• 대한전자공학회논문지SD
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• 제44권9호
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• pp.10-17
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• 2007

기존의 트랜지스터 기반의 논리 연산자를 비휘발성 소자인 MTJ(Magnetic Tunneling Junction)로 대체하는 자기논리(magneto-logic) 회로는 그동안 기억 소자 분야에만 국한되어온 MTJ를 스핀전자공학 분야의 새로운 응용으로 논리 회로까지 확장하여 적용 가능하게 한다. 자기논리 회로는 회로 면적 면에서 우수하고 전원이 꺼져도 정보를 유지할 수 있는 장점을 가지고 있다. 또한, 불(Boolean) 연산을 수행함에 있어서 유연성을 보여, 단순히 입력을 바꾸는 것만으로도 한 MTJ 소자로 모든 논리 연산자를 구현 가능하게 한다. 이로써 물리적으로 완성된 회로 내에서, 재구성 가능한 자기논리 회로를 설계할 수 있다. 본 논문에서는 종래의 다층 입력 구조의 MTJ에 비해, 공정이 간단하고, 보다 유연한 함수 구현 능력을 갖는 단층 입력 구조의 새로운 MTJ 소자를 제안하며, 그 예로, 4비트 그레이 카운터를 설계하여 그 동작을 이전 논문에서 제안된 바 있는 macro-model을 보완 적용하여 검증하였다.

• 복식문화연구
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• 제6권3호
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• pp.185-200
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• 1998

The eldest son of the crown prince is very important social status next to the crown prince deciding fundamentals of a state in Chosun dynasty which laying stress royal authority. Accordingly, Chakbong(冊封) of the eldest son of the crown prince has been done independently like as Chakrei(冊禮) of the crown prince. The existig record of Chakrei(冊禮) of the eldest son of the crown prince. The existing record of Charkrei(冊禮) of the eldest son of the crown prince are Hyunjongwangseon(顯宗王世孫), Euisoseson(懿昭世孫), Youngjowangseson(英祖王世孫), Hungjongwangseson(憲宗王世孫) of 4 books for Chakreidogameuigue(冊禮都監儀軌) being preserved in Kyujangkak(奎章閣). The transition of classified clothes are stated on Wangse sonchakreidogameuiguebanchado(王世孫冊禮都監儀軌班次圖) for Chakrei(冊禮) of the eldest son of the crown prince. Its details are as below. Finally, there is no changes in constitution of the costume of the eldest son of the crown prince Chakrei(冊禮) called as Ssanggodong(雙童髮)·Gongjungchak(空頂 )·Ojangbok(五章服) on documentary records depsitefo no explanation of Banchado(班次圖). Secondly, The classified clothes of the eldes sion of the crown prince Hcakreibanchado(冊禮班次圖) are on . We have acknowledged that Kwanmo(冠帽) of Dangbukwanwon(堂部官院) has been changed from Heugrib(黑笠) to Samo(紗帽) since Youngjowangseson(英祖王世孫), Euibok(衣服) from Chungpo(靑袍) to Nokdanryung(綠團領), the costume of Euijangsu(儀仗手) from Chunggun(靑巾) to Whangchorib(黃草笠) and changed again to Hongpimoja(紅皮帽子), Chungeui(靑衣) changed to Hongeui(紅衣). Also we know that Kwanmo(冠帽) of Kyogun(轎軍) has been changed to Pimoja(皮帽子) with high top, Chungeui(靑衣) changed to Hongeui(紅衣). The costume of Byulgam(別監) has been changed from Nokgun(綠巾) to Jogun( 巾), Nokpo(綠袍) changed to Pimoja(皮帽子) with high top, Chungeui(靑衣) changed to Hongeui(紅衣). The costume of Byulgam(別監) has been changed from Nokgun(綠巾) to Jogun( 巾), Nokpo(綠袍) changed to Hongpo(紅袍), that of Suri(書吏) changed from Chungeui(靑衣) to Huekeui(黑衣). Accordingly, the transition of costume color to red stands for the briliance. Thirdly, regarding the constitution of the eldest son of the crown prince Chakrei(冊禮), that of Euisoseson(懿昭世孫) & Youngjowangseson(英祖王世孫) are same for Unggolta(態骨朶), Youngjagi(令字旗), Keumdungja(金 子), Eundungja(銀 子), Mojul( 節), Jaksun(雀扇), Chungkae(靑蓋), Chungyangsol(靑陽率). In case of Hunjongseson(懿昭世孫), Baktakgi(白澤旗) is added. On Youngjowangseson(英祖王世孫), Chungilsol(靑日率) and Kiringi(麒麟旗) are added. However, we know that the constitution of the eldestson of the crown prince Hunjong(憲宗) Chakrei(冊禮) is quite different that of previous constitution. i.e. : Hongae(紅蓋), Baktakgi(白澤旗), Samkaggi(三角旗), Kagdangi(角端旗), Byukbonggi(碧鳳旗), Jujakgi(朱雀旗), Kuemdungja(金 子), Eundungja(銀 子), Eunribgwa(銀立瓜), Kuemhwanggwa(金 瓜), Eunhwhanggwa(銀 瓜), Kuemwolbu(金鉞斧), Bongsun(鳳扇), Huegkae(黑蓋). Also the kinds of Eujanggi(儀仗旗) are various which are similar to the constitution of The Crown Prince(世子) Chakrei(冊禮).

• 사상체질의학회지
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• 제13권1호
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• pp.8-16
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• 2001

We analyzed 57 types of herbal medicines for Soeumin, clinically applied in Dongyisoosebowon. In order co discover the standard of herbal classification for the Sasang Constitutions, four concepts of Sasang Medicine were applied. These included 'Sadangron (theory of four groups)', 'Seungganggaehap(ascending-descending and gathering-dispersing)', 'Pyorihanyoul(exterior-interior and hot-cold)', and 'Hyungchiaekmi(fragrance, smell, bodily fluid and taste)'. According to these analyzing methods of herbal properties, we have reached the following conclusions: 1. Lee Je-ma first established the physiology of the internal organs of the Sasang Constitutions through the understanding of constitutional pathology. Dr. Lee then classified herbal medicines into four constitutional groups by observing the herbal effects according to such perspective of organ physiology and pathology. 2. Among the Sasang concepts applied in the analysis of herbal properties based on the physiology and pathology of Sasang constitutions, 'Seungganggaehap (ascending-descending and gathering-dispersing)' was found to be the most useful. Meanwhile, 'Sadangron, (the theory of four groups - Spirit, Qi, Blood and Essence),' along with 'Pyorihanyoul (exterior-interior and hot-cold)' and 'Hyungchiaekmi (fragrance, smell, bodily fluid and taste)' were partially useful. 3. Herbal medicines for Soeumin are characterized by ascending energetics that protect the Yang Qi. The 'Exterior heat disease' is treated with herbal medicines that raise the "Exterior Yang" in three different way: by tonifying Qi. by tonifying Blood and by releasing exterior. The 'Interior cold disease' is treated with herbal medicines that descend "Interior Yin" in two ways. One by warming the stomach, and the other by regulating Qi. 4. Cases where a whole category of herbs with the same effect have been applied co one constitution, are most frequent among Shaoyin herbs. There was an intimate connection between the treatment methods and the traditional effects of herbs for 'Soewnin'. These discoveries allowed us to see that the development of the pharmacology of the Sasang Constitutional pathology more progressed in 'Soeumin'. *analysing simple herbs of "DongEuiBoGam JangBu" we compare JangBu of traditional oriental medicine with JangBu of Sasang Constitutional Medicine. So we can comprehend the JangBu's difference of traditional-oriental with sasang-constitional medicine.

• 생명과학회지
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• 제25권4호
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• pp.406-415
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• 2015

본 연구에서, 우리는 동의보감에서 옹저에 대한 한약재 처방전인 길경탕(GGT), 대황목단탕(DHMDT), 사간탕(SGT), 소청룡탕(SCRT), 시호청간탕(SHCGT), 십육미류기음(SYMYKE) 과 황흑산(HHS)에 대한 항산화능과 항암과 항균활성에 대한 생리활성에 대한 연구를 수행하였다. 총 페놀 함량은 길경탕 ＜ 십육미류기음 ＜ 소청룡탕 ＜ 시호청간탕 ＜ 대황목단탕 ＜ 사간탕 ＜ 황흑산의 순서대로 함량이 풍부하였다. 이들 중 황흑산은 SOD 유사활성, 환원력과 DPPH 라디칼과 ABTS 라디칼의 소거능이 가장 뛰어났다. 흥미롭게도, 이들 시료의 총페놀 함량과 그들의 항산화능과의 상관도는 높게 나타났다. 모든 시료에서 인간대장세포인 HCT-116에서 항암활성을 나타냈으며, 특히 황흑산은 가장 낮은 활성을 나타낸 길경탕보다도 7배 높은 항암활성을 보였다. 또한, 대장균인 Escherichia coli와 위염을 발생시키는 Helicobacter pylori 균에 대한 항균 활성을 시행한 결과 사간탕, 소청룡탕, 십육미류기음과 황흑산에서 항균활성이 보였다. 결과를 종합하여 볼 때, 한약재 처방전은 항산화와 생리활성물질의 소재로서의 가치가 있음을 알 수 있었다.

• 한국지반공학회지:지반
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• 제9권4호
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• pp.103-118
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• 1993

이 논문은 1991년 7월 21일에 경기도 용인군과 산사태에 대한 자료 및 현장조사 결과를 토대로 2600여 개소에 산사태 면적이 466ha 이상이었다. 한 산사태는 단시간의 집중호우에 의하여 유발된 안성군 일부 지역에 집중호우에 의하여 발생한 작성한 것이다. 이 지역의 산사태 발생규모는 조사 결과 밝혀진 바에 의하면 이 지역에 발생 것으로서, 당일우량이 114mm이상이고 최대시 우량이 40m 이상인 지역(면단위)에서 산사태가 발생하였으며 최대시우량이 62mm 이상인 지역은 모두 산사태가 발생했음을 알 수 있다. 달봉산 일대에 대한 현장조사에 의한 형태학적 검토에 의하면,활동깊이 비(D/L)를 사용하는 Walker의 분류법을 사용했을 때, 20%가 평행활동, 50%가 유동 형태로 분류되었으며 30%는 유동과 활동의 중간형태였고 회전활동으로 분류되는 것은 거의 없었다. 산사태의 90%이상이 사면 경사 20$^{\circ}$-40$^{\circ}$, 활동사면길이 50m이하에서 발생하였고, 사면활동시발점은 50%가 7부 능선 이상 에 위치하고 있었다. 이 지역에서는 수종에 따르는 삼림의 산사태 억제효과상 차이를 볼 수 없었다.

• 한국임상수의학회지
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• 제19권3호
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• pp.303-311
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• 2002

질병을 유발하는 세균의 분리와 동정, 그리고 그 세균에 대한 항생제 감수성 검사는 치료에 효과적인 항생제를 선택하는 데에 있어서 중요하다 본 연구의 목적은 항생제 감수성의 경향을 알아보고 치료를 위한 효과적인 항생제 선택을 위해 세균을 동정하는 것이었다. 1999년 7월부터 2000년 9월 사이에 서울대학교 수의과대학 부속동물병원에 내원한 개로부터 실험재료를 채취하여 호기배양을 실시하였다. 피부(63개), 뇨(45개), 외이도(31개), 안결막(18개)으로부터 채취한 총 157개 시료를 이용하였다 내원한 환자의 피부, 외이도, 결막에서 가장 많이 분리된 세균은 S. intermedius였다. 내원한 환자의 뇨에서 가장 많이 분리된 세균은 E. coli 였다. 분리된 그람 양성 세균의 대부분은 ampicillin(80.6%), erythromycin(68.8%), penicillin(86.2%), tetracycline(89.2%) 에 대해 저항성을 나타내었다. 반면, 분리된 그람 음성 세균의 대부분은 ampicillin(73.4%), trimethoprim-sulfa(53.3%) 에 대해 저항성을 나타내었다 E. coli는 ciprofloxacin(6l.5%), piperacillin(69.2%) 에 대해 저항성을 나타내었다 분리 동정된 세균의 채취부위에 따른 항생제 감수성의 차이는 뇨중의 S. aureus를 제외하고는 특이할 만한 사항이 없었다.

• 미생물학회지
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• 제33권4호
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• pp.257-261
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• 1997

겨울철 소양호에서 세균 군집 구조를 파악하고자 총세균수와 EUB338, ALF1b, BET4a, GAM42a와 CF probe 등 fluorescent rRNA targeted oligonucleotide probe 와 반응하는 세균 개체수를 수심별로 측정하였다. 총세균수는 $0.7{\times}10^6{\sim}1.1{\times}10^6cell{\cdot}ml^{-1}$이였으며, 5 m와 10 m 수층에서 높게 나타났다. 총세균수에 대한 Eubacteria의 비율은 34~90%이였으며, 5 m와 10 m에서 낮게 나타났다. Proteobacteria ${\alpha}$-group은 Eubacteria의 10.8-28.7%, ${\beta}$-group은 4.5-53.5%, ${\gamma}$-group은 4.9-35.5%, 그리고 Cytophaga-Flavobacterium group은 6.1-21.1%이였다. 0-5 m 수심에서는 ${\beta}$-group이 28.6-53.5%로 우점하고 있었으며, 10 m에서는 ${\gamma}$-group이 35.5%로 우점하였다. 30, 50 m 수심에서는 ${\alpha}$-group과 Cytophaga-Flavobacterium group이 우점하였다. 세균 군집 구조로 보면 0-2 m, 5-10 m 그리고 30-50 m의 3개층은 각각 독특한 특징을 나타내었다. 이 방법으로 호수 생태계에 대한 새로운 정보를 얻을 수 있었다.

• 동의생리병리학회지
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• 제20권6호
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• pp.1530-1537
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• 2006

Platycodi Radix, the root of Platycodon grandiflorum A. DC (Campanulaceae), commonly known as Doraji in Korea (Chinese name, 'Jiegeng', and Japanese name, 'Kikyo') has been used as an expectorant in traditional Oriental medicine. Extracts from the roots of P. grandiflorum have been reported to have wide ranging health benefits. In Korea, Platycodi Radix is also used as a food and employed as a folk remedy for adult diseases, such as bronchitis, asthma and pulmonary tuberculosis, hyperlipidemia, diabetes, and inflammatory diseases, and as a sedative. Several studies on its chemical and immunopharmacological effects including immunostimulation and antitumor activity have been performed. However, the relevant molecular mechanisms are poorly understood. Platycodi Radix, the root of Platycodon grandiflorum A. DC (Campanulaceae), commonly known as Doraji in Korea (Chinese name, 'Jiegeng', and Japanese name, 'Kikyo') has been used as an expectorant in traditional Oriental medicine. Extracts from the roots of P. grandiflorum have been reported to have wide ranging health bensfits. In Korea, Platycodi Radix is also used as a food and employed as a folk remedy for adult diseases, such as bronchitis, asthma and pulmonary tuberculosis, hyperlipidemia, diabetes, and inflammatory diseases, and as a sedative. Several studies on its chemical and immunopharmacological effects including immunostimulation and antitumor activity have been performed. However, the relevant molecular mechanisms are poorly understood. In the present study, we investigated the effects of an aqueous extract from the roots of P. grandiflorum AEPG) on the cell growth of human lung adenocarcinoma NCI-H460 cells in order to understand its anti-proliferative mechanism. AEPG treatment down-regulated the cyclin D1 expression in both transcriptional and translational levels without alteration of cyclin E. In AEPG-treated cells, the levels of cyclin-dependent kinase (C아) 6 mRNA and protein were significantly inhibited, but the levels of Cdk2 and Cdk4 were slightly inhibited by treatment of AEPG. AEPG treatment induced a marked accumulation of Cdk inhibitors, p16 and p27. However, AEPG treatment did not affect not only retinoblastoma protein (pRB) but also tumor suppressor p53 protein expression. The present results indicated that AEPG-induced inhibition of lung cancer cell proliferation is associated with the blockage of G1 phase progression through induction of Cdk inhibitors such as p16 and p27, and inhibition of cyclin D1 and Cdk6. AEPG exposure, as offered by this study, provides cluse for the mechanism of AEPG action. Taken together, these findings suggest that P. grandiflorum has strong potential for development as an agent for prevention and treatiment against human lung cancer.

• 생약학회지
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• 제28권4호
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• pp.215-224
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• 1997

Gamijiyu-tang (GJT) described originally in the Dong Eui Bo Gam, a traditional reference for oriental medicine in the Korea, has been clinically used for treatment of chronic liver disease. In order to evaluate scientifcally a hepatoprotective effect of GJT in the liver fibrotic disease, the present study investigated how GJT improves a hepatic function in the dimethylnitrosamine (DMN)-treated rat. DMN treatment caused a significant increase of relative liver weight to the body at 28 days after DMN induction. Administration of with a clinical dose decreased significantly the sAST level $(158.8{\pm}7.76\;IU/L)$ elevated by DMN in jection (p<0.01). A similar phenomenon was also observed at change of both Salt and Salt level in the GJT and/or DMN-treated animal (p<0.01, p<0.05, respectively). A remarkable increase of hydroxyproline was observed by treatment of DMN with comparing to the normal rat $(361.9{\pm}7.35\;vs.\;1278.1{\pm}52.9\;{\mu}g/g\;tissue,\;p<0.01)$. This was significantly reduced by a simultaneous treatment of GJT with DMN for 21 days (p<0.05), but not recovered completely to its normal value. In addition. GJT administration ameliorated conspicuously the DMN-induces histopathological changes of liver such as hemorrhage. Cell necrosis and fibrosis. Tak'en together, results described here demonstrated scientifically in first the medicinal efficacy of GJT by using in vivo animal model, indicating that GJT improves the DMN-induced hepatic injury through reducing an excessive accumulation of collagen and histopathological changes. The decreased collagen content may be a pivotal process for GJT to improve hepatic function in the DMN-induced liver fibrosis. The present study suggests that GJT may be useful for and applicable to the treatment of hepatic fibrosis in chronic liver disease.

• 한국의사학회지
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• 제25권2호
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• pp.155-193
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• 2012

From the part "歷代醫學姓氏(Historic Doctors)" in "醫林撮要(Uirimchualyo)", the following has been noticed and concluded. 1. Because acupuncture was originated from stony needle, the word "石(sok)" contains the meaning of needle, and from this point on, words like 石(sok), 砭石(pyumsok), 箴石(Jamsok), 鑱石(Chamsok) had been derived. 2. The word 砭石(pyumsok) used in "Hwangjenaekyong(Yellow Emperor's Canon of Medicine or Hwangdineijing)" should be interpreted as acupuncture in a verb form, not a noun form. 3. 鑱石(Chamsok) or 鑱鍼(Chamchim) was used for surgical treatment for tumor, by cutting open tumors and pressing the pus out. Therefore, 砭石(pyumsok), 鑱石(Chamsok) are the same kind of needles, and 鑱鍼(Chamchim) is the tool improved from 鑱石(Chamsok) used in the Bronze Age. 4. Kwakpak put a note on 鑱石(Chamsok) in "山海經(Sanhaekyong)" that reads "it is defined as 砥鍼(Jichim) and treats tumor." This let us know the shape of 石(sok), 砭石(pyumsok), 鑱(Chamsok), 鑱鍼(Chamchim), and the stone that can be used as a surgical tool with slim & sharp shape is obsidian. 5. Because obsidian is only found around Mt. Baekdu and limited area in South Korea & Japan in Asia, it is closely related with the life & medical environment of the tribe "Mt. Baekdu". 6. The development of 鑱鍼(Chamchim) was influenced by surgical treatment used in early stage of civilization, and its origin is traced upto Gochosun dynasty. Korea's own traditional medical knowledge is derived from this surgical treatment skill. 7. Because the acupuncture is originated from Gochosun dynasty, 鍼(chim) was derived from 箴(Jam) of 箴石(Jamsok), 䥠(Chim) & 䥠(Chim) both were used for a time being, and finally settled into 鍼(Chim). 8. The word 針(Chim) showed up at Myung dynasty, and started to be used in Korea from early Chosun dynasty. 9. In the early Chosun dynasty, 鍼(Chim) was used for medical term, and 針(Chim) for non-medical term. In the mid Chosun dynasty, 針(Chim) was used as a term for tool, and 鍼(Chim) as a term for acupunctural medical treatment. 10. Under the order of King Sunjo, Dr. Yesoo Yang published "醫林撮要(Uirimchualyo)", added "醫林撮要續集(Sequel to Uirimchualyo)", and added "歷代醫學姓氏(Historic Doctors)" again which eventually made totally 13 books of "醫林撮要(Uirimchualyo)". In addition, many parts of "醫林撮要續集(Sequel to Uirimchualyo)" were quoted in "東醫寶鑑(Donguibogam)", and influenced much in publishing "Donguibogam". 11. In "歷代醫學姓氏(Historic Doctors)" of "醫林撮要(Uirimchualyo)", the same way in "Donguibogam", referred to 針(Chim) as a term for a needle, and 鍼(Chim) as a term for Acupuncture. 12. From the usage of 針(Chim) & 鍼(Chim), shown in "鄕藥集成方(Hyangyakjipsungbang)", "醫林撮要(Uirimchualyo)" and "東醫寶鑑(Donguibogam)", we can notice the spirit of doctors who tried to take over the legitimacy of Korean tradition, and their elaboration & historical view that expresses confidence on our own medical technology, through the wording 鍼(Chim).