Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Cyclo(Dehydrohistidyl-L-Tryptophyl), an Inhibitor of Nitric Oxide Production from a Fungal Strain, Fb956

  • Noh, Hyun-Jeong (Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Sohn, Mi-Jin (Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Yu, Hyung-Eun (Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Yoo, Ick-Dong (Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Won-Gon (Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology)
  • Published : 2007.10.30
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Abstract

In the course of screening for nitric oxide inhibitors in activated microglial BV-2 cells, cyclo(dehydrohistidyl-L-tryptophyl) was isolated from solid-state fermentation cultures of an unidentified fungal strain, Fb956. Its structure was determined by spectroscopic methods including 2D NMR and chiral TLC analyses. Cyclo(dehydrohistidyl-L-tryptophyl) was found to have an inhibitory activity on nitric oxide production with an $IC_{50}$ of $6.5\;{\mu}M$ in activated BV-2 cells. The structure determination and biological activity of cyclo(dehydrohistidyl-L-tryptophyl) was reported for the first time in this study.

Keywords

References

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