• Tribology and Lubricants
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• 제30권3호
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• pp.139-145
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• 2014

Nowadays, most micro-patterns are manufactured during flow line production. However, a conventional rotary chemical mechanical polishing (CMP) system has a limited throughput for the fabrication of large and flexible electronics. To overcome this problem, we propose a novel linear roll-CMP system for the planarization of large-area electronics. In this paper, we present a statistical analysis on the linear roll-CMP process of copper-clad laminate (CCL) to determine the impacts of process parameters on the material removal rate (MRR) and its non-uniformity (NU). In the linear roll-CMP process, process parameters such as the slurry flow rate, roll speed, table feed rate, and down force affect the MRR and NU. To determine the polishing characteristics of roll-CMP, we use Taguchi's orthogonal array L16 (44) for the experimental design and F-values obtained by the analysis of variance (ANOVA). We investigate the signal-to-noise (S/N) ratio to identify the prominent control parameters. The "higher is better" for the MRR and "lower is better" for the NU were selected for obtaining optimum CMP performance characteristics. The experimental and statistical results indicate that the down force and roll speed mainly affect the MRR and the down force and table feed rate determine the NU in the linear roll-CMP process. However, over 186.3 N of down force deteriorates the NU because of the bending of substrate. Roll speed has little relationship to the NU and the table feed rate does not impact on the MRR. This study provides information on the design parameter of roll-CMP machine and process optimization.

• Ocean and Polar Research
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• 제35권1호
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• pp.15-26
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• 2013

The toxic, Harmful Algal Blooms (HABs) caused by the Cochlodinium polykrikoides have a serious impact on the coastal waters of Korea. In this study, the acoustic detection system was developed for rapid HABs detection, based on the acoustic backscattering properties of the C. polykrikoides. The developed system was mainly composed of a pulser-receiver board, a signal processor board, a control board, a network board, a power board, ultrasonic sensors (3.5 and 5.0 MHz), an environmental sensor, GPS, and a land-based control unit. To evaluate the performance of the system, a trail was done at a laboratory, and two in situ trials were conducted: (1) when there was no red tide, and (2) when there was red tide. In the laboratory evaluation, the system performed well in accordance with the number of C. polykrikoides in the received level. Second, under the condition when there was no red tide in the field, there was a good correlation between the acoustic data and sampling data. Finally, under the condition when there was red tide in the field, the system successfully worked at various densities in accordance with the number of C. polykrikoides, and the results corresponded with the sampling data and monitoring result of NFRDI (National Fisheries Research & Development Institute). From the laboratory and field evaluations, the developed acoustic detection system for early detecting HABs has demonstrated that it could be a significant system to monitor the occurrence of HABs in coastal regions.

• Journal of Biosystems Engineering
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• 제33권1호
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• pp.30-37
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• 2008

Dynamic excitation and response analysis is an acceptable method to determine some of physical properties of agricultural product for quality evaluation. There is a difference in the internal viscoelasticity between sound and defective fruits due to the difference of geometric structures, thereby showing different vibration characteristics. This study was carried out to develop a portable piezoelectric film-based glove sensor system that can separate internally damaged watermelons from sound ones using an acoustic impulse response technique. Two piezoelectric sensors based on polyvinylidene fluoride (PVDF) films to measure an impact force and vibration response were separately mounted on each glove. Various signal parameters including number of peaks, energy ratio, standard deviation of peak to peak distance, zero-crossing rate, and integral value of peaks were examined to develop a regression-estimated model. When using SMLR (Stepwise Multiple Linear Regression) analysis in SAS, three parameters, i.e., zeros value, number of peaks, and standard deviation of peaks were selected as usable factors with a coefficient of determination ($r^2$) of 0.92 and a standard error of calibration (SEC) of 0.15. In the validation tests using twenty watermelon samples (sound 9, defective 11), the developed model provided good capability showing a classification accuracy of 95%.

• Journal of Biosystems Engineering
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• 제33권1호
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• pp.38-44
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• 2008

The freight vehicle is mostly used to transport the fruit. Shock and impact generated by the freight vehicle may give serious damage to fruits hence to reduce the fruits damage, the optimum packaging design during transportation by vehicle is required. In order to design the packaging system for fruit transportation optimally, the comprehension of characteristic for vibration and shock acting on vehicles under various road conditions and loading methods is required. This research was performed to analyze the shock characteristics, acceleration level and power spectral density (PSD) of the fruit transportation vehicles under several travel roads and positions. The vibration signal was measured and analyzed at the transportation vehicle operating on the road of three different surface conditions. The maximum acceleration was measured at the rear-end of the vehicle, and the acceleration in the direction of up-and-down (z-axis) was much greater than those in the directions of back-and-forth (x-axis) or right-and-left (y-axis). The peak acceleration in the direction of up-and-down (z-axis) at the vehicle driving on the expressway, the local road paved with concrete, and unpaved local road were 5.3621 G, 8.232 G, and 14.162 G respectively. PSD at 2.44 Hz showed maximum value at all road conditions. The maximum values of PSD on the expressway, a local road paved with concrete, and unpaved local road were 0.0075222 $G^2/Hz$, 0.058655 $G^2/Hz$, and 0.24598 $G^2/Hz$ respectively. The value of PSD decreased with an increase of the vibration frequency of the transportation vehicle. In most cases, the vibration frequency was below 20 Hz during transportation.

• 마이크로전자및패키징학회지
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• 제27권3호
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• pp.61-67
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• 2020

본 논문에서는 FEM(유한요소) 기법을 사용하여 칩이 실장되는 않은 substrate와 칩이 실장된 substrate의 warpage를 해석하여 칩의 실장이 warpage에 미치는 영향을 비교·분석하였다. 또한, warpage를 감소시키기 위한 substrate의 층별 두께의 영향도 분석과 층별 두께 조건을 다구찌법에 의한 신호 대 잡음 비로 분석하였다. 해석 결과에 의하면 칩이 실장되면 substrate의 warpage는 패턴의 방향이 변할 수 있고, 칩이 실장되면서 패키지의 강성도(stiffness)가 증가하고, 패키지 상·하의 열팽창계수의 차이가 작아지면서 warpage는 감소하였다. 또한, 칩이 실장되지 않은 substrate를 대상으로 설계 파라메타의 영향도 분석 결과에 의하면 warpage를 감소시키기 위해서는 회로층 중에서 내층인 Cu1과 Cu4를 중점 관리하고, 다음으로 바닥면의 solder resist 층의 두께와 Cu1과 Cu2 사이의 프리프레그 층의 두께를 관리해야 한다.

• 한국인터넷방송통신학회논문지
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• 제14권6호
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• pp.93-98
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• 2014

고유가 시대에 대체 에너지를 찾고, 개인의 건강 증진 추세에 따라 점점 자전거를 이용하는 사람이 증가하고 있고, 이에 따라 자전거 교통사고 또한 증가되고 있다. 자전거 교통사고의 경우, 탑승자에게 사고의 충격량이 고스란히 전달되기 때문에 신체적 위험도가 높다. 그렇기 때문에 스스로 사고를 신고하기 어려워 사고에 대한 신속한 대응을 하지 못 할 수가 있다. 그래서 본 논문에서는 사고 발생 시 자전거에 장착된 사고 알림 장치를 통해 사고를 감지하고 감지된 신호를 바탕으로 GPS 장치에 의해 사고 위치 확인 후, 스마트폰의 어플리케이션을 이용하여 문자전송 및 사고위치 정보를 전송함으로서 탑승자의 안전성을 향상시키는 목적으로 자전거 사고 알림 시스템을 개발하였다. 그리고 실험을 통해 사고 발생 이후 2차 피해를 막기 위한 신속한 사고 대응 방법을 구축하여 구현한 시스템의 효율성을 확인할 수 있었다.

• Journal of Gastric Cancer
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• 제11권1호
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• pp.16-22
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• 2011

Purpose: Eupatilin is an antioxidative flavone and a phytopharmaceutical derived from Artemisia asiatica. It has been reported to possess anti-tumor activity in some types of cancer including gastric cancer. Eupatilin may modulate the angiogenesis pathway which is part of anti-inflammatory effect demonstrated in gastric mucosal injury models. Here we investigated the anti-tumor effects of eupatilin on gastric cancer cells and elucidated the potential underlying mechanism whereby eupatilin suppresses angiogenesis and tumor growth. Materials and Methods: The impact of eupatilin on the expression of angiogenesis pathway proteins was assessed using western blots in MKN45 cells. Using a chromatin immunoprecipitation assay, we tested whether eupatilin affects the recruitment of signal transducer and activator of transcription 3 (STAT3), aryl hydrocarbon receptor nuclear translocator (ARNT) and hypoxia-inducible factor-$1{\alpha}$ (HIF-$1{\alpha}$) to the human VEGF promoter. To investigate the effect of eupatilin on vasculogenesis, tube formation assays were conducted using human umbilical vein endothelial cells (HUVECs). The effect of eupatilin on tumor suppression in mouse xenografts was assessed. Results: Eupatilin significantly reduced VEGF, ARNT and STAT3 expression prominently under hypoxic conditions. The recruitment of STAT3, ARNT and HIF-$1{\alpha}$ to the VEGF promoter was inhibited by eupatilin treatment. HUVECs produced much foreshortened and severely broken tubes with eupatilin treatment. In addition, eupatilin effectively reduced tumor growth in a mouse xenograft model. Conclusions: Our results indicate that eupatilin inhibits angiogenesis in gastric cancer cells by blocking STAT3 and VEGF expression, suggesting its therapeutic potential in the treatment of gastric cancer.

• 인터넷정보학회논문지
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• 제21권2호
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• pp.19-26
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• 2020

This paper analyses the feasibility of using implantable antennas to detect and monitor tumors. We analyze this setting according to the wireless propagation loss and signal fading produced by human bodies and their environment in an indoor scenario. The study is based on the ITU-R propagation recommendations and prediction models for the planning of indoor radio communication systems and radio local area networks in the frequency range of 300 MHz to 100 GHz. We conduct primary estimations on 915 MHz and 2.4 GHz operating frequencies. The path loss presented in most short-range wireless implant devices does not take into account the human body as a channel itself, which causes additional losses to wireless designs. In this paper, we examine the propagation through the human body, including losses taken from bones, muscles, fat, and clothes, which results in a more accurate characterization and estimation of the channel. The results obtained from our simulation indicates a variation of the return loss of the spiral antenna when a tumor is located near the implant. This knowledge can be applied in medical detection, and monitoring of early tumors, by analyzing the electromagnetic field behavior of the implant. The tumor was modeled under CST Microwave Studio, using Wisconsin Diagnosis Breast Cancer Dataset. Features like the radius, texture, perimeter, area, and smoothness of the tumor are included along with their label data to determine whether the external shape has malignant or benign physiognomies. An explanation of the feasibility of the system deployment and technical recommendations to avoid interference is also described.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1863-1869
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• 2014

The amplification of telomerase component (TERC) gene could play an important role in generation and treatment of haematological malignancies. This present study was aimed to investigate copy number amplification status of TERC gene in chronic myeloid leukaemia (CML) patients who were being treated with imatinib mesylate (IM). Genomic DNA was extracted from peripheral blood of CML-IM Resistant (n=63), CML-IM Respond (n=63) and healthy individuals (n=30). TERC gene copy number predicted (CNP) and copy number calculated (CNC) were determined based on $Taqman^{(R)}$ Copy Number Assay. Fluorescence in situ hybridization (FISH) analysis was performed to confirm the normal signal pattern in C4 (calibrator) for TERC gene. Nine of CML patients showed TERC gene amplification (CNP=3), others had 2 CNP. A total of 17 CML patients expressed CNC>2.31 and the rest had 2.31>CNC>1.5. TERC gene CNP value in healthy individuals was 2 and their CNC value showed in range 1.59-2.31. The average CNC TERC gene copy number was 2.07, 1.99 and 1.94 in CML-IM Resistant patients, CML-IM Respond and healthy groups, respectively. No significant difference of TERC gene amplification observed between CML-IM Resistant and CML-IM Respond patients. Low levels of TERC gene amplification might not have a huge impact in haematological disorders especially in terms of resistance towards IM treatment.

• 대한전자공학회논문지SP
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• 제44권4호통권316호
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• pp.101-108
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• 2007

고성능 네트워크와 분산처리구조가 병렬처리와 함께 결합되면, 전체적인 디지털 신호처리 시스템의 계산능력, 신뢰도, 다양성을 향상시킨다. 본 논문에서는, 발전된 형태의 수중레이더 (sonar) 알고리즘인 수중정합장처리 (Matched-Field Processing MFP)를 위한 병렬처리 알고리즘을 디자인하고 다중 DSP 프로세서 기반의 병렬처리 시스템 상에서 성능분석과 함께 최적의 병렬처리 솔루션을 제안한다. 각각의 병렬 알고리즘은 특정한 도메인에서 주어진 계산량을 분산시키며 이를 통한 속도향상을 추구한다. 필요한 연산량과 형태에 따라서 병렬 알고리즘은 각기 다른 성능향상을 보여준다. 또한, 알고리즘의 계산량 분산방식 프로세서간의 통신방식, 알고리즘의 복잡도, 프로세서의 속도, 목적하는 시스템의 구성에 따라서 다양한 성능지표를 보여준다. 제안하는 주파수와 출력값 기반의 병렬 알고리즘은 상당한 계산량을 요구하는 수중정합처리 알고리즘을 적절히 다중 프로세서에 균형 있게 분산시켜 프로세서의 개수와 비례하는 성능향상을 보여주고 있다.