Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Aspochalasin I, a Melanogenesis Inhibitor from Aspergillus sp.

  • Choo, Soo-Jin (Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Yun, Bong-Sik (Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Ryoo, In-Ja (Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Young-Hee (Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
  • Yoo, Ick-Dong (Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology)
  • Published : 2009.04.30
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Abstract

In the course of screening for the melanogenesis inhibitors, aspochalasin I was isolated from solid-state culture of Aspergillus sp. Fb020460. Its structure was determined by spectroscopic analysis including mass spectroscopy and NMR analysis. Aspochalasin I potently inhibited melanogenesis in Mel-Ab cells with an $IC_{50}$ value of $22.4{\mu}M$ without cytotoxicity.

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References

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