• Biomedical Science Letters
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• v.21 no.2
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• pp.77-83
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• 2015

Soy proteins have been extensively studied because of its multiple health benefits. However, the effects of soy proteins on human cervical cancer cells are still unclear. Therefore, this study investigated the effects of soy proteins on HeLa cells and human fibroblasts by using soybean peptides (SPs). SPs selectively increased the generation of reactive oxygen species and apoptosis in HeLa cells but not in fibroblasts. In addition, SPs suppressed the migration of HeLa cells. Although the molecular mechanisms underlying the effects of SPs on human cervical cancer cells need to be investigated further, our findings provide insights on the therapeutic effects of soy protein on cervical cancer.

• Membrane Journal
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• v.6 no.4
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• pp.189-195
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• 1996

It is concluded from this study that human consumption of very low TDS water does not leach minerals from the body that cause ill health effects because; -The human body's own control mechanism of homeostasis and internal body secretions keep tight controls on body fluid composition regardless of drinking water TDS for a normal person under normal csonditions. -The unofficial WHO document's proposed guideline of a 100m/l lower limit for drinking water due to mineral leaching and subsequent ill health was not found to be scientifically or physiologically credible. Leaching of minerals from the body is not officially recognized by WHO. -The experience of the U.S. Navy, Army, NASA and dommunity demonstrations do not support ill health symptoms caused by consumption of low TDS drinking water. -Millions of people regularly consume maturally occurring low TDS water without symptoms of ill health.

• Infection and chemotherapy
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• v.50 no.4
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• pp.346-349
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• 2018

In 2015, rapid human immunodeficiency virus (HIV) testing was implemented in all 25 public health centers in Seoul. During March and December 2015, 20,987 rapid HIV tests were performed, of which 116 (0.5%) were positive. Compared to those of the period before application of the rapid HIV test in place of conventional enzyme immunoassay method, the number of HIV tests performed and the number of positive results increased by sevenfold and twofold, respectively. In conclusion, expansion of the provision of rapid HIV tests in public health centers increased the number of voluntary HIV tests.

• Health Policy and Management
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• v.19 no.4
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• pp.1-17
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• 2009

The purpose of this study was to find factors affecting health of the rural residents. The data were collected from a sample of 2,587 people aged from 40 to 70 in the year 2005-2006, Wonju City and Pyeongchang County, Gangwon-do, Korea. The theoretical model adopted in this study was the Lalonde's health field(human biology, environment, lifestyle, and health care organization). SF-12 was used to measure subjective health status. In the category of human biology, men were healthier than women. Age and BMI showed negative relation to health status. Income, education and social support showed positive relation to health status in the environment category. In the category of life style, stress showed negative relation to health status. Medical expenses showed negative relation to health status in the category of health care organization. After converting SF-12 score to percentage score, the health determinants portions were 47% lifestyle, 26% environment, 18% human biology and 9% health care organization. These findings suggest that life style, environment and biology are main factors in determinants of health. Especially stress in the life style category is more focused for the community health promotion. We also may be able to improve income, education and social support in the environment category with self empowerment efforts, community supports and government helps. Finally greater attention must be payed to life style in the future health planning and budget allocation priority in the healthcare area.

• Journal of Environmental Health Sciences
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• v.41 no.5
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• pp.358-367
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• 2015

Objectives: This study was performed to evaluate the analytical method for PAH metabolites in human urine using enzyme hydrolysis and solid-phase extraction coupled with LC-(ESI)-MS/MS technique. Methods: We employed HPLC tandem mass spectrometry techniques with appropriate pre-treatment for analysis of 16 OH-PAHs in human urine. Samples were hydrolysis by ${\beta}$-flucuronidase/Aryl sulfatase, and target compounds were extracted by solid-phase extraction with a strata-x cartridge. Cross-validation was performed between Eulji University and Green Cross laboratories with 200 human urine samples. Results: The accuracies were between 90.3% and 118.8%, and precisions (relative standard deviations) were lower than 10%. The linearity obtained was satisfying for the 16 OH-PAH compounds, with a coefficient of determination ($r^2$) higher than 0.99. The results of cross-validation at the two organizations were compared by ICC (interclass correlation coefficient) values. The cross-validation results were excellent or good for all compounds. Conclusion: An analytical method was validated for low nanogram levels of 16 OH-PAHs in human urine. Also, satisfying results were obtained for method validation such as accuracy, precision and ICC of cross-validation.

• Journal of Digital Convergence
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• v.10 no.4
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• pp.297-308
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• 2012

This study is intended to estimate the demand for the green health industry market, to seek for the strategies to develop human resources and to provide fundamental data for development of local green health industry specialization programs in the manner of investigating the intentions to participate in and opinions about the green health industry. Data were collected from 190 and surveyed from 5 to 19 in November 2010. Based upon the priority survey and factor analyses of educational contents for development of human resources specializing in the green health industry, there is some difference in the classification of all domains between the two groups, however the results concerning the cognition of the language education of educational contents and the priority of medical tourism marketing are similar between the two groups. As one of the biggest problems with medical tourism is the difficulty of communication during medical examination and treatment, it is desirable to develop professional human resources with global competitiveness based on customized education as well as excellent language skills by the specialized fields of green health industry.

• Journal of the Ergonomics Society of Korea
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• v.32 no.4
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• pp.321-331
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• 2013

Objective: The aim of this study is to review the literatures on the regulation, standard and guideline for the human vibration in Korea and other countries. Background: This review can be used to prevent various diseases caused by the human vibration as a basis for the development of the policy. Results: In Korea, the general employers' duties related to human vibration are set forth the Health Measures(Article 24) in the Occupational Safety and Health Act. And then an employer shall take measures to protect the health of the workers concerned by improving other working conditions relating to working hours for the vibration prevention measures referred to in Article 24 of the Act. The European Union adopted a Directive in 2002 on minimum requirements for the health and safety of workers exposed to vibration. New Regulations on Vibration at Work will be introduced in Great Britain on 2005 to implement the Directive. In the U.S., both ANSI and ACGIH adopted the ISO standard for measurement and suggested exposure action and limit values. In Japan, the Ministry of Labor decided that the vibration syndrome among operators of rock drills and riveters etc. could be included in an occupational disease(1947). In addition, ISO standard was based on proposals and draft documents of many countries such as U.K, Japan and European, etc. Conclusion: In Korea, Occupational Safety and Health Act prevent vibration to health, but do not include exposure limits. It is therefore important to consider the new duties regarding to vibration risks added to the general duties.

• Journal of Korean Society of Rural Planning
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• v.25 no.4
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• pp.57-64
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• 2019

The purpose of this study was to investigate the general characteristics of the elderly who participate in the planting activities of weekend farms and the effect of the planting activity levels on the subjective health, depression, and human relationships of the elderly. Data were collected and analyzed using subjective health, depression, and human relationship measures that can represent physical, mental, and social health. The main results were as follows. The educational level, the status of spouses, and the number of diseases of the general characteristics of the elderly who participated in the weekend farm showed significant differences in all subjective health, depression, and human relationships. Plant cultivation activity level was positively correlated with the subjective health of the elderly and had a significant effect. The higher the level of plant cultivation activity, the more positively it affected the human relationship. Plant cultivation activity was negatively correlated with the depression of the elderly.

• Molecules and Cells
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• v.46 no.9
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• pp.558-572
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• 2023

Chronic obstructive pulmonary disease (COPD) will be the third leading cause of death worldwide by 2030. One of its components, emphysema, has been defined as a lung disease that irreversibly damages the lungs' alveoli. Treatment is currently unavailable for emphysema symptoms and complete cure of the disease. Hyaluronan (HA) and proteoglycan link protein 1 (HAPLN1), an HA-binding protein linking HA in the extracellular matrix to stabilize the proteoglycan structure, forms a bulky hydrogel-like aggregate. Studies on the biological role of the full-length HAPLN1, a simple structure-stabilizing protein, are limited. Here, we demonstrated for the first time that treating human alveolar epithelial type 2 cells with recombinant human HAPLN1 (rhHAPLN1) increased TGF-β receptor 1 (TGF-β RI) protein levels, but not TGF-β RII, in a CD44-dependent manner with concurrent enhancement of the phosphorylated Smad3 (p-Smad3), but not p-Smad2, upon TGF-β1 stimulation. Furthermore, rhHAPLN1 significantly increased sirtuins levels (i.e., SIRT1/2/6) without TGF-β1 and inhibited acetylated p300 levels that were increased by TGF-β1. rhHAPLN1 is crucial in regulating cellular senescence, including p53, p21, and p16, and inflammation markers such as p-NF-κB and Nrf2. Both senile emphysema mouse model induced via intraperitoneal rhHAPLN1 injections and porcine pancreatic elastase (PPE)-induced COPD mouse model generated via rhHAPLN1-containing aerosols inhalations showed a significantly potent efficacy in reducing alveolar spaces enlargement. Preclinical trials are underway to investigate the effects of inhaled rhHAPLN1-containing aerosols on several COPD animal models.

• Biomedical Science Letters
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• v.11 no.3
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• pp.337-341
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• 2005

This study was undertaken to clerify the cytotoxic effect of syringic acid by colorimetric assay on human cancer cells. For the evaluation of cytotoxicity of syringic acid, the cell viability and cell adhesion activity of syringic acid on cancer cells, human oral epithelioid carcinoma cells were determined using by colorimetric assays such as MTT (3-[4,5­dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay and XTT (2,3-bis-[2-methoxy-4-nitro-5-sulfophenyl]­2H-tetrazolium-5-caboxanilide) assay, respectively after human oral epithelioid carcinoma cells were treated with syringic acid for 48 hours. In this study, the cell viability of syringic acid on human oral epithelioid carcinoma cells showed a significant decrease by MTT assay compared with control, and also, the cell adhesion activity by XTT assay was decreased significantly in these cells after cells were treated with various concentrations of syringic acid for 48 hours. $MTT_{50}\;and\;XTT_{50}\;were\;282.3\;{\mu}M\;and\;418.8{\mu}M$ syringic acid, respectively. These results suggest that syringic acid shows midcytotoxic effect on human oral epithelioid carcinoma cells by the decreasement of the cell viability and the cell adehision activity assessed by colorimetric assay in these cultures.