• Journal of the Chungcheong Mathematical Society
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• v.21 no.4
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• pp.501-510
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• 2008

The distribution of the sum of n independent random variables having exponential distributions with different parameters ${\beta}_i$ ($i=1,2,{\ldots},n$) is given in [2], [3], [4] and [6]. In [1], by using Laplace transform, Jasiulewicz and Kordecki generalized the results obtained by Sen and Balakrishnan in [6] and established a formula for the distribution of this sum without conditions on the parameters ${\beta}_i$. The aim of this note is to present a method to find the distribution of the sum of n independent exponentially distributed random variables with different parameters. Our method can also be used to handle the case when all ${\beta}_i$ are the same.

• Communications of the Korean Mathematical Society
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• v.24 no.3
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• pp.341-351
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• 2009

The notion of rough sets was introduced by Z. Pawlak in the year 1982. The notion of a $\Gamma$-semigroup was introduced by M. K. Sen in the year 1981. In 2003, Y. B. Jun studied the roughness of sub$\Gamma$-semigroups, ideals and bi-ideals in i-semigroups. In this paper, we study rough prime ideals and rough fuzzy prime ideals in $\Gamma$-semigroups.

• Journal of the Korean Statistical Society
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• v.33 no.1
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• pp.35-58
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• 2004

For fixed positive integers and $\textit{k}\;(n\;{\geq}\;{\textit{k}}\;+\;2)$, the exact probability distributions of non-overlapping and overlapping patterns of two failures separated by (i) exactly $textsc{k}$ successes, (ii) at least $\textit{k}$ successes and (iii) at most $\textit{k}$ successes have been obtained for Bernoulli independent and Markov dependent trials by using combinatorial technique. The waiting time distributions for the first occurrence and the $r^{th}$ (r > 1) occurrence of the patterns have also been obtained.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.7 no.1
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• pp.119-131
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• 2013

With the explosive growth of computer networks, many remote service providing servers and multi-server network architecture are provided and it is extremely inconvenient for users to remember numerous different identities and passwords. Therefore, it is important to provide a mechanism for a remote user to use single identity and password to access multi-server network architecture without repetitive registration and various multi-server authentication schemes have been proposed in recent years. Recently, Tsaur et al. proposed an efficient and secure smart card based user authentication and key agreement scheme for multi-server environments. They claimed that their scheme satisfies all of the requirements needed for achieving secure password authentication in multi-server environments and gives the formal proof on the execution of the proposed authenticated key agreement scheme. However, we find that Tsaur et al.'s scheme is still vulnerable to impersonation attack and many logged-in users' attack. We propose an extended scheme that not only removes the aforementioned weaknesses on their scheme but also achieves user anonymity for hiding login user's real identity. Compared with other previous related schemes, our proposed scheme keeps the efficiency and security and is more suitable for the practical applications.

• Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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• v.4
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• pp.81-107
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• 2001

Ziel dieser Arbeit ist es, die Probleme der semantischen Interpretationen der heutigen deutschen Anaphern im $oberfl\"{a}chenstrukturell$ einfachen Satz mit Hilfe von Langackers 'C-Command' und Chomskys 'Government and Binding Theorie' zu $l\"{o}sen$. Bis Anfang der 70er Jahren wurden die koreferentiellen Erscheinungen zwischen NPs meist durch den von Langacker eingefuhrten 'precede and command' Begriff $gel\"{o}st$. Aber dieser Begriff ist $h\"{o}chst\;abitr\"{a}r$ auf theoretischen $Gr\"{u}nden$ und empirisch $inad\"{a}quat$. Reinhart versuchte, einige Schwierigkeiten mit Bezug auf Koreferenz-Beziehungen zwischen NPs zu $l\"{o}sen$, indem er command durch c-command ersetzte. Mit Hilfe von 'c-command'-Relationen werden manche Probleme, die bisher theoretisch nicht $erkl\"{a}rt$ werden konnten, befriedigend $gel\"{o}st$. Chomsky schlagt 'Binding Conditions' vor, um die semantischen Interpretationen der Anaphern im einfachen Satz zu behandeln. Die von ihm vorgeschlagenen 3 Bedingungen sind: (i) Eine Anapher $mu\ss$ in ihrer 'governing' Kategorie gebunden sein, (ii) Eine pronominale NP $mu\ss$ in ihrer 'governing' Kategorie frei sein, (iii) Eine lexikalische NP $mu{\ss}\;\"{u}berall$ frei sein. Dabei versteht man Anapher unter Reflexivpronomen, die pronominale NP unter Personalpronomen, und die lexikalische NP unter Referenz- Ausdruck. Aber in der vorliegenden Arbeit fassen ein Reflexivpronomen und ein Personalpronomen zu einer Anapher zusammen. Aufgrund der 'Binding Conditions' werden viele Fragen der semantischen Interpretationen, vor allem der komplementaren Verteilungen von den im einafchen Satz erscheinenden Anaphern erschlossen.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.1241-1245
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• 2015

Background: Thyroid carcinoma is the most common malignancy of the endocrine organs. Although the majority of thyroid cancer patients experience positive outcomes, anaplastic thyroid carcinoma is considered one of the most aggressive malignancies. Current therapeutic regimens do not confer a significant survival benefit, and new therapies are urgently needed. Oncolytic herpes simplex virus (oHSV) may represent a promising therapy for cancer. In the present study, we investigated the therapeutic effects of a third-generation HSV vector, $G47{\Delta}$, on various human thyroid carcinoma cell lines in vitro. Two subcutaneous (s.c.) models of anaplastic thyroid carcinoma were also established to evaluate the in vivo anti-tumor efficacy of $G47{\Delta}$. Materials and Methods: The human thyroid carcinoma cell line ARO, FRO, WRO, and KAT-5, were infected with $G47{\Delta}$ at different multiplicities of infection (MOIs) in vitro. The survival rates of infected cells were calculated each day. Two s.c. tumor models were established using ARO and FRO cells in Balb/c nude mice, which were intratumorally (i.t.) treated with either $G47{\Delta}$ or mock. Tumor volumes and mouse survival times were documented. Results: $G47{\Delta}$ was highly cytotoxic to different types of thyroid carcinomas. For ARO, FRO, and KAT-5, greater than 30% and 80% of cells were killed at MOI=0.01 and MOI=0.1, respectively on day 5. WRO cells displayed modest sensitivity to $G47{\Delta}$, with only 21% and 38% of cells killed. In the s.c. tumor model, both of the anaplastic thyroid carcinoma cell lines (ARO and FRO) were highly sensitive to $G47{\Delta}$; $G47{\Delta}$ significantly inhibited tumor growth and prolonged the survival of mice bearing s.c. ARO and FRO tumors. Conclusions: The oHSV $G47{\Delta}$ can effectively kill different types of human thyroid carcinomas in vitro. $G47{\Delta}$ significantly inhibited growth of anaplastic thyroid carcinoma in vivo and prolonged animal survival. Therefore, $G47{\Delta}$ may hold great promise for thyroid cancer patients.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.6
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• pp.2245-2254
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• 2013

A vulnerability index was developed for drought by using trend analysis and Delphi method. Twelve indicators were selected based on three groups, i.e., hydrological, meteorological, and humanistic groups. Data were collected from Nakdong river watershed. Three trend tests, i.e., Mann-Kendall, Hotelling-Pabst, and Sen's trend tests, were performed for standardizing the indicators and Delphi method was used to estimate the weights for individual indicators. The drought vulnerability index was calculated for seven regions in the Nakdong watershed and Hapcheon turned out to be the most vulnerable region among the study regions. The drought vulnerability index developed in this study can be applied to other regions in Korea for establishing national water resources management plan.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.4
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• pp.383-398
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• 2023

Dihydroaustrasulfone alcohol (DA), the synthetic precursor of a natural compound (austrasulfone) isolated from the coral species Cladiella australis, has shown cytotoxic effects against cancer cells. However, it is unknown whether DA has antitumor effects on nasopharyngeal carcinoma (NPC). In this study, we determined the antitumor effects of DA and investigated its mechanism of action on human NPC cells. The MTT assay was used to determine the cytotoxic effect of DA. Subsequently, apoptosis and reactive oxygen species (ROS) analyses were performed by using flow cytometry. Apoptotic and PI3K/AKT pathway-related protein expression was determined using Western blotting. We found that DA significantly reduced the viability of NPC-39 cells and determined that apoptosis was involved in DA-induced cell death. The activity of caspase-9, caspase-8, caspase-3, and PARP induced by DA suggested caspase-mediated apoptosis in DA-treated NPC-39 cells. Apoptosis-associated proteins (DR4, DR5, FAS) in extrinsic pathways were also elevated by DA. The enhanced expression of proapoptotic Bax and decreased expression of antiapoptotic BCL-2 suggested that DA mediated mitochondrial apoptosis. DA reduced the expression of pPI3K and p-AKT in NPC-39 cells. DA also reduced apoptosis after introducing an active AKT cDNA, indicating that DA could block the PI3K/AKT pathway from being activated. DA increased intracellular ROS, but N-acetylcysteine (NAC), a ROS scavenger, reduced DA-induced cytotoxicity. NAC also reversed the chances in pPI3K/AKT expression and reduced DA-induced apoptosis. These findings suggest that ROS-mediates DA-induced apoptosis and PI3K/AKT signaling inactivation in human NPC cells.

• Journal of the Korean Wood Science and Technology
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• v.17 no.4
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• pp.83-88
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• 1989

목재의 섬유방향에 경사진 균열의 모-드I과 모-드II의 혼합모-드파괴시의 파괴거동을 조사하기 위하여 라왕(Shorea Spp.)의 LA시스템에 있어서 서로 다른 경사각도를 가진 SEN시험편(Single edge notch specimen)에 대하여 휨 시험을 행하였다. 얻이진 결과는 혼합모-드파괴시, 모-드I응력확대계수$K_I$과 모-드II응력확대계수$K_II$간에 일정한 상호작용이 존재한다는 것을 나타내었다. 또한, 모-드I과 모-드II의 임계응력확대계수(Critical stress intensity factor) $K_{IC}$와 $K_{IIC}$ 이용하여 혼합모-드파괴시의 $K_I$과 $K_II$간의 상호관계를 규정할 수 있었으며, 이미 보고된 여러 실험식과 본 실험결과를 비교하여 가장 적합한 관계로서 아래와 같은 관계를 얻을 수 있었다.

• Kyungpook Mathematical Journal
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• v.48 no.1
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• pp.101-108
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• 2008

In this paper we study the existence of global small solutions of the Cauchy problem for the non-isotropically perturbed nonlinear Schr$\"{o}$dinger equation: $iu_t\;+\;{\Delta}u\;+\;{\mid}u{\mid}^{\alpha}u\;+\;a{\Sigma}_i^d\;u_{x_ix_ix_ix_i}$ = 0, where a is real constant, 1 $\leq$ d < n is a integer is a positive constant, and x = $(x_1,x_2,\cdots,x_n)\;\in\;R^n$. For some admissible ${\alpha}$ we show the existence of global(almost global) solutions and we calculate the regularity of those solutions.