• 가정과삶의질연구
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• 제24권5호
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• pp.223-237
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• 2006

This study explores how well parents and their children recognize the social attitudes of one another. Mothers, fathers and youths were asked to state their own opinion on various social issues then predict their children's, fathers' and mothers' responses(attributed attitudes). Empirical evaluation of the possible socialization consequences of actual versus attributed attitudes leads to a series of hypotheses. The data were collected from single students at a university in Seoul and their parents. Included in the seven social attitude were sexuality, educational, economic, political, ecological, religious and family issues. Analysis of the responses 98-110 triads, each consisting a mother, a father and a young adult child showed that both mothers and fathers were limited in their ability to gauge the attitudes of their children. Guided by attribution theory, this study tested several hypothesized relationships between the actual response of mother, the actual response of the father, the perceived response of the mother, the perceived response of the father and the actual response of the child. The theoretical model was tested with AMOS 5.0, utilizing path analysis, which is a form of structural equation modeling with manifest variables. Overall model fit was assessed by examining GFI, NFI, TLI, CFI and RMR. Results of the data analysis can be summarized as follows. First, the children perceived their mothers and fathers to be highly similar in their opinions and the actual responses of the mothers and the fathers were considerably correlated. Second, the fathers' responses whether attributed or actual were more predictive than the mothers' responses to their children's opinions. The alternative model suggests considerable support for the attribution theory. Indeed, within a family, the actual opinions of parents appear to have little direct bearing on the child's orientations, except when the actual orientations are perceived and reinterpreted by the children. It is not what parents think, but what their children think they think that predicts their offsprings' attitudes.

• 응용통계연구
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• 제20권3호
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• pp.423-440
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• 2007

본 논문의 목적은 기업 신용점수에 영향을 미치는 기업 인적자원 요소들을 찾아서 기업 신용점수 모형을 구축하는 것이다. 모형 구축을 위해 사용된 자료는 2005년 한국직업능력개발원의 인적자본 기업패널 (Human Capital Corporate Panel, HCCP) 설문조사 자료와 한국신용평가(주)의 KIS-신용평점모델에서 생성된 기업 신용점수이다. 모형 구축을 위한 독립변수는 McLagan (1989)의 '인적자원 바퀴모델'을 토대로 인적자본 기업패널 설문조사 문항을 선택하여 사용하였으며, 종속변수로는 기업 신용평가점수를 사용하였다. 또한 기업 인적자원 관련 변수를 이용한 기업 신용점수 모형 구축을 위해 로지스틱 회귀모형을 사용하였다. 모형 구축 결과 최종적으로 선택된 변수는 22개였다 영역별로 세분화해서 살펴보면 대분류 기준으로 HRD 영역은 6개, HRM 영역은 15개, 기타 1개이고, 중분류 기준으로 개인개발 2개, 경력개발 2개, 조직개발 2개, 조직직무설계 1개, 인적자원계획 4개, 정보체계 2개, 보상 및 장려 6개, 복지후생 1개, 노사관계 1개, 기업규모 1개가 선택되었다. 구축된 모형을 평가하기 위하여 10등급 교차타당성 분석을 통한 오분류율, G-mean은 각각 30.81, 68.27이었다. 그리고 반응율은 가장 좋은 십분위가 가장 나쁜 십분위보다 약 6.08배가 크고 점차 감소하는 경향을 보이고 있다. 그러므로 구축된 모형은 기업 인적자원 관련 변수를 이용해 기업 신용점수를 측정하는데 적당한 모형이라는 결론을 내릴 수 있다

• 대한기계학회논문집A
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• 제33권1호
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• pp.27-33
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• 2009

Human postural responses appeared to have stereotyped modality, such as ankle mode, knee mode and hip mode in response to various perturbations. We examined whether human postural control gain of full-state feedback could be decoupled along with the eigenvector. To verify the model, postural responses subjected to fast backward perturbation were used. Upright posture was modeled as 3-segment inverted pendulum incorporated with feedback control, and joint torques were calculated using inverse dynamics. Postural modalities such as ankle, knee and hip mode were obtained from eigenvectors of biomechanical model. As oppose to the full-state feedback control, independent eigenvector control assumes that modal control input is determined by the linear combination of corresponding modality. We used optimization method to obtain and compare the feedback gains for both independent eigenvector control and full-state feedback control. As a result, we found that simulation result of eigenvector feedback was not competitive in comparison with that of full-state feedback control. This implies that the CNS would make use of full-state body information to generate compensative joint torques.

• 대한인간공학회지
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• 제31권6호
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• pp.793-800
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• 2012

Objective: This study investigated the problems that could be faced with when engineers try to improve the affective quality using the DMAIC model. Background: Affective quality is considered one of the most influential factors for the competitive power of consumer products and many engineers make effort to improve the affective quality. Since the Six Sigma process is effective and wide-used method for quality improvement, it can also be used to improve the affective quality. However six sigma tools cannot be directly used for affective quality because of the subjective and qualitative characteristics of the human affection. Method: Investigate the goals, processes and key factors of DMAIC model and find the difficulties to use six sigma tools for the affective quality. Results: Most of the problems arise from measuring and quantifying the human affective response level and understanding the relationship between the human affective factors. Conclusion: Both the protocol for measuring human affection and the monitoring system to find the affective response change for the product or service are required. Application: The results of this study could be helpful for the engineers not specialized in ergonomics to improve the affective quality in systematic approach.

• Molecules and Cells
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• 제19권2호
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• pp.167-179
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• 2005

The cells of metazoans respond to DNA damage by either arresting their cell cycle in order to repair the DNA, or by undergoing apoptosis. This response is highly conserved across species, and many of the genes involved in this DNA damage response have been shown to be inactivated in human cancers. This suggests the importance of DNA damage response with regard to the prevention of cancer. The DNA damage checkpoint responses vary greatly depending on the developmental context, cell type, gene expression profile, and the degree and nature of the DNA lesions. More valuable information can be obtained from studies utilizing whole organisms in which the molecular basis of development has been well established, such as Drosophila. Since the discovery of the Drosophila p53 orthologue, various aspects of DNA damage responses have been studied in Drosophila. In this review, I will summarize the current knowledge on the DNA damage checkpoint response in Drosophila. With the ease of genetic, cellular, and cytological approaches, Drosophila will become an increasingly valuable model organism for the study of mechanisms inherent to cancer formation associated with defects in the DNA damage pathway.

• 대한의용생체공학회:의공학회지
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• 제19권5호
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• pp.495-502
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• 1998

Y.C. Fung[1]에 의한 연조직의 점탄성에 관한 수학적 모델이론 (Fung's Quasi-linear vlscoelastic theory)을 이용하여 인간의 인두조직의 점탄성(vlscoelatlcity)특성을 측정하기 위하여 반복성하중(cyclic load) ,응력완화 (tensile stress relaxation), incremental load, 그리고 일축성인장 (uniaxial tensile) 시험 등을 실시하였다. 실험적으로 측정한 인두조직의 점탄성특성이 이미 조사된 다른 조직의 점탄성특성과 정량적으로 비교되었다. 인두조직의 점탄성특성의 정량화를 위하여 Y.C.Fung의 수학적 모델이 적용되었는데 응력완화(tensile stress relaxation) 시험 측정결과로부터 도출된 표준화된 응력완화(reduced stress relaxation)함수 G(t)와 일축성인장(uniaxial tensile)시험에서 도출된 탄성반응(elastic response)함수 5(t)를 이용하여 시간에 따른 응력의 궤적을 산출하여 이를 반복성 하중(cyclic load)실험에서 측정된 결과와 비교, 분석하였다. 이러한 인두조직의 점탄성특성에 관한 연구결과는 향후 유한요소를 이용한 인두의 생체역학적 모델의 기본 데이터로 이용될 수 있다.

• BMB Reports
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• 제48권8호
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• pp.445-453
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• 2015

Endoplasmic Reticulum (ER) is an organelle where most secretory and membrane proteins are synthesized, folded, and undergo further maturation. As numerous conditions can perturb such ER function, eukaryotic cells are equipped with responsive signaling pathways, widely referred to as the Unfolded Protein Response (UPR). Chronic conditions of ER stress that cannot be fully resolved by UPR, or conditions that impair UPR signaling itself, are associated with many metabolic and degenerative diseases. In recent years, Drosophila has been actively employed to study such connections between UPR and disease. Notably, the UPR pathways are largely conserved between Drosophila and humans, and the mediating genes are essential for development in both organisms, indicating their requirement to resolve inherent stress. By now, many Drosophila mutations are known to impose stress in the ER, and a number of these appear similar to those that underlie human diseases. In addition, studies have employed the strategy of overexpressing human mutations in Drosophila tissues to perform genetic modifier screens. The fact that the basic UPR pathways are conserved, together with the availability of many human disease models in this organism, makes Drosophila a powerful tool for studying human disease mechanisms. [BMB Reports 2015; 48(8): 445-453]

• Clinical and Experimental Vaccine Research
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• 제13권1호
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• pp.10-20
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• 2024

Animal models are essential in medical research for testing drugs and vaccines. These models differ from humans in various respects, so their results are not directly translatable in humans. To address this issue, humanized mice engrafted with functional human cells or tissue can be helpful. We propose using humanized mice that support the engraftment of human hematopoietic stem cells (HSCs) without irradiation to evaluate vaccines that influence patient immunity. For infectious diseases, several types of antigens and adjuvants have been developed and evaluated for vaccination. Peptide vaccines are generally used for their capability to fight cancer and infectious diseases. Evaluation of adjuvants is necessary as they induce inflammation, which is effective for an enhanced immune response but causes adverse effects in some individuals. A trial can be done on humanized mice to check the immunogenicity of a particular adjuvant and peptide combination. Messenger RNA has also emerged as a potential vaccine against viruses. These vaccines need to be tested with human immune cells because they work by producing a particular peptide of the pathogen. Humanized mice with human HSCs that can produce both myeloid and lymphoid cells show a similar immune response that these vaccines will produce in a patient.

• 한국산업보건학회지
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• 제7권1호
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• pp.87-98
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• 1997

In this study, subway train vibration has been measured to characterize the whole body vibration of Seoul subway lines for various human postures. Results show that the floor vibration level of the subway trains in the vertical direction is higher than that in other directions. At the standing human posture, vibration level of the head in the right-left direction are increased while that in the vertical direction is decreased. It is assumed that the different flexibility of the human body and the rolling motion of the subway trains are the main cause. At the sitting posture with back seat on, vibration level in the right and left direction at the human ischial tuberosities is lower than that in other directions. Results also show that there were little difference between back-seat on model and back-seat off model. Transmissibility analysis shows how the subway vibration affects the response of a human body.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2000년도 추계학술대회논문집A
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• pp.522-528
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• 2000

Dynamic characteristics of seated human body were investigated by measuring apparent masses of eight different seating subjects exposed to vertical vibration. Two types of vibration signals - one is random signals over 1 to 30Hz having flat spectral density and the other is signals measured on seat rail in passenger car under driving conditions - were employed. It was found that the apparent masses are highly dependent on vibration level rather than type of the vibration signals. Based on the apparent mass measurements, a mathematical model of the human body in seating posture was developed by using genetic algorithm. Three-degree-of-freedom model was satisfactory in describing apparent mass of seated human body.