• 대한두경부종양학회지
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• 제23권2호
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• pp.153-156
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• 2007

목적 : 투석을 받고 있는 진행된 두경부암 환자에서 Cisplatin 동시 화학방사선 요법의 타당성과 약물역동학에 대해 연구하였다. 방법 : 57세 말기 신장병을 앓고 있던 남자환자가 임상 병기 3기의 외이도 암을 진단 받고 종양 완전 절제술을 시행하였다. 수술 후 6개월에 환자는 국소 부위 재발하였다. 절단술과 술후 5200cGy, 26fx의 방사선 치료 시행에도 불구하고 다시 국소 부위 재발 보여 3주기동안 Cisplatin 기반의 방사선 화학 병합 요법 치료를 하였다. 총 3주간 Cisplatin $20mg/m^2$를 투여했으며 화학 요법 1일째 30분 동안 Cisplatin을 정주하고 30분 후 혈액투석을 4시간 동안 시행하였다. 화학요법 3일째와 5일째에도 혈액투석을 시행하였다. 환자의 혈장 시료는 Cisplatin 정주 후 특정한 시간에 채취되었다. 결과 : Cisplatin 동시 화학방사선요법 3차 시행 후 환자의 종괴 크기는 현저하게 감소하였다. Cisplatin의 최대 혈장 농도는 총 platinum은 $0.74{\mu}g/ml$였고 free platinum은 $0.37{\mu}g/ml$로 이었다. AUC 값은 총 platinum은 $94.7{\mu}g{\cdot}h/ml$, free platinum은 $11.3{\mu}g{\cdot}h/ml$이었다. 결론 : 투석을 받는 진행된 두경부암 환자에서 Cisplatin 동시 화학방사선요법을 시행한 증례를 보고하며 이들 환자에서 정용량의 Cisplatin 동시 화학방사선요법이 감내할 만하다고 제안한다.

• Journal of Preventive Medicine and Public Health
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• 제39권2호
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• pp.149-158
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• 2006

Objectives : We wanted to evaluate the economic value of a pharmaceutical product, Kremezin, for treating patients with chronic renal failure (CRF) by estimating the amount of cost savings due to its effect for delaying the initiation of dialysis treatments. Methods : We defined a conventional treatment for CRF accompanied by Kremezin therapy as 'the treatment group' and only conventional treatment as 'the alternative group.' The types of costs included were direct medical and nonmedical costs and costs of productivity loss. The information on the effect of Kremezin was obtained from the results of earlier clinical studies. Cost information was derived from the administrative data for 20 hemodialysis and 20 peritoneal dialysis patients from one tertiary care hospital, and also from the administrative data of 10 hemodialysis patients from one free-standing dialysis center. Per-capita cost savings resulting from Kremezin therapy were separately estimated for the cases with delay for the onset of hemodialysis and the cases with immediate performance of peritoneal dialysis. By computing the weighted average for the cases of hemodialysis and peritoneal dialysis, the expected per-capita cost savings of a patient with CRF was obtained. Using a discount rate of 5%, future cost savings were converted to the present value. Results : The present value of cumulative cost savings per patient with CRF from the societal perspective would be $18,555,000{\sim}29,410,000$ Won or $72,104,000{\sim}112,523,000$ Won if Kremezin delays the initiation of dialysis by 1 or 4 years. Conclusions : The estimated amount of cost savings resulting from treating CRF patients with Kremezin confirms that its effect for delaying the onset of dialysis treatments has a considerable economic value.

• 대한치과마취과학회지
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• 제3권2호
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• pp.98-102
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• 2003

Patients in end-stage renal disease (ESRD) and chronic renal failure present a number of challenges to the anesthesiologist. They may be chronically iii and debilitated and have the potential for multiorgan dysfunction. A 65-year-old male patient with ESRD was scheduled for oral cancer surgery under general anesthesia. He was in regular hemodialysis three times a week and secondary hypertension with left ventricular hypertrophy was accompanied. He also had chronic metabolic acidosis and hyperkalemia. The day after hemodialysis, general anesthesia was carried out. Uneventful anesthetic induction using thiopental and vecuronium and nasotracheal intubation were carried out. General anesthesia was maintained with isoflurane for 9 hours. During the anesthesia, he did not have any problem but persistently increasing serum potassium level. After anesthetic emergence, he was transferred to intensive care unit for mechanical ventilation. So we report this successful case of anesthetic management in a patient with ESRD for oral cancer surgery, which massive bleeding and long anesthetic time were inevitable in, from the preoperative preparation to anesthetic emergence.

• Journal of Trauma and Injury
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• 제34권4호
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• pp.299-304
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• 2021

Atypical hemolytic uremic syndrome (aHUS) is a rare, progressive, life-threatening condition of thrombotic microangiopathy characterized by thrombocytopenia, microangiopathic hemolytic anemia, and renal impairment. The mechanisms underlying aHUS remain unclear. Herein, we present the first case in the literature of aHUS after a traumatic injury. A 55-year-old male visited the emergency department after a traumatic injury caused by a tree limb. Abdominal computed tomography revealed a rectal wall defect with significant air density in the perirectal space and preperitoneum, implying rectal perforation. Due to the absence of intraperitoneal intestinal perforation, we performed diverting sigmoid loop colostomy. An additional intermittent simple repair was performed due to perianal and anal injuries. One day postoperatively, his urine output abruptly decreased and serum creatinine level increased. His platelet level decreased, and a spiking fever occurred after 2 days. The patient was diagnosed with acute renal failure secondary to aHUS and was treated with fresh frozen plasma replacement. Continuous renal replacement therapy (CRRT) was also started for oliguria and uremic symptoms. The patient received CRRT for 3 days and intermittent hemodialysis thereafter. After hemodialysis and subsequent supportive treatment, his urine output and renal function improved. The hemolytic anemia and thrombocytopenia also gradually improved. Dialysis was terminated on day 22 of admission and the patient was discharged after recovery. This case suggests that that a traumatic event can trigger aHUS, which should be considered in patients who have thrombocytopenia and acute renal failure with microangiopathic hemolytic anemia. Early diagnosis and appropriate management are critical for favorable outcomes.

• 대한영상의학회지
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• 제84권2호
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• pp.477-482
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• 2023

매립혈액투석카테터 삽입을 위한 접근로 선택에서 쇄골하정맥은 이후에 동정맥루 접근로 형성을 위해 가능한 사용을 피하는 경로이다. 그러나 반복적 삽관으로 접근 가능한 정맥이 소진되거나 기대여명이 길지 않고 응급 투석이 필요한 경우 쇄골하정맥을 선택할 수 있다. 그러나 쇄골하정맥을 통한 혈액투석카테터 삽입에는 기술적인 어려움이 있다. 쇄골하정맥은 종종 상대정맥과 직각을 형성하여 굵은 혈관초삽입시 혈관 손상을 초래할 수 있다. 상지 거상 상태에서 혈관초를 삽입하는 방법은 각도를 완만하게 유도하여 이러한 문제를 극복하는데 도움을 줄 수 있다. 고식적앙와위 자세로 시술 중 상대정맥 손상이 있었던 환자와 연달아 내원하여 상지 거상 후 안전하게 혈액투석카테터를 삽입한 환자의 각각의 증례를 통해 상지 거상법이 도움이 될 수 있음을 보고하고자 한다.

• 한국융합학회논문지
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• 제10권5호
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• pp.385-395
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• 2019

본 연구는 혈액투석환자의 사회적지지와 회복탄력성이 환자역할행위 이행에 미치는 영향을 파악하고, 혈액투석 환자의 환자역할행위 이행 증진을 위한 간호중재 프로그램의 기초자료를 제공하고자 시도되었다. 연구방법은 D광역시에 위치한 일개 종합병원에서 정기적으로 혈액투석 치료를 받고 있는 만성콩팥병 환자 131명의 설문지를 최종 분석하였다. 연구의 분석결과 혈액투석환자의 사회적지지는 $3.93{\pm}0.84$점, 회복탄력성은 $2.67{\pm}0.80$점이었고, 환자역할행위 이행은 $3.99{\pm}0.80$점으로 나타났다. 사회적지지가 높을수록 회복탄력성과 환자역할행위 이행이 증가하며 회복탄력성이 높을수록 환자역할행위 이행이 증가하는 것으로 나타났다. 대상자의 환자역할행위 이행에 영향을 미치는 요인으로 투석횟수, 사회적지지, 회복탄력성이 있었고 모형의 설명력은 44.0%이었다. 환자역할행위 이행을 증진시키기 위해서는 회복탄력성을 활용하고 사회적지지를 지속적으로 유지하는 간호중재 프로그램을 연구, 개발이 필요할 것으로 생각된다.

• Journal of Nutrition and Health
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• 제22권1호
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• pp.32-35
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• 1989

Serum lipid peroxide levels in 25 chronic renal failure patients undergoing hemodialysis were examined by determining TBA reaction with spectrofluorometry. The lipid peroxide levels, 208.9$\pm$88.4nmol/ml, in the patient group was significantly higher than 152.4$\pm$43.9nmol/ml of 48 control healthy subjects. It is likely that the elevated serum lipid peroxide levels can play a role in increasing tendency of hemorrhage and incidence of atherosclerosis in chronic renal failure patients.

• 대한간호학회지
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• 제46권4호
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• pp.598-609
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• 2016

Purpose: The purpose of this study was to examine effects of a dietary program based on self-efficacy theory on dietary adherence, physical status and quality of life (QoL) in hemodialysis patients. Methods: A non-equivalent control group pre-post test design was used. The intervention group received the dietary program for 8 weeks from August 4 to September 26, 2014. The control group received only usual care. Results: ANCOVA showed that dietary adherence (F=64.75, p <.001) was significantly different between the two groups. Serum albumin (F=12.13, p =.001), interdialytic weight gain (F=56.97, p <.001), calories (F=15.80, p <.001) as physical status indices were significantly different, but serum potassium (F=2.69, p =.106) and serum phosphorus (F=1.08, p =.303) showed no significant difference between the two groups. In terms of health-related QoL, the physical component scale (F=10.05, p =.002) and the mental component scale (F=16.66, p <.001) were significantly different between the two groups. In addition, in terms of diet related QoL, diet level (F=35.33, p <.001) and satisfaction level (F=15.57, p <.001) were significantly different between the two groups, but dietary impact level (F=1.23, p =.271) was not significantly different. Conclusion: Findings show that the dietary program based on self-efficacy theory is an effective nursing intervention program to improve adherence to diet, and to maintain physical status and QoL for hemodialysis patients.

• 디지털융복합연구
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• 제10권5호
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• pp.301-305
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• 2012

본 연구는 혈액투석 환자의 피로와 피로조절행위를 파악하고 그 관계를 규명하여 효과적인 피로 중재 프로그램을 개발하는데 기초 자료를 마련하고자 시도되었다. 연구 대상자는 서울지역에 소재한 3차 의료기관 혈액투석실에서 정기적인 혈액투석을 받는 환자 107명이며, 자료수집기간은 2010년 8월 2일부터 14일까지였다. 수집된 자료는 SPSS WIN 12.0을 이용하여 분석하였다. 본 연구 결과 대상자의 피로는 평균 77.1점이었고, 피로조절행위 빈도는 15개 항목 중 평균 8.8개를 사용하는 것으로 나타났으며, 피로조절행위 효율성은 평균 22.8점이었다. 대상자의 피로는 피로조절행위와 통계적으로 유의한 순상관관계(r=.45, p=.000)가 있는 것으로 나타났다. 이상의 연구 결과를 통해, 혈액투석 환자의 피로는 높은 수준이며, 피로를 감소시키기 위한 피로조절행위를 시행하고는 있으나 그 효율성이 낮다는 것을 확인할 수 있었다. 따라서 혈액투석 환자의 피로를 감소시키기 위한 근거기반 피로중재 프로그램을 개발하고 그 효과성을 검증하는 연구가 지속되어야 할 것이다.

• Journal of Chest Surgery
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• 제48권1호
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• pp.46-51
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• 2015

Background: Maintenance of adequate vascular access for hemodialysis is important in patients with end-stage renal disease. Once arteriovenous fistula (AVF) occlusion occurs, the patient should be treated with rescue therapy. This study was performed to evaluate the results of a rescue therapy for AVF occlusion. Methods: From January 2008 to December 2012, 47 patients who underwent surgical rescue therapy for AVF occlusion after graft AVF formation, were enrolled in this study. The patients were divided into two groups, namely the graft repair group (group A, n=19) and the thrombectomy group (group B, n=28). Postoperative results of both groups were analyzed retrospectively. Results: There were no statistically significant differences in the clinical characteristics between the two groups. In terms of the duration of AVF patency after the first rescue therapy, group A showed a longer AVF patency duration than group B ($24.5{\pm}21.9$ months versus $17.7{\pm}13.6$ months), but there was no statistically significant difference (p=0.310). In terms of the annual frequency of AVF occlusion after the rescue therapy of group A was lower than that of group B (0.59 versus 0.71), but there was no statistically significant difference (p=0.540). The AVF patency rates at 1, 2, 3, and 5 years after the first rescue therapy in group A were 52.6%, 31.5%, 21.0%, and 15.7%, respectively, and those in group B, they were 32.1%, 25.0%, 17.8%, and 7.14%, respectively. There was no statistically significant difference (p=0.402). Conclusion: Graft repair revealed comparable results. Although there was no statistically significant difference, the patent duration and annual frequency of AVF occlusion of group A were better than those of group B. Therefore, graft repair is considered as a safe and useful procedure for maintaining graft AVF.