• Journal of the Economic Geographical Society of Korea
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• v.9 no.3
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• pp.318-340
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• 2006

In the last decade, there has been a widespread interest in knowledge production activities as a new engine of endogeneous growth. In the knowledge-based economy, there has been a growing importance of the patent as the index of knowledge production. Much literature suggests that knowledge production activities tend to be spatially concentrated and formed the clusters in the advanced economies. The purpose of this paper is to analyze spatial-temporal patterns of knowledge production activities in Korea based on a data set of patents from 1981-2000. This paper uses spatial statistical methods and GIS to explore the spatial dimensions of knowledge production activities in Korea. Through this research, it was found that knowledge production activities were unevenly distributed. The knowledge production activity measured by patent counts is highly concentrated in a limited number of cities. The top 10 cities accounted for 68.5% of the total number of patents in the period of 1981-2000, suggesting the existence of a strong concentration of knowledge production activities in Korea. The locations of knowledge production activities by themselves represented a strong spatial autocorrelation. The concentration of knowledge production activities in Korea is spatially correlated to the concentration of adjacent neighboring cities. The location of knowledge production activities is not free from a spatial context and spillover of knowledge production activities are heavily bounded within geographic limits, forming a spatial cluster. There appear some quite a large spatial cluster around the seoul metropolitan area.

• Molecules and Cells
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• v.37 no.7
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• pp.547-553
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• 2014

Glioblastoma multiforme (GBM) is one of the most common brain malignancies and has a very poor prognosis. Recent evidence suggests that the presence of cancer stem cells (CSC) in GBM and the rare CSC subpopulation that is resistant to chemotherapy may be responsible for the treatment failure and unfavorable prognosis of GBM. A garlic-derived compound, Z-ajoene, has shown a range of biological activities, including anti-proliferative effects on several cancers. Here, we demonstrated for the first time that Z-ajoene specifically inhibits the growth of the GBM CSC population. CSC sphere-forming inhibition was achieved at a concentration that did not exhibit a cytotoxic effect in regular cell culture conditions. The specificity of this inhibitory effect on the CSC population was confirmed by detecting CSC cell surface marker CD133 expression and biochemical marker ALDH activity. In addition, stem cell-related mRNA profiling and real-time PCR revealed the differential expression of CSC-specific genes, including Notch, Wnt, and Hedgehog, upon treatment with Z-ajoene. A proteomic approach, i.e., reverse-phase protein array (RPPA) and Western blot analysis, showed decreased SMAD4, p-AKT, 14.3.3 and FOXO3A expression. The protein interaction map (http://string-db.org/) of the identified molecules suggested that the AKT, ERK/p38 and $TGF{\beta}$ signaling pathways are key mediators of Z-ajoene's action, which affects the transcriptional network that includes FOXO3A. These biological and bioinformatic analyses collectively demonstrate that Z-ajoene is a potential candidate for the treatment of GBM by specifically targeting GBM CSCs. We also show how this systemic approach strengthens the identification of new therapeutic agents that target CSCs.

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.1603-1614
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• 2010

As the Kyoto protocol and Bali road-map, our country is expected to be included to the emission reduction controlled country of greenhouse gas, so we are now urgent situation to take an action in the level of government. In this research, environment friendly rail logistics and combined transport were treated to meet with the green growth policy of our government. Major problems of Ui-wang ICD suggested in this research are short of yards, unutilized public CY, inconvenience use by non-share holders. It is necessary to improve rail logistic infrastructure, that is, additional expansion of yard, direct operation by KORAIL and regular unloading system are needed. such improvement can not be solved just by the endeavor of business body. Rail logistic infra & Integrated freight terminal has a tendency of SOC, which require tremendous amount of investment, so there are some limit in doing by private sector itself, now it's time to do by the government level. The improvement of rail logistic infrastructure in the level of government is possible by the policy of environment friendly green logistic support which is related with Logistic Policy Basic Law, so government should prepare detailed directives to activate Integrated freight terminal.

• Proceedings of the Korean Society of Embryo Transfer Conference
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• 2002.11a
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• pp.113-113
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• 2002

The stimulatory effect of EGF and FSH on oocyte maturation have been reported in various mammalian species. And some reports presented FSH enhanced the effect of EGF on oocyte maturation. But, the interaction between EGF and FSH on nuclear maturation of mammalian oocytes is not fully understood. We observed the effect of EGF and FSH on nuclear maturation during in vitro maturation of mouse oocytes. Also, we examined the interaction between EGF and FSH on nuclear maturation of mouse oocytes using the EGFR inhibitor or FSH inhibitor. Germinal vesicle (GV) stage oocytes were obtained from 3-4weeks PMSG primed BCFI hybrid mice and cultured in TCM-199 medium with 0.4%PVP supplemented with/without EGF (1ng/ml), FSH (1ug/ml), EGFR specific tyrosine kinase inhibitors: Tyrphostin AG 1478 (500nM), MAP kinase kinase inhibitor : U0126 (20uM) or PD 98059 (100uM) for 14-l5hr. Rapid staining method were used for the assessment of nuclear maturation. Nuclear maturation rates of EGF indjor FSH-treated group were significantly higher than those of control group. Treatment of EGFR inhibitor significantly block the nuclear maturation of GV oocyte in EGF-treated group, but it did not block those of GV oocyte in FSH-treated or FSH and EGF-treated group. Treatment of FSH inhibitor(U0126, PD98059) significantly block the nuclear maturation of EGF-treated group, FSH-treated and FSH and EGF-treated group. These results show that EGF has a stimulatory effect as well as different action pathway with FSH on in-vitro maturation of mouse oocyte in vitro. Therefore, further studies will be needed to find the signaling pathway of EGF associated with nuclear maturation.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.6
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• pp.901-908
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• 2014

Blueberries and strawberries are highly perishable and easily contaminated with microorganisms. To maintain the quality of these commodities during refrigerated storage, the effects of two packaging materials as well as passive modified atmosphere packaging on the quality of blueberries and strawberries were investigated. The harvested blueberries and strawberries were first treated with combined non-thermal treatment of aqueous chlorine dioxide and fumaric acid, followed by packaging with polyolefin film (6,000 mL $O_2/m^2{\cdot}24hr{\cdot}atm$ at $24^{\circ}C$) and polyamide/polyamide/polyethylene film (PA/PA/PE, 60 mL $O_2/m^2{\cdot}24hr{\cdot}atm$ at $24^{\circ}C$), respectively. After combined sanitizer treatment, the populations of total aerobic bacteria in blueberries and strawberries were reduced by 2.50 and 1.97 log CFU/g while those of yeast and molds were reduced by 1.95 and 2.18 log CFU/g, respectively, compared with the control. In particular, microbial growth in these samples packed with PA/PA/PE film was reduced during refrigerated storage. In addition, the blueberries and strawberries packed with PA/PA/PE film underwent lower weight loss than those packed with polyolefin film during storage. These results suggest that appropriate packaging with proper gas permeability is necessary to maintain the quality of blueberries and strawberries during refrigerated storage.

• The Korean Journal of Mycology
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• v.23 no.2 s.73
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• pp.129-138
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• 1995

DNA fragment being able to restore in vitro activity of ${\beta}-1,3-glucan$ synthase was cloned by transformation of the Saccharomyces cerevisiae LP353 mutant strain with genomic library constructed in the YCp50. For the selection of transformants which showed no detectable phenotype linked to recovery of the defect in ${\beta}-1,3-glucan$ synthase activity, the colony autoradiography was succesfully applied. The restriction map of the cloned DNA fragment, which is 8.5-kb in length, was constructed. Both the YEplac195 and the YCp50 carrying the 8.5-kb fragment increased ${\beta}-1,3-glucan$ synthase activity of LP353 by two fold. Neither the YEplac195 nor the YCp50 carrying the 8.5-kb DNA fragment, however, complemented the temperature-dependent osmotic sensitivity which is another distinctive phenotype of LP353. Subcloning experiments indicated that a functional region was located in 4.8-kb BglII-KpnI fragment. The 4.8-kb fragment was also able to increase the level of ${\beta}-1,3-glucan$ content in cell wall as well as the resistance of cells to cell wall lytic enzyme, ${\beta}-1,3-glucanase$. The growth rate of the LP353 with 4.8-kb fragment was almost same as that of wild type strain in liquid medium with 1.2 M sorbitol at nonpermissive temperature. Taken these results together, the 4.8-kb fragment seemed to contain the BGS2 gene for ${\beta}-1,3-glucan$ synthase activity in yeast S. cerevisiae.

• Korean Journal of Agricultural and Forest Meteorology
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• v.12 no.4
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• pp.298-306
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• 2010

In this study, we evaluated the performance of Korea Land Data Assimilation System (KLDAS) for the estimation of evapotranspiration (ET) by comparing the modeled against the observed ET at Gwangneung deciduous forest of KoFlux site (GDK) from 2006 to 2008. Although the magnitudes of ET by KLDAS overestimated the observed ET, the seasonal patterns of KLDAS ET were comparable with the correlation coefficient of 0.78. The difference between the KLDAS ET and the observed ET was larger in spring and summer due to rapid plant growth and frequent rainfalls with high cloud cover, respectively. Compared to the ET estimated by NASA Global Land Data Assimilation System (GLDAS) with $0.25^{\circ}$ and $1^{\circ}$ resolution, the ET by KLDAS with 10 km resolution showed better agreement with the observation at the GDK site. Albeit further improvement is necessary, our results suggest that KLADS can be used as a practical tool to map ET and to examine its spatiotemporal variability over the Korean Peninsula.

• Korean Journal of Agricultural and Forest Meteorology
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• v.1 no.1
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• pp.12-19
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• 1999

CERES-rice, a rice growth simulation model, was used in conjunction with daily weather data to figure out the spatial variation of the phenology and yields of paddy rice at 168 rice cultivation zone units(CZU) of Kyunggi Province in 1997. Two sets of cultivar specific coefficients, which represent early and mid-season maturing varieties, were derived from field experiments conducted at two crop experiment stations. The minimum data set to run the model for each CZU (daily maximum and minimum temperature, solar irradiance, and rainfall) was obtained by spatial averaging of existing 'Digital Map of Korean Climate'(Shin et al., 1999). Soil characteristics and management information at each CZU were available from the Rural Development Administration. According to a preliminary test using 5 to 9 years field data, trends of the phasic development(heading and physiological maturity), which were obtained from the model adjusted for these coefficients, were in good agreement with the observed data. However, the simulated inter-annual variation was somewhat greater than the reported variation. Rough rice yields of the early maturing cultivar calculated by the model were comparable with the reported data in terms of both absolute value and inter -annual variation. But those of the mid season cultivar showed overestimation. After running the simulation model runs with 1997 weather data for 168 CZU's, rough rice yields of the 168 CZU's calculated by the model were aggregated into corresponding 33 counties by acreage-weighting to facilitate direct comparison with the reported statistics from the Ministry of Agriculture and Forestry. The simulation results were good at 22 out of the 26 counties with reportedly increasing yield trend with respect to the past 9 years average.

• Journal of Korea Technology Innovation Society
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• v.15 no.2
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• pp.299-322
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• 2012

Biotechnology is considered a new propeller to national economic growth. Although BT-based converging technology is one of keywords in nowadays, few studies analyze the characteristics of Korean BT convergence market. This study has conducted the analysis of BT-based converging technology market by using patent database in KIPO (Korean Intellectual Property Office) from 2000 to 2010. We, especially, have classified BT convergence into homogeneous and heterogeneous ones, and compare the nature of BT convergence market with that of non-convergence one. To achieve the object of this study, the following methods are used: concentration across IPC technological classes; concentration of patenting activity across firms; PFS (Patent Family Size) index. Furthermore, according to FOS technology-industry table, we have intended to find new converging industry of BT heterogeneous converging technologies. As very few studies have focused on Korean converging technology market so far, this analysis is considered to be meaningful. It is found that the market of BT converging technology is rather robust than that of BT non-converging one, which refers that BT convergence shows the tendency of concentration towards few technologies by few conglomerate firms in Korea. Meanwhile, we have derived a BINET keyword map to research the convergence of sub-technologies in detail and the related industries. We expect the implications of this study to be utilized in establishing the BT-based converging technology policy.

• Journal of Digital Convergence
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• v.14 no.7
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• pp.339-345
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• 2016

While a game market has been growing consistently world widely, a market of arcade or video game has been detained. In this stagnation, the latest one in 2015, "Super Mario Maker" of Mario series that's been running in good for 30 years, the notable sale and growth of which are extraordinary. As for a study in customizing, a literature of game customizing and studies that are foregone were mostly handling contents about a game character. In the survey that's done in this thesis about knowledge and needs in customizinge game users have, it was shown they want to customize sides of a rule and a character. I analyzed what the main factors are in this game which uses a main concept of customizing and the reason for high profits and popularity. As a result of the analysis, four features, possibility to customize a game rule, share data among users, collaboration in marketing with NFC figure characters, offering updates with sustained and new customizing features were found out. I am certain a game customizing will be helping to meet users and be used for various industries without limit of existing character.