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Two Polymorphisms of Interleukin-4 Gene in Korean Adult Periodontitis  

Kang, Byung-Yong (Research Institute for Life Science, Sahmyook University)
Choi, Young-Kyu (Dr. Chois Dental Office)
Choi, Wook-Hwan (Dr. Chois Dental Office)
Kim, Ki-Tae (Seoulin Bioscience Institute, Seoulin Bioscience, Co., Ltd)
Choi, Sung-Sook (Department of Food Science, Sahmyook College)
Kim, Kyungjae (Department of Pharmacy, Sahmyook University)
Ha, Nam-Joo (Department of Pharmacy, Sahmyook University)
Publication Information
Archives of Pharmacal Research / v.26, no.6, 2003 , pp. 482-486 More about this Journal
Abstract
Adult periodontitis is a multifactorial disease characterized by multple genetic and environmental factors. In view of the importance of interleukin-4 (IL-4) gene as a genetic factor for adult periodontitis, we investigated the relationship between two polymorphisms (-590 C $\rightarrow$ T polymorphism and 70 bp repeat polymorphism) of the human IL-4 gene and adult periodontitis in the Korean population. Genomic DNA was extracted from white blood cells of 32 adult periodontitis patients and 150 normal controls, respectively. There were no significant differences in the allele, genotype and haplotype distributions of two polymorph isms between normal controls and adult periodontitis group. Therefore, our results suggest that IL-4 gene locus contributes little to the interindividual susceptibility for adult periodontitis in Korean population.
Keywords
Adult periodontitis; Cytokine; Korean population;
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