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A Case of Pharmacokinetics of Cisplatin in Concurrent Chemoradiation for Hemodialysis Patient with Advanced Head and Neck Cancer  

Jeon, Youn-Joo (Departments of Internal Medicine, St. Vincent's Hospital)
Shim, Byoung-Yong (Departments of Internal Medicine, St. Vincent's Hospital)
Kim, Hyung-Wook (Departments of Internal Medicine, St. Vincent's Hospital)
Lee, Sang-Hun (Departments of Internal Medicine, St. Vincent's Hospital)
Lee, Ho-Sang (Departments of Internal Medicine, St. Vincent's Hospital)
Park, Cheol-Whee (Departments of Internal Medicine, St. Vincent's Hospital)
Kim, Su-Zy (Departments of Radiation Oncology, St. Vincent's Hospital)
Kuh, Hyo-Jeong (Catholic Research Institutes of Medical Science)
Kim, Hoon-Kyo (Departments of Internal Medicine, St. Vincent's Hospital)
Publication Information
Korean Journal of Head & Neck Oncology / v.23, no.2, 2007 , pp. 153-156 More about this Journal
Abstract
Objectives : We study the feasibility and pharmacokinetics of cisplatin concurrent chemoradiation for advanced head and neck cancer patient undergoing hemodialysis. Materials and Methods : A 57-year old male with end stage renal disease developed stage III external auditory canal cancer. Complete resection surgery was done. Postoperative 6 months, local recurrence was occurred. Despite excision and adjuvant radiotherapy, local tumor was recurred. We decided to treat a cisplatin concurrent chemoradiotherapy. Cisplatin was administered at a dose of $20mg/m^2$ for 30 min. Hemodialysis was started 30 min after completion of the cisplatin infusion and performed for 4 hours. Hemodialysis was performed on day 3 and 5 of chemotherapy. Plasma samples were collected at specified times after administration of cisplatin. Result : At the end of the third cycle of cisplatin concurrent chemoradiotherapy, the tumor size was markedly decreased. The maximum plasma concentrations of plasma platinum and free platinum were 0.74 and $0.37{\mu}g/ml$ respectively. The area under the curve of plasma platinum and free platinum were 94.7 and $11.3{\mu}g{\cdot}h/ml$ respectively. Conclusion : We report a case of Cisplatin concurrent chemoradiation for hemodialysis patient with advanced head and neck cancer and suggest full dose cisplatin concurrent chemoradiotherpay is tolerable for these patients.
Keywords
Pharmacokinetics; Cisplatin; Head and neck cancer; Hemodialysis;
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