• BMB Reports
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• v.43 no.5
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• pp.362-368
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• 2010

Dermcidin is a human antibiotic peptide that is secreted by the sweat glands and has no homology to other known antimicrobial peptides. As an initial step toward understanding dermcidin's mode of action at bacterial membranes, we used homonuclear and heteronuclear NMR to determine the conformation of the peptide in 50% trifluoroethanol solution. We found that dermcidin adopts a flexible amphipathic $\alpha$-helical structure with a helix-hinge-helix motif, which is a common molecular fold among antimicrobial peptides. Spin-down assays of dermcidin and several related peptides revealed that the affinity with which dermcidin binds to bacterial-mimetic membranes is primarily dependent on its amphipathic $\alpha$-helical structure and its length (>30 residues); its negative net charge and acidic pI have little effect on binding. These findings suggest that the mode of action of dermcidin is similar to that of other membrane-targeting antimicrobial peptides, though the details of its antimicrobial action remain to be determined.

• Bulletin of the Korean Chemical Society
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• v.32 no.6
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• pp.2008-2014
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• 2011

Serotonin or 5-hydroxytryptamine subtype 2C ($5-HT_{2C}$) receptor belongs to class A amine subfamily of G-protein-coupled receptor (GPCR) super family and its ligands has therapeutic promise as anti-depressant and -obesity agents. So far, bovine rhodopsin from class A opsin subfamily was the mostly used X-ray crystal template to model this receptor. Here, we explained homology model using beta 2 adrenergic receptor (${\beta}$2AR), the model was energetically minimized and validated by flexible ligand docking with known agonists and antagonists. In the active site Asp134, Ser138 of transmembrane 3 (TM3), Arg195 of extracellular loop 2 (ECL2) and Tyr358 of TM7 were found as important residues to interact with agonists. In addition to these, V208 of ECL2 and N351 of TM7 was found to interact with antagonists. Several conserved residues including Trp324, Phe327 and Phe328 were also found to contribute hydrophobic interaction. The predicted ligand binding mode is in good agreement with published mutagenesis and homology model data. This new template derived homology model can be useful for further virtual screening based lead identification.

• Journal of Advanced Navigation Technology
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• v.20 no.5
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• pp.462-467
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• 2016

Dispersion management (DM) combining with mid-spans spectral inversion (MSSI) is one of the various techniques compensating for the distorted optical signals. For the flexible implementation of this configured link, the compensation characteristics in the optical link with artificial distribution of the gradually ascending and descending of single mode fiber (SMF)'s lengths and residual dispersion per span (RDPS) as the number of fiber spans are assessed as a function of the control positions of net residual dispersion (NRD). It is confirmed that the best compensation is obtained by distributing gradually ascending or descending of SMF's lengths and RDPS capable to place NRD control position at fiber span, in which optical pulse width is most narrow.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.22 no.2
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• pp.162-168
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• 2008

In this paper, the RCF(Resistive Companion Form) analysis method is applied to analyze small signal stability of power systems including thyristor controlled FACTS(Flexible AC Transmission System) equipments such as TCSC(Thyristor Controlled Series Capacitor). The eigenvalue sensitivity analysis algorithm in discrete systems based on the RCF analysis method is presented and applied to the power system including TCSC. As a result of simulation, the RCF analysis method is very useful to precisely calculate the variations of eigenvalues or newly generated unstable oscillation modes after periodic switching operations of TCSC. Also the eigenvalue sensitivity analysis method based on the RCF analysis method enabled to precisely calculate eigenvalue sensitivity coefficients of controller parameters about the dominant oscillation mode after periodic switching operations in discrete systems. These simulation results are different from those of the conventional continuous system analysis method such as the state space equation and showed that the RCF analysis method is very useful to analyze the discrete power systems including periodically operated switching equipments such as TCSC.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.33B no.1
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• pp.144-152
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• 1996

In this paper, a pulse-mode digital multilayer neural network with a massively parallel yet compact and flexible network architecture is presented. Algebraicneural operations are replaced by stochastic processes using pseudo-random pulse sequences and simple logic gates are used as basic computing elements. The distributions of the results from the stochastic processes are approximated using the hypergeometric distribution. A statistical model of the noise(error) is developed to estimate the relative accuracy associated with stochastic computing in terms of mean and variance. Numerical character recognition problems are applied to the network to evaluate the network performance and to justify the validity of analytic results based on the developed statistical model. The network architectures are modeled in VHDL using the mixed descriptions of gate-level and register transfer level (RTL). Experiments show that the statistical model successfully predicts the accuracy of the operations performed in the network and that the character classification rate of the network is competitive to that of ordinary Back-Propagation networks.

• Journal of the HCI Society of Korea
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• v.1 no.1
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• pp.29-36
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• 2006

Tactile displays can provide useful information without disturbing others and are particularly useful for people with visual or auditory impairments. They can also complement other displays. In this paper, we present a new vibrotactile display device for wearable, mobile, and ubiquitous computing environments. The proposed vibrotactile device has a $5{\times}5$ array configuration for displaying complex information such as letters, numbers, and haptic patterns as well as simple directional ques and situation awareness alarms. Commercially available coin-type vibration motors are embedded vertically in flexible mounting pads in order to best localize vibrations on the skin. An embedded microprocessor controls the motors sequentially with an advanced tracing mode to increase recognition rate. User studies with the vibrotactile device on the top of the foot show 86.7% recognition rate for alphabet characters after some training. In addition, applying vibrotactile device to driving situation shows 83.9% recognition rate. We also propose some potentially useful application scenarios including Caller Identification for mobile phones and Navigation Aids for GPS systems while driving.

• Journal of the Korea institute for structural maintenance and inspection
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• v.19 no.3
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• pp.55-63
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• 2015

Post-installed concrete set anchors are installed after the concrete hardened. These anchors increasing usage in development of construction equipment and flexible construction. The anchor loaded in shearing exhibits various failure modes such as steel failure, concrete failure, concrete pryout, depending on the shear strength of steel, the strength of concrete, edge distance and anchor interval, etc,. In this study, the objective is to investigate the effects of the variations like anchor embedment depth, edge distance and concrete strength on experimental and finite element analysis of shear failure behavior of post-installed concrete set anchor for light load embedded in concrete. The results of embedment depth experiments show that concrete strength has much affection on the shallow embedment depth. Concrete strength has no much affection with anchor interval and edge distance parameter and both experimental results occurred same failure mode. By comparing the experimental results that occurred steel failure mode show that as strong as concrete strength are the displacement results are small.

• Structural Engineering and Mechanics
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• v.37 no.6
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• pp.671-684
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• 2011

Deciding on an optimal sensor placement (OSP) is a common problem encountered in many engineering applications and is also a critical issue in the construction and implementation of an effective structural health monitoring (SHM) system. The present study focuses with techniques for selecting optimal sensor locations in a sensor network designed to monitor the health condition of Dalian World Trade Building which is the tallest in the northeast of China. Since the number of degree-of-freedom (DOF) of the building structure is too large, multi-modes should be selected to describe the dynamic behavior of a structural system with sufficient accuracy to allow its health state to be determined effectively. However, it's difficult to accurately distinguish the translational and rotational modes for the flexible structures with closely spaced modes by the modal participation mass ratios. In this paper, a new method of the OSP that computing the mode shape matrix in the weak axis of structure by the simplified multi-DOF system was presented based on the equivalent rigidity parameter identification method. The initial sensor assignment was obtained by the QR-factorization of the structural mode shape matrix. Taking the maximum off-diagonal element of the modal assurance criterion (MAC) matrix as a target function, one more sensor was added each time until the maximum off-diagonal element of the MAC reaches the threshold. Considering the economic factors, the final plan of sensor placement was determined. The numerical example demonstrated the feasibility and effectiveness of the proposed scheme.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.12
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• pp.32-40
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• 2018

In order to avoid excessive vibration, it is required to carry out a vibration analysis of heat-exchanger/nuclear-reactor at the design stage. Information of eigen-frequency in the vibration problem is required to evaluate safety of heat-exchange/nuclear reactor. This paper describes a numerical method, Galerkin's method, to solve the eigenvalue problem occurred in a cantilever beam. The beam is restrained with added mass and spring at the free end or a node point of a mode shape. The numerical results of eigen-frequency were compared with simple analytical and experimental results given by simple approach and simple test, respectively. It is found that Galerkin's method is applicable to estimate the eigen-frequency of the cantilever beam. The frequencies become lower with increasing the added mass and the frequencies increase with the spring force. It is shown the heavy added mass has a role of support on the flexible tube. The eigen-frequency of the first mode, for the system with the added mass mounted at the free end, can be calculated by the approximate analytical method existing with more or less accuracy.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.18 no.6
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• pp.889-894
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• 1993

Asychronous Transfer Mode (ATM) provides the means to transport different types of bursty traffic such as voice, video, and bulk data. To handle more efficiently the traffic sources and to increase the bandwidth utilization as much as possible, flexible statistical multiplexing schemes must be adopted for the ATM networks. This paper presents an efficient computational procedure to calculate the queue state distribution in a finite buffer queueing system with a number of independent input sources, and the cell loss probability is exactly calculated with the use of this recursion computation method. The cell loss probability is related to a ATM multiplexer with a homogeneous ON-OFF source is also investigated through numerical examples.