Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
권호 표지
DOI QR코드

DOI QR Code

A Case of Middle Mediastinal Malignant Paraganglioma

중간 세로칸 악성 곁신경절종

  • Park, Sung-Bum (Department of Medicine, Sungkyunkwan University School of Medicine) ;
  • Park, Silvia (Department of Medicine, Sungkyunkwan University School of Medicine) ;
  • Bang, Sun-Ha (Department of Medicine, Sungkyunkwan University School of Medicine) ;
  • Kim, Eun-Kyung (Department of Medicine, Sungkyunkwan University School of Medicine) ;
  • Jeon, Kyeong-Man (Department of Medicine, Sungkyunkwan University School of Medicine) ;
  • Koh, Won-Jung (Department of Medicine, Sungkyunkwan University School of Medicine) ;
  • Suh, Gee-Young (Department of Medicine, Sungkyunkwan University School of Medicine) ;
  • Chung, Man-Pyo (Department of Medicine, Sungkyunkwan University School of Medicine) ;
  • Kim, Ho-Joong (Department of Medicine, Sungkyunkwan University School of Medicine) ;
  • Kwon, O-Jung (Department of Medicine, Sungkyunkwan University School of Medicine) ;
  • Go, Young-Hyeh (Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Um, Sang-Won (Department of Medicine, Sungkyunkwan University School of Medicine)
  • 박성범 (성균관대학교 의과대학 내과학교실) ;
  • 박실비아 (성균관대학교 의과대학 내과학교실) ;
  • 방선하 (성균관대학교 의과대학 내과학교실) ;
  • 김은경 (성균관대학교 의과대학 내과학교실) ;
  • 전경만 (성균관대학교 의과대학 내과학교실) ;
  • 고원중 (성균관대학교 의과대학 내과학교실) ;
  • 서지영 (성균관대학교 의과대학 내과학교실) ;
  • 정만표 (성균관대학교 의과대학 내과학교실) ;
  • 김호중 (성균관대학교 의과대학 내과학교실) ;
  • 권오정 (성균관대학교 의과대학 내과학교실) ;
  • 고영혜 (삼성서울병원 병리학교실) ;
  • 엄상원 (성균관대학교 의과대학 내과학교실)
  • Received : 2010.09.17
  • Accepted : 2010.10.13
  • Published : 2011.02.28
Download PDF
⟨ Previous Next ⟩

Abstract

Pheochromocytomas are neuroendocrine tumors of chromaffin cell that originate in the paraganglia of the adrenal medulla. Approximately 10% of pheochromocytomas are found in the extra-adrenal paraganglia and are called paragangliomas. However, cases of middle mediastinal paragangliomas are very rare. In this case, the patient presented with a voice change and a headache. A middle mediastinal soft tissue mass with marked enhancement was detected on computed tomography of the chest. The 24-hour urine catecholamine level was markedly elevated. The middle mediastinal mass was biopsied via mediastinoscopy and the resulting immunohistochemical staining was compatible with a diagnosis of middle mediastinal paraganglioma. The mass was resected surgically and the symptoms were relieved.

Keywords

References

  1. Adler JT, Meyer-Rochow GY, Chen H, Benn DE, Robinson BG, Sippel RS, et al. Pheochromocytoma: current approaches and future directions. Oncologist 2008;13:779-93. https://doi.org/10.1634/theoncologist.2008-0043
  2. Joynt KE, Moslehi JJ, Baughman KL. Paragangliomas: etiology, presentation, and management. Cardiol Rev 2009;17:159-64. https://doi.org/10.1097/CRD.0b013e3181a6de40
  3. Plouin PF, Gimenez-Roqueplo AP. Pheochromocytomas and secreting paragangliomas. Orphanet J Rare Dis 2006;1:49. https://doi.org/10.1186/1750-1172-1-49
  4. Lee JA, Duh QY. Sporadic paraganglioma. World J Surg 2008;32:683-7. https://doi.org/10.1007/s00268-007-9360-4
  5. Young WF Jr. Paragangliomas: clinical overview. Ann NY Acad Sci 2006;1073:21-9. https://doi.org/10.1196/annals.1353.002
  6. Scholz T, Schulz C, Klose S, Lehnert H. Diagnostic management of benign and malignant pheochromocytoma. Exp Clin Endocrinol Diabetes 2007;115:155-9. https://doi.org/10.1055/s-2007-970410
  7. Petri BJ, van Eijck CH, de Herder WW, Wagner A, de Krijger RR. Phaeochromocytomas and sympathetic paragangliomas. Br J Surg 2009;96:1381-92. https://doi.org/10.1002/bjs.6821
  8. Havekes B, Lai EW, Corssmit EP, Romijn JA, Timmers HJ, Pacak K. Detection and treatment of pheochromocytomas and paragangliomas: current standing of MIBG scintigraphy and future role of PET imaging. Q J Nucl Med Mol Imaging 2008;52:419-29.
  9. Moran CA, Suster S, Fishback N, Koss MN. Mediastinal paragangliomas. A clinicopathologic and immunohistochemical study of 16 cases. Cancer 1993;72:2358-64. https://doi.org/10.1002/1097-0142(19931015)72:8<2358::AID-CNCR2820720811>3.0.CO;2-B
  10. Gallivan MV, Chun B, Rowden G, Lack EE. Intrathoracic paravertebral malignant paraganglioma. Arch Pathol Lab Med 1980;104:46-51.
  11. Kim Y, Park SY, Ko YG, Ha JW, Chung N, Chang BC, et al. A case of intrapericardial pheochromocytoma. Korean J Med 2006;70:434-8.
  12. Chrisoulidou A, Kaltsas G, Ilias I, Grossman AB. The diagnosis and management of malignant phaeochromocytoma and paraganglioma. Endocr Relat Cancer 2007;14:569-85. https://doi.org/10.1677/ERC-07-0074
  13. Lloyd RV, Sisson JC, Shapiro B, Verhofstad AA. Immunohistochemical localization of epinephrine, norepinephrine, catecholamine-synthesizing enzymes, and chromogranin in neuroendocrine cells and tumors. Am J Pathol 1986;125:45-54.
  14. McNicol AM. Histopathology and immunohistochemistry of adrenal medullary tumors and paragangliomas. Endocr Pathol 2006;17:329-36. https://doi.org/10.1007/s12022-006-0004-2
  15. Tischler AS. Pheochromocytoma and extra-adrenal paraganglioma: updates. Arch Pathol Lab Med 2008;132: 1272-84.