• Pediatric Infection and Vaccine
• /
• v.16 no.1
• /
• pp.24-30
• /
• 2009

The vaccines has been developed over the first two hundred years since Jenner's smallpox vaccination. In modern days, vaccination has had the largest impact on the incidence and persistence of infections. Although natural infection induces lifelong immunity, the assumption that the vaccine also confers permanent protection has been reconsidered following outbreaks of measles in students who had been vaccinated 15-20 years prior to infection in the US in the 1980s. Clinical studies have proposed several mechanisms such as vaccine failure in some individuals and the subsequent loss of immunity after vaccination. An ideal vaccine is relatively easy to define, but few real vaccines approach the ideal. Many difficulties account for the failure in producing these ideal vaccines. However, recent advances in methods for studying immune response to pathogens have provided a better understanding of immune mechanisms. Based on these findings, the development of good vaccine formulations allowing stimulation of optimal and prolonged protective immunity and immunization policies or schedules should lead to the introduction of vaccines for previously resistant organisms.

• Nuclear Engineering and Technology
• /
• v.17 no.1
• /
• pp.53-67
• /
• 1985

The severe core meltdown accident, which is not included as a design basis accident, has high consequence and low probability of occurrence and turns out to be a major risk factor in the overall risk assessment. The physical mechanisms of containment failure in core meltdown accidents are identified as steam explosion, debris bed coolability, hydrogen burning, steam spike and concrete interaction. The state of technology review is made for each subtopic about the previous and current researches for better understanding of the phenomenon.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.12 no.1
• /
• pp.187-196
• /
• 1992

This paper estimates the bearing capacity of the eccentrically loaded footing by the upper bound of limit analysis method. Meyerhof method and Saran method used the limit equilibrium method in the estimation of bearing capacity. But, in this study the bearing capacity is estimated by the upper bound method. In applying the upper bound, the result depends on the failure mechanism. So this analysis uses the conventional failure mechanisms or the modified failure mechanisms. The comparisions are made between the results from this analysis and those obtained from the limit equilibrium method. Also, the influences of the parameters-eccentricity, internal friction angle, surcharge, G-value, and base friction of the footing on the bearing capacity factors have been examined.

• Journal of Power System Engineering
• /
• v.10 no.2
• /
• pp.117-123
• /
• 2006

Woven fabrics composites are used as primary structural components in many applications because of their superior properties that offer high specific strength and stiffness. However, the complexity of the fabric structure makes understanding of their failure behavior very difficult. Also, laminate woven fabrics CFRP have unique failure mechanisms such as fiber bridging, fiber/matrix crack and so on. In particular, the delamination phenomenon of the composite materials is one of the most frequent failure mechanisms. So, we estimated interlaminar fracture and damage in composites using as ENF specimen by a 3 point bending test. And AE characteristics were examined for crack propagation on plain woven CFRP. We obtained the following conclusions from the results of the evaluation of the 3 point bending fracture test and AE characteristic estimation. AE counts of maximum crack length were obtained as $85.97{\times}10^4\;and\;93{\times}10^3\;for\;a_0/L=0.3$ and 0.6, respectively. Also the maximum amplitudes were over 80dB at both $a_0/L=0.3\;and\;0.6$. $G_{IIc}$ at that's $a_0/L$ ratio were obtained with $1.07kJ/m^2\;and\;3.79kJ/m^2$.

• Smart Structures and Systems
• /
• v.18 no.3
• /
• pp.525-540
• /
• 2016

The CFRP-confined circular concrete-filled steel tubular column is composed of concrete, steel, and CFRP. Its failure mechanics are complex. The most important difficulties are lack of an available method to establish a relationship between a specific damage mechanism and its acoustic emission (AE) characteristic parameter. In this study, AE technique was used to monitor the evolution of damage in CFRP-confined circular concrete-filled steel tubular columns. A fuzzy c-means method was developed to determine the relationship between the AE signal and failure mechanisms. Cluster analysis results indicate that the main AE sources include five types: matrix cracking, debonding, fiber fracture, steel buckling, and concrete crushing. This technology can not only totally separate five types of damage sources, but also make it easier to judge the damage evolution process. Furthermore, typical damage waveforms were analyzed through wavelet analysis based on the cluster results, and the damage modes were determined according to the frequency distribution of AE signals.

• Steel and Composite Structures
• /
• v.13 no.5
• /
• pp.473-487
• /
• 2012

An experimental study was performed to investigate the seismic performance of steel reinforced concrete (SRC) special-shaped columns. For this purpose, 17 steel reinforced concrete special-shaped column specimens under low-cyclic reversed load were tested, load process and failure patterns of the specimens with different steel reinforcement were observed. The test results showed that the failure patterns of these columns include shear-diagonal compression failure, shear-bond failure, shear-flexure failure and flexural failure. The failure mechanisms and characteristics of SRC special-shaped columns were also analyzed. For different SRC special-shaped columns, based on the failure characteristics and mechanism observed from the test, formulas for calculating ultimate shear capacity in shear-diagonal compression failure and shear-bond failure under horizontal axis and oblique load were derived. The calculated results were compared with the test results. Both the theoretical analysis and the experimental results showed that, the shear capacity of T, L shaped columns under oblique load are larger than that under horizontal axis load, whereas the shear capacity of +-shaped columns under oblique load are less than that under horizontal axis load.

• International Journal of Naval Architecture and Ocean Engineering
• /
• v.10 no.3
• /
• pp.403-412
• /
• 2018

Medium-scale tests were conducted to measure and observe the strength and failure behavior of freshwater ice rubble. A custom box measuring $3.05m{\times}0.94m{\times}0.94m$, with Plexiglas walls was built so that failure mechanisms could be observed. Ice rubble beams of nominal thickness 50 cm were produced by placing randomly sized ice pieces into the box filled with water at its freezing temperature. After the specified consolidation time, ranging between 0.2 and 70.5 h, the ice rubble beam was deformed by pushing a platen vertically downwards though the center of the beam until failure. For consolidation times less than 4 h, the ice beam failed progressively and tended to fail by shearing on macroscopic scale. At times greater than 4 h the beam failed by bending. The change in failure behaviour has been attributed to the degree of bonding between ice blocks.

• Proceedings of the Korea Concrete Institute Conference
• /
• 1999.10a
• /
• pp.609-612
• /
• 1999

This study presents the plastic analysis for the flexural and shear strength of RC beams related to anchorage failure. Five failure mechanisms based on the upper bound solution were constructed and the ultimate strength equations were formulated from them. The parametric study herein was carried out to observe the variation of the controlling failure mechanism depending on the parameters in the ultimate strength equations. The results of the parametric study show that controlling failure mechanism and ultimate strength are determined through the interaction of each parameter. This indicated that respective structural configuratins must be treated in a unified manner. Additionally this study proposes the scope of the parameter to induce the flexural of RC deep beams.

• Nuclear Engineering and Technology
• /
• v.29 no.5
• /
• pp.368-374
• /
• 1997

This paper presents a new approach to the evaluation of an accident management strategy when an operator action is involved. This approach classifies the failure in implementing a given strategy into 4 possible mechanisms, and provides their corresponding quantification methods : 1) the failure to formulate correct intention by operators, 2) the failure to take an adequate action following a correct diagnosis, 3) the failure of a system operation following an adequate action, and 4) the failure due to a delayed action. The proposed method was applied to assess a cavity flooding strategy that uses containment spray system (CSS), and the result shows that the method is more appropriate in evaluating accident management strategies when human action is involved.

• Proceedings of the KIEE Conference
• /
• 1988.07a
• /
• pp.339-342
• /
• 1988

Typical magnetic bubble propagation failure modes of ion implanted magnetic bubble computer memory devices were observed and their failure mechanisms were analize. The skidding failure mode is due to the pushing of a strong repulsive charged wall. If this pushing is stronger than the edge affinity of the bubble in the cusp, the bubble moves out of the cusp when it is supposed to stay there. The stripeout failure modes across the adjacent track or along the track can be explained by considering the relative strength of the charged wall and the edge affinity encountered by both ends of the stripe. The skipping of the first cusp of a track is believed to be due to the whipping motion of the charged wall. The bubble moves directly to the second cusp via the long charged wall pointing to the second cusp skipping the first cusp.