• The Korean Journal of Food And Nutrition
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• v.28 no.6
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• pp.965-972
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• 2015

This study was conducted to evaluate the neuroprotective effects of Cheonggukjang extract in in-vitro and in-vivo models. T98G-human glioblastoma cells were pretreated with various concentrations (1~10 mg/mL) of Cheonggukjang extract for 24 h and then exposed to $H_2O_2$ (1 mM) for 3 h. The neuroprotective effects of Cheonggukjang extract were measured using a CCK-8 kit assay, total antioxidant capacity (TAC) assay, reactive oxygen species (ROS) assay, and lactate dehydrogenase (LDH) release assay. The early stage focal ischemia rodent model was used as the in-vivo neurotoxicity model. Various concentrations (10~200 mg) of Cheonggukjang extract were administered to the animal models for 1 week. Peripheral blood was analyzed for glutathione peroxidase (GPx) expression by ELISA, and infarct volume reduction was analyzed by TTC staining. Cheonggukjang extract significantly (p<0.05) increased cell viability in T98G cells against $H_2O_2$ as well as against the induced neurotoxicity. Indeed, treatment with the Cheonggukjang extract induced a decrease in ROS and LDH expression and increased TAC significantly (p<0.05). However, Cheonggukjang extract did not induce a decrease in infarct volume or an increase in GPx expression in the in-vivo model. Despite the limitation in neuroprotection, Cheonggukjang extract may be useful for treating ROS injury.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.41 no.3
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• pp.199-206
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• 2005

As the basic study about improvement of yellow croaker drift gill net fishing implement and development of the fishing system, this study drew problem after synthetically analyzing hauling system of yellow croaker drift gill net used in the coast of Chuja Island and tested several characters and analyzed in hauling process with 5 step net hauler model for improving the problem. The analysis results are as follows. When the angle between axises of drum centers was small, it showed the tendency that hauling time was fast. Hauling time was faster when drum was 5 step rather than 3 step. When drum was 5 step, slippery phenomenon was small and hauling was stable. Tension was larger when drum was 5 step rather than 3 step. When drum was 5 step, the range of change of the maximum and minimum value was small and hauling was stable. When drum was 3 step, there was following formula between hauling time ($Ht_3$) and angle between axises of drum centers ($A_g$) $Ht_3$ : ($7.15Hs^{-0.81}$) $A_g^{-0.81}$, when drum was 5 step there was following formula.$Ht_5$ : ($6.45Hs^{-0.75}$) $A_g0.10$, here, Hs is hauling speed. When drum was 3 step and hauling speed was 28cm/sec, tension was $T=0.08A_8^3-1.60A_g^3-0.49A_g+369.56(r=0.99)$, when drum was 5 step, tension was, $T=-0.01A_g^3+1.96A_g^2-34.05A_g+414.58$ (r-0.99), here, T was tension(g).

• Journal of the military operations research society of Korea
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• v.18 no.2
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• pp.114-125
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• 1992

A policy of periodic replacement with minimal repair at failure is considered for a complex system. Under such a policy the system is replaced at periodic times. iT(i=1,2, $\ldots$), while minimal repair is performed at any intervening system failures. The cost of the j-th minimal repair to the component which fails at age t is g(C(t). $c_j$ (t)), where C(t) is the age-dependent random part, $c_j$(t) is the deterministic part which depends on the age and the number of the minimal repair to the component, and g is a positive nondecreasing continuous function. The cost of replacement is expensive when the number of failures occurring in (0. T) is greater than a threshold level. The problem of determining the optimal replacement period, $T^{\ast}$, which minimizes the total expected cost per unit time over an infinite time horizon is considered. Various special cases are considered.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.37 no.1
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• pp.96-103
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• 2014

A steady-state controllable M/G/1 queueing model operating under the (TN) policy is considered where the (TN) policy is defined as the next busy period will be initiated either after T time units elapsed from the end of the previous busy period if at least one customer arrives at the system during that time period, or the time instant when Nth customer arrives at the system after T time units elapsed without customers' arrivals during that time period. After deriving the necessary system characteristics such as the expected number of customers in the system, the expected length of busy period and so on, the total expected cost function per unit time in the system operation is constructed to determine the optimal operating policy. To do so, the cost elements associated with such system characteristics including the customers' waiting cost in the system and the server's removal and activating cost are defined. Then, the optimal values of the decision variables included in the operating policies are determined by minimizing the total expected cost function per unit time to operate the system under consideration.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6649-6651
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• 2013

Background: Mdm2 binds to the amino-terminus of p53 to induce its degradation and a single nucleotide polymorphism in the MDM2 promoter region (T309G) has been reported to increase the risk of several carcinomas, such as gastric cancer. However, the results of published studies to analyze the association between MDM2 T309G and gastric cancer havve often conflicted. Methods: To better illustrate the filiation between MDM2 T309G and gastric cancer, we performed a meta-analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of the relationship. The pooled ORs were performed for 4 models, additive, recessive, co-dominant model, and dominant. Results: Nine published case-control studies including 3,225 gastric cancer cases and 4,118 controls were identified. The MDM2 T309G polymorphism was associated with a significantly increased risk of gastric cancer risk when all studies were pooled into the meta-analysis (GG versus TT, OR=1.57; 95%CI=1.57-2.12; p=0.003) and GG versus GT/TT, OR=1.52; 95%CI=1.217-1.90; p<0.001). Furthermore, Egger's test did not show any evidence of publication bias (P = 0.608 for GG versus TT). Conclusion: Our results suggest that the MDM2 T309G polymorphism is indeed associated with a significantly increased risk of gastric cancer.

• Journal of Biomedical Engineering Research
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• v.19 no.5
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• pp.495-502
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• 1998

A mathematical model of viscoelasticity on the material property of human pharyngeal tissue utilizing Y.C. Fung's Quasi-linear viscoelastic theory is proposed based on cyclic load, stress relaxation, incremental load, and uniaxial tensile load tests. The material properties are characterized and compared with other biological materials' results. The mathematical model is proposed by combining two characteristic functions determined from the stress relaxation and uniaxial tensile load tests. The reduced stress relaxation function G(t) and elastic response function S(t) are obtained from stress relaxation test and uniaxial tensile load test results respectively. Then the model describing stress-time history of the tissue is implemented utilizing two functions. The proposed model is evaluated and validated by comparing the model's cyclic behaviour with experimental results. The model data could be utilized as an important information for constructing 3-dimensional biomechanical model of human pharynx using FEM(Finite Element Method).

• Kyungpook Mathematical Journal
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• v.48 no.4
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• pp.593-611
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• 2008

Global attractivity and oscillatory behavior of the following nonlinear impulsive parabolic differential equation which is a general form of many population models $$\array{\{{{\frac {{\partial}u(t,x)}{{\partial}t}=\Delta}u(t,x)-{\delta}u(t,x)+f(u(t-\tau,x)),\;t{\neq}t_k,\\u(t^+_k,x)-u(t_k,x)=g_k(u(t_k,x)),\;k{\in}I_\infty,}\;\;\;\;\;\;\;\;(*)$$ are considered. Some new sufficient conditions for global attractivity and oscillation of the solutions of (*) with Neumann boundary condition are established. These results no only are true but also improve and complement existing results for (*) without diffusion or impulses. Moreover, when these results are applied to the Nicholson's blowflies model and the model of Hematopoiesis, some new results are obtained.

• Journal of Digital Convergence
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• v.19 no.4
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• pp.151-157
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• 2021

Recently, IoT technology has been applied to various cloud environments, requiring accurate verification of various information generated by IoT devices. However, due to the convergence of IoT technologies and 5G technologies, accurate analysis is required as IoT information processing is rapidly processed. This paper proposes a blockchain-based multi-IoT verification model for overlay cloud environments. The proposed model multi-processes IoT information by further classifying IoT information two layers (layer and layer) into bits' blockchain to minimize the bottleneck of overlay networks while ensuring the integrity of information sent and received from embedded IoT devices within local IoT groups. Furthermore, the proposed model allows the layer to contain the weight information, allowing IoT information to be easily processed by the server. In particular, transmission and reception information between IoT devices facilitates server access by distributing IoT information from bits into blockchain to minimize bottlenecks in overlay networks and then weighting IoT information.

• Journal of Korea Society of Industrial Information Systems
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• v.18 no.6
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• pp.39-49
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• 2013

In recent, many countries and research institutes have been studying how to construct the high-speed subscriber access network. Task Force team of IEEE 802.3ah has accomplished the standardization of EPON which is the next generation subscriber access network. EPON doesn't still have the bandwidth enough to support the new service(e.g various multimedia service) which demands the high bandwidth. For these new multimedia services,10G EPON is the next generation subscriber access network which expanded the up-down bandwidth range of 1G EPON 10 times in order to support demanding high bandwidth. We have proposed the model which can accommodate IEEE 802.1 AVB traffics smoothly in 10G EPON and suggesting the Intra-ONU scheduling model which makes this model operate effectively.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.33 no.3
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• pp.63-70
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• 2010

Based on the known results of the expected busy periods for the triadic Min (N, T, D) and Max (N, T, D) operating policies applied to a controllable M/G/1 queueing model, a relation between them is constructed. Such relation is represented in terms of the expected busy periods for the simple N, T and D, and the dyadic Min (N, T), Min (T, D) and Min (N, D) operating policies. Hence, if any system characteristics for one of the two triadic operating policies are known, unknown corresponding system characteristics for the other triadic operating policy could be obtained easily from the constructed relation.