| 1 |
Alexopoulou, L., Holt, A.C., Medzhitov, R. and Flavell, R.A. (2001). Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature, 413, 732- 738
|
| 2 |
Ben-Ali, M., Barbouche, M.R., Bousnina, S., Chabbou, A. and Dellagi, K. (2004). Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients. Clin. Diagn. Lab. Immunol., 11, 625- 626
|
| 3 |
Brierley, M.M. and Fish, E.N. (2002). Review: IFN-alpha/beta receptor interactions to biologic outcomes: understanding the circuitry. J. Interferon. Cytokine. Res., 22, 835-845
DOI
ScienceOn
|
| 4 |
Cluff, C.W., Baldridge, J.R., Stover, A.G., Evans, J.T., Johnson, D.A., Lacy, M.J., Clawson, V.G., Yorgensen, V.M., Johnson, C.L., Livesay, M.T., Hershberg, R.M. and Persing, D.H. (2005). Synthetic toll-like receptor 4 agonists stimulate innate resistance to infectious challenge. Infect. Immun., 73, 3044-3052
DOI
ScienceOn
|
| 5 |
Hayashi, F., Smith, K.D., Ozinsky, A., Hawn, T.R., Yi, E.C., Goodlett, D.R., Eng, J.K., Akira, S., Underhill, D.M. and Aderem, A. (2001). The innate immune response to bacterial flagellin is mediated by Toll- like receptor 5. Nature, 410, 1099-1103
DOI
ScienceOn
|
| 6 |
Kaisho, T., Hoshino, K., Iwabe, T., Takeuchi, O., Yasui, T. and Akira, S. (2002). Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation. Int. Immunol., 14, 695-700
DOI
ScienceOn
|
| 7 |
Kariko, K., Ni, H., Capodici, J., Lamphier, M. and Weissman, D. (2004). mRNA is an endogenous ligand for Toll-like receptor 3. J. Biol. Chem., 279, 12542-12550
DOI
ScienceOn
|
| 8 |
Kawai, T., Takeuchi, O., Fujita, T., Inoue, J., Muhlradt, P.F., Sato, S., Hoshino, K. and Akira, S. (2001). Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J. Immunol., 167, 5887-5894
DOI
|
| 9 |
Lau, C.M., Broughton, C., Tabor, A.S., Akira, S., Flavell, R.A., Mamula, M.J., Christensen, S.R., Shlomchik, M.J., Viglianti, G.A., Rifkin, I.R. and Marshak-Rothstein, A. (2005). RNAassociated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J. Exp. Med., 202, 1171-1177
DOI
ScienceOn
|
| 10 |
Leadbetter, E.A., Rifkin, I.R., Hohlbaum, A.M., Beaudette, B.C., Shlomchik, M.J. and Marshak-Rothstein, A. (2002). Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature, 416, 603-607
DOI
ScienceOn
|
| 11 |
Lorenz, E., Mira, J.P., Frees, K.L. and Schwartz, D.A. (2002). Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch. Intern. Med., 162, 1028-1032
DOI
ScienceOn
|
| 12 |
Lu, M., Zhang, M., Takashima, A., Weiss, J., Apicella, M.A., Li, X.H., Yuan, D. and Munford, R.S. (2005). Lipopolysaccharide deacylation by an endogenous lipase controls innate antibody responses to Gram-negative bacteria. Nat. Immunol., 6, 989-994
DOI
ScienceOn
|
| 13 |
Marshak-Rothstein, A. (2006). Toll-like receptors in systemic autoimmune disease. Nat. Rev. Immunol., 6, 823-835
DOI
ScienceOn
|
| 14 |
Medzhitov, R. (2001). Toll-like receptors and innate immunity. Nat. Rev. Immunol., 1, 135-145
DOI
ScienceOn
|
| 15 |
Medzhitov, R. and Janeway, C. Jr. (2000). The Toll receptor family and microbial recognition. Trends Microbiol., 8, 452-456
DOI
ScienceOn
|
| 16 |
Takeuchi, O., Sato, S., Horiuchi, T., Hoshino, K., Takeda, K., Dong, Z., Modlin, R.L. and Akira, S. (2002). Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol., 169, 10-14
DOI
|
| 17 |
O'Brien, A.D., Rosenstreich, D.L., Scher, I., Campbell, G.H., MacDermott, R.P. and Formal, S.B. (1980). Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene. J. Immunol., 124, 20-24
|
| 18 |
Saitoh, S., Akashi, S., Yamada, T., Tanimura, N., Kobayashi, M., Konno, K., Matsumoto, F., Fukase, K., Kusumoto, S., Nagai, Y., Kusumoto, Y., Kosugi, A. and Miyake, K. (2004). Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization. Int. Immunol., 16, 961-969
DOI
ScienceOn
|
| 19 |
Tabeta, K., Georgel, P., Janssen, E., Du, X., Hoebe, K., Crozat, K., Mudd, S., Shamel, L., Sovath, S., Goode, J., Alexopoulou, L., Flavell, R.A. and Beutler, B. (2004). Tolllike receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl. Acad. Sci. USA 101, 3516-3521
DOI
ScienceOn
|
| 20 |
Toshchakov, V., Jones, B.W., Perera, P.Y., Thomas, K., Cody, M.J., Zhang, S., Williams, B.R., Major, J., Hamilton, T.A., Fenton, M.J. and Vogel, S.N. (2002). TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat. Immunol., 3, 392- 398
DOI
ScienceOn
|
| 21 |
Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H. and Bauer, S. (2004). Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science, 303, 1526-1529
DOI
ScienceOn
|
| 22 |
Eder, W., Klimecki, W., Yu, L., von Mutius, E., Riedler, J., Braun-Fahrlander, C., Nowak, D. and Martinez, F.D. (2004). Toll-like receptor 2 as a major gene for asthma in children of European farmers. J. Allergy Clin. Immunol., 113, 482-488
DOI
ScienceOn
|
| 23 |
Iwasaki, A. and Medzhitov, R. (2004). Toll-like receptor control of the adaptive immune responses. Nat. Immunol., 5, 987-995
DOI
ScienceOn
|
| 24 |
Lee, J.Y., Zhao, L., Youn, H.S., Weatherill, A.R., Tapping, R., Feng, L., Lee, W.H., Fitzgerald, K.A. and Hwang, D.H. (2004). Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Tolllike receptor 6 or 1. J. Biol. Chem., 279, 16971-16979
DOI
ScienceOn
|
| 25 |
Pulendran, B., Kumar, P., Cutler, C.W., Mohamadzadeh, M., Van Dyke, T. and Banchereau, J. (2001). Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J. Immunol., 167, 5067-5076
DOI
|
| 26 |
Eldridge, M.W. and Peden, D.B. (2000). Allergen provocation augments endotoxin-induced nasal inflammation in subjects with atopic asthma. J. Allergy Clin. Immunol., 105, 475-481
DOI
ScienceOn
|
| 27 |
Gao, J.J., Filla, M.B., Fultz, M.J., Vogel, S.N., Russell, S.W. and Murphy, W.J. (1998). Autocrine/paracrine IFN-alphabeta mediates the lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: pivotal role of Stat1alpha in induction of the inducible nitric oxide synthase gene. J. Immunol., 161, 4803-4810
|
| 28 |
Hoebe, K., Georgel, P., Rutschmann, S., Du, X., Mudd, S., Crozat, K., Sovath, S., Shamel, L., Hartung, T., Zahringer, U. and Beutler, B. (2005). CD36 is a sensor of diacylglycerides. Nature, 433, 523-527
DOI
ScienceOn
|
| 29 |
Querec, T., Bennouna, S., Alkan, S., Laouar, Y., Gorden, K., Flavell, R., Akira, S., Ahmed, R. and Pulendran, B. (2006). Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. J. Exp. Med., 203, 413-424
DOI
ScienceOn
|
| 30 |
Braun-Fahrlander, C., Riedler, J., Herz, U., Eder, W., Waser, M., Grize, L., Maisch, S., Carr, D., Gerlach, F., Bufe, A., Lauener, R.P., Schierl, R., Renz, H., Nowak, D. and von Mutius, E. (2002). Environmental exposure to endotoxin and its relation to asthma in school-age children. N. Engl. J. Med., 347, 869-877
DOI
ScienceOn
|
| 31 |
Krauss, J.H., Seydel, U., Weckesser, J. and Mayer, H. (1989). Structural analysis of the nontoxic lipid A of Rhodobacter capsulatus 37b4. Eur. J. Biochem., 180, 519-526
DOI
ScienceOn
|
| 32 |
Munford, R.S. and Hall, C.L. (1986). Detoxification of bacterial lipopolysaccharides (endotoxins) by a human neutrophil enzyme. Science, 234, 203-205
DOI
|
| 33 |
Hagberg, L., Hull, R., Hull, S., McGhee, J.R., Michalek, S.M. and Svanborg Eden, C. (1984). Difference in susceptibility to gram-negative urinary tract infection between C3H/ HeJ and C3H/HeN mice. Infect. Immun., 46, 839-844
|
| 34 |
Seong, S.Y. and Matzinger, P. (2004). Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses. Nat. Rev. Immunol., 4, 469- 478
DOI
ScienceOn
|
| 35 |
Zhang, H., Tay, P.N., Cao, W., Li, W. and Lu, J. (2002). Integrin- nucleated Toll-like receptor (TLR) dimerization reveals subcellular targeting of TLRs and distinct mechanisms of TLR4 activation and signaling. FEBS Lett., 532, 171-176
DOI
ScienceOn
|
| 36 |
Bochud, P.Y., Hawn, T.R. and Aderem, A. (2003). Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling. J. Immunol., 170, 3451-3454
DOI
|
| 37 |
Ogus, A.C., Yoldas, B., Ozdemir, T., Uguz, A., Olcen, S., Keser, I., Coskun, M., Cilli, A. and Yegin, O. (2004). The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease. Eur. Respir. J., 23, 219- 223
DOI
ScienceOn
|
| 38 |
Letiembre, M., Echchannaoui, H., Bachmann, P., Ferracin, F., Nieto, C., Espinosa, M. and Landmann, R. (2005). Tolllike receptor 2 deficiency delays pneumococcal phagocytosis and impairs oxidative killing by granulocytes. Infect. Immun., 73, 8397-8401
DOI
ScienceOn
|
| 39 |
Michel, O., Kips, J., Duchateau, J., Vertongen, F., Robert, L., Collet, H., Pauwels, R. and Sergysels, R. (1996). Severity of asthma is related to endotoxin in house dust. Am. J. Respir. Crit. Care. Med., 154, 1641-1646
DOI
ScienceOn
|
| 40 |
Beutler, B. (2004). Inferences, questions and possibilities in Toll-like receptor signalling. Nature, 430, 257-263
DOI
ScienceOn
|
| 41 |
Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K. and Akira, S. (2002). Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol., 3, 196-200
DOI
ScienceOn
|
| 42 |
Fitzgerald, K.A., Rowe, D.C., Barnes, B.J., Caffrey, D.R., Visintin, A., Latz, E., Monks, B., Pitha, P.M. and Golenbock, D.T. (2003). LPS-TLR4 Signaling to IRF-3/7 and NF- {kappa}B Involves the Toll Adapters TRAM and TRIF. J. Exp. Med., 198, 1043-1055
DOI
ScienceOn
|
| 43 |
Werner, M., Topp, R., Wimmer, K., Richter, K., Bischof, W., Wjst, M. and Heinrich, J. (2003). TLR4 gene variants modify endotoxin effects on asthma. J. Allergy Clin. Immunol., 112, 323-330
DOI
ScienceOn
|
| 44 |
Kitchens, R.L., Ulevitch, R.J. and Munford, R.S. (1992). Lipopolysaccharide (LPS) partial structures inhibit responses to LPS in a human macrophage cell line without inhibiting LPS uptake by a CD14-mediated pathway. J. Exp. Med., 176, 485-494
DOI
ScienceOn
|
| 45 |
Lee, J.Y. and Hwang, D.H. (2006). The modulation of inflammatory gene expression by lipids: mediation through Tolllike receptors. Mol. Cells, 21, 174-185
|
| 46 |
Nagai, Y., Akashi, S., Nagafuku, M., Ogata, M., Iwakura, Y., Akira, S., Kitamura, T., Kosugi, A., Kimoto, M. and Miyake, K. (2002). Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat. Immunol., 3, 667-672
DOI
|
| 47 |
Tian, J., Avalos, A.M., Mao, S.Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., Hua, J., An, L.L., Audoly, L., La Rosa, G., Bierhaus, A., Naworth, P., Marshak-Rothstein, A., Crow, M.K., Fitzgerald, K.A.,Latz, E., Kiener, P.A. and Coyle, A.J. (2007). Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat. Immunol., 8, 487-496
DOI
ScienceOn
|
| 48 |
Hemmi, H., Kaisho, T., Takeda, K. and Akira, S. (2003). The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J. Immunol., 170, 3059-3064
DOI
|
| 49 |
Lorenz, E., Mira, J.P., Cornish, K.L., Arbour, N.C. and Schwartz, D.A. (2000). A novel polymorphism in the tolllike receptor 2 gene and its potential association with staphylococcal infection. Infect. Immun., 68, 6398-6401
DOI
|
| 50 |
Smirnova, I., Mann, N., Dols, A., Derkx, H.H., Hibberd, M.L., Levin, M. and Beutler, B. (2003). Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proc. Natl. Acad. Sci. USA, 100, 6075-6080
DOI
ScienceOn
|
| 51 |
Medzhitov, R., Preston-Hurlburt, P. and Janeway, C.A. Jr. (1997). A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature, 388, 394-397
DOI
ScienceOn
|
| 52 |
Thorne, P.S., Kulhankova, K., Yin, M., Cohn, R., Arbes, S.J. Jr. and Zeldin, D.C. (2005). Endotoxin exposure is a risk factor for asthma: the national survey of endotoxin in United States housing. Am. J. Respir. Crit. Care. Med., 172, 1371-1377
DOI
ScienceOn
|
| 53 |
Woods, J.P., Frelinger, J.A., Warrack, G. and Cannon, J.G. (1988). Mouse genetic locus Lps influences susceptibility to Neisseria meningitidis infection. Infect. Immun., 56, 1950-1955
|
| 54 |
Honda, K., Yanai, H., Negishi, H., Asagiri, M., Sato, M., Mizutani, T., Shimada, N., Ohba, Y., Takaoka, A., Yoshida, N. and Taniguchi, T. (2005). IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature, 434, 772-777
DOI
ScienceOn
|
| 55 |
Agnese, D.M., Calvano, J.E., Hahm, S.J., Coyle, S.M., Corbett, S.A., Calvano, S.E. and Lowry, S.F. (2002). Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gramnegative infections. J. Infect. Dis., 186, 1522-1525
DOI
ScienceOn
|
| 56 |
Harte, M.T., Haga, I.R., Maloney, G., Gray, P., Reading, P.C., Bartlett, N.W., Smith, G.L., Bowie, A. and O'Neill, L.A. (2003). The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense. J. Exp. Med., 197, 343-351
DOI
|
| 57 |
Lee, J.Y., Sohn, K.H., Rhee, S.H. and Hwang, D. (2001). Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J. Biol. Chem., 276, 16683-16689
DOI
ScienceOn
|
| 58 |
Tabeta, K., Hoebe, K., Janssen, E.M., Du, X., Georgel, P., Crozat, K., Mudd, S., Mann, N., Sovath, S., Goode, J., Shamel, L., Herskovits, A.A., Portnoy, D.A., Cooke, M., Tarantino, L.M., Wiltshire, T., Steinberg, B.E.. Grinstein, S. and Beutler, B. (2006). The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat. Immunol., 7, 156-164
DOI
ScienceOn
|
| 59 |
Yang, Y., Liu, B., Dai, J., Srivastava, P.K., Zammit, D.J., Lefrancois, L. and Li, Z. (2007). Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages. Immunity, 26, 215-226
DOI
ScienceOn
|
| 60 |
DiPerna, G., Stack, J., Bowie, A.G., Boyd, A., Kotwal, G., Zhang, Z., Arvikar, S., Latz, E., Fitzgerald, K.A. and Marshall, W.L. (2004). Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors. J. Biol. Chem., 279, 36570-36578
DOI
ScienceOn
|
| 61 |
Krieg, A.M. (2000). The role of CpG motifs in innate immunity. Curr. Opin. Immunol., 12, 35-43
DOI
ScienceOn
|
| 62 |
Echchannaoui, H., Frei, K., Schnell, C., Leib, S.L., Zimmerli, W. and Landmann, R. (2002). Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation. J. Infect. Dis., 186, 798-806
DOI
ScienceOn
|
| 63 |
Lazarus, R., Klimecki, W.T., Raby, B.A., Vercelli, D., Palmer, L.J., Kwiatkowski, D.J., Silverman, E.K., Martinez, F. and Weiss, S.T. (2003). Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies. Genomics, 81, 85-91
DOI
ScienceOn
|
| 64 |
Stack, J., Haga, I.R., Schroder, M., Bartlett, N.W., Maloney, G., Reading, P.C., Fitzgerald, K.A., Smith, G.L. and Bowie, A.G. (2005). Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence. J. Exp. Med., 201, 1007-1018
DOI
ScienceOn
|
| 65 |
Schnare, M., Barton, G.M., Holt, A.C., Takeda, K., Akira, S. and Medzhitov, R. (2001). Toll-like receptors control activation of adaptive immune responses. Nat. Immunol., 2, 947-950
DOI
ScienceOn
|
| 66 |
Jiang, Z., Georgel, P., Du, X., Shamel, L., Sovath, S., Mudd, S., Huber, M., Kalis, C., Keck, S., Galanos, C., Freudenberg, M. and Beutler, B. (2005). CD14 is required for MyD88-independent LPS signaling. Nat. Immunol., 6, 565- 570
DOI
ScienceOn
|
| 67 |
Kang, T.J. and Chae, G.T. (2001). Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. FEMS Immunol. Med. Microbiol., 31, 53-58
DOI
|
| 68 |
Lee, J.Y., Lowell, C.A., Lemay, D.G., Youn, H.S., Rhee, S.H., Sohn, K.H., Jang, B., Ye, J., Chung, J.H. and Hwang, D.H. (2005). The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4. Biochem. Pharmacol., 70, 1231-1240
DOI
ScienceOn
|
| 69 |
Takeuchi, O., Kawai, T., Muhlradt, P.F., Morr, M., Radolf, J.D., Zychlinsky, A., Takeda, K. and Akira, S. (2001). Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int. Immunol., 13, 933-940
DOI
ScienceOn
|
| 70 |
Poltorak, A., He, X., Smirnova, I., Liu, M.Y., Van Huffel, C., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B. and Beutler, B. (1998). Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science, 282, 2085-2088
DOI
ScienceOn
|
| 71 |
Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.M. and Hoffmann, J.A. (1996). The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell, 86, 973-983
DOI
ScienceOn
|
| 72 |
Medzhitov, R., Preston-Hurlburt, P., Kopp, E., Stadlen, A., Chen, C., Ghosh, S. and Janeway, C.A. Jr. (1998). MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell., 2, 253-258
DOI
ScienceOn
|
| 73 |
Kurt-Jones, E.A., Popova, L., Kwinn, L., Haynes, L.M., Jones, L.P., Tripp, R.A., Walsh, E.E., Freeman, M.W., Golenbock, D.T., Anderson, L.J. and Finberg, R.W. (2000). Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat. Immunol., 1, 398-401
DOI
ScienceOn
|
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