• 생물정신의학
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• 제24권2호
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• pp.68-74
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• 2017

Objectives It is well known that problem drinking is associated with alterations of brain structures and functions. Brain functions related to alcohol consumption can be determined by the resting state functional connectivity in various resting state networks (RSNs). This study aims to ascertain the alcohol effect on the structures forming predetermined RSNs by assessing their cortical thickness. Methods Twenty-six abstinent male patients with alcohol dependence and the same number of age-matched healthy control were recruited from an inpatient mental hospital and community. All participants underwent a 3T MRI scan. Averaged cortical thickness of areas constituting 7 RSNs were determined by using FreeSurfer with Yeo atlas derived from cortical parcellation estimated by intrinsic functional connectivity. Results There were significant group differences of mean cortical thicknesses (Cohen's d, corrected p) in ventral attention (1.01, < 0.01), dorsal attention (0.93, 0.01), somatomotor (0.90, 0.01), and visual (0.88, 0.02) networks. We could not find significant group differences in the default mode network. There were also significant group differences of gray matter volumes corrected by head size across the all networks. However, there were no group differences of surface area in each network. Conclusions There are differences in degree and pattern of structural recovery after abstinence across areas forming RSNs. Considering the previous observation that group differences of functional connectivity were significant only in networks related to task-positive networks such as dorsal attention and cognitive control networks, we can explain recovery pattern of cognition and emotion related to the default mode network and the mechanisms for craving and relapse associated with task-positive networks.

• Journal of Microbiology and Biotechnology
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• 제19권4호
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• pp.368-371
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• 2009

In the course of screening for the melanogenesis inhibitors, aspochalasin I was isolated from solid-state culture of Aspergillus sp. Fb020460. Its structure was determined by spectroscopic analysis including mass spectroscopy and NMR analysis. Aspochalasin I potently inhibited melanogenesis in Mel-Ab cells with an $IC_{50}$ value of $22.4{\mu}M$ without cytotoxicity.

• Journal of Microbiology and Biotechnology
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• 제17권10호
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• pp.1717-1720
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• 2007

In the course of screening for nitric oxide inhibitors in activated microglial BV-2 cells, cyclo(dehydrohistidyl-L-tryptophyl) was isolated from solid-state fermentation cultures of an unidentified fungal strain, Fb956. Its structure was determined by spectroscopic methods including 2D NMR and chiral TLC analyses. Cyclo(dehydrohistidyl-L-tryptophyl) was found to have an inhibitory activity on nitric oxide production with an $IC_{50}$ of $6.5\;{\mu}M$ in activated BV-2 cells. The structure determination and biological activity of cyclo(dehydrohistidyl-L-tryptophyl) was reported for the first time in this study.

• Bulletin of the Korean Chemical Society
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• 제29권5호
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• pp.1051-1054
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• 2008

The entropy production in a non-equilibrium state based on the reversible Oregonator model of the Belousov-Zhabotinskii (BZ) reaction system has been studied. The reaction affinity and the reaction rate for the individual steps have been calculated by varying the concentrations of key variables in the system. The result shows a linear relationship between the reaction affinity and the reaction rate in the given concentration range. However, the overall entropy calculated on the basic assumption that the entropy in a reaction system corresponds to the summation of a product of reaction affinity and reaction rate of individual steps shows a nonlinearity of the reaction system. The results well agrees with the fact that the entropy production is not linear or complicated function in a non-linear reaction system.

• Communications for Statistical Applications and Methods
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• 제25권6호
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• pp.619-631
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• 2018

Functional data analysis continues to attract interest because advances in technology across many fields have increasingly permitted measurements to be made from continuous processes on a discretized scale. Particulate matter is among the most harmful air pollutants affecting public health and the environment, and levels of PM10 (particles less than 10 micrometers in diameter) for regions of California remain among the highest in the United States. The relatively high frequency of particulate matter sampling enables us to regard the data as functional data. In this work, we investigate the dominant modes of variation of PM10 using functional data analysis methodologies. Our analysis provides insight into the underlying data structure of PM10, and it captures the size and temporal variation of this underlying data structure. In addition, our study shows that certain aspects of size and temporal variation of the underlying PM10 structure are associated with changes in large-scale climate indices that quantify variations of sea surface temperature and atmospheric circulation patterns.

• 대한화학회지
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• 제57권2호
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• pp.216-220
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• 2013

The hydroalumination of cyclopropane has been investigated using the B3LYP density functional method employing several split-valence basis sets. It is shown that the reaction proceeds via an intermediate weakly bound complex and a four-centered transition state. Calculations at higher levels of theory were also performed at the geometries optimized at the B3LYP level, but only slight changes in the barriers were observed. Structural parameters for the transition state are also reported.

• Biomolecules & Therapeutics
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• 제24권2호
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• pp.147-155
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• 2016

Chaetominine is a quinazoline alkaloid originating from the endophytic fungus Aspergillus fumigatus CY018. In this study, we showed evidence that chaetominine has cytotoxic and apoptotic effects on human leukemia K562 cells and investigated the pathway involved in chaetominine-induced apoptosis in detail. Chaetominine inhibited K562 cell growth, with an $IC_{50}$ value of 35 nM, but showed little inhibitory effect on the growth of human peripheral blood mononuclear cells. The high apoptosis rates, morphological apoptotic features, and DNA fragmentation caused by chaetominine indicated that the cytotoxicity was partially caused by its pro-apoptotic effect. Under chaetominine treatment, the Bax/Bcl-2 ratio was upregulated (from 0.3 to 8), which was followed by a decrease in mitochondrial membrane potential, release of cytochrome c from mitochondria into the cytosol, and stimulation of Apaf-1. Furthermore, activation of caspase-9 and caspase-3, which are the main executers of the apoptotic process, was observed. These results demonstrated that chaetominine induced cell apoptosis via the mitochondrial pathway. Chaetominine inhibited K562 cell growth and induced apoptotic cell death through the intrinsic pathway, which suggests that chaetominine might be a promising therapeutic for leukemia.

• 한국조리학회지
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• 제12권4호
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• pp.116-130
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• 2006

This research was accomplished to analyze the preference and the actual using patterns of the bakery products using functional ingredients by subjects' age. This survey was examined by the self-administered questionnaire method for 374 female subjects in Suwon. All respondents preferred breads than confectionaries with functional ingredients. As for the products of cooking ingredients, cookies, roll-cake, cake, chocolate, the preference of teenagers was higher than those of the other groups. Subjects preferred potatoes, fruits, rice and green tea as functional ingredients. Over thirties showed the high preference over beans, vegetables, mushrooms, ginseng and oriental herbs while fruits were highly preferred in teenagers and twenties. The ratio of using the bakery products with functional ingredients once or twice a week was higher in over thirties than those of the other groups. Subjects answered that they generally spent $3,000won\sim5,000won$ on those products. Functionality of products was considered as the more important factor in thirties than in the other groups. The lack of information about these products and functional ingredients was reported by teenagers and twenties. These results would be basic data for marketing or improvement of baking products with functional ingredients.

• 복식문화연구
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• 제14권6호
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• pp.1056-1068
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• 2006

The purpose of this study is to examine the changes and the using condition of functional cosmetics through articles of newspaper and the survey on functional cosmetics. The data analysis examined newspaper articles that demonstrate a grasp of the general trends of cosmetics, and these articles were chosen from the "Cosmetics Newspapers" and the "Jangeop Newspaper" with content primarily emphasizing articles about cosmetics. All articles on functional cosmetics were collected for the period from 2000 to 2005, and excluding repeated articles a total of 703 cases were examined. In addition, a survey was performed to examine how much women are using functional cosmetics and what the current state of their use is. This survey was conducted from October $1{\sim}20$, 2004, and respondents consisted of 350 adult females living in the areas of Daejeon, North and South Chungcheong Provinces and Daegu. Responses from a total of 302 individuals were included in the data analysis. The results of this study show a situation where the current use of functional cosmetics is gradually increasing, and because of external changes in the skin resulting from the development of modern society, functional cosmetics are being used by women as a means of increasing their opportunities for personal expression due to their skin improvement effects as well as increased confidence and a sense of satisfaction.

• 한국사회정책
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• 제19권3호
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• pp.185-214
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• 2012

에스핑앤더슨으로 촉발된 복지국가에 대한 연구가 유형화 논의를 통해 학문적으로 발전하는 가운데 동아시아 국가들의 급속한 경제성장에 관한 연구는 복지국가 유형화 논의시기와 맞물리면서 1990년대 후반부터는 '동아시아복지국가'에 대한 연구로 발전하기 시작하였다. 국내외에서 이루어진 이러한 연구들은 동아시아복지국가의 유형 및 개별 복지국가의 성격 규명, 더 나아가 기존의 국제복지국가 비교연구의 학문적 발전에도 크게 기여하였다. 다만, 서구 복지국가의 이론적 논의에 근거해 비교적 단시간 내에 많은 수의 동아시아복지국가 비교연구가 생산된 반면 동아시아복지국가 및 복지체제의 개념 및 정의 자체에 대해서는 충분히 다뤄지지 못한 아쉬움이 있다. 본 연구는 변수화 및 지표의 비교에 다소 치우쳐져있던 동아시아복지국가 논의에서 개념적 논의의 중요성 및 그 유용성을 강조하여 연구방법론적 기여를 하고자 한다. 이에 따라, 본 논문은 먼저 개념구조 및 집합이론을 논하고, 비교사회정책연구에서 집합이론을 활용한 개념화방법들을 소개한다. 이어서 복지국가 연구에서 유용하게 채용될 수 있는 기능적 등가물(functional equivalence)에 대해 논하고 이를 바탕으로 현재까지의 동아시아복지국가 연구를 비판적으로 검토한다. 마지막으로 앞서 설명한 개념구조들 및 집합이론을 활용하여, 동아시아복지국가 비교연구의 개념화작업 단계에서 기능적 등가물 개념을 채용할 수 있는 방안들을 제안한다.