• Ocean and Polar Research
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• 제44권1호
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• pp.1-11
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• 2022

Hypoxia can affect water-atmosphere methane flux by controlling the production and consumption processes of methane in coastal areas. Seasonal methane concentration and fluxes were quantified to evaluate the effects of seasonal hypoxia in Dangdong Bay (Gyeongsangnamdo, Jinhae Bay, South Korea). Sediment-water methane flux increased more than 300 times during hypoxia (normoxia and hypoxia each 6, 1900 µmol m^-2 d^-1), and water-atmospheric methane flux and bottom methane concentration increased about 2, 10 times (normoxia and hypoxia each 190, 420 µmol m^-2 d^-1; normoxia and hypoxia each 22, 230 nM). Shoaling of anaerobic decomposition of organic matter in the sediments during the hypoxia (August) was confirmed by the change of the depth at which the maximum hydrogen sulfide concentration was detected. Shoaling shortens the distance between the water column and methanogenesis section to facilitate the inflow of organic matter, which can lead to an increase in methane production. In addition, since the transport distance of the generated methane to the water column is shortened, consumption of methane will be reduced. The combination of increased production and reduced consumption could increase sediment-aqueous methane flux and dissolved methane, which is thought to result in an increase in water-atmospheric methane flux. We could not observe the emission of methane accumulated during the hypoxia due to stratification, so it is possible that the estimated methane flux to the atmosphere was underestimated. In this study, the increase in methane flux in the coastal area due to hypoxia was confirmed, and the necessity of future methane production studies according to oxygen conditions in various coastal areas was demonstratedshown in the future.

• The Korean Journal of Physiology and Pharmacology
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• 제25권6호
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• pp.517-523
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• 2021

The present study aims to investigate the impact of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia. Thirty Sprague-Dawley rats were randomly divided into five groups, including normal diet group, and diabetes model (DM) group, DM + metformin treatment (DMM) group, DMM + hypoxia treatment (DMMH) group and DMMH + hydrogen-rich water (DMMHR) group. We found that the levels of lactic acid, pyruvate and lactate dehydrogenase were significantly lower in the blood of DMMHR group than DMMH group. Superoxide dismutase and glutathione levels in liver and heart were significantly higher in DMMH group after hydrogen-rich water treatment, while malondialdehyde and oxidized glutathione levels were decreased in DMMHR group when compared with DMMH group, which indicates that hydrogen-rich water could reduce oxidative stress. qPCR analysis demonstrated that that pro-apoptotic genes Bax/Caspase-3 were upregulated in DM group and metformin treatment suppressed their upregulation (DMM group). However, hypoxic condition reversed the effect of metformin on apoptotic gene expression, and hydrogen-rich water showed little effect on these genes under hypoxia. HE staining showed that hydrogen-rich water prevented myocardial fiber damages under hypoxia. In summary, we conclude that hydrogen-rich water could prevent lactate accumulation and reduce oxidant stress in diabetic rat model to prevent hypoxia-induced damages. It could be served as a potential agent for diabetes patients with metformin treatment to prevent lactic acidosis and reduce myocardial damages under hypoxic conditions.

• 한국해안해양공학회:학술대회논문집
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• 한국해안해양공학회 1995년도 정기학술강연회 발표논문 초록집
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• pp.108-109
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• 1995

Hypoxia has persisted during summer in the bottom water of the lower portion of the Rappahannock Estuary, a western shore tributary of Chesapeake Bay. A laterally integrated two-dimensional, real-time model, consisting of linked hydrodynamic and water quality models, was developed to study the contributing processes for hypoxia. The hydrodynamic model gives the information of physical transport processes, both advective and diffusive, to the water quality model, which simulates the spatial and temporal distributions of eight water quality state variables. (omitted)

• 해양환경안전학회지
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• 제22권7호
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• pp.854-862
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• 2016

본 연구에서는 2010년 여름에 천수만에서 저층해수를 채집하여 용존산소와 영양염 농도를 측정하였다. 또한 benthic chamber내의 해수시료를 시계열로 채집하는 자동화된 Benthic Lander를 설치하여 해수-퇴적물간 영양염 플럭스를 측정하였다. 오염된 인공호수 유출수가 들어오는 천수만 북쪽에서는 저층수의 용존산소는 2 mg/l로 hypoxia의 존재 가능성이 확인되었다. 반면 남쪽 천수만 입구의 저층 용존산소는 5 mg/l이었다. 영양염은 용존산소와 반대의 분포 경향을 보였고, N/P ratio의 변화는 hypoxia에 의해 발생된 인산염의 탈착과 용출 때문으로 보인다. 만 북쪽 해역의 유기탄소 산화율과 산소소비율은 남쪽 만 입구 해역보다 약 2배 큰 값을 보였고, 영양염 benthic flux는 천수만 북쪽에서 4내지 6배 높았다. 이러한 결과는 해수-퇴적물간 물질 플럭스를 정확히 추정하기 위해서는 hypoxia의 역할에 대한 이해가 중요하다는 점을 시사해준다.

• 한국수산과학회지
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• 제49권1호
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• pp.45-52
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• 2016

This experiment investigated changes in metabolic rate (MO₂), critical oxygen saturation (S_crit), and blood chemistry of olive flounder Paralichthys olivaceus exposed to progressive hypoxia and returned to normoxic water at 20°C. The normoxic standard metabolic rate (SMR) and routine metabolic rate (RMR) were 69.5-83.9 and 70.2-156.4 mg O₂ kg^-1h^-1, respectively based on fish weight. S_crit was 31.0% dissolved oxygen (DO) at 20°C. After returning the fish to 70% DO following exposure to hypoxia (20% DO), MO₂ increased two-fold compared to the normoxic SMR and then decreased into the range of the RMR with time. Blood PO₂ and plasma lactate decreased significantly after exposure to hypoxia (20% DO) and then increased as ambient oxygen saturation decreased. Cortisol levels increased as ambient oxygen saturation decreased, but the levels decreased rapidly in the range of the normoxic control when the fish were returned to ambient water with 70% DO. Plasma glucose levels increased when the fish were returned to normoxic water after exposure to a progressively more hypoxic condition.

• 한국수산과학회지
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• 제38권2호
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• pp.106-111
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• 2005

We studied the cardio-respiratory properties in the Japanese amberjack (Seriola quinqueradiata) during acute hypoxia exposure. Fish were exposed to three levels of hypoxia (80, 60 or 50 mmHg) for 60 min at $25^{\circ}C$. Cardiovascular parameters (cardiac output; Q, heart rate; HR, stroke volume; SV, blood pressure; $P_{DA}$) changed little from pre-exposure values during both 80 and 60 mmHg of hypoxia. During 50 mmHg of hypoxia, the fish showed a bradycardia which significantly affected Q, whereas no change in SV. $P_{DA}$ increased transiently. Arterial oxygen partial pressure ($PaO_2$) immediately reduced along with a decrease of the water oxygen partial pressure ($P_WO_2$). Arterial $O_2$ content ($CaO_2$) decreased significantly only after 60 min of 50 mmHg of hypoxia. Arterial pH (pHa) and hematocrit value (Hct) did not change significantly. Comparing the effects of different levels of hypoxia, oxygen delivery to the tissues ($Q\;{\times}\;CaO_2$) should be maintained a constant over a broad range of $P_WO_2$, however, severely depressed below 50 mmHg of hypoxia.

• 해양환경안전학회지
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• 제26권1호
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• pp.65-74
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• 2020

본 연구에서는 당동만을 중심으로 빈산소가 발생하는 물리적 해양환경 특성을 파악하고, 로지스틱 회귀분석을 이용해 빈산소 발생확률을 예측하였다. 관측 자료를 분석한 결과, 브런트-바이살라 주파수는 수심이 깊은 만 입구보다 수심이 얕은 만 내측에서 더 크게 나타났다. 이는 당동만 내측에서 담수 유입으로 인해 표층 염분이 낮아져 강한 밀도 성층이 형성되었기 때문이다. 시간적으로는 6월 ~ 9월까지 리차드슨 수와 브런트 바이살라 주파수가 매우 높게 나타났고, 9월 2일 이후로는 성층이 완화되어 감소하는 경향을 보였다. 당동만에서 관측된 용존산소 및 수온, 염분 자료를 분석한 결과, 저층의 용존산소 농도는 공통적으로 표층과 저층의 수온차에 가장 큰 영향을 받는 것으로 나타났다. 한편, 수심차(dz)를 고정된 변수로 두고, 수온차(dt)의 변화에 의한 빈산소의 발생 확률의 변화를 계산한 결과, 수심차(dz)가 각각 5 m, 10 m, 15 m, 20 m일 경우, 수온차(dt)는 8℃, 7℃, 5℃, 3℃일 때 빈산소 발생확률이 70 %를 상회하는 것으로 나타났다. 이는 당동만에서 수심차(dz)가 커질수록 빈산소 발생에 필요한 수온차(dt)는 작아지게 된다는 것을 뜻하며, 특히 당동만에서 수심차(dz)가 20 m 내외인 지역은 빈산소가 발생하기 매우 쉬운 환경이라는 것을 알 수 있었다.

• 한국환경과학회지
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• 제24권2호
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• pp.163-174
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• 2015

The Youngsan Lake was constructed to supply agricultural water to the extensive rice fields in the basin of the lake in 1981. Hypoxia has often developed in the bottom water of the lake during the warm season although the water depth is relatively shallow (< 16 m). We investigated the spatial and temporal variations of dissolved oxygen (DO) and physical properties such as water temperature, salinity and turbidity to elucidate the effects of change in physical properties on DO dynamics in the lake. Vertical profiles of DO, temperature, salinity, and water density were also explored to verify the development of stratification in relation to DO variation in the water column. Hypoxia (DO < $2mg\;L^{-1}$) was not observed in the upper regions whereas hypoxia was detected in the lower regions during the warm season. Thermocline generally developed in the lower regions during the warm season unlike the previous studies in which no thermocline was observed. However, water column was well mixed when freshwater water was discharged from the reservoir through the sluice gate of the dike. DO concentrations also decreased when halocline or pycnocline developed during the dry season suggesting that the vertical stratification of water column affects DO dynamics although the water depth is shallow in the Youngsan lake.

• 한국해양학회지:바다
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• 제28권3호
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• pp.95-120
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• 2023

메탄은 아주 중요한 온실기체로, 최근 20년간 같은 양의 이산화탄소에 비해 약 85배 높은 온실효과를 갖고 있다. 천연가스 사용 증가와 온난화에 따른 빙권의 해동으로 대기 중 메탄 농도는 빠르게 상승하고 있다. 또한, 현재 진행 중인 해수 온도 상승으로 가스-하이드레이트(얼음-기체 복합체) 붕괴가 전 지구적으로 발생할 것으로 예상되고, 궁극적으로 막대한 양의 메탄이 해수 및 대기로 누출될 것으로 예상된다. 또한, 연안 해양 저산소층 또한 온실기체 생성 대기로 유출시킬 수 있다. 특히, 현재 진행 중인 지구 온난화와 연안 해역 부영양화로 인해, 해저 저산소층은 전 세계적으로 그 크기와 기간이 급격히 늘어나고 있다. 이러한 해저 저산소층은, 산화-환원 대를 퇴적 표층 얕은 지역 또는 해수 내로 이동시켜, 메탄의 대기 용출을 용이하게 하고 궁국적으로 지구 온난화를 가중시킬 수 있다. 하지만, 해저 저산소층과 메탄 발생을 포함한, 메탄 연구는 한국뿐만 아니라, 전 세계적으로 아주 미미한 수준이다. 따라서, 이 리뷰논문은 자연환경 내 메탄의 복잡한 상호작용 이해를 통해, 연안 해저 저산소층 발달과 메탄의 관계를 파악, 나아가 한국 내 메탄 연구 활성화에 기여하는데 목적이 있다.

• 동의생리병리학회지
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• 제18권6호
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• pp.1733-1739
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• 2004

The water extract of Hwangryunhaedog-tang(HRHDT} has been traditionally used for treatment of ischemic heart and brain damage in oriental medicine. However, little is known about the mechanism by which the water extract of HRHDT rescues cells from these damages. This study was designed to investigate the protective mechanisms of HRHDT on hypoxia-induced cytotoxicity in H9c2 cardiomyoblast cells. Hypoxia, markedly decreased the viability of H9c2 cells, which was characterized with apparent apoptptic features such as chromatin condensation as well as fragmentation of genomic DNA and nuclei. However, HRHDT significantly reduced hypoxia-induced cell death and apoptotic characteristics. Also, HRHDT prevented the mitochondrial dysfunction including the disruption of mitochondria membrane permeability transition (MPT) and an increase in expression of anti-apoptotic Bcl-2 proteins in hypoxia-H9c2 cells. Taken together, this study suggests that the protective effects of the water extract of HRHDT against hypoxic damages may be mediated by the modulation of Bcl-2 and Bak expression.