• Journal of Sensor Science and Technology
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• v.24 no.5
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• pp.311-318
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• 2015

The excess use and generation of various toxic gases from many industrial complexes and plant facilities have increased the possibility of leakage or explosion accidents, which can cause fatal damage to human beings in the wide range of neighboring area. To prevent the exposure to the fatal toxic gases, it is very important to monitor the leakage of toxic gases using gas sensors in real time. Various types of gas sensors, which can be classified as semiconductor, electrochemical, optical, and catalytic combustion types according to the operating principles, have been developed. In this review, the operation principles of gas sensors are explained and the performance of those sensors is compared. The state-of-the-art gas sensor technologies developed by research institutes or companies are reviewed also.

• Proceedings of the Society of Korea Industrial and System Engineering Conference
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• 2002.05a
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• pp.25-30
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• 2002

The problem of qualitative reliability system is very important issue in the digitalized nuclear power plant, because the failure of its system brings about extravagant economic loss, extensive environment destruction, and fatal damage of human. Therefore this study is to develop the reliability evaluation model through the normalized scoring model by the quantitative and qualitative factors considering the advanced safety factors In the Advanced Pressurized water Reactor 1400MWe(APR 1400) under uncertainty Especially, the qualitative factors considering the information and human factors for the systematic and rational justification have been closely analyzed. The reliability evaluation model can be simply applied in real fields in order to minimize the industrial accident and human error in the digitalized nuclear power plant.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.25 no.6
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• pp.23-35
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• 2002

The problem of system reliability is very important issue in the digitalized nuclear power plant, because the failure of its system brings about extravagant economic loss, environment destruction, and fatal damage of human. Therefore the purpose of this study has developed the reliability evaluation model through the scoring model by the quantitative and qualitative factors in order to justify the evaluation considering the advanced safety factors in the Advanced Pressurized water Reactor 1400MWe(APR 1400MWe) under uncertainty. Especially, the qualitative factors considering the human, information control, and quality factors for the systematic and rational justification have been closely analyzed. The proposed model can be simply applied in real fields in order to minimize the industrial accidents in the digitalized nuclear power plant.

• Toxicological Research
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• v.31 no.1
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• pp.33-40
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• 2015

Bee venom (BV) has long been used in traditional Eastern and Western medicine for chronic inflammation, pain and skin therapy. Human exposure to BV, however, often causes unwanted adverse effects and is even fatal in some cases. Phospholipase $A_2$ ($PLA_2$) of BV is now suspected to play a key role in these adverse effects. We investigated the potential use of $PLA_2$-free bee venom (PBV) as a replacement for BV in cosmetic products. PBV prepared by molecular weight cut-off ultrafiltration exhibits a superior profile in comparison with regular BV, by inhibiting elastase activity and suppressing the induction of nitric oxide (NO) and metalloproteinase-9 (MMP-9), while retaining the effects of cell proliferation and protection against ultraviolet B (UVB)-induced damage in human dermal fibroblast cells. PBV thus appears to be more promising than BV as a cosmetic ingredient with a reduced potential for adverse reactions in the recipient.

• Journal of the East Asian Society of Dietary Life
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• v.9 no.2
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• pp.230-244
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• 1999

1) Table salt (=NaCl=common salt=salt) is scientifically characterized, and the significant role in dietary and daily life has generally been discussed from the standpoint of human ecology. 2) In dietary life, salt fundamentally gives a deliciousness to dishes and nutro-physiologically functions to keep homeostasis in the body. Meanwhile, the excessive intake of salt often causes the high blood pressure and induces several fatal diseases. 3) In daily life, salt derivatives(Na-, Cl-compound) are quite useful widely over food, clothing and housing. Meanwhile, some of them especially organochlorine compounds often pollute the environment and damage the humans and or ecology as so-called environmental hormone resulting in dioxins. 4) For the ambivalence of salt in health and environment, humans, but not salt, are wholly responsible. The fact would go not only to salt but also generally to resources on the earth. 5) Humans should adequately be moderate in utilizations and consumptions of salt and or resources. Everything must be kept with in bounds. This conception would surely bring the stable maintenance and the sound development to the system of human ecology as well as global ecology.

• Journal of the Korea Society for Simulation
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• v.29 no.3
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• pp.1-8
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• 2020

When enemy drones infiltrate large urban areas, various forms of great republics are deployed in large areas to respond. Due to the characteristics of a large number of government-run aircraft, the residual coal, other than the hit bullet, falls into various sizes of debris after its own explosion. The damage rate was analyzed by dividing the debris into anti-aircraft guns and guided weapons by deriving four factors: critical speed, fragmentation mass, initial speed of debris, and object collision speed, which can cause damage to human life as the debris falls to the ground. In the future, the North is expected to infiltrate the capital city of Seoul by operating unmanned aerial vehicles, which are asymmetric forces, and the damage could be minimized by setting up pre-fatal and fire-restricted zones to minimize casualties between responses.

• Proceedings of the Safety Management and Science Conference
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• 2009.04a
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• pp.35-43
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• 2009

The specific feature of trains as a means of transportation is that, on one side, at once they can carry big loads but, at the same time, if an accident occurs, it potentially leads to many human casualties or big material losses. Especially, train accidents caused by bad weather conditions result in many fatal losses of human lives and property. In Korea many railways run either in mountainous areas or along rivers thus making them especially susceptible to natural hazards. The types of damages inflicted by heavy rains resulting from rapidly changing meteorological conditions are diverse; and not only their scope is big but also they repeat regularly. Consequently, this study analyses the reasons why such effects of heavy rains on the railway conditions, damage to the railways caused by heavy rains or cases of stone fall as well as other types of accidents are not avoided. Study also, on the basis of laws related to movement in poor weather conditions and specifics of train braking, identifies systematic and technical problems and suggests and emphasizes new complex measures on their prevention.

• Journal of the Korea Safety Management & Science
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• v.11 no.1
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• pp.1-6
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• 2009

The specific feature of trains as a means of transportation is that, on one side, at once they can carry big loads but, at the same time, if an accident occurs, it potentially leads to many human casualties or big material losses. Especially, train accidents caused by bad weather conditions result in many fatal losses of human lives and property. In Korea many railways run either in mountainous areas or along rivers thus making them especially susceptible to natural hazards. The types of damages inflicted by heavy rains resulting from rapidly changing meteorological conditions are diverse; and not only their scope is big but also they repeat regularly. Consequently, this study analyses the reasons why such effects of heavy rains on the railway conditions, damage to the railways caused by heavy rains or cases of stone fall as well as other types of accidents are not avoided. Study also, on the basis of laws related to movement in poor weather conditions and specifics of train braking, identifies systematic and technical problems and suggests and emphasizes new complex measures on their prevention.

• Journal of the Korean Institute of Gas
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• v.17 no.6
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• pp.83-89
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• 2013

Energy industry facilities can cause fatal damage for internal industry employee as well as external general people because handling various kinds of gas and harmful substance might be spread to large scale severe accident by fire, explosion, and toxic gas leakage. In order to prevent these accidents, quantification by damage effect on structure and human is tried by using quantitative risk assessment, but it is difficult to process instantly exceptional cases and requires knowledge of expert. This paper aims to minimize exceptional cases and knowledge of expert, and present risk with human perceptible. So, we designed and developed zone-base risk analysis system that can compute risk of zone in real time at that point using database and incremental model.

• Tuberculosis and Respiratory Diseases
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• v.87 no.1
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• pp.52-64
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• 2024

Chronic respiratory diseases such as idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and respiratory infections injure the alveoli; the damage evoked is mostly irreversible and occasionally leads to death. Achieving a detailed understanding of the pathogenesis of these fatal respiratory diseases has been hampered by limited access to human alveolar tissue and the differences between mice and humans. Thus, the development of human alveolar organoid (AO) models that mimic in vivo physiology and pathophysiology has gained tremendous attention over the last decade. In recent years, human pluripotent stem cells (hPSCs) have been successfully employed to generate several types of organoids representing different respiratory compartments, including alveolar regions. However, despite continued advances in three-dimensional culture techniques and single-cell genomics, there is still a profound need to improve the cellular heterogeneity and maturity of AOs to recapitulate the key histological and functional features of in vivo alveolar tissue. In particular, the incorporation of immune cells such as macrophages into hPSC-AO systems is crucial for disease modeling and subsequent drug screening. In this review, we summarize current methods for differentiating alveolar epithelial cells from hPSCs followed by AO generation and their applications in disease modeling, drug testing, and toxicity evaluation. In addition, we review how current hPSC-AOs closely resemble in vivo alveoli in terms of phenotype, cellular heterogeneity, and maturity.