• 대한중풍순환신경학회지
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• 제7권1호
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• pp.17-22
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• 2006

Objectives : Uwhangchungsimwon (UC) is one of the famous herbal medicine frequently used for stroke, hypertension, and atherosclerosis, etc. Therefore, we intended to examine if UC could have therapeutic effect on arterial stiffness by assessing Cardio-Ankle Vascular lndex (CAVI). Methods : We enrolled 38 healthy male subjects (28±4.41 years old) and divided them into two groups (UC and control group). The UC group (N=22) were treated with 1 pill of UC and monitored by CAVI every hour for 6 hours. The control group(N=16) did not receive any medicine and were also monitored by CAVI the same manner as the UC group. In both group, we also assessed each subject's Yin-Yang pattern score by the diagnostic scoring system. In analysis, we compared the difference of CAVIs between the UC and the control group considering subject's Yin-Yang pattern. Results : There was no significant difference in the change of CAVI between the UC and the control group. After excluding Yang-pattern subjects in both group, however, we could observe that CAVI decreased significantly 5 hours after UC administration compared with the corresponding CAVI in the control group (P=0.025). In the repeated measure analysis, the between-subjects effect had statistical significance (P=0.035). Conclusion : According to these results, we suggest that UC have therapeutic effect on arterial stiffness especially after taking oriental medical diagnosis into consideration.

• Archives of Pharmacal Research
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• 제28권9호
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• pp.1027-1030
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• 2005

The antidiabetic-activity-guided fractionation and isolation of the $80\%$ EtOH extracts obtained from cultivated Korean Rhubarb rhizomes (Rheum undulatum, Polygonaceae) led to the isolation and characterization of one stilbene, desoxyrhapontigenin(1) and two anthraquinones, emodin (2) and chrysophanol (3). Their structures were established by chemical and spectroscopic methods. Compounds 1, 2, and 3 inhibited postprandial hyperglycemia by 35.8, 29.5, $42.3\%$, respectively.

• 대한한방내과학회지
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• 제40권6호
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• pp.1051-1062
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• 2019

Objectives: Chest pain presents diagnostic and therapeutic challenges because of its various etiologies. Many patients have chest pain from unknown causes and persistent chest pain in spite of standard treatment. The purpose of this study was to investigate the effectiveness of a Korean herbal medicine called Pyungjinsujeom-san (PSS) in relieving chest pain. Methods: We reviewed the electronic medical records of patients who visited the Korean Medical Clinic of Cardiology at Kyunghee University Hospital at Gangdong from January 2009 to July 2019, with the chief complaint of chest pain and who were treated with PSS. The mean severity of chest pain measured on the Numerical Rating Scale was compared before and after the administration of PSS. Results: The mean severity of chest pain of 20 patients decreased significantly from 6.80±1.61 to 1.35±0.9 after taking PSS (p<0.001). Most patients had symptoms of phlegm and food retention, including indigestion, postprandial fullness, and epigastric pain.Conclusions: These results suggest that PSS may be effective in relieving chest pain from various causes, particularly in patients with symptoms of phlegm and food retention.

• Korean Journal of Acupuncture
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• 제33권4호
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• pp.176-182
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• 2016

Objectives : This study was designed to analyze the characteristic of heart rate variability(HRV) changes between Deficiency Pattern and Excess Pattern in Stroke Patients admitted to the hospital. Methods : We measured heart rate variability of stroke patients who were admitted to the Department of Korean Internal medicine, Stroke and Neurological Disorders Center from February 1, 2015 to May 30, 2016. We recruited a total of 28 stroke patients and heart rate variability tests were performed on the first day of admission, 2weeks after admission, and 4 weeks after admission. Results : VLF and LF/HF ratio significantly increased over time in Deficiency Pattern group compared with those in the Excess Pattern group. Conclusions : This results suggest that the parasympathetic function of Deficiency Pattern group is lower than that of the Excess Pattern group, resulting in imbalance of the autonomic nervous system.

• 대한중풍순환신경학회지
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• 제20권1호
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• pp.43-52
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• 2019

■ Objectives The purpose is to report the case of Korean medicine in the treatment of bilateral superior altitudinal hemianopia after a stroke. ■ Methods The patient was treated with acupuncture, electroacupuncture, bee venom, and herbal medicine. The visual field defect was assessed using humphrey visual field analyzer and confrontation visual field test. ■ Results After treatment, humphrey visual field analyzer and confrontation visual field test showed improvement in field of vision ■ Conclusion This study suggested that Korean medical treatment could be an effective option for treating visual field defect after stroke.

• 대한중풍순환신경학회지
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• 제19권1호
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• pp.55-62
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• 2018

A patient with right upper limb weakness was diagnosed with idiopathic polyneuropathy and received a series of Korean Medicine including acupuncture, electroacupuncture, bee venom acupuncture, and administration of herbal medicine BacJung-hwan for 17 days of hospitalization period. The progression of the weakness was measured by Hand grip tester, neuralgia and numbness were measured by the NRS(Numerical Rating Scale) scores. After treatment, the right grip strength improved from 12kg to 35kg and the right upper limb neuralgia of the NRS5 was improved to NRS2. The present case study suggests that the potential effects of Korean Medicine treatment for idiopathic polyneuropathy.

• 지식경영연구
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• 제23권3호
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• pp.285-311
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• 2022

본 연구에서는 S-O-R 프레임워크를 기반으로 개인에 대한 자극(유튜브 채널의 영상 특성, 유튜버 특성, 실시간 방송 특성)이 어떻게 유기체(지각된 유용성, 지각된 즐거움, 사회적 존재감)를 형성하고, 이것이 시청자 반응(지속시청의도, 유료후원의도)에 영향을 미치는지를 유튜브 실시간 방송 환경에서 검증해 보고자 한다. 이를 위해 연구모형 및 가설을 구성하였고, 유튜브 플랫폼의 실시간 방송 채널 서비스 이용자를 대상으로 수집한 369부의 설문자료를 분석하였다. 분석결과, 일부 영상 특성, 유튜버 특성, 실시간 방송 특성이 시청자의 지각된 유용성, 지각된 즐거움, 사회적 존재감에, 더 나아가 지속시청의도, 유료후원의도에 유의한 영향을 미치는 것을 확인하였다. 결론에서 연구결과의 이론적 및 실무적 시사점을 논의하였다.

• 동의생리병리학회지
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• 제16권6호
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• pp.1201-1206
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• 2002

In oriental medicine, human being is classified into four groups according to their body constitution status (;tae-yang, tae-eum, so-yang, and so-eum persons) considering the differences in function of internal organs and characteristics. Four body constitution, called 'sa-sang' has been recognized as an important factor for diagnosing the patients before madical teratment. Yet, the criteria to divide body constitutions or its scientific principle are not clearly defined. As an initial effort to elucidate biological priciples underlying four body constitution groups, we studied genetic variations among three constitution groups (tae-eum, so-yang, and so-eum persons). Noting distinct responses to ingested food and administered drugs among three groups, SNPs and haplotype experiments were performed in 2D6, 2C9, and 1A2 DNA regions of the cytochrome P450 gene. Significant variability in SNPs types was found in 2D6 region. Moreover, haplotyping in 2D6 region showed relatively high occurrences of haplotype 3 and 5 in so-eum person, haplotype 6 in tae-eum person, and hyplotype 1 in so-yang person. These results indicate that individuals with different body constitutions respond differently to ingested food and drugs, which might reflect constitution-specific genetic background. The genetic approach would therefore be useful to reveal intrinsic differences among four constitution body groups in the responsiveness to various drugs and external stimulations to human body.

• 대한한방내과학회지
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• 제39권4호
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• pp.839-845
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• 2018

This is a case report of a 57-year-old patient diagnosed with bradycardia and atrioventricular (AV) block. The chief complaint of the patient was palpitation and dizziness. An electrocardiogram (ECG) showed a second degree AV block with 2:1 AV conduction. The patient was treated with Korean medicine, including herbal medicine, for 35 days. After 2 weeks of treatment, the heart rate increased from 33 to 56 and the follow-up electrocardiogram showed normal findings. The symptoms of palpitation and dizziness were also improved. The effect on heart rate, ECG, and symptoms lasted until the end of the treatment. This case report demonstrated that Korean medicine could be effective for treatment of symptomatic bradycardia with AV block.

• 대한한방내과학회지
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• 제37권4호
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• pp.653-660
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• 2016

Objectives: The purpose of this study was to investigate the effects of Korean medicine on patients with idiopathic Parkinson’s disease.Methods: The charts of 47 patients diagnosed with idiopathic Parkinson’s disease in the Department of Internal Korean medicine, Stroke and Neurological Disorders Center, Kyung Hee University Hospital, Gangdong between August 2012 and July 2016 were reviewed. The Unified Parkinson’s disease rating scale (UPDRS) was administered before and after treatment with Korean medicine.Results: Thee average UPDRS Ⅱ+Ⅲ, UPDRS Ⅱ, and UPDRS Ⅲ of the 47 patients decreased significantly from 22.26±15.15, 10.19±7.53, and 12.06±8.35, respectively, pretreatment to 16.96±13.63, 7.47±6.44, and 9.49±7.73, respectively, post-treatment. The average postural instability and gait difficulty (PIGD), tremor, and bradykinesia also significantly improved post-treatment.Conclusions: These results provide evidence that Korean medicine can improve the activities of daily living and motor function of patients with idiopathic Parkinson’s disease. In particular, Korean medicine may be effective for the treatment of PIGD, tremor, and bradykinesia.