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http://dx.doi.org/10.4333/KPS.2007.37.2.085

Preparation and Evaluation of Cubic Liquid Crystalline Phase Gel and Cubosome containing Polyethoxylated Retinamide  

Kyong, Kee-Yeol (Cosmetics R&D Center, LG H&H Ltd.)
Jee, Ung-Kil (College of Pharmacy, Chungnam Natioinal University)
Cho, Wan-Goo (College of Alternative Medicine, Jeonju University)
Publication Information
Journal of Pharmaceutical Investigation / v.37, no.2, 2007 , pp. 85-94 More about this Journal
Abstract
The objective of this study is to prepare a stable delivery systems containing polyethoxylated retinamide(PERA) - derivatives of retinoic acid, effective anti-wrinkle and anti-acne agent. Cubic liquid crystalline phase gel (CLCPG) and cubosomes containing various concentrations of PERA were prepared to investigate the physicochemical properties. Furthermore, stability and transdermal absorption efficacy of the CLCPG containing PERA were investigated in comparison with oil-in-water (O/W) emulsions which are predominantly used as a topical formulation. CLCPG increase the stability of PERA in comparison with O/W emulsion. For tropical application, CLCPG containing PERA shows higher moisturizing effect than that of O/W emulsion. In skin permeation test, CLCPG shows higher PERA deposit on epidermis. With its specific physicochemical property caused by the glyceryl oleate, CLCPG itself could be used for stabilizer of various actives and applied as an effective delivery system for topical application. Cubosome, nano-sized dispersed CLCPG, is also expected to be applied in a various field of industry like food, cosmetics and pharmaceuticals.
Keywords
Polyethoxylated retinamlde; Cubic liquid crystalline phase gel; Cubosome; Delivery; Glyceryl oleate; Anti-aging;
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  • Reference
1 O.-H. Mills and A.-M. Kligman, Treatment of acne by vitamin A (Retinol). Seminars in Derm., 1, 245-249 (1982)
2 W. Leesajakul, M. Nakano, A. Taniguchi and T. Handa, Interaction of cubosome with plasma components resulting in the destabilization of cubosomes in plasma, Colloids and Surfaces B: Biointerfaces, 34, 253-258 (2004)   DOI   ScienceOn
3 E.-J. Van Scott and R.-J. Yu, Alpha hydroxy acids: therapeutic potentials, Canadian J. Dermatol., 1, 108-112 (1989)
4 E. Tom, Long term effects after topical application of active palmitate, J. Appl. Cosmetol., 12, 25-30 (1994)
5 Y-S. Song, B-Y. Chung, S-G. Park, M-E. Park, S-J. Lee, W-G. Cho and S-H. Kang, Polyethoxylated retinamide as an anti-wrinkle agent, Cosmetics and Toiletries, 114(6), 53-58 (1999)
6 H. Oikarinen, A. Oikarinen, E. Tan, R. Abergel and C. Meeker, Modulation of procollagen gene expression by retinoids, J Clin. Invest., 75, 1545-1553 (1985)   DOI
7 R. Beach and C. Kenny, Vitamin A augments collagen production by corneal endothelial cells, Biochem. Biophys. Res. Commun., 114, 395-402 (1983)   DOI   ScienceOn
8 M. Tanaka, Recent development of skincare products in japan from the biological standpoint, Fragrance J., 9, 13-23 (1994)
9 S.-G. Alderson, M.-D. Barratt and J.-G. Black, Effect of 2hydroxy acids on guinea-pig footpad stratum corneum, Int. J. Cosmet., Sci., 6, 91-100 (1984)   DOI   ScienceOn
10 A.-M. Kligman, Topical tretinoin: indications, safety, and effectiveness, Cutis., 39(6), 486-488 (1987)
11 T. Shukuwa, A.-M. Kligman, M. Christenser and T. Stoudemayer, The effect of short-term topical tretinoin on photo-damaged skin, J. Dermatological Science, 4, 2, 137-146 (1992)
12 P. Morganti, B. James and S. D. Randazzo, The effect of gelatin-glycine on skin hydration, J. Appl. Cosmetol., 8, 81-88 (1990)
13 J. Schreiber and H. Albrecht, Hair care products with disperse liquid crystals exhibiting the cubic phases, DE Patent App. 10,057,769 (2002)
14 J.-H. Fendler, Membrane mimetic chemistry, Wiley Intersciences. New York, USA, pp. 158-18 (1982)
15 R.-M. Handjani-Vila, A. Riber, B. Rondot and G. Banlerghie, Dispersions of lamellar phase of non-ionic lipids in cosmetic products, Int. J. Cosmet. Sci., 1, 303-314 (1979)   DOI   ScienceOn
16 L. Tomas and L. Kare, Particles, method of preparing said particles and uses thereof, US Patent 5,531,925 (1996)
17 M. Nakano, A. Sugita, H. Matsuoka and T. Handa, Small-angle X-ray scattering and $^{13}C$ NMR investigation on the internal structure of Cubosomes, Langmuir, 17, 3917-3922 (2001)   DOI   ScienceOn
18 E. Esposito, M. Drechsler, P. Mariani, E. Sivieri, R. Bozzini, L. Montesi, E. Menegatti and R. Cortesi, Nanosystems for skin hydration: a comparative study, International J. of Cosmetic Science, 29, 39-47 (2007)   DOI   ScienceOn
19 P.- T. Spicer and K.-L. Hayden, Novel process for producing cubic liquid crystalline nanoparticles (Cubosomes), Langmuir, 17, 5748-5756 (2001)   DOI   ScienceOn
20 M. Almgren, K. Edwards and J. Gustafsson, Cryo transmission electron microscopy of thin vitrified samples. Curr. Opin. Colloid Interface Sci., 1, 270-278 (1996)   DOI   ScienceOn
21 M. Almgren, K. Edwards and G. Karlsson, Cryo transmission electron microscopy of liposomes and related structure, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 174, 3-21 (2000)   DOI   ScienceOn