-349
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• 2018

In 2015, rapid human immunodeficiency virus (HIV) testing was implemented in all 25 public health centers in Seoul. During March and December 2015, 20,987 rapid HIV tests were performed, of which 116 (0.5%) were positive. Compared to those of the period before application of the rapid HIV test in place of conventional enzyme immunoassay method, the number of HIV tests performed and the number of positive results increased by sevenfold and twofold, respectively. In conclusion, expansion of the provision of rapid HIV tests in public health centers increased the number of voluntary HIV tests.

• IMMUNE NETWORK
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• 제22권3호
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• pp.21.1-21.21
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• 2022

As far the current severe coronavirus disease 2019 (COVID-19), respiratory disease is still the biggest threat to human health. In addition, infectious respiratory diseases are particularly prominent. In addition to killing and clearing the infection pathogen directly, regulating the immune responses against the pathogens is also an important therapeutic modality. Sirtuins belong to NAD+-dependent class III histone deacetylases. Among 7 types of sirtuins, silent information regulator type-1 (SIRT1) played a multitasking role in modulating a wide range of physiological processes, including oxidative stress, inflammation, cell apoptosis, autophagy, antibacterial and antiviral functions. It showed a critical effect in regulating immune responses by deacetylation modification, especially through high-mobility group box 1 (HMGB1), a core molecule regulating the immune system. SIRT1 was associated with many respiratory diseases, including COVID-19 infection, bacterial pneumonia, tuberculosis, and so on. Here, we reviewed the latest research progress regarding the effects of SIRT1 on immune system in respiratory diseases. First, the structure and catalytic characteristics of SIRT1 were introduced. Next, the roles of SIRT1, and the mechanisms underlying the immune regulatory effect through HMGB1, as well as the specific activators/inhibitors of SIRT1, were elaborated. Finally, the multitasking roles of SIRT1 in several respiratory diseases were discussed separately. Taken together, this review implied that SIRT1 could serve as a promising specific therapeutic target for the treatment of respiratory diseases.

• Toxicological Research
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• 제23권2호
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• pp.97-105
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• 2007

Toll-like receptors (TLRs) playa crucial role in initiating and regulating innate and adaptive immune responses by detecting invading microbial pathogens. TLRs can also respond to non-microbial molecules derived from damaged tissue. Accumulating evidence suggests that deregulation of TLRs results in the dysfunction of immune system and ultimately increases the risk of many immune and inflammatory diseases including infectious diseases, allergy, and autoimmune diseases. Therefore, understanding how the immune system is controlled by TLRs will provide new insight to find the way to prevent or treat infectious diseases and immune disorders.

• Tuberculosis and Respiratory Diseases
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• 제80권4호
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• pp.401-402
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• 2017

• Parasites, Hosts and Diseases
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• 제61권1호
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• pp.15-23
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• 2023

Concerns about foodborne illnesses caused by Kudoa septempunctata are steadily growing, but reports of K. septempunctata in clinical and food specimens related to food poisoning in Korea are limited. This study aimed to genetically identify K. septempunctata in patients with acute diarrhea and in clinical and food samples related to food poisoning caused by sashimi consumption. Both real-time and nested polymerase chain reaction assays were performed to detect K. septempunctata 18S and 28S rDNA genes in the stools of 348 patients with acute diarrhea, 11 samples (6 stool and 5 rectal swab samples) from patients with food poisoning, and 2 raw Paralichthys olivaceus samples collected from a restaurant where a food poisoning incident occurred. K. septempunctata was identified in 5 clinical specimens (4 stools and 1 rectal swab) and 1 P. olivaceus sashimi sample. All detected K. septempunctata were of genotype ST3. This is the first study to identify K. septempunctata in both patients and food samples with epidemiological relevance in Korea, providing evidence that it is a pathogen that causes food poisoning. Also, this is the first study to confirm the presence of K. septempunctata genes in rectal swabs. Despite continuing suspected occurrences of Kudoa foodborne outbreaks, the rate of identification of K. septempunctata is very low. One reason for this is the limitation in obtaining stool and vomit samples for the diagnosis of Kudoa infection. We strongly suggest the inclusion of rectal swabs among the diagnostic specimens for Kudoa food poisoning.

• Parasites, Hosts and Diseases
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• 제50권2호
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• pp.133-136
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• 2012

Visceral leishmaniasis (VL) is a life-threatening infection caused by Leishmania species. In addition to typical clinical findings as fever, hepatosplenomegaly, and cachexia, VL is associated with autoimmune phenomena. To date, VL mimicking or exacerbating various autoimmune diseases have been described, including systemic lupus erythematosus (SLE), rheumatoid arthritis, and autoimmune hepatitis (AIH). Herein, we presented a patient with VL who had overlapping clinical features with SLE, AIH, as well as antimitochondrial antibody (AMA-M2) positive primary biliary cirrhosis.

• Mycobiology
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• 제36권1호
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• pp.10-12
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• 2008

In recent years, there has been a rapid decrease in amphibian populations worldwide, and infectious diseases have been associated with this decline. Diseased frogs inhabiting Korea were collected from fields, and the diseases were identified by morphological and molecular analyses. Two fungal diseases-saprolegniasis and chromomycosis-were detected in the frogs. Saprolegniasis caused by Saprolegnia spp. was found in Rana plancyi chosenica from Gangwon-do and Rana huanrenensis from Chungbuk. Chromomycosis, which is caused by infection with Cladosporium cladosporioides, was detected in Rana catesbeiana from Busan.