• IMMUNE NETWORK
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• 제15권4호
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• pp.177-185
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• 2015

Although rheumatoid arthritis (RA) is the most common chronic inflammatory autoimmune disease, diagnosis of RA is currently based on clinical manifestations, and there is no simple, practical assessment tool in the clinical field to assess disease activity and severity. Recently, there has been increasing interest in the discovery of new diagnostic RA biomarkers that can assist in evaluating disease activity, severity, and treatment response. Proteomics, the large-scale study of the proteome, has emerged as a powerful technique for protein identification and characterization. For the past 10 years, proteomic techniques have been applied to different biological samples (synovial tissue/fluid, blood, and urine) from RA patients and experimental animal models. In this review, we summarize the current state of the application of proteomics in RA and its importance in identifying biomarkers and treatment targets.

• 대한치과기공학회지
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• 제32권1호
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• pp.47-56
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• 2010

As Korea is entering an aging society, the number of elderly people who need new denture or who have problems with their existing denture or adjacent tissue is increasing and it will double in 2018. Therefore, denture clinician system will lessen patients financial burden and introduce market economy to the dental prosthesis field. Therefore, Korea needs to adopt denture clinician system as soon as possible as USA or Canada to increase people s accessibility in quality and quantity. Denture clinician will determine the size and shape of denture after performing oral examination, make impression using various materials, fabricate denture, deliver and adjust completed denture to the patient, repair denture, and carry out financial management in the denture fabricating company or manage human resources. Considering denture clinicians services, American and European education system seems to be close to our system. Therefore, in this study, basic curriculums of several countries in Europe and America were reviewed and curriculum that meets Korean situation was suggested.

• BMB Reports
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• 제48권4호
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• pp.200-208
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• 2015

The field of redox proteomics focuses to a large extent on analyzing cysteine oxidation in proteins under different experimental conditions and states of diseases. The identification and localization of oxidized cysteines within the cellular milieu is critical for understanding the redox regulation of proteins under physiological and pathophysiological conditions, and it will in turn provide important information that are potentially useful for the development of novel strategies in the treatment and prevention of diseases associated with oxidative stress. Antioxidant enzymes that catalyze oxidation/reduction processes are able to serve as redox biomarkers in various human diseases, and they are key regulators controlling the redox state of functional proteins. Redox regulators with antioxidant properties related to active mediators, cellular organelles, and the surrounding environments are all connected within a network and are involved in diseases related to redox imbalance including cancer, ischemia/reperfusion injury, neurodegenerative diseases, as well as normal aging. In this review, we will briefly look at the selected aspects of oxidative thiol modification in antioxidant enzymes and thiol oxidation in proteins affected by redox control of antioxidant enzymes and their relation to disease. [BMB Reports 2015; 48(4): 200-208]

• Asian Journal of Atmospheric Environment
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• 제10권2호
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• pp.114-123
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• 2016

A change in chemical compositions of Asian dust (AD) particles can dramatically alter their optical properties, cloud-forming properties, and health effects. The present study was undertaken to evaluate this aging of AD particles by means of two complementary methods (i.e., the traditional spot test and the most advanced micro-PIXE analytical technique) for single particle analysis. Size-classified particles were sampled at the rural peninsula of Korea (Byunsan, 35.37N; 126.27E) during AD event and non-AD period in 2004. Sulfate was principally enriched on the particles in the size range of $7.65-10.85{\mu}m$ collected during AD event. The average number fraction of coarse particles ($>2.05{\mu}m$) containing chloride was 16.2% during AD event. Relatively low particles containing nitrate compared to those containing sulfate and chloride were found in AD event. Micro-PIXE elemental maps indicated that a large number of AD particles were internally mixed with man-made zinc. The highest peaks of EC and OC concentrations were appeared at $0.01-0.43{\mu}m$ particle aerodynamic diameter. High EC concentration in $PM_1$ was might be caused by the Saemangeum Seawall Project that was being conducted during our field measurement.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제12권3호
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• pp.7-14
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• 2006

The purpose of this study was to analyze the elderly welfare facilities in Germany, which already entered into the aging society. Especially, the multipurpose and large elderly welfare facilities, where more than 50 elderly people lived, were analyzed. For this purpose, a field study was conducted between January 13 and February 3, 2005. This study tried to find out the architectural characteristics and trends of elderly welfare facility. There are about 9200 elderly welfare facilities in Germany, and about 7% of the elderly people over 65 years old live there. As for the multipurpose elderly welfare facilities, there are about 5800 facilities, 64% of the total facilities. The elderly welfare facility carries out single function at the early stage, and adds up another functions step by step. In general, the facility is managed with focusing on two main functions (care function and residential function). In a small town, the care function is the major one of the facility. However, in the city, the major functions of the facilities are both care and residential function, which are elderly residence or safeguard house.

• Journal of Pharmaceutical Investigation
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• 제37권2호
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• pp.85-94
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• 2007

The objective of this study is to prepare a stable delivery systems containing polyethoxylated retinamide(PERA) - derivatives of retinoic acid, effective anti-wrinkle and anti-acne agent. Cubic liquid crystalline phase gel (CLCPG) and cubosomes containing various concentrations of PERA were prepared to investigate the physicochemical properties. Furthermore, stability and transdermal absorption efficacy of the CLCPG containing PERA were investigated in comparison with oil-in-water (O/W) emulsions which are predominantly used as a topical formulation. CLCPG increase the stability of PERA in comparison with O/W emulsion. For tropical application, CLCPG containing PERA shows higher moisturizing effect than that of O/W emulsion. In skin permeation test, CLCPG shows higher PERA deposit on epidermis. With its specific physicochemical property caused by the glyceryl oleate, CLCPG itself could be used for stabilizer of various actives and applied as an effective delivery system for topical application. Cubosome, nano-sized dispersed CLCPG, is also expected to be applied in a various field of industry like food, cosmetics and pharmaceuticals.

• 정보관리학회지
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• 제32권3호
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• pp.341-360
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• 2015

노령화사회에서 노인을 위한 서비스는 도서관의 새로운 도전이다. 본 연구는 노인의 독서 장애요인과 노안에 대해 살펴보고, 노인의 독서를 용이하게 만드는 한글 큰글자도서의 출판과 수집 및 이용가능성을 조사하였다. 큰글자도서의 출판과 유통에 대하여는 국립중앙도서관 소장 서지리스트와 교보문고의 재고리스트를 기초로 하고, 공공도서관에서 접근가능한 큰글자도서는 한국도서관협회가 보급한 큰글자도서 리스트와 기존의 도서관 장애인서비스 현황조사 데이터를 기초로 하여, 이용가능한 큰글자도서의 유형, 종수와 권수, 출판연도, 주제, 중복성 등을 분석하였다. 분석결과에 따라 문제점을 식별하고 큰글자도서의 서지통정, 수집 확대, 도서관의 노인 독서 진흥 방안 및 후속 연구를 제언하였다.

• 패션비즈니스
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• 제11권1호
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• pp.75-85
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• 2007

This study aims to develop the hospital clothing for dementia patient, which can bring them higher quality of life by giving them psychological and emotional satisfaction. As for the research method and contents, the authors searched the characteristics of aging society and dementia patient, mainly concentering on the related researches and publications. In addition, the characteristics of current domestic clothes design trend for dementia patient and design preference were studied by looking into previous studies. Also, on the characteristics of overseas design was examed by looking into sites on dementia, actual clothes and related catalogues. The development and evaluation of the design of clothes for dementia patient was conducted and which was based on the above researches. Then, the patients hospital clothing was designed and made. And also the discussion was followed with related field experts such as medical doctor and nurses, carer-givers, patient clothing manufacturers and professors of clothing textiles. Finally the authors designed and manufactured six patient clothes including one for male, one for female, two for common use in hospital, one for disable male dementia and one for disable female dementia. The developted clothes got high marks on beauty and symbolism in the evaluation by the experts. The design development of dementia patient clothes in this research will help the dementia patients' psychological comfortness and social protection.

• The Korean Journal of Physiology and Pharmacology
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• 제24권2호
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• pp.129-135
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• 2020

SHP2 is an unusual protein phosphatase that functions as an activator for several signaling pathways, including the RAS pathway, while most other phosphatases suppress their downstream signaling cascades. The physiological and pathophysiological roles of SHP2 have been extensively studied in the field of cancer research. Mutations in the PTPN11 gene which encodes SHP2 are also highly associated with developmental disorders, such as Noonan syndrome (NS), and cognitive deficits including learning disabilities are common among NS patients. However, the molecular and cellular mechanism by which SHP2 is involved in cognitive functions is not well understood. Recent studies using SHP2 mutant mice or pharmacological inhibitors have shown that SHP2 plays critical role in learning and memory and synaptic plasticity. Here, we review the recent studies demonstrating that SHP2 is involved in synaptic plasticity, and learning and memory, by the regulation of the expression and/or function of glutamate receptors. We suggest that each cell type may have distinct paths connecting the dots between SHP2 and glutamate receptors, and these paths may also change with aging.

• 한국농촌건축학회논문집
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• 제15권2호
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• pp.41-51
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• 2013

In the midst of growing demand for rural life of urban dwellers, this study tried to investigate the difference in behavior and recognition about urban rural exchange between Korea and Japan. For this, this study utilized 2,000 total samples of the survey conducted by MLIT in Japan, because Japan has experienced a low birth rate and aging population earlier and actively promoting urban rural exchange program than South Korea. The result of the analysis is as follows. First, the needs for rural life of urban dwellers are similar both in Japan and South Korea. However, Japanese prioritize future efforts to current efforts. Second, urban dwellers' activities in rural areas were classified into three categories; field trips and hands-on activities, cruise and circulating activities, and leisure activities. Third, similarly three types of visit or intercourse of urban dwellers into rural areas were classified; repeatedly visit the same place as 'iterative type', visit a new place as 'new pioneer type', and not yet determined as 'undefined type'. Variables such as age of household, income, number of inmate, and number of children were analyzed linked to these three types of visit or intercourse in a Discriminant analysis. As a result, only 'age of household', however, turned out to be the crucial factor which influence decisively distinguishing characteristics of these three types of visit into rural areas.