• The Journal of Economics, Marketing and Management
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• v.10 no.4
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• pp.13-24
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• 2022

Purpose: Although numerous research has covered content on trends in the adoption and use of wearable devices, their uses across several sectors such as healthcare, gaming, and fashion, there seems to be a considerable paucity with regard to empirical research focusing on the solutions for factors that undermine the effectiveness of wearable devices in healthcare. The present research aims to highlight what has been covered on wearable devices in healthcare while highlighting the limitations for future research. Research design, data, and methodology -The present authors conducted one of the most famous qualitative literature approach which has been called as PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) statement. The selecting criteria for eligible prior studies was estimated by whether studies are suitable for the current research, identifying they are peer-reviewed and issued by notable publishers between 2017 and 2022. Result - Our results indicated that (1) Increasing the Affordability and User Education on Wearable Devices in Healthcare (2) Tackling the Technological Issues in Wearable Devices to Promote Healthcare Delivery (3) Solving Security and Privacy Issues Associated with Wearable Devices (4) Promoting Standards and Appropriate Regulations for Wearable Devices. Conclusion - To add, resolving the technological issues associated with wearable devices in healthcare will ensure that the new devices in the market will have longer battery life, multiple functions, and enhanced accuracy, thus ensuring that patients receive better care. Necessary interventions are taken on time to avoid any deleterious consequences such as proliferating mortality rates among the different patient groups.

• International Journal of Internet, Broadcasting and Communication
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• v.15 no.4
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• pp.261-269
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• 2023

We propose to design a Holochain-based security and privacy protection system for resource-constrained IoT healthcare systems. Through analysis and performance evaluation, the proposed system confirmed that these characteristics operate effectively in the IoT healthcare environment. The system proposed in this paper consists of four main layers aimed at secure collection, transmission, storage, and processing of important medical data in IoT healthcare environments. The first PERCEPTION layer consists of various IoT devices, such as wearable devices, sensors, and other medical devices. These devices collect patient health data and pass it on to the network layer. The second network connectivity layer assigns an IP address to the collected data and ensures that the data is transmitted reliably over the network. Transmission takes place via standardized protocols, which ensures data reliability and availability. The third distributed cloud layer is a distributed data storage based on Holochain that stores important medical information collected from resource-limited IoT devices. This layer manages data integrity and access control, and allows users to share data securely. Finally, the fourth application layer provides useful information and services to end users, patients and healthcare professionals. The structuring and presentation of data and interaction between applications are managed at this layer. This structure aims to provide security, privacy, and resource efficiency suitable for IoT healthcare systems, in contrast to traditional centralized or blockchain-based systems. We design and propose a Holochain-based security and privacy protection system through a better IoT healthcare system.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.49 no.2
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• pp.55-62
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• 2012

Convergence of information technology (IT) and medical devices enables people to measure health-related information ubiquitously, such as measuring blood glucose at home and checking cardiac signals during exercise and it allows us to access to medical care anywhere and anytime. Nowadays, the market for U-healthcare medical devices is growing rapidly, but guidelines for the evaluation of safety and effectiveness of such devices remain to be formulated. We performed a study on the development of safety and performance evaluation method for portable, hand-held, U-healthcare medical devices. We reviewed current guidelines and standards for home-health devices from the Korea Food and Drug Administration (KFDA) and related international committees such as the ISO/IEEE and CE. We summarized the test methods and items for the evaluation of safety and performance related to U-healthcare medical devices from the above guidelines and standards. We defined requirements for a U-healthcare medical device to demonstrate good performance. In conclusion, we propose an evaluation method for U-healthcare medical devices, which will help improve the safety and reliability of these devices.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.47 no.1
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• pp.65-73
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• 2021

It is very important to control the inflammation of the skin because it can develop into diseases such as atopy as well as scarring and aging. In this work, we recently identified the in vitro synthesis of specialized pro-resolving mediators (SPMs) known to control inflammation in the human body and the applicability of cosmetics. Using recombinant protein of lipoxygenase from Glycine max, we succeeded to prepare mixtures of mono- or di-hydroxy DHA named as S-SPMs and used them for in vitro efficacy test. To investigate anti-inflammatory effect of S-SPMs, mRNA level of TNF-α and IL-6 were analyzed. Under UVB exposed condition, expression of both were decreased by S-SPMs treatment. And we observed reduced production of nitric oxide (NO) by S-SPMs application under the condition with diesel particulate matter (DPM). At the same experimental condition, malondialdehyde (MDA) production was decreased by S-SPMs, indicating the inhibitory effect of S-SPMs in lipid peroxidation. In addition, S-SPMs treatment resulted in reduction of matrix metalloproteinases-1 (MMP-1) expression and elevation of procollagen type I synthesis. Together with this, mRNA level of filaggrin and loricrin were increased by S-SPMs, indicating enhancement of skin barrier function. These results demonstrate that S-SPMs is a good candidate to develop as a cosmetic ingredient for anti-inflammation, anti-wrinkle, and improvement of skin barrier function.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.15 no.5
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• pp.308-314
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• 2022

This study deals with the technology Convergence Analysis by IPC Code-Based Social Network Analysis of Healthcare Patents filed in Korea. The relationship between core technologies is visualized using Social Network Analysis. At the subclass level of healthcare patents, 1,155 cases (49.4%) of patents with complex IPC codes were investigated, and as a result of Social Network Analysis on them, the IPC codes with the highest Degree Centrality were A61B, G16H, and G06Q, in that order. The IPC codes with the highest Betweenness Centrality are in the order of A61B, G16H, and G06Q. In addition, it was confirmed that healthcare patents consist of two large technology clusters. Cluster-1 corresponds to related business models centered on A61B, G16H and G06Q, and Cluster-2 is consisting of H04L, H04W and H04B. The technology convergence core pairs of the healthcare patent is [G16H-A61B] and [G16H-G06Q] in Cluster-1, and [H04L-H04W] in Cluster-2. The results of this study can contribute to the development of core technologies for healthcare patents.

• Molecules and Cells
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• v.26 no.1
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• pp.18-25
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• 2008

Arsenic trioxide (ATO) can affect many biological functions such as apoptosis and differentiation in various cells. We investigated the involvement of ROS and GSH in ATO-induced HeLa cell death using ROS scavengers, especially N-acetylcysteine (NAC). ATO increased intracellular ${O_2}^{{\cdot}-}$ levels and reduced intracellular GSH content. The ROS scavengers, Tempol, Tiron and Trimetazidine, did not significantly reduce levels of ROS or GSH depletion in ATO-treated HeLa cells. Nor did they reduce the apoptosis induced by ATO. In contrast, treatment with NAC reduced ROS levels and GSH depletion in the ATO-treated HeLa cells and prevented ATO-induced apoptosis. Treatment with exogenous SOD and catalase reduced the depletion of GSH content in ATO-treated cells. Catalase strongly protected the cells from ATO-induced apoptosis. In addition, treatment with SOD, catalase and NAC slightly inhibited the G1 phase accumulation induced by ATO. In conclusion, NAC protects HeLa cells from apoptosis induced by ATO by up-regulating intracellular GSH content and partially reducing the production of ${O_2}^{{\cdot}-}$.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.4 no.1
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• pp.9-14
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• 2010

According to graying of population and income enlargement of people, interest about U-Healthcare of new form fusing with IT technology are enlarged. Need a estimation technology and standard of test method for safety and performance considering usage environment of U-Healthcare medical device. In this research, developed the standard of test method for usage environment safety and performance of U-Healthcare medical device referring IEC standards and KS standards.

• Health Policy and Management
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• v.34 no.1
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• pp.4-16
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• 2024

Smart hospitals involve the use of recent ICT (information and communications technology) technologies to improve healthcare access, efficiency, and effectiveness. Standardization in smart hospital technologies is crucial for interoperability, scalability, policy formulation, quality control, and maintenance. This study reviewed relevant international standards for smart hospitals and the organizations that develop them. Specific attention was paid to robotics in smart hospitals and the potential for standardization in this area. The study used online resources and existing standards to analyze technologies, standards, and practices in smart hospitals. Key technologies of smart hospitals were identified. Relevant standards from ISO (International Organization for Standardization) and IEC (International Electrotechnical Commission) were mapped to each core technology. Korea's leadership in smart hospital technology were highlighted. Approaches for standardizing smart hospitals were proposed. Finally, potential new international standard items for robotics in smart hospitals were identified and categorized by function: sampling, remote operation, delivery, disinfection, and movement tracking/contact tracing. Standardization in smart hospital technologies is crucial for ensuring interoperability, scalability, ethical use of artificial intelligence, and quality control. Implementing international standards in smart hospitals is expected to benefit individuals, healthcare institutions, nations, and industry by improving healthcare access, quality, and competitiveness.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.10 no.3
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• pp.99-109
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• 2015

The investment in healthcare industry has recently increased not only for global ventures but also for the domestic ventures. However, there has been hardship of founding and investment caused by healthcare startups characteristics that are costly and time consuming. In this study, the applicability of 'Lean Startup' theory to healthcare ventures was explored through the case of a domestic startup which accomplished funding from VC and KOSDAQ after establishing based on its technology in healthcare industry. There have been numerous case studies that applied 'Lean Startup' to IT industry. However, this case study that applied 'Lean Startup' to healthcare industry have some implications as follow: First, it is critical to conduct a hypothesis testing at initial research stage through R&D of 'MVP' (Minimum Viable Product) as the prototype testing is strictly prohibited in healthcare industry. Second, healthcare R&D teams ought to be well organized as startup teams and all researchers should be equipped with entrepreneurship as the licensing process in healthcare industry is time-consuming and costly due to issues like clinical studies. Lastly, management skills as smart and light as 'Lean Startup' are required in order to encourage young engineers' technology startups.

• Clinical and Experimental Reproductive Medicine
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• v.39 no.4
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• pp.166-171
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• 2012

Objective: We compared the assisted reproductive technology (ART) outcomes among infertile women with polycystic ovary syndrome (PCOS) treated with IVM, conventional IVF, GnRH agonist, and GnRH antagonist cycles. Methods: The prospective study included a total of 67 cycles in 61 infertile women with PCOS. The women with PCOS were randomized into three IVF protocols: IVM/IVF with FSH and hCG priming with immature oocyte retrieval 38 hours later (group A, 14 cycles), GnRH agonist long protocol (group B, 14 cycles), and GnRH antagonist multi-dose flexible protocol (group C, 39 cycles). IVF outcomes, such as clinical pregnancy rate (CPR), implantation rate (IR), miscarriage rate (MR), and live birth rate (LBR), were compared among the three groups. Results: Age, BMI, and basal FSH and LH levels did not differ among the three groups. The number of retrieved oocytes and 2 pronucleus embryos was significantly lower in group A compared with groups B and C. The CPR, IR, MR, and LBR per embryo transfer showed no differences among the three groups. There was no incidence of ovarian hyperstimulation syndrome in group A. Conclusion: The IR, MR, and LBR in the IVM cycles were comparable to those of the GnRH agonist and GnRH antagonist cycles. The IVM protocol, FSH and hCG priming with oocyte retrieval 38 hours later, is an effective ART option that is comparable with conventional IVF for infertile women with PCOS.