• Toxicological Research
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• v.23 no.3
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• pp.207-214
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• 2007

Chronic oxidative stress produced by exposure to environmental chemicals or pathophysiological states can lead animals to aging, carcinogenesis and degenerative diseases. Indirect antioxidative mechanisms, in which natural or synthetic agents are used to coordinately induce the expression of cellular antioxidant capacity, have been shown to protect cells and organisms from oxidative damages. Electrophile and free radical detoxifying enzymes, which were originally identified as the products of genes induced by cancer chemopreventive agents, are members of this protective system. The NFE2 family transcription factor Nrf2 was found to govern expression of these detoxifying enzymes, and screening for Nrf2-regulated genes has identified many gene categories involved in maintaining cellular redox potential and protection from oxidative damage as Nrf2 downstream genes. Further, studies using Nrf2-deficient mice revealed that these mutant mice showed more susceptible phenotypes towards exposure to environmental chemicals/carcinogens and in oxidative stress related disease models. With the finding that cancer chemopreventive efficacy of indirect antioxidants (enzyme inducers) is lost in the absence of Nrf2, a central role of Nrf2 in the antioxidative protective system has been firmly established. Promising results from cancer prevention clinical trials using enzyme inducers propose that pharmacological interventions that modulate Nrf2 can be an effective strategy to protect tissues from oxidative damage.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.12
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• pp.400-413
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• 2017

It is necessary for inmates released from prison to recover their career capital in order to function normally in society. Failure to adapt to the society may not only make them unhappy but could also aggravate social safety nets. Therefore, it is critical to examine the recovery of career capital. For this study, we conducted in-depth interviews of 10 rehabilitation recipients who were supported by Korea Rehabilitation Agency. For qualitative analysis, several career topics were analyzed, such as obstacles in recovering career capital, efforts in overcoming these obstacles, what is helpful for them to overcome the obstacles and what is required for them to adapt to the career life and others. Analysis results found that the rehabilitation beneficiaries suffered loses to their career capital due to their incarceration, suffered from the loss of pride and became despondent in the process of recovery of career capital due to the negative social perception toward their social self, fear of social stigma and devaluation of themselves. In addition, the fear of possible negative evaluation was a critical factor in making their social activities more challenging. Conversely, it was found that social support in the recovery process of career capital has a positive effect. In particular, emotional support from spouses, employers, family members and friends are the most positive factors. Concerning efforts at adapting to careers, it was found that an active, leading and positive attitude toward the career were critical, showing that positive evaluation and recognition in family and social relations and the experience of success in the career were positive elements in enhancing a sense of pride. In summary, it was found that in the recovery process of career capital, dysfunctional beliefs had a negative effect, while social support had a positive effect, on the recovery of career capital.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.2
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• pp.440-451
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• 2021

The purpose of this study is to develop and validate the parental roles and responsibilities for young children. A survey was conducted on 301 parents with children attending preschools. The parental roles and responsibilities scale were determined from a total of 60 items and 11 sub-factors based on the criteria for goodness, validity, and reliability of items (i.e., factor load ≥ 0.5; AVE ≥ 0.5; CR ≥ 0.7; Cronbach's alpha ≥ 0.7). The parental roles and responsibilities scale include 'hygiene management' (4 items), 'physical activities' (6 items), 'survival and health care' (6 items), 'cognitive development' (5 items), 'emotional stability' (5 items), 'social skills' (6 items), 'social norms and values' (7 items), 'physical environment' (5 items), 'protection' (5 items), 'family community consciousness and family tradition' (4 items), and 'the role and responsibility of parents for childcare institutions' (7 items). It is significant that the indicators on the parental roles and responsibilities for young children were developed and verified to fit the situation in Korea. Findings will help identify the characteristics of parental role responsibilities and serve as a basis for efficient communication between parents and preschoolers.parental role responsibilities and serve as a basis for efficient communication between parents and preschools.

• Food Science and Preservation
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• v.21 no.2
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• pp.254-263
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• 2014

This study was carried out to analyze the effects of water and 70% ethanol extract on the antioxidative and antidiabetic activities of Smilax china L., a vine shrub belonging to the lily family. The activities of the extracts were measured based on the total phenolic and flavonoid contents and through on the results of the antioxidant tests, such as the electron-donating ability, ABTs radical scavenging activities, SOD-like activity, xanthine oxidase inhibition effect, antioxidant protection factor (PF), TBARs content and ACE inhibition activity, and ${\alpha}$-glucosidase, and ${\alpha}$-amylase inhibition activity. The resulting total phenolic and flavonoid contents of the 70% ethanol extract from S. china L. were greater than those of the water extract from S. china L. With regard to the results of the antioxidant tests, such as the electron-donating ability, ABTs radical scavenging activity, SOD-like activity, xanthine oxidase inhibition effect, antioxidant protection factor (PF), and TBARs content, those from the 70% ethanol extract from S. china L. were greater than those from the water extract from S. china L. Also, with regard to the ACE inhibition effect and ${\alpha}$-glucosidase and ${\alpha}$-amylase inhibition, those from the 70% ethanol extract from S. china L. were greater than those from the water extract from S. china L. All these findings show that the 70% ethanol extract from S. china L. has greater antioxidative and antidiabetic effects and can be used as a preventive agent for oxidation and diabetes.

• Journal of Korean Society of Rural Planning
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• v.21 no.2
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• pp.163-175
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• 2015

This study aimed to analyze factors of importance and performance picked by customers of Bibijeong, a farm restaurant operated by the local community of Wanju-gun. Major points include: Recognition paths mostly were word of mouth and mass media, types of visit were in the company of friends, family members or work colleagues, and purposes of visit included consumption of meal and identifying features of the restaurant. Secondly, factor analysis showed that level of facility, atmosphere/cleanness, diversity of menu, employees, ingredients and network. The Cronbach Alpha coefficient was +0.6. Thirdly, average of importance of factors was 3.861 while average performance was 3.429. IPA analysis showed that employee(communication, customer contact) in the first quadrant proved the need for fast improvement through training. Atmosphere/cleanness (interior atmosphere, table clean, kitchen cleanliness, clean dishes, interion design) and employee(proficiency, menu recognition), foodstuff(freshness, origin, safety) in the second quadrant showed that the marketing strategy of improvement as well as maintaining current status is needed, including regular training and hygiene inspection. The third quadrant contains facilities(disability, baby, fire protection) and food menu(food packing, various menu, creative menu, menu description), network(village economic links), which showed the need for gradual improvement. The forth quadrant contains network(sights's near contains. The results so far can be summed into the statement that overcoming the basic functionality of providing meals and linking the restaurant with local attractions and local economy would be need, as well as building up the image of unique farm restaurant with local features, so that Bibijeong can serve as the centerpiece of community and foundation of exchange with other areas.

• Molecular & Cellular Toxicology
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• v.1 no.2
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• pp.73-77
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• 2005

Nickel is the one of potent environmental, the occupational pollutants and the classified human carcinogens. It is a serious hazard to human health, when the metal exposure. To prevent human diseases from the heavy metals, it is seemingly important that understanding of how nickel exerts their toxicity and carcinogenic effect at a molecular and a genomic level. The process of nickel absorption has been demonstrated as phagocytosis, iron channel and diffusion. Uptaked nickel has been suggested to induce carcinogenesis via two pathways, a direct DNA damaging pathway and an indirect DNA damaging pathway. The former was originated from the ability of metal to generate Reactive Oxygen Species (ROS) and the reactive intermediates to interact with DNA directly. Ni-generated ROS or Nickel itself, interacts with DNAs and histones to cause DNA damage and chromosomal abnormality. The latter was originated from an indirect DNA damage via inhibition of DNA repair, or condensation and methylation of DNA. Cells have ability to protect from the genotoxic stresses by changing gene expression. Microarray analysis of the cells treated with nickel or nickel compounds, show the specific altered gene expression profile. For example, HIF-I (Hypoxia-Inducible Factor I) and p53 were well known as transcription factors, which are upregulated in response to stress and activated by both soluble and insoluble nickel compounds. The induction of these important transcription factors exert potent selective pressure and leading to cell transformation. Genes of metallothionein and family of heat shock proteins which have been known to play role in protection and damage control, were also induced by nickel treatment. These gene expressions may give us a clue to understand of the carcinogenesis mechanism of nickel. Further discussions on molecular and genomic, are need in order to understand the specific mechanism of nickel toxicity and carcinogenicity.

• Journal of the Korean Society of Clothing and Textiles
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• v.30 no.1 s.149
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• pp.20-30
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• 2006

The purposes of this study were to investigate demographic profiles between the consumer group under high time pressure(HTP) and the group under low time pressure(LTP) during the shopping, to examine the level of association between the fashion information sources and time pressure variable, to determine the difference in clothing benefits sought between HTP and LTP, and to determine the difference in purchase criteria. We distributed questionnaires to 600 women aged in 20-65. The reliable 562 questionnaires were used for a statistical analysis. Data analyses were conducted with SPSS program on t-test, cluster analysis, factor analysis, and Chi square test. We obtained the following results: There was a significant association between demographic variables such as age, occupation, education, residence area, & family cycle and time pressure variable. Fashion information sources were classified into 4 factors. HTP searched information on fashion products using more various sources than LTP did. There was also a significant difference between HTP and LTP in clothing benefit sought. Four clothing benefit factors such as trendy/social position, economic value, protection/comfort, and makeup of body shape were sought more by HTP than by LTP. In addition, HTP considered significantly more purchase criteria such as color/pattern, comfort, quality, suitability, material, sewing finishing, coordination, price, brand, easy care, and country of origin than LTP.

• Korean Journal of Social Welfare
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• v.69 no.4
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• pp.75-97
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• 2017

This study examined the effect of female adolescent's the victimization experience of sexual assault to suicidal ideation. Futhermore, defined the moderation effects of parent-adolescent TSL communication in associations between the victimization experience of sexual assault and suicidal ideation. Participants were 1,032, South Korea middle and high school Female students in a national community sample. Data was analyzed by multiple-regression analysis with SPSS 18.0. The results indicates that the victimization experience of sexual assault was 16.2%. There is a positive relationship between victimization experience of sexual assault and suicidal ideation. Also, parent-adolescent TSL communication had a moderating effect of protection factor between sexual assault and suicidal ideation. Result show, the solution for prevention on sexual assault of adolescent is to open the discussion regarding the solution and improvement of family function in order to reduce the frequency of suicidal ideation.

• Journal of the Korean Institute of Landscape Architecture
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• v.41 no.5
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• pp.38-45
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• 2013

Buffer green space in the residential area is a mechanism for improving the residential environment and also significant for residential life satisfaction and its various social roles. Accordingly, this study aimed to discover the effect of the buffer green space, which was established to minimize environmental influences of the residential environment, on residential life satisfaction. For this purpose, a survey was conducted on residents in Myeongji Residential Area where the buffer green space was installed, to examine the factors of the buffer green space and to analyze its causal relation with residential life satisfaction. The SPSS(statistical package for social science) 21 program was used for analysis and factorial analysis, correlation analysis and multiple regression analysis were executed. As a result, the roles of the buffer green space in Myeong-ji Residential Area included residential comfort, disaster protection, green space usability and environmental ecological property. In the overall accrued factorial contribution rate, residential comfort was very high with 40.54% out of total 62.48%. In addition, the residential comfort and green area usability had a higher correlation with residential life satisfaction. However, the significant level of disaster protection and environmental ecological property were 0.725 and 0.898, respectively, which were not significant as a preference factor in multiple regression analysis. Accordingly, the buffer green space for improving residential comfort and green space usability was confirmed to enhance residential life satisfaction.

• Journal of Korean Home Economics Education Association
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• v.25 no.1
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• pp.137-153
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• 2013

The purpose of this study was to research the influence of experienced school violence as a victim on the coping behavior of adolescents and to investigate moderating effects of self regulatory ability which are the desirable coping behaviors as protection factor for adolescents who experienced as victim by school violence. The subjects of this study were 319 students from year 1 to year 3 of total 6 middle schools who experienced school violence as a victim in Daegu and the research tool is questionnaires which are consist of general characteristics of the subjects, experience of school violence scale, self regulatory ability scale, family healthy scale and coping behavior scale. In order to analyze the data of the study, factor analysis, relational regression, linear regression analysis and moderated multiple regressions were used. The main results of this study were as following. First, there was significant correlation between the adolescents who experienced school violence, self regulatory ability and the coping behaviors. Second, adolescents who experienced school violence as victim act more aggressive coping behavior than other coping behavior. Third, while experience of school violence as victim influence adolescents' coping behaviors, it was found that self regulatory ability affect role in the regulation. cognitive self regulatory ability are in charge of controlling the aggressive coping behaviors.