• Microbiology and Biotechnology Letters
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• v.46 no.4
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• pp.326-333
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• 2018

In this study, we identified methods to improve heat stability and skin permeability of functional protein biopolymers, such as growth factors, enzymes, and peptides. The biopolymers participate in cellular activation and catalytic functions in vivo. Therefore, when applied to cosmetics, their efficacies are expected to be helpful for skin care. However, they have disadvantages that include instability to heat and low skin permeability due to their high molecular weight. To overcome these problems, we searched for a composition that increases heat stability. Stability was improved using a polymeric humectant having a long polyethylene glycol length, compared with a mono-molecular structure humectant. Next, to enhance skin permeation, a permeation enhancing peptide was selected from a phage library. The permeation enhancing peptide can be commonly used to promote the permeation of growth factors, enzymes, and peptides. Screening was performed on the polymeric humectant formulation. One dominant peptide from the modified-screening method was identified. Furthermore, it was confirmed that the permeability of the peptide was better than that of the peptide developed through a screening system based on phosphate-buffered saline. The data indicate that the polymeric humectant formulation will be helpful for increasing the heat stability of protein ingredients and that skin permeability could be increased by a formulation-specific, penetration-enhancing peptide.

• The Journal of the Korea institute of electronic communication sciences
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• v.13 no.6
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• pp.1397-1404
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• 2018

Due to the technical difficulties and high cost for obtaining 3-dimensional structure data, sequence-based approaches in proteins have not been widely acknowledged. A motif can be defined as any segments in protein or gene sequences. With this simplicity, motifs have been actively and widely used in various areas. However, the motif itself has not been studied comprehensively. The value of this study can be categorized in three fields in order to analyze the human proteins using artificial intelligence method: (1) Based on our best knowledge, this research is the first comprehensive motif analysis by analyzing motifs with all human proteins in Protein Data Bank (PDB) associated with the database of Enzyme Commission (EC) number and Structural Classification of Proteins (SCOP). (2) We deeply analyze the motif in three different categories: pattern, statistical, and functional analysis of clusters. (3) At the last and most importantly, we proposed random motif frequency(RMF) matric that can efficiently distinct the characteristics of proteins by identifying interface residues from non-interface residues and clustering protein functions based on big data while varying the size of random motif.

• Transactions of the Korean hydrogen and new energy society
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• v.29 no.6
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• pp.559-569
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• 2018

Catalytic supports made of carbon have many advantages, such as high coking resistance, tailorable pore and surface structures, and ease of recycling of waste catalysts. Moreover, they do not require pre-reduction. In this study, ash-free coal (AFC) was obtained by the thermal extraction of carbonaceous components from raw coal and its performance as a carbon catalytic support was compared with that of well-known activated carbon (AC). Nickel was dispersed on the carbon supports and the resulting catalysts were applied to the steam reforming of toluene (SRT), a model compound of biomass tar. Interestingly, nickel catalysts dispersed on AFC, which has a very small surface area (${\sim}0.13m^2/g$), showed higher activity than those dispersed on AC, which has a large surface area ($1,173A/cm^2$). X-ray diffraction (XRD) analysis showed that the particle size of nickel deposited on AFC was smaller than that deposited on AC, with the average values on AFC ${\approx}11nm$ and on AC ${\approx}23nm$. This proved that heteroatomic functional groups in AFC, such as carboxyls, can provide ion-exchange or adsorption sites for the nano-scale dispersion of nickel. In addition, the pore structure, surface morphology, chemical composition, and chemical state of the prepared catalysts were analyzed using Brunauer-Emmett-Taylor (BET) analysis, transmission electron microscopy (TEM), scanning electron microscopy (SEM), x-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, and temperature-programmed reduction (TPR).

• The Journal of Society for e-Business Studies
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• v.24 no.1
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• pp.29-48
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• 2019

Recently, product design innovation to improve user experience has been perceived as a core element of enterprise competitiveness due to the fierce market competition and decrease of the technological gap between companies, but there is insufficient services to support the product experience evaluation of small and medium-sized companies (SMCs). The aim of this study is to develop a web-based product user experience evaluation and certification system supporting product design practices for SMCs. For system interface design, we conducted systematic functional requirement elicitation methods such as user survey, workflow analysis, user task definition, and function definition. Then main functions, information structure, navigation method, and detailed graphic user interfaces were developed with consideration of user interactions and requirements. In particular, it provides the databases for evaluation efficiency to support the evaluation process above a certain level of performance and efficiency, and knowledge databases to utilize in the evaluation and product design improvement. With help of the developed service platform, It is expected that the service platform would enhance SMCs' product development capability with regard to the user experience evaluation by connecting the consulting firms with SMCs.

• Journal of the Korean Applied Science and Technology
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• v.36 no.1
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• pp.165-173
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• 2019

Hydrazine[$N_2H_4$] is a typical propellant for a rocket fuel in the field of aerospace. Since it is very toxic and harmful to the environment, various environmentally-friendly propellants have been developed. In this study, relatively a safe propellant, hydroxylammonium nitrate[$NH_3OHNO_3$], was prepared via a neutralization reaction of hydroxylamine[$NH_2OH$] and nitric acid[$HNO_3$]. FT-IR was used to analyze the chemical composition, chemical structure and functional groups of HAN. Thermogravimetric analysis showed the decomposition temperature of HAN. Ion chromatography was also used to evaluate the content of nitrate ions. It was proved that the peaks of FT-IR at $3161cm^{-1}$ and $1324cm^{-1}$ indicates the functionalities of N-H and N-O present in HAN. The decomposition temperature of HAN synthesized at pH 5 to 7 was $120-140^{\circ}C$, and pH 8 resulted in higher decomposition temperature than $140^{\circ}C$. Meanwhile, the sample obtained from pH 6-7 showed the concentration of nitric acid ion with 70%.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.37 no.1
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• pp.12-22
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• 2019

This study derived the design aspects by carrying out the case study of Neunggok prehistoric remains park, Ansansingil historic park and Yongjuk historic park to which are taken measures to preserve undesignated cultural heritages after studying the related laws & regulations and the systems as the design conditions of historic park preserving buried cultural heritages. The results of the study are as follows. First, according to the laws & regulations related to the historical parks, the historic sites should be preserved and utilized at the same time and can have history-related facility spaces, squares, rest spaces, exercise spaces, education & culture space, and convenience spaces. Second, by the space organization and the circulation system emphasizing only the preservation of buried cultural heritages, the feature-preservation space and the functional space are separated and due to not accepting the usage behavior considering peripheral land use, the effectiveness of the historical park was low. Third, the passive feature-preservation methods such as the preservation of the exposed site in architectural methods, the reproduction of the dugout hut, and the planting Royal azaleas or displaying stone after covering up the location of the pit dwellings with soil and the usage mainly for viewing have weakened the identity of the historical park. Fourth, the fence preventing users' access interferes experiencing the features, and the vertical structure protecting the upper part of the exposed features has overwhelmed the landscape of the historical parks. Fifth, it was difficult to figure out the feature space only by the texts mainly on terminologies and the excavation photographs presented on the information signs which introduce the buried cultural heritages.

• Korean journal of applied entomology
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• v.60 no.1
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• pp.79-90
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• 2021

Landscape composition and structure are important factors determining biological diversity including pests and natural enemires in agricultural ecosystem. This study was conducted to indentify effect of landscape composition on occurrence of lepidopteran pest population in Geochang, Gyoungdnam. For this, orchard characteristics and management practices were surveyed in 80 conventional apple orchards in Geochang, Korea, along with the monitoring of pest population densities. The landscape features of each surveyed orchard also obtained by extracting information from the public-service map. Grapholita molesta was the most dominat and damaging pest followed by Phyllonorycter ringoniella and Carposina sasakii in trap catches. Adoxophyes paraorana occurrences were low. Farmers spray insecticides and fungicides ap. 12.4 times per year respectively while acaricides were sprayed 2.4 times. Major landscape features such as surrounding apple orchard or paddy field did not influence the pest populations but presence of plum, peach, wild peach, graph, and even abandoned orchards significantly resulted in higher pest population mostly on G. molesta. C. sasakii population was higher in orchards with grape, peach, and P. ringoniella with peach, grape, abandoned orchards and jujube. Results highlight the need of landscape management not only for the rural amenity but also for increasing functional diversity of agroecosystem as well as reducing pest population.

• Ecology and Resilient Infrastructure
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• v.7 no.4
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• pp.308-319
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• 2020

In this study, the field applicability of the recently constructed multifunctional fishway in Seomunbo, Yeongcheon-si, and Gyeongsangbuk-do were examined. The analysis variables were R/C slab (S1) and R/C+S/C slab (S2), the underground passage standard areas (width × length) were 1.4 m × 0.2 m, 1.4 m × 0.3 m, and 1.4 m × 0.6 m, and the flow velocities were 0.8, 1.2, and 1.6 m/s. As a result of the analysis, the safety of the design of Seomunbo was evaluated. The analysis showed compared to the Seomoon Weir fishway, the maximum stress of S2 decreased by 24 - 32%, the bending moment of the underground passage decreased by 16 - 33%, the maximum stress of the sidewall decreased by 20 - 36%. In addition, the bending moment of the upper slab decreased by 17 - 33%, the maximum stress of the upper slab decreased by 9 - 28%, and the bending moment decreased by 19 - 33%. Complementation was required in the following percentages: 18% and 14% for the maximum stress and bending moment of the underground passage, respectively, 15% and 17% for the maximum sidewall stress and bending moment, respectively, and 11% and 16% for the upper slab maximum stress and bending moment, respectively. The results showed that S2 was superior to that of the Seomoon Weir fishway, and the underground passage size of 1.4 m × 0.3 m was superior to those of 1.4 m × 0.2 m and 1.4 m × 0.6 m, and R/C+S/C slab was superior to that of R/C slab. The findings are expected to be useful for constructing and designing the multifunctional fishway.

• Applied Chemistry for Engineering
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• v.22 no.5
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• pp.467-472
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• 2011

This study investigated illite/polypropylene (PP) composite filament formation via melt-spinning and evaluated their physical properties to prepare functional fibers using natural materials. When composite filaments were formed, the composite filaments exhibited smaller fiber diameters compared to that of neat PP filament because of the lubricant effect of illite induced by its layered structure. Moreover, fluorination effect increased interfacial affinity and dispersion in the polymer, resulting in smaller diameter of fluorinated illite/PP composite filament, which was 2/3 of the neat PP filament diameter. Addition of raw and fluorinated illite improved thermal stability of illite/PP composite filament. Raw illite/PP composite filament cannot be used for a practical application, because it broke during drawing process, whereas the fluorinated illite/PP composite filament can be used for a practical application, because it exhibited similar tensile strength of the neat PP filament and 50% increased modulus. Even with improved illite/PP interfacial affinity and illite dispersion in the polymer, illite/PP composite filament formed microcomposite, because non-expandable illite had strongly bound layers, resulting in only a little illite exfoliation and PP intercalation into illite.

• Membrane Journal
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• v.31 no.3
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• pp.219-227
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• 2021

Molecularly imprinted membrane (MIM) is a porous polymer membrane incorporating with the molecular recognizing sites. In this study, the supporting P(AN-co-MA) asymmetric membrane was prepared by nonsolvent induced phase separation (NIPS) method. And then, MIM with lysozyme template sites was prepared using the surface imprinting method on the P(AN-co-MA) asymmetric membrane introducing a photoactive iniferter and then photo-grafting. The P(AN-co-MA) asymmetric membrane was modified with 3-chloropropyltrimethoxysilane and dithiocarbamate as a photoactive iniferter. To prepare a lysozyme imprinted membrane, the modified P(AN-co-MA) membrane was copolymerized with acrylamide as a functional momomer, N,N'-methylene bisacrylamide as a crosslinker and lysozyme as a template in the UV irradiation environment. The lysozyme imprinted MIM was analyzed by using SEM, FT-IR and EDS measurements. Its results confirm that all the P(AN-co-MA) membranes have an asymmetric structure and the iniferter group is successfully introduced on the membrane surface. The process parameters were adjusted to obtain MIM having the excellent lysozyme adsorption. The maximum lysozyme adsorption capacity reaches at 2.7 mg/g, which is 13 times higher than that of the non imprinted membrane (NIM). The permselective membrane filtration experiments of ovalbumin to lysozyme show that the P(AN-co-MA) MIM preferentially bounds a greater amount of lysozyme.