• Title/Summary/Keyword: Human Effect

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The Regulatory Effect of Zhengan Xifeng-tang on Pro-inflammatory Cytokine in Human Brain Astrocytes (인간 뇌 성상세포에서 진간식풍탕의 사이토카인 조절 효과)

  • Ryu Hyun Hee;Lee Seoung Geun;Lee Key Sang
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.18 no.2
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    • pp.490-495
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    • 2004
  • Brain cells produce cytokines and chemokines during the inflammatory process of many neuronal diseases both in animal models and in patients. Inflammatory cytokines are the main responsible for the onset of inflammatory cascade. During the past decade, a growing corpus of evidence has indicated an important role of these cytokines in the development of brain damage. ZhenganXifeng-tang (ZGXFT) is a Korean herbal prescription, which has been successfully applied for the treatment of various neuronal diseases. However, its effect in experimental models remains unknown. Astrocytes are predominant neuroglial cells of the central nervous system and are actively involved in cytokine-mediated events in inflammatory disease. An inflammatory response associated with β-amyloid (Aβ) and interleukin (IL)-1β is responsible for the pathology of inflammation disease. To investigate the biological effect of ZGXFT, the author examined cytotoxicity, effect of cytokines (IL-6 and IL-8) secretion and expression of cyclooxygenase-2 (COX-2) on human astrocytoma cell line U373MG stimulated with IL-1β plus M fragment 25-35 (Aβ [25-35]). ZGXFT by itself had no effect on cell viability on human astrocytoma cells. The secretion of IL-6 and IL-8 was inhibited by pre-treatment with ZGXFT in human astrocytoma cells. In addition, the expression of COX-2 was induced by IL-1β plus AB[25-35] and was partially inhibited by treatment with ZGXFT. The author demonstrates the regulatory effects of inflammatory reactions by ZGXFT in human astrocytes for the first time and suggest the anti-inflammatory effect of ZGXFT may reduce and delay pathologic events of inflammatory disease.

Human Capital Investment Expenditures: A Comparison of Female-Headed and Married-Couple Households (미국가계의 인적자본에 대한 투자)

  • 이윤금
    • Journal of the Korean Home Economics Association
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    • v.35 no.4
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    • pp.229-242
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    • 1997
  • the purpose of this study is to investigate the effect of household type on human capital enhancement expenditures and to compare the difference in these expenditures between female-hemale-headed and married-couple households. Data for this study were from the 1990-91 Consumer Expenditure Survey(CES) and consisted of a sample of 7,225 married-couple and 1,391 female-headed households with children under age 18. The dependent variable to measure human capital expenditures was the sum of four sub-components-education reading leisure and health care expenditures. Tobit analysis with a dummy variable for household type was used to identify the effect of household type on the dollars spent on human capital expenditures. The effect of household type was significant in human capital expenditures indicating that female-headed households spent significantly less for this category than did married-couple household holding other factors constant. the findings of this study suggested that income from a public assistance program was associated with lesser expenditures on human capital while social security income source was associated with greater human capital expenditures, It was also found that the addition of family members between ages of 6 and 17 positively affected human capital expenditures. Understanding these factors is useful for family resource management professionals who work with female-headed households.

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Mediating Effects of Trusts on the Relationship between Human Capitals and Organizational Citizenship Behaviors in Hotel Firms (인적자본과 조직시민행동의 관계에서 신뢰의 매개효과 -호텔기업을 중심으로- )

  • Kang, Sang-Muk;Ha, Yong-Kyu;Chung, Yeon-Hong
    • The Journal of the Korea Contents Association
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    • v.10 no.5
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    • pp.387-397
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    • 2010
  • The purpose of this study tried to reveal how human capitals of deluxe hotels located in Seoul affects corporate trust and organizational citizenship behaviors. In addition, it tries to find out the mediating effect that the trust among coworkers have contributed to human capital and organizational citizenship behaviors. The result of this study shows that Human capital have a great effect on the trust among employees and organizational citizenship behaviors. And it has been outed that the trust between the company and employees is a mediating effect between human capital and organizational citizenship behaviors. The results of this research shows that for competitive advantage under the competitive environment of the hotel industry, in addition to human resource management and organizational management, the management system which emphasizes the importance of human capital and the trust among company members should be built.

Study of Channel Model Characterization of Human Internal Organ in On-Body System at 2.45 GHz (2.45 GHz On-Body 시스템에서 인체 내부 장기에 따른 채널 모델 특징 연구)

  • Jeon, Jaesung;Choi, Jaehoon;Kim, Sunwoo
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.25 no.1
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    • pp.62-69
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    • 2014
  • In this paper, WBAN(Wireless Body Area Network) On-body system using the surface-oriented antenna about the impact of human internal organs were analyzed through experiments. The received signal strength is measured for effect of human using the human model and the phantom of torso. Experiments are performed in anechoic chamber without moving and measured by Vector Network Analyzer. This paper confirms the effect of human body by comparing the human model and the phantom of torso. And also know the human internal organs effect on the antennas loss of received signal strength by measured data.

Antioxidant Effect of Citri Reticulatae Pericarpium Extract on Oxidative Stress-Mediated Cytotoxicity In Cultures

  • Ha, Dae-Ho
    • Biomedical Science Letters
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    • v.14 no.1
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    • pp.33-38
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    • 2008
  • In order to examine oxidative stress of reactive oxygen species and the antioxidant effect of Citri Reticulatae Pericarpium (CRP) extract, human skin melanoma cells were treated with various concentrations of hydrogen peroxide ($H_2O_2$). Antioxidant effect of CRP extract on $H_2O_2$-induced cytotoxicity, cell viability, DPPH-radical scavenging activity and superoxide dismutase (SOD)-like activity. In this study, $H_2O_2$ decreased cell viability of cultured human skin melanoma cells in dose- and time-dependent manners, and then, midcytotoxicity value (MCV) was determined at $60\;{\mu}M$ after human skin melanoma cells were cultured for 5 hours in the media containing $20{\sim}60\;{\mu}M$ of $H_2O_2$, respectively. The $H_2O_2$ was on cultured human skin melanoma cells because MCV of $H_2O_2$ was lower than $100\;{\mu}M$. In the antioxidant effect of CRP extract, CRP extract increased cell viability DPPH-radical scavenging activity and SOD-like activity. From these results, it is suggested that $H_2O_2$ was very toxic on cultured human skin melanoma cells. And also, CRP extract has the antioxidant effect on $H_2O_2$-induced cytotoxicity.

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IT Governance Mediated the Effect of Human Resource Capability on Information Systems Outsourcing Success (인적자원능력이 정보시스템 아웃소싱 성공에 미치는 영향에 있어서 IT거버넌스의 매개효과)

  • Lee, Jong-Man
    • The Journal of the Korea Contents Association
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    • v.9 no.7
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    • pp.285-293
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    • 2009
  • The purpose of this paper is to examine IT governance mediated the effect of human resource capability on information systems outsourcing success. The survey method was used for this paper, and data from a total of 108 companies that were listed greater than $10 million were used for the analysis. And structural equation model was used to analyze the data. The results of this empirical study is summarized as followings. First, human resource capability do not have a direct effect on information systems outsourcing success but IT governance mediates the effect of human resource capability. Second, preparedness capability and relationship capability have positive effect on the IT governance. The findings have significant implications for IT governance in information systems outsourcing.

Invitro Anticancer Effect of Chinese Cabbage Kimchi Fractions (배추김치 분획물의 in vitro 항암효과)

  • 박건영;조은주;이숙희;강갑석
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.28 no.6
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    • pp.1326-1331
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    • 1999
  • In vitro anticancer effect of Chinese cabbage kimchi fractions was investigated by using human cancer cells, AGS human gastric adenocarcinoma cells and HT 29 human colon adenocarcinoma cells. The Chinese cabbage kimchi(fermented for 4 days at 15oC) was fractionated into 7 groups, methanol extract, hexane fraction(fr.), methanol soluble fr., dichloromethane fr., ethylacetate fr., butanol fr. and aqueous fr.. Chinese cabbage kimchi fractions inhibited the growth of AGS and HT 29 cancer cells as dose dependent. In particular, the dichloromethane fr. showed the highest inhibitory effect among other fractions. When the dichloromethane fr.(0.2mg/ml) was treated, the number of AGS and HT 29 survival cancer cells reduced to 12$\times$104/ml and 11$\times$104/ml compared to 166$\times$104/ml and 50$\times$104/ml of the controls, respectively. Chinese cabbage kimchi fractions also inhibited the DNA synthesis of the cancer cells. They inhibited the DNA synthesis of AGS human gastric adenocarcinoma cells more efficiently than that of HT 29 human colon adenocarcinoma cells. These results indicate that Chinese cabbage kimchi fractions show in vitro anticancer activity and the dichloromethane fr. among them reveals the highest effect.

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The Effect of Special Education Teacher's Self-leadership on Life Satisfaction : Focusing on job satisfaction mediation effect

  • Kim, Kyung-Shin
    • Journal of the Korea Society of Computer and Information
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    • v.22 no.11
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    • pp.151-160
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    • 2017
  • IIn this paper, I investigate the effect of special education teachers' self-leadership on job-satisfaction. The data was collected from 141 special education teachers to analyze the correlations between self-leadership, job and life satisfaction. In addition, another purpose is to analyze how self-leadership influence on job satisfaction (human relationship, assigned tasks) and life satisfaction. The results are shown as follows. First, self-expectation and goal setting, self-expectation and human relationship, human relationship and assigned tasks have meaningful correlation. Second, self-expectation and self-rewarding are sub-factors of self-leadership that have great influence on human relationship which is a subordinate factor of job satisfaction and assigned tasks. Third, self-expectation and self-rewarding are factors of self-leadership that have a great influence on life satisfaction. Finally, it shows that self-leadership has an effect on life satisfaction through assigned task, which is a factor of job satisfaction. However, through human relationship, self-leadership does not have a meaningful effect on life satisfaction. This study is significant by finding sub-factors which influence special education teacher's self leadership, job satisfaction and life satisfaction by using Bootstrap method.

Individual and Organizational Effect of IT Human Resources on Career Satisfaction, Career Prospects and Career Commitment (IT인력의 개인과 조직특성이 경력만족, 경력전망 및 경력몰입에 미치는 영향에 관한 연구)

  • Park, Se-Youn;Cho, Nam-Wook
    • The Journal of Society for e-Business Studies
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    • v.14 no.3
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    • pp.87-105
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    • 2009
  • This paper investigates the effect of individual and organizational factors of IT human resources on their career satisfaction, career prospect and career commitment. In this paper, a quantitative method was used to study the effect; A survey of IT developers and IT related employees was conducted. Factor analyses and regression analyses were used in verifying the consequences. As a result, followings were found:From the individual perspective, the self-esteem of IT human resource showed the most significant effect on career satisfaction and the desire for career success had significant effect on career commitment. Among organizational factors, the fairness of evaluation showed the most significant effect on both career prospect and career commitment. It has been also shown that organizations should provide more opportunities for individual growth to enhance career prospect. Finally, career prospect affected career satisfaction; Both career satisfaction and career prospect showed effect on career commitment. This research provided guidelines in enhancing the career commitment of IT human resources, thereby effectively managing IT human resources.

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