• Proceedings of the KIEE Conference
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• 1999.11b
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• pp.153-156
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• 1999

In this paper, we design a GA-fuzzy precompensated PID controller for the load frequency control of two-area interconnected power system. Here, a fuzzy precompensated PID controller is designed as a fuzzy logic-based precompensation approach for PID controller. This scheme is easily implemented simply by adding a fuzzy precompensator to an existing PID controller. And we optimize the fuzzy precompensator with a genetic algorithm for complements the demerit such as the difficulty of the component selection of fuzzy controller, namely, scaling factor membership function and control rules.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.51 no.2
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• pp.83-92
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• 2002

In this paper, we design a GA-fuzzy precompensator for enhancement of power system stability. Here, a fuzzy prerompensator is designed as a fuzzy logic-based precompensation approach for Power System Stabilizer(PSS). This scheme is easily implemented simply by adding a fuzzy precompensator to an existing PSS. And we optimize the fuzzy precompensator with a genetic algorithm for complements the demerit such as the difficulty of the component selection of fuzzy controller, namely, scaling factor, membership function and control rules. Simulation results show that the proposed control technique is superior to a conventional PSS in dynamic responses over the wide range of operating conditions and is convinced robustness and reliableness in view of structure.

• Structural Engineering and Mechanics
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• v.55 no.2
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• pp.299-313
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• 2015

In this paper, an optimization process using Genetic Algorithm (GA) that mimics biological processes is presented for optimum design of planar frames with semi-rigid connections by selecting suitable standard sections from a specified list taken from American Institute of Steel Construction (AISC). The stress constraints as indicated in AISC-LRFD (American Institute of Steel Construction - Load and Resistance Factor Design), maximum lateral displacement constraints and geometric constraints are considered for optimum design. Two different planar frames with semi-rigid connections taken from the literature are carried out first without considering concrete slab effects in finite element analyses and the results are compared with the ones available in literature. The same optimization procedures are then repeated for full and semi rigid planar frames with composite (steel and concrete) beams. A program is developed in MATLAB for all optimization procedures. Results obtained from this study proved that consideration of the contribution of the concrete on the behavior of the floor beams provides lighter planar frames.

• Journal of Microbiology and Biotechnology
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• v.19 no.6
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• pp.542-546
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• 2009

Leaves are the major biomass-producing organs in herbaceous plants and mainly develop during vegetative stage by activities of shoot apical meristem. There is a strong correlation between leaf number and bolting, a characteristic phenotype during the transition to reproductive phase in Arabidopsis thaliana. In order to study interactions between leaf number and bolting, we isolated a Landsberg erecta-derived mutant named multifolial (mfo1) that produces increased number of leaves and bolts at the same time as the wild type. Through positional cloning and allelism test, mfo1 was found to be an allele of a previously reported mutant, altered meristem program1-1 (amp1-1) that is defective in a glutamate carboxypeptidase and bolts earlier than its wild type, Columbia ecotype, with the increased number of leaves. The bolting time differences between mfo1 and amp1, despite the same phenotype of many leaves, suggest the existence of genetic factor(s) differently function in each ecotype in the presence of mfo1/amp1 mutation.

• Journal of Ginseng Research
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• v.41 no.4
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• pp.435-443
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• 2017

Panax ginseng is one of the most universally used herbal medicines in Asian and Western countries. Most of the biological activities of ginseng are derived from its main constituents, ginsenosides. Interestingly, a number of studies have reported that ginsenosides and their metabolites/derivatives-including ginsenoside (G)-Rb1, compound K, G-Rb2, G-Rd, G-Re, G-Rg1, G-Rg3, G-Rg5, G-Rh1, G-Rh2, and G-Rp1-exert anti-inflammatory activities in inflammatory responses by suppressing the production of proinflammatory cytokines and regulating the activities of inflammatory signaling pathways, such as nuclear factor-${\kappa}B$ and activator protein-1. This review discusses recent studies regarding molecular mechanisms by which ginsenosides play critical roles in inflammatory responses and diseases, and provides evidence showing their potential to prevent and treat inflammatory diseases.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2015.05a
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• pp.132-133
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• 2015

Efficient scheduling and resource management are the key factor to reduce construction project budget (e.g., labor cost, equipment cost, material cost, etc.). Resource-based line of balance (LOB) technique has been used to complement the limitations of time-driven scheduling techniques (e.g., critical-path method). Optimizing construction alternatives contributes cost savings while honoring the project deadline. However, existing LOB scheduling is lack of identifying optimal resource combination. This study presents a method which identifies the optimal construction alternatives, hence achieving resource minimization in a repetitive construction by using genetic algorithm (GA). The method provides efficient planning tool that enhances the usability of the system.

• Genomics & Informatics
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• v.12 no.4
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• pp.136-144
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• 2014

Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations (CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic factors of diseases. Recent experimental findings have shed light on the links between different genome architectures and CNV mutagenesis. In this review, we summarize various genomic features and discuss their contributions to CNV formation. Genomic repeats, including both low-copy and high-copy repeats, play important roles in CNV instability, which was initially known as DNA recombination events. Furthermore, it has been found that human genomic repeats can also induce DNA replication errors and consequently result in CNV mutations. Some recent studies showed that DNA replication timing, which reflects the high-order information of genomic organization, is involved in human CNV mutations. Our review highlights that genome architecture, from DNA sequence to high-order genomic organization, is an important molecular factor in CNV mutagenesis and human genomic instability.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.18 no.1
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• pp.103-109
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• 2009

This paper presents structural design optimization of a micro milling machine for minimum weight and compliance using a genetic algorithm with dynamic penalty function. The optimization procedure consists of two design stages, which are the static and dynamic design optimization stages. The design problem, in this study, is to find out thickness of structural members which minimize the weight, the static compliance and the dynamic compliance of the micro milling machine under several constraints such as dimensional constraints, maximum compliance limit, and safety factor criterion. Optimization results showed a great reduction in the static and dynamic compliances at the spindle nose of the micro milling machine in spite of a little decrease in the machine weight.

• Archives of Pharmacal Research
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• v.26 no.6
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• pp.482-486
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• 2003

Adult periodontitis is a multifactorial disease characterized by multple genetic and environmental factors. In view of the importance of interleukin-4 (IL-4) gene as a genetic factor for adult periodontitis, we investigated the relationship between two polymorphisms (-590 C $\rightarrow$ T polymorphism and 70 bp repeat polymorphism) of the human IL-4 gene and adult periodontitis in the Korean population. Genomic DNA was extracted from white blood cells of 32 adult periodontitis patients and 150 normal controls, respectively. There were no significant differences in the allele, genotype and haplotype distributions of two polymorph isms between normal controls and adult periodontitis group. Therefore, our results suggest that IL-4 gene locus contributes little to the interindividual susceptibility for adult periodontitis in Korean population.

• Journal of Mechanical Science and Technology
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• v.20 no.10
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• pp.1541-1547
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• 2006

An efficient procedure to obtain the optimal stacking sequence and the minimum weight of stiffened laminated composite curved panels under several loading conditions and stiffener layouts has been developed based on the finite element method and the genetic algorithm that is powerful for the problem with integer variables. Often, designing composite laminates ends up with a stacking sequence optimization that may be formulated as an integer programming problem. This procedure is applied for a problem to find the stacking sequence having a maximum critical buckling load factor and the minimum weight. The object function in this case is the weight of a stiffened laminated composite shell. Three different types of stiffener layouts with different loading conditions are investigated to see how these parameters influence on the stacking sequence optimization of the panel and the stiffeners. It is noticed from the results that the optimal stacking sequence and lay-up angles vary depending on the types. of loading and stiffener spacing.