• 생명과학회지
• /
• 제18권8호
• /
• pp.1090-1095
• /
• 2008

근내지방 축적이 왕성하게 진행되는 12개월 및 27개월령 사이에 유전자발현이 증가하는 inducible cAMP early repressor (ICER) 유전자의 클로닝 및 유전자발현 특성을 규명하기 위하여 한우조직별, 근육 내 조지방 함량에 따라 마블링 high- 및 low 한우 각 4두와 3두씩을 공시하였다. ddRT-PCR 분석을 통하여 증폭된 300 bp PCR 산물 및 EST 서열을 중심으로 1.5 kb 한우 ICER cDNA를 염기서열 분석하였으며, 조직별 유전자발현분석결과, 식이지방이 흡수되는 소장 조직에서 ICER 유전자의 발현량이 가장 높았다. 아울러, 같은 근육타입인 등심 및 우둔조직 사이에서 ICER 유전자발현은 등심조직에서 2.5배 많이 발현하였다. 한우 마블링 high, low 두 그룹 간 유전자발현 분석 결과, high 그룹에서 ICER 유전자발현이 4배 이상 증가하는 것으로 분석되었다. 따라서, ICER 유전자는 가축의 마블링과 밀접한 관련이 있는 유전자임이 사료된다.

• 한국콘크리트학회:학술대회논문집
• /
• 한국콘크리트학회 2004년도 춘계 학술발표회 제16권1호
• /
• pp.814-817
• /
• 2004

Deterioration due to de-icer salt occurs in practice in concrete pavement, dike, barrier and similar structure. This paper reports the results of effect of de-icer salt on. durability of concrete structure in winter. To protect concrete structure from damage by de-icer salt in winter, the exposure test was performed using three countermeasures such as increase in design strength upto $350kg/cm^2$, application of ggbf slag powder, and concrete sealer. Of these, the method of increase in design strength upto $350kg/cm^2$ showed better durability for deterioration by de-icer salt.

• Journal of Power Electronics
• /
• 제18권2호
• /
• pp.456-466
• /
• 2018

This paper introduces the development of a de-icer based on a full-bridge modular multilevel converter (FMMC). The FMMC can generate a wide range of DC voltages owing to its modularity, scalability, and redundancy, which makes it suitable for ice-melting applications. First, operating principles and voltage ranges are analyzed when FMMC is applied as a mobile de-icer. Second, two new startup strategies, constant modulation index and constant power startup strategies, are proposed. Third, the main control strategies of the de-icer are proposed. Fourth, a novel rated-current zero-power test scheme is proposed to simplify test conditions. Finally, a 10 kV 1.5 kA mobile MMC de-icer is designed and built, and experiments are carried out to validate the proposed startup, control strategies, and rated-current zero-power test scheme.

• 한국콘크리트학회:학술대회논문집
• /
• 한국콘크리트학회 2005년도 추계 학술발표회 제17권2호
• /
• pp.523-526
• /
• 2005

In order to traffic safety during winter season, snowfall and cold area has been spread the deicing chemicals, and the spraying amount is increasing every year. Use of deicing chemicals has been and will continue to be a major part of highway snow and ice control methods. Chloride-containing chemicals such as calcium chloride or rock salt are main deicers for the road. Extensive use of chloride deicers is, however, the source of substantial cost penalties due to their corrosive action and acceleration to deterioration concrete structures. Deterioration due to de-icer salt occurs in practice in concrete pavement, dike, barrier and similar structure. This paper reports the results of effect of de-icer salt on durability of concrete structure in winter. To protect concrete structure from damage by de-icer salt in winter, the exposure test was performed using three methods such as increase in design strength upto 32MPa application of granulated blast furnace slag powder, and concrete sealer. Of these, the method of increase in design strength upto 32MPa showed better durability for deterioration by de-icer salt.

• 한국콘크리트학회:학술대회논문집
• /
• 한국콘크리트학회 2005년도 봄학술 발표회 논문집(II)
• /
• pp.221-224
• /
• 2005

In order to traffic safety during winter season, snowfall and cold area has been spread the deicing chemicals, and the spraying amount is increasing every year. Use of deicing chemicals has been and will continue to be a major part of highway snow and ice control methods. Chloride-containing chemicals such as calcium chloride or rock salt are main deicers for the road. Extensive use of chloride deicers is, however, the source of substantial cost penalties due to their corrosive action and acceleration to deterioration concrete structures. Deterioration due to de-icer salt occurs in practice in concrete pavement, dike, barrier and similar structure. This paper reports the results of effect of de-icer salt on durability of concrete structure in winter. To protect concrete structure from damage by de-icer salt in winter, the exposure test was performed using three methods such as increase in design strength upto 35MPa application of granulated blast furnace slag powder, and concrete sealer. Of these, the method of increase in design strength upto 35MPa showed better durability for deterioration by de-icer salt.

• 보건행정학회지
• /
• 제19권4호
• /
• pp.98-120
• /
• 2009

The purpose of this study is to elicit preference for drug listing decision criteria and to estimate the ICER threshold in South Korea using the discrete choice experiment (DCE) method. To collect the data, a DCE survey was administered to a subject sample either educated in the principle concepts of pharmacoeconomics or were decision makers within that field. Subjects chose between alternative drug profiles differing in four attributes: ICER, uncertainty, budget impact and severity of disease. The orthogonal and balanced designs were determined through computer algorithm to take the optimal set of drug profiles. The survey employed 15 hypothetical choice sets. A random effect probit model was used to analyze the relative importance of attributes and the probabilities of a recommendation response. Parameter estimates from the models indicated that three attributes (ICER, Impact, Severity of disease) influenced respondents' choice significantly(p${\pm}$0.001). In addition, each parameter displayed an expected sign. The Lower the ICER, the higher the probability of choosing that alternative. Respondents also preferred low levels of uncertainty and smaller impact on health service budget. They were also more likely to choose drugs for serious diseases rather than mild or moderate ones. Uncertainty however is not statistically significant. The ICER threshold, at which the probability of a recommendation was 0.5, was 29,000,000 KW/QALY in expert group and 46,500,000 KW/QALY in industry group. We also found that those in our sample were willing to accept high ICER to get medication for severe diseases. This study demonstrates that the cost-effectiveness, budget impact and severity of disease are the main reimbursement decision criteria in South Korea, and that DCE can be a useful tool in analyzing the decision making process where a variety of factors are considered and prioritized.

• 한국임상약학회지
• /
• 제28권1호
• /
• pp.40-50
• /
• 2018

Objective: This study presented the analysis period, the complexity of combined therapy and comparator choice as the key limitations in the economic evaluation of new drugs, and discussed programs for coping with these limitations. Methods: This study evaluated the post-evaluation, risk-sharing agreement, extra funding program, and flexible incremental cost-effectiveness ratio (ICER) threshold as actions or programs that would increase accessibility to costly new drugs. The study also presented the cases of other countries. The application of the post-evaluation was considered to deal with high uncertainty regarding new drugs. Results: The risk-sharing agreement was introduced in European countries as well as South Korea and has been responsible for the shift from using the financial schemes to outcome-based schemes. The drug funding program has had troubled in securing stable extra funds. The application of higher ICER in the economic evaluation of expensive and innovative oncology drugs was criticized because of the inequity between oncology patients and patients with other diseases. Conclusion: Therefore, introducing and applying actions that would increase the accessibility to costly new drugs in South Korea have been deemed necessary after careful reviews and discussions with various stakeholders (insurer, policy makers, pharmaceutical companies and patients).

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권4호
• /
• pp.2533-2540
• /
• 2013

Background: Although screening is necessary where gastric cancer is particularly common in Asia, the performance outcomes of mass screening programs have remained unclear. This study was conducted to evaluate cost-effectiveness outcomes of the national cancer screening program (NCSP) for gastric cancer in South Korea. Materials and Methods: People aged 40 years or over during 2002-2003 (baseline) were the target population. Screening recipients and patients diagnosed with gastric cancers were identified using the NCSP and Korea Central Cancer Registry databases. Clinical outcomes were measured in terms of mortality and life-years saved (LYS) of gastric cancer patients during 7 years based on merged data from the Korean National Health Insurance Corporation and National Statistical Office. We considered direct, indirect, and productivity-loss costs associated with screening attendance. Incremental cost-effectiveness ratio (ICER) estimates were produced according to screening method, sex, and age group compared to non-screening. Results: The age-adjusted ICER for survival was 260,201,000-371,011,000 Korean Won (KW; 1USD=1,088 KW) for the upper-gastrointestinal (UGI) tract over non-screening. Endoscopy ICERs were lower (119,099,000-178,700,000 KW/survival) than UGI. To increase 1 life-year, additional costs of approximately 14,466,000-15,014,000 KW and 8,817,000-9,755,000 KW were required for UGI and endoscopy, respectively. Endoscopy was the most cost-effective strategy for males and females. With regard to sensitivity analyses varying based on the upper age limit, endoscopy NCSP was dominant for both males and females. For males, an upper limit of age 75 or 80 years could be considered. ICER estimates for LYS indicate that the gastric cancer screening program in Korea is cost-effective. Conclusion: Endoscopy should be recommended as a first-line method in Korea because it is beneficial among the Korean population.

• 한국재난정보학회 논문집
• /
• 제11권4호
• /
• pp.548-555
• /
• 2015

본 연구에서는 동절기 교통안전을 위해 교량 구조물에 사용되는 제설제에 의한 염화물 침투 특성을 조사하여 사용수명을 평가하기 위해 수행되었다. 이 연구에서는 준공 후 공용기간이 약 10년이 경과한 10개 교량의 지점에서 깊이별 염화물 농도 분포를 조사하여 제설제에 의한 염해를 예측하기 위한 표면 염화물 농도와 확산계수를 도출하였다. 얻어진 정보를 바탕으로 Life-365 프로그램을 이용하여 각 지점의 사용수명을 평가하였다. 대상 교량의 사용수명 평가 결과 10개 지점 모두 100년 이상의 사용수명을 가질 것으로 판단되었다. 추가적으로 콘크리트의 배합에 기인한 확산계수를 구하여 제설제에 의한 염해와 해수에 의한 염해의 경우에 대해 확산특성을 비교 분석하고 사용수명을 평가하였다.

• Journal of Animal Science and Technology
• /
• 제52권4호
• /
• pp.265-270
• /
• 2010

본 실험은 지방대사에 영향을 주는 후보 유전자의 발현양상을 조사하기 위하여 bovine mesenchymal stem cell을 이용하여 체외에서 지방분화를 유도하였고, 지방분화 경과에 따른 지방관련 후보유전자의 발현양상을 분석 하였다. Oil red-O 염색법을 이용하여 지방 분화양상을 조사한 결과, 지방 분화 단계별(0, 2, 4 및 6일)로 붉게 염색된 지방적이 증가되었음을 확인하였고, 지방대사의 indicator인 PPAR$\gamma$와 FABP4 유전자는 지방분화 0일과 비교하여 6일에는 각각 3.11배와 3.11배가 증가하였다. 또한 지방대사와 관련이 있다고 추측되는 ICER, NOV, HSPB1 및 SDH 유전자의 발현양상을 조사한 결과, 지방분화 동안 ICER 유전자는 계속적으로 증가하여 6일은 0일에 비해 4.12배의 유의적인 증가를 보인 반면, NOV, HSPB1 및 SDH 유전자의 발현양은 0일 이후 계속적으로 감소하여, 6일에서 각각 2.89배, 3.18배 및 2.36배의 감소를 나타냈다. 본 실험에서, 등심조직에서 근내지방도에서 차이를 나타냈던 ICER, NOV, HSPB1 및 SDH 유전자를 보다 구체적이고 직접적으로 세포에서 지방분화를 통해 연관성을 조사했을 때, 지방분화와 직접적으로 관련되어 있는 것으로 나타났으며, 지방 대사를 조절하는 유전자로 추정된다.