• Title/Summary/Keyword: Form parameter

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재조합 인간 GM-CSF의 수용체에 관한 연구

  • 이부연;최상운;이정옥;공재양
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1994.04a
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    • pp.307-307
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    • 1994
  • 본 실험에서는 유전자 재조합으로 제조한 〔$^{125}$/I〕-labeled human GM-CSF를 사용하여 GM-CSF의 HL-60 cell의 표면에 존재하는 GM-CSF 수용체의 특성을 밝히고 수용체에 대한 binding parameter를 확인하고 Immunex(미국) 사에서 제조한 Prokine(Sargramostim)과 Sigma사에서 구입한 GM-CSF(C-9666)를 표준물질로 하여 (주) Lucky에서 제조한 GM-CSF(LBD-005)의 수용체에 대한 결합율을 측정, 각각 비교하고자 하였다. 한편 LBD-005는 glycosylation된 form과 안된 form의 혼합물이므로 당화의 정도가 수용체에 대한 결합에 미치는 영향을 알아보기 위해 glycosylated form과 혼합물(LBD-005)의 수용체에 대한 결합율을 측정 비교하였다.

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Necessary conditions in the optimal control of nonlinear integral equations

  • Wang, Fu-Yang;Lee, In-Beum;Chang, Kun-Soo
    • 제어로봇시스템학회:학술대회논문집
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    • 1989.10a
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    • pp.947-951
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    • 1989
  • A Class of nonlinear distributed parameter control problems is first stated in a partial differential equation form in multi-index notion and then converted into an integral equation form. Necessary conditions for optimality in the form of maximum principle are then derived in Sobolev space W$^{l}$, p/(1 leq. p .leq. .inf.)..

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Performance Comparison of Four-Parameter Correlation Equations of the Enthalpy of Vaporization

  • Lee, Kyoung-Youl;Park, Kyoung-Kuhn
    • International Journal of Air-Conditioning and Refrigeration
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    • v.14 no.3
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    • pp.118-123
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    • 2006
  • A few commonly used correlation equations of the enthalpy of vaporization essential to the analysis of refrigeration cycles are reviewed. A new four-parameter correlation equation is proposed assuming that the enthalpy of vaporization could be represented with a linear form of the temperature and an additional function which slowly decreases as the temperature increases. It is not a common practice to measure the enthalpy of vaporization by experiment; therefore, performance of the new correlation is examined using numeric data from the ASHRAE tables for 22 pure substance refrigerants. The new correlation equation and other existing ones are fitted to the data optimizing the root mean squared deviation. All data points are weighted equally and NBP (normal boiling point) is used as a fixed point since the NBP is important for refrigeration application. The new four-parameter equation yields an average absolute deviation of 0.05% for 22 refrigerants which is smaller than those of other four-parameter equations, such as Guermouche-Vergnaud (0.08%), Aerebrot (0.13%), Radoz-Lyderson (0.08%), and Somayajulu four-parameter equation (0.08%).

Mixed $H^{2}$/$H^{\infty}$ controller design for linear system with time delay and parameter uncertainty (시간지연 및 파라미터 불확실성을 갖는 선형시스템의 혼합 $H^{2}$/$H^{\infty}$ 제어기 설계)

  • 이갑래;정은태;박홍배
    • 제어로봇시스템학회:학술대회논문집
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    • 1996.10b
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    • pp.560-564
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    • 1996
  • A mixed H$^{2}$/$H^{\infty}$ controller design method for linear systems with time delay in all variables and parameter uncertainties in all system matrices is proposed. Robust $H^{\infty}$ performance and H$^{2}$ performance condition that accounts for model-matching of closed loop system and disturbance rejection is also derived. With expressing uncertain system with linear fractional transformation form, we transform the robust stability and performance problem to the H$^{2}$/$H^{\infty}$ optimization problem and design a mixed H$^{2}$/$H^{\infty}$ controller. Using the proposed method, mixed H$^{2}$/$H^{\infty}$ controller for underwater vehicle with time delay and parameter variations are designed. Simulations of a design example with hydrodynamic parameter variations and disturbance are presented to demonstrate the achievement of good robust performance.t performance.ance.

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Proposal of a New Parameter for Extra Straining Effects (이차적인 변형률효과를 나타내는 새로운 변수의 제안)

  • 명현국
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.18 no.1
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    • pp.184-192
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    • 1994
  • The parameters such as Richardson numbers or stability parameters are widely used to account for the extra straining effects due to three-dimensionality, curvature, rotation, swirl and others arising in paractical complex flows. Existing expressions for the extra strain in turbulence models such as $k-{\epsilon}$ models, however, do not satisfy the tensor invariant condition representing the coordinate indifference. In the present paper, considering the characteristics of both the mean strain rate and the mean vorticity, a new parameter to deal with the extra straining effects is proposed. The new parameter has a simple form and satisfies the tensor invariant condition. A semi-quantitative analysis between the present and previous parameters for several typical complex flows suggests that the newly proposed parameter is more general and adequate in representing the extra straining effects than the previous ad-hoc parameters.

Bayesian Estimation of Three-parameter Bathtub Shaped Lifetime Distribution Based on Progressive Type-II Censoring with Binomial Removal

  • Chung, Younshik
    • Journal of the Korean Data Analysis Society
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    • v.20 no.6
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    • pp.2747-2757
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    • 2018
  • We consider the MLE (maximum likelihood estimate) and Bayesian estimates of three-parameter bathtub-shaped lifetime distribution based on the progressive type II censoring with binomial removal. Jung, Chung (2018) proposed the three-parameter bathtub-shaped distribution which is the extension of the two-parameter bathtub-shaped distribution given by Zhang (2004). Jung, Chung (2018) investigated its properties and estimations. The maximum likelihood estimates are computed using Newton-Raphson algorithm. Also, Bayesian estimates are obtained under the balanced loss function using MCMC (Markov chain Monte Carlo) method. In particular, BSEL (balanced squared error loss) function is considered as a special form of balanced loss function given by Zellner (1994). For comparing theirs MLEs with the corresponding Bayes estimates, some simulations are performed. It shows that Bayes estimates is better than MLEs in terms of risks. Finally, concluding remarks are mentioned.

Numerical Solution of Steady Flow and Heat Transfer around a Rotating Circular Cylinder (가열된 회전원주를 지나는 정상유동 및 열전달해석)

  • 부정숙;이종춘
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.17 no.12
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    • pp.3135-3147
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    • 1993
  • A numerical method is presented which can solve the steady flow and heat transfer from a rotating and heated circular cylinder in a uniform flow for a range of Reynolds number form 5 to 100. The steady response of the flow and heat transfer is simulated for various spin parameter. The effects on the flow field and heat transfer characteristics known as lift, drag and heat transfer coefficient are analyzed and the streamlines, velocity vectors, vorticity, temperature distributions around it were scrutinized numerically. As spin parameter increases the region of separation vortex becomes smaller than upper one and the lower region will vanish. The lift force, a large part is due to the pressure force, increases as the Reynolds number and it increases linearly as spin parameter increases. The pressure coefficient changes rapidly with spin parameter on the lower surface of the cylinder and the vorticity is sensitive to the spin parameter near separation region. As spin parameter increases the maximum heat coefficient and the thin thermal layer on front region are moved to direction of rotation. However, with balance between the local increase and decrease, the overal heat transfer coefficient is almost unaffected by rotation.

Optimal ρ acceleration parameter for the ADI iteration for the real three dimensional Helmholtz equation with nonnegative ω

  • Ma, Sangback
    • Journal of the Korean Society for Industrial and Applied Mathematics
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    • v.3 no.2
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    • pp.1-4
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    • 1999
  • The Helmholtz equation is very important in physics and engineering. However, solution of the Helmholtz equation is in general known as a very difficult phenomenon. For if the ${\omega}$ is negative, the FDM discretized linear system becomes indefinite, whose solution by iterative method requires a very clever preconditioner. In this paper we assume that ${\omega}$ is nonnegative, and determine the optimal ${\rho}$ parameter for the three dimensional ADI iteration for the Helmholtz equation. The ADI(Alternating Direction Implicit) method is also getting new attentions due to the fact that it is very suitable to the vector/parallel computers, for example, as a preconditioner to the Krylov subspace methods. However, classical ADI was developed for two dimensions, and for three dimensions it is known that its convergence behaviour is quite different from that in two dimensions. So far, in three dimensions the so-called Douglas-Rachford form of ADI was developed. It is known to converge for a relatively wide range of ${\rho}$ values but its convergence is very slow. In this paper we determine the necessary conditions of the ${\rho}$ parameter for the convergence and optimal ${\rho}$ for the three dimensional ADI iteration of the Peaceman-Rachford form for the real Helmholtz equation with nonnegative ${\omega}$. Also, we conducted some experiments which is in close agreement with our theory. This straightforward extension of Peaceman-rachford ADI into three dimensions will be useful as an iterative solver itself or as a preconditioner to the the Krylov subspace methods, such as CG(Conjugate Gradient) method or GMRES(m).

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An Adaptive Algorithm Applied to a Design of Robust Observer

  • Son, Young-Ik;Hyungbo Shim;Juhoon Back;Jo, Nam-Hoon
    • Journal of Mechanical Science and Technology
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    • v.17 no.10
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    • pp.1443-1449
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    • 2003
  • Primary goal of adaptive observers would be to estimate the true states of a plant. Identification of unknown parameters is of secondary interest and is achieved frequently with the persistent excitation condition of some regressors. Nevertheless, two problems are linked to each other in the classical approaches to adaptive observers; as a result, we get a good state estimate once after a good parameter estimate is obtained. This paper focuses on the state estimation without parameter identification so that the state is estimated regardless of persistent excitation. In this direction of research, Besancon (2000) recently summarized that most of adaptive observers in the literature share one common canonical form, in which unknown parameters do not affect the unmeasured states. We enlarge the class of linear systems from the canonical form of (Besancon, 2000) by proposing an adaptive observer (with additional dynamics) that allows unknown parameters to affect those unmeasured states. A recursive algorithm is presented to design the proposed dynamic observer systematically. An example confirms the design procedure with a simulation result.