• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.10
• /
• pp.4177-4183
• /
• 2015

Background: Gastric cancer is the second leading cause of cancer-related death in Asia, and the majority type is gastric adenocarcinoma (GAC). Most GAC patients die of recurrence and metastasis. Cancer stem cells (CSCs) have been thought to be responsible for the initiation, development, metastasis, and ultimately recurrence of cancer. In this study, we aimed to investigate expression and clinical significance of CSCs markers, CD133 and Lgr5, and vasculogenic mimicry (VM) in primary GAC. Materials and Methods: Specimens from 261 Chinese patients with follow-up were analyzed for CD133, Lgr5 protein expression and VM by immunohistochemical and histochemical staining. The Pearson Chi's square test was used to assess the associations among the positive staining of these markers and clinicopathological characteristics. Postoperative overall survival time was were studied by univariate and multivariate analyses. Results: In GAC tissues, positive rates of 49.0%, 38.7%, and 26.8% were obtained for CD133, Lgr5, and VM, respectively. The mean score of microvessel density (MVD) was $21.7{\pm}11.1$ in GAC tissues. There was a significantly difference between the positive and negative groups. There was a positive relationship between the VM, the expression of CD133 and Lgr5, and the score of MVD and the grades of tumor, lymph node metastasis, TNM stages (all p<0.05). The overall mean survival time of the patients with CD133, Lgr5, VM, and MVD (${\geq}22$) positive expression was lower than that of patients with negative expression. The score of MVD, positive expression of CD133 and VM were independent prognostic factors of GAC (p<0.05). Conclusions: VM, and expression of CD133, Lgr5, and the score of MVD are related to grades of tumor, lymph node metastasis, TNM stages, and overall mean survival time. It is suggested that CSCs and VM could play an important role in the evolution of GAC.

• Environmental Analysis Health and Toxicology
• /
• v.20 no.2 s.49
• /
• pp.109-121
• /
• 2005

A chemical ranking and scoring (CRS-Korea) system was developed and proposed to use as the first step to prioritize the toxic chemicals for the purpose of monitoring and detailed risk assessment that might follow as necessary. The CRS-Korea system takes a basic concept of risk assessment (both human health risk and ecological risk) in that risk score is determined by the product of toxicity score and exposure score. Included in the toxicity category are acute toxicity, chronic/sub -chronic toxicity, carcinogenicity, and other toxicity. The exposure category consists of quantity released to the environment, bioconcentration, and persistence. A consistent scheme and a comprehensive chemical data base are offered in the CRS-Korea system to calculate a score for the each component in the two categories by using specific physicochemical, fate, and toxic properties and the quantity of the chemical used. The toxicity score is obtained by adding up all the individual scores for the components in the toxicity category. The exposure score is determined by multiplication of the score of the quantity released with the sum of persistent score and bioconcentration score. Equal weight is given to the toxicity score and the exposure score. As the CRS-Korea system was applied to identify 50 national priority chemicals, it was found that significant data gap exists on toxicity and fate properties and that the uncertainty associated with estimating the quantify released to the environment is notably high. The proposed CRS system is only a screening tool in the first step toward the priority setting and should be used with expert judgement and other considerations necessary.

• Health Policy and Management
• /
• v.15 no.2
• /
• pp.53-69
• /
• 2005

This study has two different objectives. First of all is to comparing results of size efficiency scoring on Public Corporation Medical Center(PCMC) by years of 1993, 1997 and 2003 using Data Envelopment Analysis (DEA). The second is to explore the relationship between revenue and PCMCs' efficiency score, and the relationship between expenses and the efficiency score in 2003. The average efficiency scores were significantly decreased by years of 1993, 1997 and 2003. The revenue per bed(revenue) in 2003 was smaller than the expenses per bed(expenses) in 2003, therefore PCMCs had deficits in 2003. The expenses was negatively related to the efficiency score. Therefore its means was that improving efficiency score decreased expenses. Contrarily, the revenue had any significant relation to the efficiency score. PCMC needs to various endeavors to improve their productivity and efficiency. One of the alternatives is reduce of work load through integration of PCMC and development of new performance index reflecting their situation and future direction.

• Journal of Internet Computing and Services
• /
• v.6 no.2
• /
• pp.85-97
• /
• 2005

At th first time in 1985, Tetris appeared, it became game that are loved to many users until now. Existent Tetris employed way to give score according to number of that is destroyed whenever line are destroyed, and give advantage about serial attack and so on, But, these score calculation method gave so fixed and simple pattern. In this paper, We design and implement the new tetris game System by score calculation method per level that Is different with existent method. That Is, this method is to compare present and before with number of destroyed line and give advantage in basis score, Also, It is going to permit strategic utilization of still more developed tetris than existent tetris using score calculation method per level.

• Plant Resources
• /
• v.2 no.2
• /
• pp.75-80
• /
• 1999

Twenty two varieties of pecan including wild types were classified based on 6 characters measured by principal component analysis score distance. The results are summarized as fellow. Twenty two varieties were classified into 5 groups based in PCA score distance. Five groups were distinctly characterized by many morphological characters. Total variation could be explained by 51%, 95%, 99% with first, third and fifth principal components respectively. Varimax rotation of the factor loading of the first factors indicated that the first component was highly loaded with leaf characters, the second component with fruit characters, but fruit length was negative loaded. The second, the third and the fourths groups of cultivars had very close genetic parentage similarity.

• Korean Journal of Hospice Care
• /
• v.3 no.2
• /
• pp.1-11
• /
• 2003

Purpose: The purpose of this study was to find out the effect of hospice home care on the pain relief and quality of life of terminal cancer patients. Method: Experimental pre and post tests were provided to a single group to see the changes of quality of life of patients who were referred to a hospice home care department after having cancer treatment. They were visited at least 8 times for the duration of 4~6 weeks and were provided a 24 hour phone call service. 41 subjects were transferred to a hospice home care department after being discharged from hospital were selected. Result: 1)The first hypothesis that "the pain score of the subjects after receiving hospice home care would be different from before receiving hospice home care would be different from before receiving hospice home care" which scored 4.06 point at the first test and 3.41 at the second did not statistically show a significant difference(t=1.421 p=1.66), even though the pain score is decreased. 2)The 2nd hypotheses that "the quality of life score of the subjects after receiving hospice home care would be different from before receiving hospice home care" which scored 2.88 point at the first test and 3.39 at the second showed a significant difference(t=-6.759, p=.000) and was supported. Regarding the changes of quality of life score, social aspect(t=-5.745, p=.000), emotional aspect(t=-5.684, p=.000), and spiritual aspect(t=-6.889, p=.000) has significantly been increased, while physical aspect has been more decreased significantly than before the hospice home care is provided(t=4.282, p=.000). Conclusion: It was effective to provide hospice home care in relieving the terminal cancer patients' pain and in improving their quality of life, even though a short term hospice home care for 4-6 weeks was provided.

• The Korean Journal of Pain
• /
• v.10 no.1
• /
• pp.21-27
• /
• 1997

Background : Previous studies have proven beneficial in labor analgesia to use subarachnoid sufentanil(alone or with adjuvant) on parturients in early first stage of labor. We designed this prospective study to evaluate analgesic efficacy and side effects of subarachnoid sufentanil plus bupivacaine in women with cervical dilatation of 7 cm greater. Methods : This was an open-label, nonrandomized trial of 32 parturients in late first stage labor who requested labor analgesia. After signing the consent form each patient received subarachnoid sufentanil (10 ${\mu}g$) and bupivacaine (2.5 mg). Patients were asked to rate their verbal pain score (0-10 scale) before regional anesthesia and 5 minutes after subarachnoid injection, and every 20 minutes thereafter until delivery or request for additional analgesia. Blood pressure, pruritus, Bromage motor block score, mode of delivery and need for supplemental analgesics were recorded. Results : Thirty women were included in the study. Mean pain scores (mean${\pm}$SD) were $8.7{\pm}1.0$ pre-spinal, $0.7{\pm}1.5$ 5 minutes post-injection, and remained less than 5 for 130 minutes after spinal injection. Of 30 patients, 24 had unassisted vaginal delivery, 4 instrumental vaginal delivery (vacuum), and 2 cesarean delivery. Of 28 patients who delivered vaginally, 19 did not require supplemental analgesics and had a delivery pain score of 5 or lower. Blood pressure decreased in three patients after spinal analgesia (p<0.05), which necessitated treatment. The Bromage motor block score was 0 in 26 patients and 1 in 4 patients. Pruritus was noted in 22 patients. Conclusion : Subarachnoid sufentanil-bupivacaine provides rapid analgesia for an effective duration of approximately 130 minutes in parturients in late first stage of labor.

• Journal of Acupuncture Research
• /
• v.28 no.6
• /
• pp.43-51
• /
• 2011

Objectives : The purpose of this research was to investigate the effect of oriental medicine public-health program on frozen shoulder patients. Methods : Oriental medicine public-health program was done to 50 frozen shoulder patients who visited Eumseong-gun public health center. Oriental medicine treatment(twice a week for 12 weeks) and prevention-educaiton program was included in public-health program. The schedule was proceeded from 16th March 2010 to 3rd June 2010. The efficacy of program was measured by visual analog scale (VAS), ROM(range of motion), Apley scratch test and Life function score, sleep quality score of their first and last visit. Then we analyzed the improvement in the same group. Results : 1. In VAS change, program showed statistically significant improvement. 2. In ROM(flexion, extension, abduction, adduction) and apley scratch test, program showed statistically significant improvement. 3. In Life function score, program showed statistically significant improvement. 4. In sleep quality score, program also showed improvement, but didn't do statistical significans. Conclusions : The above results suggest that oriental medicine public-health program can be used as effective method for frozen shoulder's treatment and care.

• Journal of Trauma and Injury
• /
• v.28 no.3
• /
• pp.177-181
• /
• 2015

Purpose: Assessment of the trauma severity associated with the prognosis of trauma patients. But we are having a lot of difficulties in assess the severity because of scarcity of current first-aid records resources. Methods: We presumed that Applying the Revised trauma score which consist of vital signs and GCS score will be helpful to assess the sevirity.This study covers the 10069 patient of Ewah womans hospital (2011.1.1.-2014.12.31) who are able to verify the GCS score from fist-aid records. Results: There is no distinctions between prehospital RTS and hospital RTS. And shows high level of correlation between prehospital RTS and ISS. Conclusion: Therefore we conclude that checking the GCS and RTS at prehospital state will be help to assess the severity of trauma patients.

• Journal of the Korea Society of Computer and Information
• /
• v.21 no.4
• /
• pp.123-129
• /
• 2016

This study had a purpose to find the correlation between academic achievement and entrance examination score using FCA and framing a concept of university academic achievement and entrance examination score and then, building concept lattice. The subject for this analysis was admission materials of freshmen in computer engineering department at A university located in Chungcheong area in 2010. Also 56 students in total were subjects for the score analysis of their first semester from 2010 to 2014. The major findings of this study were as follows. We organized and extracted many-valued context, concept lattice, associated rules using FCA. And we analyzed the correlation between University academic achievement and entrance examination score using FCA. The conclusions were as follows. We could get meaningful analyzed results using FCA. University academic achievement had lower relativeness with entrance examination score and female students had higher university academic achievement than male students. The improvement points are summarized below. It is necessary to improve the ratio and application method of the university admission factors and to increase the regular admission for a university. And programs for completing College-preparatory programming for male students in low university academic achievement are necessary.