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Antidiabetic Stilbene and Anthraquinone Derivatives from Rheum undulatum  

Choi Sang Zin (Natural Products Laboratory, College of Pharmacy, SungKyunKwan University)
Lee Sung Ok (Natural Products Laboratory, College of Pharmacy, SungKyunKwan University)
Jang Ki Uk (Natural Products Laboratory, College of Pharmacy, SungKyunKwan University)
Chung Sung Hyun (Pharmacology Lab, College of Pharmacy, Kyung Hee University)
Park Sang Hyun (Pharmacology Lab, College of Pharmacy, Kyung Hee University)
Kang Hee Chol (Natural Products Project, R&D Center of Pharmaceuticals of Science & Technology)
Yang Eun Young (Natural Products Project, R&D Center of Pharmaceuticals of Science & Technology)
Cho Hi Jae (Natural Products Project, R&D Center of Pharmaceuticals of Science & Technology)
Lee Kang Ro (Natural Products Laboratory, College of Pharmacy, SungKyunKwan University)
Publication Information
Archives of Pharmacal Research / v.28, no.9, 2005 , pp. 1027-1030 More about this Journal
Abstract
The antidiabetic-activity-guided fractionation and isolation of the $80\%$ EtOH extracts obtained from cultivated Korean Rhubarb rhizomes (Rheum undulatum, Polygonaceae) led to the isolation and characterization of one stilbene, desoxyrhapontigenin(1) and two anthraquinones, emodin (2) and chrysophanol (3). Their structures were established by chemical and spectroscopic methods. Compounds 1, 2, and 3 inhibited postprandial hyperglycemia by 35.8, 29.5, $42.3\%$, respectively.
Keywords
Rheum undulatum; Polygonaceae; Stilbene; Anthraquinone; Antidiabetic;
Citations & Related Records

Times Cited By Web Of Science : 20  (Related Records In Web of Science)
Times Cited By SCOPUS : 22
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1 Kim, D. K., Choi, S. U., and Ryu, S. Y., Cytotoxic constituents of Rumex japonicus. Yakhak Hoeji, 42, 233-237 (1998)
2 Ko, S. K., Lee, S. M., and Whang, W. K., Anti-platelet aggregation activity of stilbene derivatives from Rheum undulatum. Arch. Pharm. Res., 22,401-403 (1999)   DOI   ScienceOn
3 Trinder, P. and Trinder P., Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J. Clin. Pathol., 22,158-161 (1969)   DOI   PUBMED
4 Ko, S. K., Whang, W. K., and Kim, I. H., Stilbene compounds from cultivated Korean Rhubarb Rhizomes. Yakhak Hoeji, 42, 1-4 (1998)
5 Bae, K. H., The medicinal plants of Korea. Kyohaksa, Seoul, Korea, p. 90, (2001)
6 Matsuda, H., Morikawa, T., Toguchida, I., Park, J. Y, Harima, S., and Yoshikawa, M., Antioxidant constituents from Rhubarbs: Structural requirements of stilbenes for the activity and structures of two new anthraquinone glucosides. Bioorg. Med. Chem., 9, 41-50 (2001)   DOI   ScienceOn
7 Chen Y. C., Shen, S. C., Lee, W. R., Hsu, F. L., Lin, H. Y, Ko, C. H., and Tseng, S. W, Emodin induces apoptosis in human promyeloleukemic HL-60 celis accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. Biochem. Pharmacol., 64, 1713-1724 (2002)   DOI   ScienceOn