• 대한의료기공학회지
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• 제19권1호
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• pp.99-115
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• 2019

Introduction : In patient with ankylosing spondylitis, when bone formation progresses, spinal fusion occurs and joint motion is severely limited. We performed Medical Gi-gong and Korean medical therapies in patient with advanced ankylosing spondylitis with spinal fusion. Case : 46-year-old male with extensive spinal fusion at the cervical and lumbar spine complains of back pain, hip pain, joint stiffness, eye pain, and digestive problems. HLA-B27 (+), mSASSS is 70. Medical Gi-gong was done 311 days for 340 days. Acupuncture, cupping, and manual treatment were performed once every 5.9 days for one year. BASDAI improved from 5.3 to 4.3, BASFI from 4.3 to 3.7, and BASMI from 6.8 to 5.8. mSASSS did not change. Conclusions : Patients with advanced ankylosing spondylitis were treated with Medical Gigong and Korean medical therapies to achieve a slight improvement.

• 한국발생생물학회지:발생과생식
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• 제23권2호
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• pp.79-92
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• 2019

Humanized mice, containing engrafted human cells and tissues, are emerging as an important in vivo platform for studying human diseases. Since the development of Nod scid gamma (NSG) mice bearing mutations in the IL-2 receptor gamma chain, many investigators have used NSG mice engrafted with human hematopoietic stem cells (HSCs) to generate functional human immune systems in vivo, results in high efficacy of human cell engraftment. The development of NSG mice has allowed significant advances to be made in studies on several human diseases, including cancer and graft-versus-host-disease (GVHD), and in regenerative medicine. Based on the human HSC transplantation, organ transplantation including thymus and liver in the renal capsule has been performed. Also, immune reconstruction of cells, of the lymphoid as well as myeloid lineages, has been partly accomplished. However, crosstalk between pluripotent stem cell derived therapeutic cells with human leukocyte antigen (HLA) mis/matched types and immune CD3 T cells have not been fully addressed. To overcome this hurdle, human major histocompatibility complex (MHC) molecules, not mouse MHC molecules, are required to generate functional T cells in a humanized mouse model. Here, we briefly summarize characteristics of the humanized mouse model, focusing on development of CD3 T cells with MHC molecules. We also highlight the necessity of the humanized mouse model for the treatment of various human diseases.

• Childhood Kidney Diseases
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• 제25권2호
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• pp.92-111
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• 2021

Purpose: Nephrotic syndrome (NS) is the most common form of glomerulopathy in children. Most pediatric patients respond to glucocorticosteroid treatment (steroid-sensitive NS, SSNS), while approximately 10-15% will remain unresponsive or later become steroid-resistant. There has been a long-standing effort to find biomarkers that may predict steroid responsiveness. Methods: We systematically reviewed current studies which investigated clinically relevant biomarkers for predicting steroid responsiveness in pediatric NS. We performed a PubMed and EMBASE search to identify eligible articles. We collected data on urinary markers, blood/serum markers (including cellular phenotypes and mRNA expression), genotypes and HLA allele frequency. Results: A total of 659 articles were identified following electronic and manual searches. After reviewing the titles, abstracts, and full texts, 72 eligible articles were finally included. Vitamin D-binding protein (VDBP) seemed to be significantly elevated in SRNS than in SSNS, in both serum and urine specimen, although further validation is required. Conclusions: The present paper narratively illustrates current understandings of potential biomarkers that may help predict steroid responsiveness. Further investigation and collaboration involving a larger number of patients are necessary.

• 한국재료학회지
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• 제32권7호
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• pp.313-319
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• 2022

Double-layer capacitors (DLCs) are developed with high surface electrodes to achieve a high capacitance value. In the present work, the initial bulk concentration of 1 mol/m³ and 3 mol /m³ are selected to show the consequential effects on the performance of a double-layer capacitor. A 1D model of COMSOL Multiphysics has been developed to analyze the electric field and potential in cell voltage, the electric displacement field and polarization induced by the field, and energy density in a double-layer structure. The electrostatics and the electric circuit modes in COMSOL are used to simulate the electrochemical processes in the double-layer structure. The analytical analysis of a double-layer capacitor with different initial bulk concentrations is investigated by using Poisson-Nernst-Plank equations. From the simulation results, the differential capacitance changes as a function of compact layer thickness and initial bulk concentration. The energy density varies with the differential capacitance and voltage window. The values of energy density are dominated by the interaction of ions in the solution and electrode surface.

• 한국재료학회지
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• 제32권6호
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• pp.293-300
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• 2022

This study investigated a graded-refractive-index (GRIN) coating pattern capable of improving the light extraction efficiency of GaN light-emitting diodes (LEDs). The planar LEDs had total internal reflection thanks to the large difference in refractive index between the LED semiconductor and the surrounding medium (air). The main goal of this paper was to reduce the trapped light inside the LED by controlling the refractive index using various compositions of (TiO₂)_x(SiO₂)_1-x in GRIN LEDs consisting of five dielectric layers. Several types of multilayer LEDs were simulated and it was determined the transmittance value of the LEDs with many layers was greater than the LEDs with less layers. Then, the specific ranges of incident angles of the individual layers which depend on the refractive index were evaluated. According to theoretical calculations, the light extraction efficiency (LEE) of the five-layer GRIN is 25.29 %, 28.54 % and 30.22 %, respectively. Consequently, the five-layer GRIN LEDs patterned enhancement outcome LEE over the reference planar LEDs. The results suggest the increased light extraction efficiency is related to the loss of Fresnel transmission and the release of the light mode trapped inside the LED chip by the graded-refractive-index.

• 한국시뮬레이션학회논문지
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• 제19권4호
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• pp.219-233
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• 2010

L-V-C 시뮬레이션 연동은 실병력이 실장비를 가지고 참여하는 Live 시뮬레이션 모델, 실병력이 모의된 장비를 가지고 참여하는 Virtual 시뮬레이션 모델, 그리고 모의된 시스템에 모의된 병력이 참여하는 Constructive 시뮬레이션 모델을 연결하여 통합 운용하는 개념으로써, 각각의 모델이 갖고 있는 장점을 취하고, 단점을 보완하며, 보다 실전적인 통합 훈련이 가능하도록 하는데 그 목적이 있다. 본 논문에서는 L-V-C 시뮬레이션 연동을 위한 연구로서, 소부대 교전훈련을 위한 Virtual-Constructive 시뮬레이션 연동개념 연구를 위한 테스트베드를 구축하여, 이를 바탕으로 V-C 시뮬레이션 연동을 위한 요구사항 및 기술을 제안 하고, 기술의 효용성을 검증하였다. 또한 본 논문의 연구 결과는 추후 임무 / 교전급 규모 부대의 L-V-C 연동을 위한 핵심기술 개발에 활용될 수 있을 것이다.

• 수완나부미
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• 제3권1호
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• pp.87-104
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• 2011

붓다고사(Buddhaghosa)는 불교승려이자 작가로써 상좌부불교에서 가장 뛰어난 승려로 유명하다. 그는 청결을 의미하는 Visudhimagga의 작가로서도 유명한데, 이 작품들은 정전(正典)문학의 백과사전이라 불리고 있으며, 담마의 다양한 보물 컬렉션이라 할 수 있다. 붓다고사는 Visuddhi의 순결함에 도달하기 위해 magga 형식을 설명하고 있고, 불교교리 전체를 조직적으로 설명하고 있다. 붓다고사는 스리랑카어로 쓰여진 atthakathā를 Magadyhi(빨리어)로 변역했다. 이러한 업적으로 그는 명예를 얻었고, 이 작품은 상좌부불교(Theravāda)를 연구하는 학자들 사이에서 신성한 텍스트로 여겨졌다. 최초의 붓다고사에 관한 전기문은 6세기에 쓰여진 Mahavamsa에 나타난다. 마하밤사에 따르면, 그는 큰 보리수가 있는 인도 마가다국에서 브라만으로 태어났다고 전해진다. 그러나 Buddhaghosa의 atthakathā를 연구한 Kosanbi박사는 붓다고사는 북인도로부터 온 인물은 아니라고 보았으며, 붓다고사가 미얀마 사람일지도 모른다고 추정했다. 그 이유는 다수의 atthakathā가 미얀마에서 발견되었기 때문이다. 미얀마뿐만 아니라, 태국 그리고 캄보디아 역시 붓다고사가 자국인이라고 주장하고 있다. 5세기부터 더 나아가 11세기 중반까지 하(下) 미얀마의 고대 쀼왕국에서 불교가 매우 번성했다는 지속적인 기록이 있다. 이는 5세기에 붓다고사 전설과 함께 불교를 활성화시켰으며, 상좌부불교와 관련된 조각품들과 비문을 연구하는데 반영되었다. 붓다고사의 자타카 해설은 붓다의 역사적 탄생을 다루고 있으며, 미얀마의 모든 청소년에게 오랫동안 교육자료로 활용되어 왔다. 또한 자타카 해설은 비석에서 중요한 부분을 차지하고 있으며, 테라코타 부조나 11세기와 12세기의 버간사원의 벽화에서도 사용된다. 이처럼 미얀마에서 비석과 테라코타 부조, 그리고 수많은 벽화들이 발견되는 것을 통해 붓다고사가 미얀마 출신이었다는 것을 확인할 수 있다.

• IMMUNE NETWORK
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• 제4권1호
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• pp.31-37
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• 2004

Background: 1-8D gene is a member of human 1-8 interferon inducible gene family and is shown to be overexpressed in fresh colon cancer tissues. Three peptides 1-6, 3-5 and 3-7 derived from 1-8D gene were shown to have immunogenicity against colon cancer. Methods: To study tumor immunotherapy of these peptides we established an adoptive transfer model. $D^{b-/-}{\times}{\beta}2$ microglobulin (${\beta}2m$) null mice transgenic for a chimeric HLA-A2.1/$D^b-{\beta}2m$ single chain (HHD mice) were immunized with irradiated peptide-loaded RMA-S/HHD/B7.1 transfectants. Spleens were removed after last immunization, and splenocytes were re-stimulated in vitro. Lymphocytes from vaccinated HHD mice were transferred together with IL-2 to the tumor bearing nude mice that were challenged S.C. with the HCT/HHD/B7 colon carcinoma cell line that was found to grow in these mice. Results: Peptide 3-5 was found to be highly effective in CTL activity. Adoptively transferred anti-peptide 3-5 cytolytic T lymphocytes caused significant retardation in tumor growth. Conclusion: This study shows that peptide 3-5 can be the most effective candidate for the vaccine of adoptive immunotherapy against colon cancer.

• Journal of Periodontal and Implant Science
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• 제45권6호
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• pp.223-228
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• 2015

Purpose: The goal of this study was to characterize the patterns of antimicrobial resistance and virulence genes in samples of Staphylococcus aureus (S. aureus) isolated from periodontitis patients. Methods: From July 2015 to August 2015, oral saliva was collected from a total of 112 patients diagnosed with periodontitis, including 80 outpatients in dental hospitals and 32 patients in dental clinics located in Seoul and Cheonan. The samples were subjected to a susceptibility test to evaluate the prevalence of antimicrobial resistance, and the pathogenic factors and antimicrobial resistance factors in the DNA of S. aureus were analyzed using polymerase chain reaction. Results: A susceptibility test against 15 antimicrobial agents showed that 88% of cultures were resistant to ampicillin, 88% to penicillin, and 2% to oxacillin. Resistance to at least two drugs was observed in 90% of cultures, and the most common pattern of multidrug resistance was to ampicillin and penicillin. Enterotoxins were detected in 65.9% of samples. The cell hemolysin gene hld was detected in 100% of cultures and hla was detected in 97.6% of samples. All strains resistant to penicillin and ampicillin had the blaZ gene. The aph(3')IIIa gene, which encodes an aminoglycoside modifying enzyme, was detected in 46.3% of samples. Conclusions: In the treatment of oral S. aureus infections, it is important to identify the pathogenic genes and the extent of antimicrobial resistance. Furthermore, it is necessary to study patterns of antimicrobial resistance and cross-infection in the context of periodontological specialties in which antimicrobials are frequently used, such as maxillofacial surgery, where the frequency of antimicrobial use for minor procedures such as implant placement is increasing.

• Tuberculosis and Respiratory Diseases
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• 제44권4호
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• pp.922-929
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• 1997

저자들은 호흡곤란으로 내원한 환자에서, 외이, 코, 기관과 기관지를 침범한 재발성 다발성 연골염 1예를 경험하였기에 보고하는 바이다.