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http://dx.doi.org/10.3339/jkspn.2021.25.2.92

Biomarkers Predicting Treatment-Response in Nephrotic Syndrome of Children: A Systematic Review  

Lee, Jiwon M. (Division of Rare Disease Management, Bureau of Chronic Disease Management, Korea Disease Control and Prevention Agency)
Ahn, Yo Han (Department of Pediatrics, Seoul National University College of Medicine)
Lim, Seon Hee (Department of Pediatrics, Seoul National University Children's Hospital)
Kang, Hee Gyung (Department of Pediatrics, Seoul National University College of Medicine)
Publication Information
Childhood Kidney Diseases / v.25, no.2, 2021 , pp. 92-111 More about this Journal
Abstract
Purpose: Nephrotic syndrome (NS) is the most common form of glomerulopathy in children. Most pediatric patients respond to glucocorticosteroid treatment (steroid-sensitive NS, SSNS), while approximately 10-15% will remain unresponsive or later become steroid-resistant. There has been a long-standing effort to find biomarkers that may predict steroid responsiveness. Methods: We systematically reviewed current studies which investigated clinically relevant biomarkers for predicting steroid responsiveness in pediatric NS. We performed a PubMed and EMBASE search to identify eligible articles. We collected data on urinary markers, blood/serum markers (including cellular phenotypes and mRNA expression), genotypes and HLA allele frequency. Results: A total of 659 articles were identified following electronic and manual searches. After reviewing the titles, abstracts, and full texts, 72 eligible articles were finally included. Vitamin D-binding protein (VDBP) seemed to be significantly elevated in SRNS than in SSNS, in both serum and urine specimen, although further validation is required. Conclusions: The present paper narratively illustrates current understandings of potential biomarkers that may help predict steroid responsiveness. Further investigation and collaboration involving a larger number of patients are necessary.
Keywords
Nephrotic syndrome; Steroid resistant; Biomarker; Treatment; Pediatric;
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