• Bulletin of the Korean Chemical Society
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• 제27권9호
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• pp.1335-1340
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• 2006

It has been found that a number of diseases are associated with mutations in the mitochondrial DNA. Therapeutic gene delivery to mitochondria has been suggested as a clinical option for these diseases. In this study, we developed a gene carrier to mitochondria by the conjugation of mitochondrial leader peptide (LP) to polyethylenimine (PEI). Mitochondrial LP conjugated PEI (PEI-LP) was synthesized with low molecular weight PEI (2,000 Da, PEI2K). Gel retardation assay showed that PEI2K-LP formed complexes at a 1.0/1 weight ratio. In addition, PEI2K-LP protected DNA from the enzymatic degradation for at least 60 min, while naked DNA was completely degraded within 20 min. PEI2K-LP was compared with LP conjugated high molecular weight PEI (25,000 Da, PEI25K) in terms of toxicity and delivery efficiency. MTT assay showed that PEI2K-LP had much lower cytotoxicity than PEI25K-LP to 293 cells. In addition, cell-free DNA delivery assay showed that PEI2K-LP delivered more DNA to mitochondria at a 1.8/1 weight ratio than naked DNA or PEI. This result suggests that PEI2K-LP may be useful for the development of mitochondrial gene therapy system with lower cytotoxicity.

• 대한한의진단학회지
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• 제11권1호
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• pp.1-24
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• 2007

Maek Kyoung(Mai Jing, 脈經) is the first chinese specialized book of diagnostics written by Wang Hee(Wang xi, 王熙) from Seo Jin(xi jin, 西晉). He assorted the contents with pulse and medical examination from Nae Kyoung(nei jing, 內經), Nan Kyoung(nan jing, 難經), Sang Han Ron(shang han lun, 傷寒論) and Jung Jang Kyoung(zhong cang jing, 中藏經). And united with his own research, he explains medical examination and the way of talking the pulse by classifying into entrance and class. Maek Kyoung(Mai Jing, 脈經) was imported Korea by Ji Chong(zhi cong, 知聰) AD 561, and he passed through Ko Ku Ryeo(gao gou li, 高句麗) with Nae Wei Jeon(nei wai dian, 內外典), Yak Seo(yao shu, 藥書), Myung Dang Do(ming tang tu, 明堂圖) and Maek Kyoung(Mai Jing, 脈經) to be naturalized in Japan. This treatise make a special study of the second volume of the Maek Kyoung. It consists of the four chapters: Pyoung Sam Kwan Eum Yang E Sip Sa Ki Maek Je II(平三關陰陽二十四氣脈第一), Pyoung In Young Sin Mun Ki Ku Jeon Hu Maek Je E(平人迎神門氣口前後脈第二), Pyoung Sam Kwan Byoung Hu Byoung Chi Eui Je Sam(平三關病侯幷治宜第三), and Pyoung Gi Kyoung Pal Maek Byoung Je Sa(平寄經八脈病第四). Bi Geup Choun Geum Yo Bang(備急千金要方) and Eui Hak Ip Mun(醫學入門) quoted from the contents in the second volume of Maek Kyoung, and Bin Ho Maek Hak(瀕湖脈學), Gi Kyoung Pal Maek Go(奇經八脈攷) and Maek Eo(脈語) extracted from contents in the second volume of the Maek Kyoung and requoted from this contents. Contents in the second volume of the Maek Kyoung have very valuable data like that, but the literature on this subject in the form of a treatise has not been yet in Korea. So I hope this study will be useful to develope Diagnostics by correcting translation and interpretation and fixing wrong translation.

• Tuberculosis and Respiratory Diseases
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• 제70권2호
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• pp.165-169
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• 2011

Pheochromocytomas are neuroendocrine tumors of chromaffin cell that originate in the paraganglia of the adrenal medulla. Approximately 10% of pheochromocytomas are found in the extra-adrenal paraganglia and are called paragangliomas. However, cases of middle mediastinal paragangliomas are very rare. In this case, the patient presented with a voice change and a headache. A middle mediastinal soft tissue mass with marked enhancement was detected on computed tomography of the chest. The 24-hour urine catecholamine level was markedly elevated. The middle mediastinal mass was biopsied via mediastinoscopy and the resulting immunohistochemical staining was compatible with a diagnosis of middle mediastinal paraganglioma. The mass was resected surgically and the symptoms were relieved.

• 한국항행학회논문지
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• 제20권6호
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• pp.511-518
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• 2016

본 연구는 RAPCON을 구성하는 구성요소를 체계별로 구분하고 체계별 운영시간 에 따른 고장율 등을 분석한다. 아울러 설계수명에 점차 도달한 RAPCON의 운영 중 발생한 유지보수비용 데이터를 토대로 남은 설계수명 기간 동안 향후 발생 가능한 유지보수 비용을 추정한다. 이런 분석결과를 통해 장비의 신뢰성 관련 선행연구들에서 주로 인용되고 있는 욕조커브 (bathtub curve) 이론과 본 연구의 비용예측 결과와의 연관성을 진단하고 안정적인 유지보수를 위한 기초자료로서 활용되고자 한다. 본 시계열 분석에 사용된 자료는 T국 공군이 구형 RAPCON을 신형으로 교체하면서, 설계수명이 다된 기존 RAPCON 운영단계에서 발생했던 50개월의 유지보수비용 데이터이다. 유지보수 비용은 6개 체계별 유지보수비용을 합한 월별 유지보수비용으로 사용하였다. ARIMA 모형을 토대로 향후 10개월 간 발생 가능한 유지보수 비용을 예측한 결과 비용이 상승할 것이라는 통계적으로 신뢰할 만한 추정 결과를 얻었다.

• 한국산학기술학회논문지
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• 제13권4호
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• pp.1777-1783
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• 2012

본 논문에서는 DC모터의 출력특성을 개선할 수 있는 새로운 구조의 DC모터 구동회로를 설계하였고 이 회로를 이용한 콘트롤러를 개발하였다. 설계된 구동 회로에 의하여 콘트롤러는 자체발진회로의 스위칭 신호를 갖는 트랜스포머를 이용하여 연속적으로 DC모터를 구동할 수 있다. 또한 최대속도시, 제어회로의 기준전압 값을 삼각파보다 높게 유지할 수 있고 모터 구동 FET를 항상 온 값을 가지도록 하여 최대출력을 얻을 수 있도록 한다. 제안된 구동회로를 활용하여 24V-500W급 DC모터속도 컨트롤러를 개발하였고 소형전동차를 제작하고 구동시험을 실시하였다. 구동테스트 및 특성 측정결과, 구동전류 12A로써 DC모터의 전진 및 후진 속도를 연속 가변 할 수 있음을 보였다. 그 밖에 과전류 감시기능, 모터과열 감시기능의 정상동작을 확인하였으며, 배터리 잔량이 20~100%까지 6단계로 표시할 수 있음을 확인하였다.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2007년도 춘계종합학술대회
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• pp.690-694
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• 2007

본 논문은 Wibro 시대를 맞아 차량내에서 인터넷이 가능하고 다양해지는 자동차 시스템에 적응하고 사용자가 자동차를 스스로 진단하고 이상이 생겼을 때 스스로 판단하여 자동차 정비소에 갔을 때 정확한 판단을 하여 신속하게 처리 할 수 있게 해 주며 자동차에 대해서 잘 모르는 운전자에게 정확한 정보를 제공한다. 주행 중에 자가 진단을 위해 임베디드 리눅스 시스템을 구축하고 자동차 와 진단 시스템의 통신을 위해 CAN과 RS232 통신을 통해 임베디드 리눅스 시스템과 통신을 한다. 또한 Wibro 시대를 맞아 디지털 흠 네트워크 가전들을 내장된 무선 네트워크와 ZigBee 시스템을 통해 언제 어디서나 웹을 통해 접근, 컨트롤 하는 임베디드 리눅스 시스템을 구축한다. 본 임베디드 리눅스 시스템은 초 경량화와 가격대비 성능 및 사용자 UI에 맞춰 시스템 구성하여 안정되고 호환성 높은 시스템을 구축한다. 그리고 미디어 플레이와 웹서버를 포팅하여 사용자 어플리케이션을 제공한다.

• 한국동물위생학회지
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• 제39권1호
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• pp.51-57
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• 2016

Fifty and forty two Salmonella enterica subspecies enterica serovar 52 Typhimurium (ST) strains were isolated from chicken and pigs, respectively, collected from markets throughout Korea from 2008 to 2011. The isolates were investigated for the presence of antimicrobial resistance and multi-drug patterns. All 50 ST isolates from chicken and 42 ST isolates from pigs were resistant to at least one of 13 antibiotics used in this study, 92.0% of ST isolates from chicken and 88.1% of ST isolates from pigs were resistant to three or more antimicrobials. As many as 3 isolates of ST isolates from chicken were resistant to 11 of 13 antimicrobials tested in this study. Only one isolate of ST isolates from pigs was resistant to 10 of 13 antimicrobials. The ACSSuT resistance phenotype was observed in 34% of the 50 isolates and 23.8% of the 42 isolates. Especially, 1 isolate from pigs had the ACSSuTAu. The high rate of antimicrobial-resist and multi-drug resistant (MDR) ST isolation may give rise to crucial public health problems. Therefore, control of antimicrobial use, and continuous monitoring of antimicrobial resistance and MDR patterns among Salmonella isolates in chicken and pig farms is necessary to ensure public health.

• 대한불안의학회지
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• 제9권2호
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• pp.106-112
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• 2013

Objective : Several reports have found abnormal levels of androgen in post-traumatic stress disorder (PTSD) patients. This abnormality in androgen is hypothesized to due to chronic psychological stress effects on the hypothalamic-pituitary-gonadal (HPG) system. The present study was conducted to estimate serum testosterone levels in PTSD patients in comparison with normal subjects. Methods : Seventy-five male Korean veterans of the Vietnam War volunteered for the study, of which eleven were excluded because of incomplete psychological assessment. To measure basal serum testosterone, blood samples were collected between 8.00 and 9.30 a.m. The clinician administered PTSD scale (CAPS), the structured clinical interview for DSM-IV (SCID), Hamilton Anxiety Rating Scale (HAM-A), Hamilton Rating Scale for Depression (HAM-D), Mini International Neuropsychiatric Interview Plus (Korean version of MINI-Plus), CES-K (Korean version of combat exposure scale). Results : The serum testosterone level of PTSD patients ($5.4{\pm}2.5ng/mL$) was higher than that of a control group ($3.1{\pm}1.7ng/mL$, p<0.001). Testosterone levels were significantly correlated with CAPS (r=.38, p<.01), HAM-A (r=.35, p<.01) and HAM-D (r=.28, p<.01) in all subjects. Conclusion : The results of the present study suggest that chronic psychological stress affects the HPG system.

• 대한불안의학회지
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• 제9권2호
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• pp.121-127
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• 2013

Objective : Several studies have reported the association between posttraumatic stress disorder (PTSD) and hypertension (HTN). The aim of this study was to evaluate the impact of PTSD symptoms on blood pressure. Methods : Korean veterans of the Vietnam War with (n=62) or without PTSD (n=87) participated in this study. The clinician administered PTSD scale (CAPS) and alcohol use disorder identification test (AUDIT) were applied. Blood pressure, pulse rate, risk factors of HTN and demographic data of the subjects were collected. Effects of potential explanatory variables on HTN were analyzed with logistic regression. Results : Diastolic blood pressure was significantly higher in PTSD group (p=0.015). However, PTSD subjects showed significantly lower pulse rate than non-PTSD subjects (p=0.004). Logistic regression analysis showed that avoidance symptom might be a predictor for hypertension (OR=1.065, p=0.030). Conclusion : These results suggest that PTSD, especially avoidance symptom, might be a risk factor on HTN in the elderly with PTSD. Further studies are needed to evaluate the change of blood pressure according to the clinical improvement of PTSD.

• 제어로봇시스템학회논문지
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• 제5권6호
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• pp.724-733
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• 1999

An effective method of system modeling and dynamic scheduling for the back-end line of semiconductor manufacturing is proposed. The virtual factory, describing semiconductor manufacturing line, is designed in detail, and then a Petri net model simulator is developed for operation and control of the modular cells of the virtual factory. The petri net model is a colored timed Petri nets (CTPNs). The simulator will be utilized to analyze and evaluate various dynamic status and operatons of manufacturing environments. The dynamic schedulaer has a hierarchical structure with the higher for planning level and the lower for dynamic scheduling level. The genetic algorithm is applied to extract optimal conditions of the scheduling algorithm. The proposed dynamic scheduling is able to realize the semiconductor manufacturing environments for the diversity of products, the variety of orders by many customers, the flexibility of order change by changing market conditions, the complexity of manufacturing processes, and the uncertainty of manufacturing resources. The proposed method of dynamic scheduling is more effective and useful in dealing with such recent pressing requirements including on-time delivery, quick response, and flexibility.