• 대한한의학방제학회지
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• 제13권2호
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• pp.41-57
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• 2005

This study has been carried out to understand the effect of Danchisoyosangagambang (DC) on the hyperglycemic mice induced with streptozotocin(STZ). Experimental groups were made diabetic mice by intraperitoneal injection of STZ(60 mg/kg of body weight) tw ice by 24 h interval and then 120 mg/kg STZ was injected again 3 days after the earlier treatment. Control group was administered mice with 0.9 % saline(2 mL/kg), and experim ental groups were administered DC extract(DCA group, 10 mg/kg/day; DCB group, 30 mg/kg/day) after hyperglycemic induction for 6 weeks. The body weight of experimental groups was lower than control. The blood glucose concentration increased continuously, rea ching to 298.9 mg/dL after 6 weeks, however, experimental groups of the DCA and DCB groups significantly(p<0.0l) decreased in the 4, 5, and 6 weeks groups. Blood glucose tolerance test was not significant between control and experimental groups. We examined the blood transaminase activities to know the effect of herbal medicine on liver function. The GOT activities were lower in group DCB than in control. The GPT activities were lower in group DCA and DCB than in control. The content of triglyceride was significantly increased in group DCA compared to control. The SOD and catalase activities were higher in the group DCA compared to control. The results of immunohistochemical study, a few of insulin positive cells observed in the control and experimental group. These results suggest that administration of DC extract to the hyperglycemic mice decreased the blood glucose level.

• 한방안이비인후피부과학회지
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• 제30권1호
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• pp.74-86
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• 2017

Objectives : This study aimed to assess the scientific evidence for the use of Hwanglyeonhaedok-tang, a traditional herbal formula, in the treatment of rhinitis, and prepare the basis for the investigational new drug application by analyzing the experimental studies. Methods : Ten electronic databases were searched up to December, 2016 without language limitation. Experimental studies on the anti-inflammatory and anti-allergic effects of Hwanglyeonhaedok-tang against rhinitis were included. We extracted data about study design, characteristics of intervention, outcomes, and pharmacological effects from the included studies and summarized them. Results : Eight hundred and thirty-three potentially relevant studies were identified, of which 18 experimental studies met our inclusion criteria. Of 18 included studies, 5 had conducted cell viability test, and all studies had reported that Hwanglyeonhaedok-tang was non-cytotoxic. Hwanglyeonhaedok-tang exhibits anti-inflammatory effect by regulating the inflammation-related cytokines including nitric oxide(NO), prostaglandin $E_2(PGE_2)$, interleukin-6(IL-6), and tumor necrosis $factor-{\alpha}(TNF-{\alpha})$ in vitro and in vivo. Hwanglyeonhaedok-tang exhibits anti-allergic effect by suppressing eosinophil, and histamine levels. Hwanglyeonhaedok-tang helps in the recovery of nasal mucous membrane by supressing goblet cells, heat shock protein 70, and substance P. Conclusions : This study suggests that Hwanglyeonhaedok-tang has the potential to be developed as therapeutic agent for rhinitis. Further experimental and clinical studies needed to be performed to prove the safety and efficacy.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1995년도 가을 학술발표회 논문집
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• pp.159-163
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• 1995

The purpose of this experimental research is to not only devlop the high-strength concrete using sea and river sand, but also investigatc mechanical properites of the high-strength concrete, such as the elastic modulus, the compressive strength of concrete cyllinder, and etc. Also, rational analytical formula for elastic modulus has been proposed together with those for the splitting tensile strength and the flexural strength to be predicted from compressive strength of conccrete cyllinder.

• 한국화재소방학회논문지
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• 제22권2호
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• pp.63-69
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• 2008

산불의 확산특성은 일반적으로 가연물의 특성, 지형, 바람조건과 같은 기상 상태등과 관련이 있다. 산불의 발달과정에 있어 수치해석을 통한 확산예측 모델은 열전달 과정에 기본을 둔 열에너지 전달에 대한 해석이 가장 일반적인 방법론이다. 산불의 발생시 열에너지의 전파속도를 해석하는 것은 화염의 생성과 열전달, 그리고 소멸에 이르는 전 과정에 대한 물리적, 화학적 해석을 통해 화염의 이동에 따른 전파속도로 추정할 수 있다. 본 논문에서는 고체연소물질의 표면화염전파에 대한 수치해석을 통해 1차원 지표화 확산모델식을 제시하였다. 1차원 확산모델식은 평지상태에서 풍속조건에 따른 화염의 전파속도 산정식으로써 지표연료의 화염유지시간, 화염의 높이, 화염의 온도, 지표연료의 착화온도 등에 대한 실험 및 이론식을 적용하였다. 실험값 및 다른 모델식과의 ROS 비교 결과, 풍속 3 m/s 이하의 조건에서는 지수함수식의 증가곡선을 나타내는 경향을 보였다. 침엽수종인 소나무 낙엽에 대한 수치해석값과 실험값을 비교한 결과, 풍속 1-2m/s 조건에서는 확산속도가 약 10% 상향예측이 되었고 풍속 3m/s 조건에서는 약 20% 하향예측 되었다. 따라서 앞으로 지표화 확산 예측을 위해 본 연구결과에서 얻어진 화염확산 알고리즘을 이용한 초기 산불확산 예측 적용이 가능할 것으로 사료된다.

• 한국방재안전학회논문집
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• 제12권3호
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• pp.51-57
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• 2019

최근 이상기후로 인한 집중호우, 대규모 태풍 등의 증가로 국지성 집중호우의 발생빈도가 높아지고 있다. 이로 인하여 국내 중소규모 하천의 유량이 급격하게 증가함에 따라 교량의 안전성에 영향을 미치고 있으며, 세굴에 대한 위험성도 증가하고 있다. 그러나 국내 교량건설기술에서는 교각 세굴심을 산정하기 위하여 해외의 교각 세굴심 산정식을 활용하고 있어 국내 하천의 유역특성을 반영하지 못하고 있는 실정이다. 따라서 본 연구는 세굴현상에 따른 교량피해를 예방하기 위한 기초연구로써, 수리모형실험을 통해 측정된 실험자료와 국내에 적용되고 있는 세굴 산정식들간의 비교 분석을 수행하였다. 또한 실험자료와 세굴 산정식의 통계분석을 통하여 Coleman(1971) 공식이 가장 우수하게 세굴심을 산정하고 있는 것을 확인하였다. 본 연구의 결과는 향후 하천설계 및 교량설계에 있어 보다 정확한 교각 세굴심을 산정하는데 활용 될 수 있을 것으로 기대된다.

• 전자공학회논문지
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• 제53권8호
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• pp.59-65
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• 2016

본 논문은 대량의 stream data를 처리하는 어플리케이션에서 하드웨어 가속기들이 접근하는 메모리가 non-cacheable에서 cacheable으로 변경됨에 따라 발생할 수 있는 데이터 일관성 문제를 고려하여 시스템 최적화를 진행하였다. 이를 위해 상위 수준 시뮬레이션을 통한 프로파일링 결과를 토대로 분석식을 만들어 활용하였다. 실험한 결과 여러 이미지 크기에서 메모리가 cacheable로 변경됨에 따라 평균 1.40배의 성능 향상을 보였다. 분석식의 주요 파라미터 최적화를 통해 최종적으로 3.88배의 성능 이득이 발생했으며, 항상 메모리가 cacheable인 경우의 성능이 항상 우월한 것은 아님을 확인할 수 있었다.

• 한국해양공학회지
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• 제23권2호
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• pp.1-7
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• 2009

This paper presents a sliding mode controller based on Ackermann's formula and applies it to stabilizing a two-wheeled mobile inverted pendulum in equilibrium. The mobile inverted pendulum is a system with an inverted pendulum on a mobile cart. The dynamic modeling of the mobile inverted pendulum was established under the assumptions of a cart with no slip and a pendulum with only planar motion. The proposed sliding mode controller was based upon a class of nonlinear systems whose nonlinear part of the modeling can be linearly parameterized. The sliding surface was obtained in an explicit form using Ackermann's formula, and then a control law was designed from reachability conditions and made the sliding surface attractive to the equilibrium state of the mobile inverted pendulum. The proposed controller was implemented in a Microchip PIC16F877 micro-controller. The developed overall control system is described. The simulation and experimental results are presented to show the effectiveness of the modeling and controller.

• 한국해양공학회지
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• 제23권6호
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• pp.71-76
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• 2009

This paper describes a statistical analysis method for predicting a coast fishing boat's effective horsepower. The EHP estimation method for small coast fishing boats was developed, based on a statistical regression analysis of model test results in a circulating water channel. The statistical regression formula of a fishing boat's effective horsepower is determined from the regression analysis of the resistance test results for 15 actual coast fishing boats. This method was applied to the effective horsepower prediction of a G/T 4 ton class coast fishing boat. From the estimation of the effective horsepower using this regression formula and the experimental model test of the G/T 4 ton class coast fishing boat, the estimation accuracy was verified under 10 percent of the design speed. However, the effective horsepower prediction method for coast fishing boats using the regression formula will be used at the initial design and hull-form development stage.

• Journal of Pharmaceutical Investigation
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• 제21권1호
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• pp.23-32
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• 1991

Dissolution profiles of ketoconazole in solid dispersion system (SDS) were investigated in the second fluid (pH 6.8) for the dissolution test (KPV). PVP K-30 and methyl cellulose were used as carriers in SDS, and chloroform as a solvent. Computer optimization technique was applied to obtain an optimum formula of SDS, and the following results were obtained; 1) Dissolution rate of ketoconazole in SDS was larger than that of pure ketoconazole in the second fluid of pH 6.8. 2) PVP K-30 and methyl cellulosr were good carriers for SDS of ketoconazole. Moerover PVP K-30 was better than methyl cellulose. 3) The optimum formula of ketoconazole SDS obtained from computer optimization technique was chloroform 175 ml, PVP K-30 5g and methyl cellulose 0.2g per 1g of ketoconazole. 4) The experimental value of $A_{60}$ (Amount released from ketoconazole tablet during 60 minutes) obtained from SDS by optimum formula agreed well with the value calculated by polynomial regression equation.

• Structural Engineering and Mechanics
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• 제21권4호
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• pp.407-422
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• 2005

Plate elements in fully profiled sandwich panels are generally subjected to local buckling failure modes and this behaviour is treated in design by using the conventional effective width method for plates with a width to thickness (b/t) ratio less than 100. If the plate elements are very slender (b/t > 1000), the panel failure is governed by wrinkling instead of local buckling and the strength is determined by the flexural wrinkling formula. The plate elements in fully profiled sandwich panels do not fail by wrinkling as their b/t ratio is generally in the range of 100 to 600. For this plate slenderness region, it was found that the current effective width formula overestimates the strength of the fully profiled sandwich panels whereas the wrinkling formula underestimates it. Hence a new effective width design equation has been developed for practical plate slenderness values. However, no guidelines exist to identify the plate slenderness (b/t) limits defining the local buckling, wrinkling and the intermediate regions so that appropriate design rules can be used based on plate slenderness ratios. A research study was therefore conducted using experimental and numerical studies to investigate the effect of plate slenderness ratio on the ultimate strength behaviour of foam supported steel plate elements. This paper presents the details of the study and the results.